10130-87-7 | 2-Methoxybenzenesulfonyl chloride

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$5.00	$4.00
250mg	98%	in stock	$10.00	$7.00
1g	98%	in stock	$15.00	$11.00
5g	98%	in stock	$38.00	$27.00
10g	98%	in stock	$52.00	$37.00
25g	98%	in stock	$99.00	$70.00
100g	98%	in stock	$360.00	$252.00

Description

• Catalog Number: AA05217
• Chemical Name: 2-Methoxybenzenesulfonyl chloride
• CAS Number: 10130-87-7
• Molecular Formula: C7H7ClO3S
• Molecular Weight: 206.6467
• MDL Number: MFCD01961367
• SMILES: COc1ccccc1S(=O)(=O)Cl

Computed Properties

• Complexity: 232
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• XLogP3: 1.9

Upstream Synthesis Route

2-Methoxybenzenesulfonyl chloride, also known as mesyl chloride, is a versatile reagent used in chemical synthesis for a variety of applications. This compound plays a crucial role in organic chemistry as a sulfonylating agent, allowing for the introduction of the mesyl group (-SO2Cl) into organic molecules.One of the primary uses of 2-Methoxybenzenesulfonyl chloride is in the protection of alcohols and amines. By reacting with these functional groups, mesyl chloride forms stable sulfonyl derivatives, thereby blocking their reactivity towards other reagents. This protective group strategy is commonly employed in multi-step organic synthesis to control the selectivity of reactions and prevent unwanted side reactions.Additionally, mesyl chloride is frequently utilized in the preparation of sulfonamides, sulfonates, and sulfones. These compounds are important intermediates in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. The mesyl group can serve as a leaving group in substitution reactions, allowing for the facile formation of carbon-sulfur bonds and enabling the construction of complex molecular structures.Furthermore, 2-Methoxybenzenesulfonyl chloride is a valuable reagent in the synthesis of heterocyclic compounds, such as benzothiazoles and benzimidazoles. The mesyl group can participate in intramolecular cyclization reactions, promoting the formation of diverse ring systems with desired functionalities.Overall, the application of 2-Methoxybenzenesulfonyl chloride in chemical synthesis extends to protecting functional groups, generating sulfonamide derivatives, facilitating carbon-sulfur bond formation, and promoting heterocyclic ring closure reactions. Its versatility and reactivity make it an indispensable tool for organic chemists seeking to design and construct complex molecules with specific properties and functions.

Literature

• 4-Methyl-2-oxo-2H-chromen-7-yl 4-meth-oxy-benzene-sulfonate.

  Acta crystallographica. Section E, Structure reports online 20111201

• N-{[4-(4-Meth-oxy-benzene-sulfonamido)-phen-yl]sulfon-yl}acetamide.

  Acta crystallographica. Section E, Structure reports online 20100701