10040-45-6 | Phenol, 4,4'-(2-pyridinylmethylene)bis-, 1,1'-bis(hydrogen sulfate), sodium salt (1:2)

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$60.00	$42.00
500mg	95%	in stock	$116.00	$81.00
1g	95%	in stock	$185.00	$130.00
5g	95.00%	in stock	$444.00	$311.00

Description

• Catalog Number: AA02312
• Chemical Name: Phenol, 4,4'-(2-pyridinylmethylene)bis-, 1,1'-bis(hydrogen sulfate), sodium salt (1:2)
• CAS Number: 10040-45-6
• Molecular Formula: C18H13NNa2O8S2
• Molecular Weight: 481.4073
• MDL Number: MFCD28009648
• SMILES: [O-]S(=O)(=O)Oc1ccc(cc1)C(c1ccccn1)c1ccc(cc1)OS(=O)(=O)[O-].[Na+].[Na+]

Computed Properties

• Complexity: 633
• Covalently-Bonded Unit Count: 3
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 5

Literature

• Comparison of patient acceptance of sodium phosphate versus polyethylene glycol plus sodium picosulfate for colon cleansing in Japanese.

  Journal of gastroenterology and hepatology 20121001

• A pilot study on the efficacy of Picolax given as a four-week course for the treatment of refractory constipation.

  Hong Kong medical journal = Xianggang yi xue za zhi 20121001

• Laxative-free CT colonography.

  The British journal of radiology 20120801

• Serial monitoring of the physiological effects of the standard Pico-Salax® regimen for colon cleansing in healthy volunteers.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20120701

• Split-dose picosulfate, magnesium oxide, and citric acid solution markedly enhances colon cleansing before colonoscopy: a randomized, controlled trial.

  Gastrointestinal endoscopy 20120301

• Laxative management in ambulatory cancer patients on opioid therapy: a prospective, open-label investigation of polyethylene glycol, sodium picosulphate and lactulose.

  European journal of cancer care 20120101

• Same-day bowel cleansing regimen is superior to a split-dose regimen over 2 days for afternoon colonoscopy: results from a large prospective series.

  Journal of clinical gastroenterology 20120101

• Same day prep for afternoon colonoscopy: everybody wins!

  Journal of clinical gastroenterology 20120101

• Budget-impact model for colonoscopy cost calculation and comparison between 2 litre PEG+ASC and sodium picosulphate with magnesium citrate or sodium phosphate oral bowel cleansing agents.

  Journal of medical economics 20120101

• Drug eruption due to sodium picosulfate.

  European journal of dermatology : EJD 20120101

• Service implications of implementing guidance for oral bowel cleansing agents in colonoscopy.

  The journal of the Royal College of Physicians of Edinburgh 20110601

• Bowel cleansing for colonoscopy: prospective randomized assessment of efficacy and of induced mucosal abnormality with three preparation agents.

  Endoscopy 20110501

• Absence of excretion of the active moiety of bisacodyl and sodium picosulfate into human breast milk: an open-label, parallel-group, multiple-dose study in healthy lactating women.

  Drug metabolism and pharmacokinetics 20110101

• Bowel preparation regimen for computed tomography colonography.

  Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes 20101201

• Evidence-based recommendations for bowel cleansing before colonoscopy in children: a report from a national working group.

  Endoscopy 20101201

• Multicenter, 4-week, double-blind, randomized, placebo-controlled trial of sodium picosulfate in patients with chronic constipation.

  The American journal of gastroenterology 20100401

• A possible troponin I leak arising from bowel preparation for elective colonoscopy - are there more implications than observed?

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20100301

• Pico-Salax versus polyethylene glycol for bowel cleanout before colonoscopy in children: a randomized controlled trial.

  Endoscopy 20091201

• A multicentre, observational study of sodium picosulfate and magnesium citrate as a precolonoscopy bowel preparation.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20091001

• [Preparation of colonoscopy: well tolerable combination preparation admitted in Germany].

  MMW Fortschritte der Medizin 20090924

• Plasma magnesium should be monitored perioperatively in patients undergoing colorectal resection.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20090701

• The rapid development of hyponatraemia and seizures in an elderly patient following sodium picosulfate/magnesium citrate (Picolax).

  Age and ageing 20090701

• Pico-salax plus two-day bisacodyl is superior to pico-salax alone or oral sodium phosphate for colon cleansing before colonoscopy.

  The American journal of gastroenterology 20090301

• Sodium picosulfate/magnesium citrate: a review of its use as a colorectal cleanser.

  Drugs 20090101

• [Optimization of perioperative management in laparoscopic hernioplasty].

  Der Anaesthesist 20080901

• A randomized controlled trial comparing the efficacy and acceptability of phospo-soda buffered saline (Fleet) with sodium picosulphate/magnesium citrate (Picoprep) in the preparation of patients for colonoscopy.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20080601

• A randomised controlled trial of a new 2 litre polyethylene glycol solution versus sodium picosulphate + magnesium citrate solution for bowel cleansing prior to colonoscopy.

  Current medical research and opinion 20080201

• OTC laxative use of sodium picosulfate â results of a pharmacy-based patient survey (cohort study).

  International journal of clinical pharmacology and therapeutics 20080201

• [Treatment with bisacodyl, picosulfate and prokinetics. Physiopathology and diagnosis of constipation].

  Pharmazie in unserer Zeit 20080101

• Factors affecting outcomes in colonoscopy.

  Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 20080101

• Comparison of colon-cleansing methods in preparation for colonoscopy--comparative efficacy of solutions of mannitol, sodium picosulfate and monobasic and dibasic sodium phosphates.

  Acta cirurgica brasileira 20080101

• Commonly used bowel preparations have significant and different effects upon cell proliferation in the colon: a pilot study.

  BMC gastroenterology 20080101

• Interaction between Shaoyao-Gancao-Tang and a laxative with respect to alteration of paeoniflorin metabolism by intestinal bacteria in rats.

  Phytomedicine : international journal of phytotherapy and phytopharmacology 20070801

• Is patient outcome affected by the administration of intravenous fluid during bowel preparation for colonic surgery?

  Annals of the Royal College of Surgeons of England 20070701

• Randomised, placebo-controlled, double-blind study to investigate the efficacy and safety of the acute use of sodium picosulphate in patients with chronic constipation.

  International journal of clinical practice 20070601

• Comparison of bisacodyl and sodium picosulphate in the treatment of chronic constipation.

  Current medical research and opinion 20070401

• A review of current issues underlying colon cleansing before colonoscopy.

  Canadian journal of gastroenterology = Journal canadien de gastroenterologie 20070201

• Randomized clinical trial comparing sodium picosulfate with mannitol on the preparation FOR colonoscopy in hospitalized patients.

  Arquivos de gastroenterologia 20070101

• [Preparation for colonoscopy using 1,000 ml Magcorol P isotonic solution in the absence of dietary restrictions or use of purgatives on the preceding day].

  Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru 20070101

• Sodium picosulfate in opioid-induced constipation: results of an open-label, prospective, dose-ranging study.

  Palliative medicine 20060601

• Which is the optimal bowel preparation for colonoscopy - a meta-analysis.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20060501

• Audit of bowel preparation with Picolax (sodium picosulfate plus magnesium citrate) for colonoscopy.

  International journal of clinical practice 20060501

• An unusual difficulty in bowel preparation for emergency colonoscopy.

  Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 20060101

• Bioavailability of glycyrrhizin from Shaoyao-Gancao-Tang in laxative-treated rats.

  The Journal of pharmacy and pharmacology 20051001

• Effects of oral sodium picosulphate Picolax on urea and electrolytes.

  Nursing standard (Royal College of Nursing (Great Britain) : 1987) 20050701

• Screening procedure for detection of stimulant laxatives and/or their metabolites in human urine using gas chromatography-mass spectrometry after enzymatic cleavage of conjugates and extractive methylation.

  Therapeutic drug monitoring 20050401

• Randomized single blind trial of two low-volume bowel preparations for screening computed tomographic colonography.

  Abdominal imaging 20050101

• Psychological well-being and symptoms in women with chronic constipation treated with sodium picosulphate.

  Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates 20050101

• Retrospective study of long-term treatment with sodium picosulfate.

  European journal of gastroenterology & hepatology 20040401

• Picoprep-3 is a superior colonoscopy preparation to Fleet: a randomized, controlled trial comparing the two bowel preparations.

  Diseases of the colon and rectum 20040201

• [Bowel preparation for colonoscopy with sodium picosulphate and magnesium citrate in children and adolescents].

  Arquivos de gastroenterologia 20040101

• Optimizing bowel preparation for multidetector row CT colonography: effect of Citramag and Picolax.

  Clinical radiology 20030901

• [Comparison of the effectiveness and tolerability of the saccharosum-sennosid-B solution and sodium-picosulfate in preparation for colonoscopy. Prospective, multicenter, randomized study].

  Orvosi hetilap 20030810

• Randomized clinical trial of intravenous fluid replacement during bowel preparation for surgery.

  The British journal of surgery 20011001

• Investigation of the effects of YM-31636, a novel 5-HT3 receptor agonist, on defecation in normal and constipated ferrets.

  European journal of pharmacology 20010720

• Analytical control of a pharmaceutical formulation of sodium picosulfate by capillary zone electrophoresis.

  Journal of chromatography. B, Biomedical sciences and applications 20010210

• The role of intestinal bacteria in the transformation of sodium picosulfate.

  Japanese journal of pharmacology 19920501

• Toxicity study with sodium picosulfate in cultured liver cells of rabbit, rat and man.

  Arzneimittel-Forschung 19810101