10101-88-9 | Sodium thiophosphate hydrate

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$106.00	$75.00
5g	95%	in stock	$299.00	$209.00
25g	95%	in stock	$1,070.00	$749.00

Description

• Catalog Number: AA04358
• Chemical Name: Sodium thiophosphate hydrate
• CAS Number: 10101-88-9
• Molecular Formula: Na3O3PS
• Molecular Weight: 180.0063
• MDL Number: MFCD00150620
• SMILES: [O-]P(=S)([O-])[O-].[Na+].[Na+].[Na+]

Computed Properties

• Complexity: 53
• Covalently-Bonded Unit Count: 4
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 4

Upstream Synthesis Route

Trisodium thiophosphate is widely utilized in chemical synthesis as a versatile reagent with diverse applications. In organic chemistry, it serves as a key component in the preparation of various pharmaceuticals, agrochemicals, and specialty chemicals. Its ability to act as a reducing agent and a sulfur-transfer reagent makes it valuable in a wide range of reactions, including desulfurization processes and the synthesis of sulfur-containing compounds. Additionally, Trisodium thiophosphate is commonly employed in the production of metal thiophosphates, which are essential precursors for catalysts, materials science, and solid-state chemistry. Its unique properties make it an indispensable tool for researchers and professionals in the field of chemical synthesis.

Literature

• Metabonomics evaluation of urine from rats administered with phorate under long-term and low-level exposure by ultra-performance liquid chromatography-mass spectrometry.

  Journal of applied toxicology : JAT 20140201

• Thiophosphate and selenite conversely modulate cell death induced by glutathione depletion or cisplatin: effects related to activity and Sec contents of thioredoxin reductase.

  The Biochemical journal 20121001

• Stereocontrolled solid-phase synthesis of phosphorothioate oligoribonucleotides using 2'-O-(2-cyanoethoxymethyl)-nucleoside 3'-O-oxazaphospholidine monomers.

  The Journal of organic chemistry 20120921

• Theoretical study on steric effects of DNA phosphorothioation: B-helical destabilization in Rp-phosphorothioated DNA.

  The journal of physical chemistry. B 20120906

• Effects of primer containing silane and thiophosphate monomers on bonding resin to a leucite-reinforced ceramic.

  Journal of dentistry 20120501

• Phosphorus-containing dendrimers against α-synuclein fibril formation.

  International journal of biological macromolecules 20120501

• Is hair analysis for dialkyl phosphate metabolites a suitable biomarker for assessing past acute exposure to organophosphate pesticides?

  Human & experimental toxicology 20120301

• Phosphorothioic acids and related compounds as surrogates for H2S--synthesis of chiral tetrahydrothiophenes.

  Journal of the American Chemical Society 20120208

• Enhanced light-activated RNA interference using phosphorothioate-based dsRNA precursors of siRNA.

  Pharmaceutical research 20111201

• Palladacycle-promoted solvolytic cleavage of O,O-dimethyl O-aryl phosphorothioates. Converting a phosphorane-like transition state to an observable intermediate.

  Inorganic chemistry 20110815

• Rearrangement of lithiated S-alkyl O,O-dialkyl thiophosphates: scope and stereochemistry of the thiophosphate-mercaptophosphonate rearrangement.

  Organic & biomolecular chemistry 20110721

• Efficient synthesis of 3-O-thia-cPA and preliminary analysis of its biological activity toward autotaxin.

  Bioorganic & medicinal chemistry letters 20110715

• Determination of 14 monoalkyl phosphates, dialkyl phosphates and dialkyl thiophosphates by LC-MS/MS in human urinary samples.

  The Science of the total environment 20110415

• The effect of divalent cations on the catalytic activity of the human plasma 3'-exonuclease.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20101201

• Cleavage of phosphorothioated DNA and methylated DNA by the type IV restriction endonuclease ScoMcrA.

  PLoS genetics 20101201

• Development of a class-specific immunochromatographic strip test for the rapid detection of organophosphorus pesticides with a thiophosphate group.

  Hybridoma (2005) 20100801

• One-flask syntheses of c-di-GMP and the [Rp,Rp] and [Rp,Sp] thiophosphate analogues.

  Organic letters 20100716

• Thiophosphorylation of free amino acids and enzyme protein by thiophosphoramidate ions.

  Bioorganic chemistry 20100401

• Identification of thioaptamer ligand against E-selectin: potential application for inflamed vasculature targeting.

  PloS one 20100101

• The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation.

  Science (New York, N.Y.) 20090717

• Determination and estimation of partitioning properties for substituted phosphates and thiophosphates.

  Environmental monitoring and assessment 20090501

• Thiophosphate analogs of c-di-GMP: impact on polymorphism.

  Nucleosides, nucleotides & nucleic acids 20090501

• Stereocontrolled synthesis of oligoribonucleoside phosphorothioates by an oxazaphospholidine approach.

  Organic letters 20090219

• Determination of dialkyl phosphates as breakdown products of organophosphorus insecticides in fruit juices by HPTLC with fluorescence detection.

  Journal of AOAC International 20090101

• Thermolytic release of covalently linked DNA oligonucleotides and their conjugates from controlled-pore glass at near neutral pH.

  Bioconjugate chemistry 20080801

• Synthesis of S-glycosyl thiophosphates, thiophosphonates and thiophosphinates by the Michaelis-Arbuzov rearrangement of anomeric thiocyanates.

  Carbohydrate research 20080317

• Deoxygenated phosphorothioate inositol phosphate analogs: synthesis, phosphatase stability, and binding affinity.

  Bioorganic & medicinal chemistry 20080315

• Glycosidations of 2-deoxy glycosyl dithiophosphates using a tagged iodine(III)-promoter for simple purification.

  Organic & biomolecular chemistry 20080307

• Role of ionization of the phosphate cosubstrate on phosphorolysis by purine nucleoside phosphorylase (PNP) of bacterial (E. coli) and mammalian (human) origin.

  European biophysics journal : EBJ 20080201

• Kinetics and mechanism of the aminolysis of aryl ethyl chloro and chlorothio phosphates with anilines.

  Organic & biomolecular chemistry 20071221

• Comparative pharmacokinetics of the organophosphorus insecticide chlorpyrifos and its major metabolites diethylphosphate, diethylthiophosphate and 3,5,6-trichloro-2-pyridinol in the rat.

  Toxicology 20070731

• Kinetics and mechanism of the aminolysis of aryl phenyl chlorothiophosphates with anilines.

  The Journal of organic chemistry 20070720

• Biodegradation of chlorferon and diethylthiophosphate by consortia enriched from waste cattle dip solution.

  Bioresource technology 20070701

• HDV ribozyme activity in monovalent cations.

  Biochemistry 20060926

• Channel phosphorylation and modulation of L-type Ca2+ currents by cytosolic Mg2+ concentration.

  American journal of physiology. Cell physiology 20060701

• Mechanism of the Escherichia coli DNA T:G-mismatch endonuclease (Vsr protein) probed with thiophosphate-containing oligodeoxynucleotides.

  Journal of molecular biology 20051028

• Determination of chlorpyrifos metabolites in human urine by reversed-phase/weak anion exchange liquid chromatography-electrospray ionisation-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050805

• Antisense recognition of the HER-2 mRNA: effects of phosphorothioate substitution and polyamines on DNA.RNA, RNA.RNA, and DNA.DNA duplex stability.

  Biochemistry 20050111

• Electrochemical detoxification of four phosphorothioate obsolete pesticides stocks.

  Chemosphere 20050101

• The 4-methylthio-1-butyl group for phosphate/thiophosphate protection in oligodeoxyribonucleotide synthesis.

  Current protocols in nucleic acid chemistry 20041201

• Reductive transformation of methyl parathion by the cyanobacterium Anabaena sp. strain PCC7120.

  Applied microbiology and biotechnology 20040801

• A comparative study of the hydrolysis pathways of substituted aryl phosphoramidate versus aryl thiophosphoramidate derivatives of stavudine.

  European journal of medicinal chemistry 20040801

• Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid.

  Bioorganic & medicinal chemistry letters 20040705

• Pre-steady-state kinetics of RB69 DNA polymerase and its exo domain mutants: effect of pH and thiophosphoryl linkages on 3'-5' exonuclease activity.

  Biochemistry 20040406

• Thermolytic 4-methylthio-1-butyl group for phosphate/thiophosphate protection in solid-phase synthesis of DNA oligonucleotides.

  The Journal of organic chemistry 20040402

• Tris(2-carboxyethyl)phosphine stabilization of RNA: comparison with dithiothreitol for use with nucleic acid and thiophosphoryl chemistry.

  Analytical biochemistry 20040201

• Thermolytic properties of 3-(2-pyridyl)-1-propyl and 2-[N-methyl-N-(2-pyridyl)]aminoethyl phosphate/thiophosphate protecting groups in solid-phase synthesis of oligodeoxyribonucleotides.

  The Journal of organic chemistry 20031226

• 3-(N-tert-butylcarboxamido)-1-propyl and 4-oxopentyl groups for phosphate/thiophosphate protection in oligodeoxyribonucleotide synthesis.

  Current protocols in nucleic acid chemistry 20030201

• Selective enrichment of sulfides, thiols and methylthiophosphates from water samples on metal-loaded cation-exchange materials for gas chromatographic analysis.

  Journal of chromatography. A 20020830

• Metal ion-catalyzed nucleic acid alkylation and fragmentation.

  Journal of the American Chemical Society 20020710

• Nucleotide affinity for a stable phosphorylated intermediate of nucleoside diphosphate kinase.

  Protein science : a publication of the Protein Society 20020701

• Effect of solute-co-ordinating solvent interactions and temperature on the EPR and electronic spectra of bis(dithiophosphato)copper(II).

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020401

• Stereochemistry at phosphorus of the reaction catalyzed by myo-inositol monophosphatase.

  Journal of medicinal chemistry 20020314

• Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L. protects human fibroblasts but not human tumour cells in vitro against ionizing radiation.

  International journal of radiation biology 20020101

• Kinetic comparison of tissue non-specific and placental human alkaline phosphatases expressed in baculovirus infected cells: application to screening for Down's syndrome.

  BMC biochemistry 20020101

• Synthesis and biochemical characterization of a phosphorylated analogue of the response regulator CheB.

  Biochemistry 20011030

• Negative ion chemical ionization GC/MS-MS analysis of dialkylphosphate metabolites of organophosphate pesticides in urine of non-occupationally exposed subjects.

  The Analyst 20010701

• Novel 3',5'-cyclic nucleotide analogue: adenosine 3',5'-cyclic boranomonophosphate.

  Organic letters 20010322