1011301-27-1 | Tenovin-3

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$17.00	$12.00
5mg	98%	in stock	$21.00	$15.00
10mg	98%	in stock	$28.00	$19.00
25mg	98%	in stock	$35.00	$25.00
50mg	98%	in stock	$42.00	$30.00

Description

• Catalog Number: AA04745
• Chemical Name: Tenovin-3
• CAS Number: 1011301-27-1
• Molecular Formula: C18H21N3OS
• Molecular Weight: 327.4438
• MDL Number: MFCD25976437
• SMILES: S=C(NC(=O)c1ccc(cc1)C(C)(C)C)Nc1ccc(cc1)N

Computed Properties

• Complexity: 417
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 23
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 3
• XLogP3: 4.5

Upstream Synthesis Route

Tenovin-3 is a potent small molecule inhibitor that has shown remarkable potential in the field of chemical synthesis. This compound has gained significant interest due to its ability to target and modulate sirtuin enzymes, specifically SIRT1 and SIRT2, which are crucial regulators of various cellular processes. Tenovin-3's unique mechanism of action involves disrupting the deacetylation activity of sirtuins, leading to alterations in gene expression and protein function.In the realm of chemical synthesis, Tenovin-3 serves as a valuable tool for researchers and chemists looking to manipulate cellular pathways and explore new therapeutic targets. By inhibiting sirtuin activity, this compound can influence the acetylation levels of histone proteins, ultimately impacting gene transcription and epigenetic regulation. This ability to modify gene expression patterns makes Tenovin-3 a versatile agent for studying cellular signaling pathways and investigating the underlying mechanisms of various diseases.Furthermore, Tenovin-3's role in chemical synthesis extends beyond basic research applications. Its targeted inhibition of sirtuins has also shown promising results in the development of novel drug candidates and therapeutic interventions. By affecting key cellular processes, such as DNA repair, cell cycle regulation, and apoptosis, Tenovin-3 offers potential avenues for designing innovative treatments for cancer, neurodegenerative disorders, and other diseases characterized by dysregulated sirtuin activity.Overall, Tenovin-3 represents a valuable asset in the toolbox of chemists and researchers, providing a versatile platform for exploring the complex interplay of molecular pathways in chemical synthesis and advancing our understanding of disease mechanisms.

Literature

• SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity.

  Bioorganic & medicinal chemistry letters 20120701