100007-53-2 | α-Etoposide

Availability
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Description

• Catalog Number: AE16046
• Chemical Name: α-Etoposide
• CAS Number: 100007-53-2
• Molecular Formula: C29H32O13
• Molecular Weight: 588.5566
• MDL Number: MFCD11109422
• SMILES: COc1cc(cc(c1O)OC)[C@H]1[C@H]2C(=O)OC[C@@H]2[C@@H](c2c1cc1OCOc1c2)O[C@@H]1O[C@@H]2CO[C@H](O[C@H]2[C@@H]([C@@H]1O)O)C

Upstream Synthesis Route

The application of a-Etoposide in chemical synthesis lies in its ability to serve as a potent inhibitor of topoisomerase II enzymes. By binding to the DNA-topoisomerase II complex, a-Etoposide prevents the resealing of DNA strands that have been cut by the enzyme during its normal cellular functions. This disruptive action leads to the accumulation of DNA breaks and ultimately triggers cell death. In the realm of chemical synthesis, a-Etoposide can be employed as a valuable tool for understanding the mechanisms of DNA manipulation and for developing novel strategies for targeted drug design. Furthermore, the unique properties of a-Etoposide make it a valuable molecule for studying DNA-protein interactions and exploring the mechanisms of enzyme inhibition in biological systems.