1006-64-0 | 2-Phenylpyrrolidine

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$6.00	$5.00
1g	98%	in stock	$17.00	$12.00
5g	98%	in stock	$34.00	$24.00
10g	98%	in stock	$67.00	$47.00
25g	98%	in stock	$167.00	$117.00
100g	98%	in stock	$667.00	$467.00

Description

• Catalog Number: AA02962
• Chemical Name: 2-Phenylpyrrolidine
• CAS Number: 1006-64-0
• Molecular Formula: C10H13N
• Molecular Weight: 147.2169
• MDL Number: MFCD01631835
• SMILES: C1CNC(C1)c1ccccc1
• NSC Number: 94961

Computed Properties

• Complexity: 116
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 1
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.8

Upstream Synthesis Route

2-Phenylpyrrolidine, also known as α-phenylpyrrolidine, is a versatile compound widely used in chemical synthesis as a key building block in the production of various pharmaceuticals, agrochemicals, and specialty chemicals. Its unique structural properties and reactivity make it a valuable precursor in the synthesis of complex organic molecules.In chemical synthesis, 2-Phenylpyrrolidine serves as a crucial intermediate for the preparation of biologically active compounds such as drugs and fine chemicals. Its incorporation into organic molecules imparts steric hindrance, asymmetric centers, and aromaticity, thereby influencing the physicochemical properties and biological activities of the final products. Additionally, its presence can enhance the potency, selectivity, and pharmacokinetic profile of pharmaceutical compounds.Due to its significance in organic synthesis, 2-Phenylpyrrolidine finds applications in the development of novel drug candidates, agrochemicals with improved efficacy, and functional materials with tailored properties. Chemists leverage its versatility to introduce structural diversity and complexity into molecular frameworks, enabling the creation of diverse chemical libraries for drug discovery and material science research.Overall, the strategic use of 2-Phenylpyrrolidine in chemical synthesis plays a pivotal role in the design and development of innovative compounds with desired biological activities and performance characteristics. Its versatile nature and ability to influence molecular structure make it an indispensable tool for advancing synthetic methodologies and enhancing the potential applications of organic chemistry in various fields.

Literature

• Highly effective asymmetric hydrogenation of cyclic N-alkyl imines with chiral cationic Ru-MsDPEN catalysts.

  Organic letters 20110819

• [Regioselectivity in the dehydrogenation of substituted ethylenediamines as nicotine models].

  Die Pharmazie 20090901

• A spectroscopic study of nicotine analogue 2-phenylpyrrolidine (PPD) using resonant two-photon ionization (R2PI), microwave, and 2D NMR techniques.

  Journal of the American Chemical Society 20090225

• Determination of the natural abundance delta15N of nicotine and related alkaloids by gas chromatography/isotope ratio mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20050101

• 1,2,5-Substituted derivatives of 2-phenylpyrrolidine.

  Acta crystallographica. Section C, Crystal structure communications 20040601

• Asymmetric alkyldifluoroboranes and their use in secondary amine synthesis.

  Organic letters 20020627