100-07-2 | 4-Methoxybenzoyl chloride

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$25.00	$18.00
25g	97%	in stock	$45.00	$31.00
100g	97%	in stock	$128.00	$90.00
500g	97%	in stock	$381.00	$267.00

Description

• Catalog Number: AA00016
• Chemical Name: 4-Methoxybenzoyl chloride
• CAS Number: 100-07-2
• Molecular Formula: C8H7ClO2
• Molecular Weight: 170.593
• MDL Number: MFCD00000687
• SMILES: COc1ccc(cc1)C(=O)Cl
• NSC Number: 86125

Computed Properties

• Complexity: 139
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• XLogP3: 2.9

Upstream Synthesis Route

4-Methoxybenzoyl chloride, also known as p-anisoyl chloride, is a versatile chemical reagent commonly utilized in organic synthesis. Its main application lies in acylation reactions, where it serves as an acylating agent to introduce the 4-methoxybenzoyl group (-CO-PhOCH3) into various organic compounds. This reaction is particularly valuable in the production of pharmaceuticals, agrochemicals, and specialty chemicals.Additionally, 4-Methoxybenzoyl chloride can also be employed in the synthesis of esters, amides, ketones, and other functionalized compounds through various chemical transformations. Its high reactivity allows for efficient and selective acylation of nucleophiles, enabling the modification of organic molecules to impart desired properties or functionalities.Moreover, this compound finds utility in the preparation of intermediates for the synthesis of bioactive molecules, dyes, and advanced materials. Its compatibility with a wide range of reaction conditions and substrates makes it a valuable tool in the toolkit of synthetic chemists for building complex molecular structures effectively.

Literature

• 4-Meth-oxy-benzoyl-meso-octa-methyl-calix[2]pyrrolidino[2]pyrrole: an acyl chloride derivative of a partially reduced calix[4]pyrrole.

  Acta crystallographica. Section E, Structure reports online 20120401

• Hydroxybenzothiazoles as new nonsteroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1).

  PloS one 20120101

• Muscarinic receptor subtypes and signalling involved in the attenuation of isoprenaline-induced rat urinary bladder relaxation.

  Naunyn-Schmiedeberg's archives of pharmacology 20111201

• N'-(4-Methoxy-benzo-yl)pyridine-2-carbohydrazide.

  Acta crystallographica. Section E, Structure reports online 20100501

• Generating a generation of proteasome inhibitors: from microbial fermentation to total synthesis of salinosporamide a (marizomib) and other salinosporamides.

  Marine drugs 20100101

• 3-(4-Methoxy-phen-yl)isochroman-1-one.

  Acta crystallographica. Section E, Structure reports online 20081101

• Synthesis of 6-O-methyl ether of Scorzocreticin and Scorzocreticoside I, metabolites from Sorzonera cretica.

  Journal of Asian natural products research 20060101

• Solvent polarity and organic reactivity in mixed solvents: evidence using a reactive molecular probe to assess the role of preferential solvation in aqueous alcohols.

  The Journal of organic chemistry 20050304