1001264-89-6 | GDC-0068

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$61.00	$43.00
10mg	98%	in stock	$87.00	$61.00
25mg	98%	in stock	$207.00	$145.00
50mg	98%	in stock	$372.00	$260.00
100mg	98%	in stock	$740.00	$518.00
250mg	98%	in stock	$1,480.00	$1,036.00

Description

• Catalog Number: AA01108
• Chemical Name: GDC-0068
• CAS Number: 1001264-89-6
• Molecular Formula: C24H32ClN5O2
• Molecular Weight: 457.99618000000004
• MDL Number: MFCD22124514
• SMILES: CC(NC[C@@H](C(=O)N1CCN(CC1)c1ncnc2c1[C@H](C)C[C@H]2O)c1ccc(cc1)Cl)C

Computed Properties

• Complexity: 622
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 32
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 2.5

Upstream Synthesis Route

The compound (2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl)-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone has proven to be a valuable tool in chemical synthesis due to its unique structural features and functional groups. It can serve as a versatile building block in the creation of various pharmaceuticals and organic compounds. Through strategic manipulation of its different functional groups, this compound can be effectively incorporated into complex molecular structures, allowing for the synthesis of new and diverse chemical entities. Its combination of a substituted phenyl group, piperazine moiety, and secondary amine functionality provides a range of reactivity that can be exploited for the creation of novel chemical scaffolds.

Literature

• Discovery and preclinical pharmacology of a selective ATP-competitive Akt inhibitor (GDC-0068) for the treatment of human tumors.

  Journal of medicinal chemistry 20120927