1025065-69-3 | Sgi-1776

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$8.00	$5.00
5mg	98%	in stock	$16.00	$11.00
10mg	98%	in stock	$24.00	$17.00
25mg	98%	in stock	$41.00	$29.00
50mg	98%	in stock	$68.00	$48.00
100mg	98%	in stock	$114.00	$80.00
250mg	98%	in stock	$193.00	$136.00
1g	98%	in stock	$520.00	$364.00

Description

• Catalog Number: AA09657
• Chemical Name: Sgi-1776
• CAS Number: 1025065-69-3
• Molecular Formula: C20H22F3N5O
• Molecular Weight: 405.4168
• MDL Number: MFCD16659064
• SMILES: CN1CCC(CC1)CNc1ccc2n(n1)c(cn2)c1cccc(c1)OC(F)(F)F

Computed Properties

• Complexity: 529
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 4.3

Literature

• Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies.

  Journal of medicinal chemistry 20151112

• Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.

  ACS medicinal chemistry letters 20131212

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma.

  Blood 20121025

• Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy.

  Journal of medicinal chemistry 20121011

• Targeting PIM kinase activity significantly augments the efficacy of cytarabine.

  British journal of haematology 20120101

• The Pim kinases: new targets for drug development.

  Current drug targets 20111201

• PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells.

  Oncotarget 20111201

• Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma.

  British journal of cancer 20111108

• Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.

  Blood 20110721

• Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells.

  Blood 20091105

• Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes.

  Molecular cancer therapeutics 20091001