1008-91-9 | 1-(4-Pyridyl)piperazine

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$6.00	$5.00
5g	98%	in stock	$23.00	$17.00
10g	98%	in stock	$42.00	$30.00
100g	98%	in stock	$393.00	$275.00
500g	98%	in stock	$1,879.00	$1,316.00

Description

• Catalog Number: AA03588
• Chemical Name: 1-(4-Pyridyl)piperazine
• CAS Number: 1008-91-9
• Molecular Formula: C9H13N3
• Molecular Weight: 163.2196
• MDL Number: MFCD00040745
• SMILES: N1CCN(CC1)c1ccncc1

Computed Properties

• Complexity: 126
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• XLogP3: 0.3

Upstream Synthesis Route

1-(Pyridin-4-yl)piperazine is a versatile chemical compound widely used in chemical synthesis as a building block for various pharmaceuticals and agrochemicals. This unique molecule serves as a key intermediate in the production of several important compounds due to its structural properties and reactivity. In organic synthesis, 1-(Pyridin-4-yl)piperazine acts as a valuable starting material for the synthesis of heterocyclic compounds, which are essential in drug discovery and development. Its functional groups allow for the modification of its structure, enabling chemists to tailor its properties for specific applications. By incorporating 1-(Pyridin-4-yl)piperazine into synthesis routes, researchers can access a wide range of bioactive molecules with diverse pharmacological activities.

Literature

• Discovery of β2 Adrenergic Receptor Ligands Using Biosensor Fragment Screening of Tagged Wild-Type Receptor.

  ACS medicinal chemistry letters 20131010

• Progress in structure based drug design for G protein-coupled receptors.

  Journal of medicinal chemistry 20110714

• Piperazines for peptide carboxyl group derivatization: effect of derivatization reagents and properties of peptides on signal enhancement in matrix-assisted laser desorption/ionization mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20110315

• Complete experimental and theoretical proton and carbon nuclear magnetic resonance spectral assignments, molecular structure and conformational study of 1-cyclohexylpiperazine and 1-(4-pyridyl)piperazine.

  Magnetic resonance in chemistry : MRC 20100101

• Design and synthesis of isoform-selective phospholipase D (PLD) inhibitors. Part II. Identification of the 1,3,8-triazaspiro[4,5]decan-4-one privileged structure that engenders PLD2 selectivity.

  Bioorganic & medicinal chemistry letters 20090415

• Structure-affinity relationships of a unique nicotinic ligand: N(1)-dimethyl-N(4)-phenylpiperazinium iodide (DMPP).

  Journal of medicinal chemistry 20011108