10147-37-2 | Isopropylsulfonyl chloride

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$10.00	$7.00
5g	98%	in stock	$24.00	$17.00
10g	98%	in stock	$38.00	$27.00
25g	98%	in stock	$62.00	$44.00
100g	98%	in stock	$204.00	$143.00
500g	98%	in stock	$713.00	$499.00

Description

• Catalog Number: AA05719
• Chemical Name: Isopropylsulfonyl chloride
• CAS Number: 10147-37-2
• Molecular Formula: C3H7ClO2S
• Molecular Weight: 142.6045
• MDL Number: MFCD00007453
• SMILES: CC(S(=O)(=O)Cl)C

Computed Properties

• Complexity: 130
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• XLogP3: 1.2

Upstream Synthesis Route

Isopropanesulfonyl chloride is a versatile reagent commonly used in organic synthesis for the installation of sulfonyl groups onto various functional groups. This compound serves as an effective sulfonylating agent due to its high reactivity and compatibility with a wide range of nucleophiles. In chemical reactions, isopropanesulfonyl chloride can act as an electrophile, reacting with nucleophiles such as amines, alcohols, and thiols to form corresponding sulfonamide, sulfonate ester, and sulfonate products, respectively. This reagent is particularly useful in the protection of amines during multi-step organic synthesis, where the sulfonyl group can be easily removed under mild conditions to regenerate the free amine. Additionally, isopropanesulfonyl chloride can be employed in the construction of diverse bioactive molecules, pharmaceutical intermediates, and agrochemicals, making it a valuable tool in the field of chemical synthesis.

Literature

• Concerted solvent processes for common sulfonyl chloride precursors used in the synthesis of sulfonamide-based drugs.

  International journal of molecular sciences 20080501

• Rate and product studies in the solvolyses of N,N-dimethylsulfamoyl and 2-propanesulfonyl chlorides.

  Organic & biomolecular chemistry 20060421