1009298-59-2 | Azd2014

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$42.00	$29.00
5mg	95%	in stock	$62.00	$44.00
10mg	95%	in stock	$80.00	$56.00
50mg	95%	in stock	$201.00	$141.00
100mg	95%	in stock	$235.00	$165.00
250mg	95%	in stock	$441.00	$309.00
1g	95%	in stock	$1,086.00	$760.00
5g	95%	in stock	$4,303.00	$3,012.00

Description

• Catalog Number: AA03978
• Chemical Name: Azd2014
• CAS Number: 1009298-59-2
• Molecular Formula: C25H30N6O3
• Molecular Weight: 462.5441
• MDL Number: MFCD22628784
• SMILES: CNC(=O)c1cccc(c1)c1ccc2c(n1)nc(nc2N1CCOC[C@@H]1C)N1CCOC[C@@H]1C

Computed Properties

• Complexity: 698
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 2.8

Literature

• Vistusertib (dual m-TORC1/2 inhibitor) in combination with paclitaxel in patients with high-grade serous ovarian and squamous non-small-cell lung cancer.

  Annals of oncology : official journal of the European Society for Medical Oncology 20180901

• Evaluation of the combination of the dual m-TORC1/2 inhibitor vistusertib (AZD2014) and paclitaxel in ovarian cancer models.

  Oncotarget 20171226

• mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection.

  Virology 20140301

• Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.

  Bioorganic & medicinal chemistry letters 20130301

• TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

  Cell metabolism 20120502

• Mammalian autophagy: core molecular machinery and signaling regulation.

  Current opinion in cell biology 20100401

• Rapamycin fed late in life extends lifespan in genetically heterogeneous mice.

  Nature 20090716

• Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

  Current biology : CB 20040727

• Regulation of longevity and stress resistance by Sch9 in yeast.

  Science (New York, N.Y.) 20010413