1025720-94-8 | BMS-777607

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$27.00	$19.00
5mg	95%	in stock	$80.00	$56.00
10mg	95%	in stock	$133.00	$93.00
25mg	95%	in stock	$319.00	$223.00
50mg	95%	in stock	$499.00	$350.00

Description

• Catalog Number: AA09885
• Chemical Name: BMS-777607
• CAS Number: 1025720-94-8
• Molecular Formula: C25H19ClF2N4O4
• Molecular Weight: 512.8926
• MDL Number: MFCD16495773
• SMILES: CCOc1ccn(c(=O)c1C(=O)Nc1ccc(c(c1)F)Oc1ccnc(c1Cl)N)c1ccc(cc1)F

Computed Properties

• Complexity: 867
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 36
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 7
• XLogP3: 4

Upstream Synthesis Route

BMS-777607 is a potent and selective inhibitor of the Met kinase, making it a valuable tool in chemical synthesis applications. Met kinase plays a crucial role in various cellular processes, including cell proliferation, survival, and motility. By inhibiting Met kinase with BMS-777607, researchers can effectively modulate these processes to study their impact on chemical reactions and pathway regulation. This compound is instrumental in the development of innovative synthetic methodologies and the exploration of new chemical pathways. Its high specificity and efficacy make it an indispensable resource for advancing the field of chemical synthesis.

Literature

• Prevention of BMS-777607-induced polyploidy/senescence by mTOR inhibitor AZD8055 sensitizes breast cancer cells to cytotoxic chemotherapeutics.

  Molecular oncology 20140501

• Identification of potent Yes1 kinase inhibitors using a library screening approach.

  Bioorganic & medicinal chemistry letters 20130801

• Impact of the small molecule Met inhibitor BMS-777607 on the metastatic process in a rodent tumor model with constitutive c-Met activation.

  Clinical & experimental metastasis 20120301

• Constitutively active c-Met kinase in PC-3 cells is autocrine-independent and can be blocked by the Met kinase inhibitor BMS-777607.

  BMC cancer 20120101

• Design, Synthesis and Biological Evaluation of a Series of Novel Axl Kinase Inhibitors.

  ACS medicinal chemistry letters 20111208

• BMS-777607, a small-molecule met kinase inhibitor, suppresses hepatocyte growth factor-stimulated prostate cancer metastatic phenotype in vitro.

  Molecular cancer therapeutics 20100601

• Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.

  Journal of medicinal chemistry 20090312