1029044-16-3 | Pexidartinib

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$45.00	$32.00
25mg	98%	in stock	$119.00	$83.00
100mg	98%	in stock	$159.00	$111.00
250mg	98%	in stock	$256.00	$179.00
1g	95%	in stock	$779.00	$545.00
5g	98%	in stock	$3,713.00	$2,599.00

Description

• Catalog Number: AB52268
• Chemical Name: Pexidartinib
• CAS Number: 1029044-16-3
• Molecular Formula: C20H15ClF3N5
• Molecular Weight: 417.8148
• MDL Number: MFCD28900745
• SMILES: Clc1cnc2c(c1)c(c[nH]2)Cc1ccc(nc1)NCc1ccc(nc1)C(F)(F)F

Computed Properties

• Complexity: 537
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 5
• XLogP3: 4.5

Literature

• Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor.

  The New England journal of medicine 20150730

• Synovial colony-stimulating factor-1 mRNA expression in diffuse pigmented villonodular synovitis.

  Clinical and experimental rheumatology 20110101

• Molecular pathways involved in synovial cell inflammation and tumoral proliferation in diffuse pigmented villonodular synovitis.

  Autoimmunity reviews 20100901

• Translocation and expression of CSF1 in pigmented villonodular synovitis, tenosynovial giant cell tumor, rheumatoid arthritis and other reactive synovitides.

  The American journal of surgical pathology 20070601