1007207-67-1 | CH5132799

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$50.00	$35.00
5mg	99%	in stock	$63.00	$44.00
10mg	99%	in stock	$94.00	$66.00
25mg	99%	in stock	$188.00	$132.00
50mg	99%	in stock	$319.00	$223.00
100mg	99%	in stock	$542.00	$379.00

Description

• Catalog Number: AA03302
• Chemical Name: CH5132799
• CAS Number: 1007207-67-1
• Molecular Formula: C15H19N7O3S
• Molecular Weight: 377.4215
• MDL Number: MFCD22419020
• SMILES: Nc1ncc(cn1)c1nc(nc2c1CCN2S(=O)(=O)C)N1CCOCC1

Computed Properties

• Complexity: 587
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• XLogP3: -0.6

Upstream Synthesis Route

CH5132799, a potent and selective inhibitor of bromodomain and extra-terminal domain (BET) proteins, plays a crucial role in chemical synthesis. By targeting BET proteins, specifically BRD4, CH5132799 inhibits the binding of BRD4 to acetylated chromatin, ultimately disrupting gene transcription and cell growth processes. This mechanism of action makes CH5132799 a valuable tool in chemical synthesis for studying epigenetic regulation and discovering new therapeutic targets. Additionally, the high potency and selectivity of CH5132799 make it a promising candidate for developing novel drug compounds with improved efficacy and safety profiles in the field of medicinal chemistry.

Literature

• Discovery and biological activity of a novel class I PI3K inhibitor, CH5132799.

  Bioorganic & medicinal chemistry letters 20110315