1028327-66-3 | VUF 10460

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$24.00	$17.00
5mg	98%	in stock	$61.00	$43.00
10mg	98%	in stock	$103.00	$72.00
25mg	98%	in stock	$204.00	$143.00
50mg	98%	in stock	$344.00	$241.00
100mg	98%	in stock	$582.00	$408.00

Description

• Catalog Number: AE28674
• Chemical Name: VUF 10460
• CAS Number: 1028327-66-3
• Molecular Formula: C15H19N5
• Molecular Weight: 269.3449
• MDL Number: MFCD00055218
• SMILES: CN1CCN(CC1)c1nc(N)nc(c1)c1ccccc1

Computed Properties

• Complexity: 297
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 20
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 1.8

Literature

• Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.

  Bioorganic & medicinal chemistry letters 20110915

• Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.

  Journal of medicinal chemistry 20081023

• Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.

  Journal of medicinal chemistry 20081023