1022150-57-7 | Sgx-523

Packsize	Purity	Availability	Price	Discounted Price
1mg	98+%	in stock	$12.00	$9.00
2mg	98+%	in stock	$20.00	$14.00
5mg	98+%	in stock	$30.00	$21.00
10mg	98+%	in stock	$43.00	$30.00
25mg	98%(HPLC)	in stock	$103.00	$73.00
50mg	98+%	in stock	$114.00	$80.00
250mg	98+%	in stock	$300.00	$210.00

Description

• Catalog Number: AE11333
• Chemical Name: Sgx-523
• CAS Number: 1022150-57-7
• Molecular Formula: C18H13N7S
• Molecular Weight: 359.4077
• MDL Number: MFCD16660190
• SMILES: Cn1ncc(c1)c1ccc2n(n1)c(nn2)Sc1ccc2c(c1)cccn2

Computed Properties

• Complexity: 494
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• XLogP3: 2.4

Literature

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Comprehensive analysis of kinase inhibitor selectivity.

  Nature biotechnology 20111030

• Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry.

  Chemistry & biology 20101124

• MET kinase inhibitor SGX523 synergizes with epidermal growth factor receptor inhibitor erlotinib in a hepatocyte growth factor-dependent fashion to suppress carcinoma growth.

  Cancer research 20100901

• Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications.

  Drug metabolism and disposition: the biological fate of chemicals 20100801

• An orally bioavailable c-Met kinase inhibitor potently inhibits brain tumor malignancy and growth.

  Anti-cancer agents in medicinal chemistry 20100101

• SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo.

  Molecular cancer therapeutics 20091201