10297-73-1 | 4-Methylsulphonylacetophenone

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$6.00	$4.00
10g	97%	in stock	$7.00	$5.00
25g	97%	in stock	$13.00	$9.00
100g	97%	in stock	$32.00	$22.00
500g	97%	in stock	$156.00	$109.00

Description

• Catalog Number: AB66022
• Chemical Name: 4-Methylsulphonylacetophenone
• CAS Number: 10297-73-1
• Molecular Formula: C9H10O3S
• Molecular Weight: 198.2389
• MDL Number: MFCD00025072
• SMILES: CC(=O)c1ccc(cc1)S(=O)(=O)C
• NSC Number: 403928

Computed Properties

• Complexity: 279
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• XLogP3: 0.9

Upstream Synthesis Route

4'-(Methylsulfonyl)acetophenone is a versatile organic compound that finds significant application in chemical synthesis. Its unique structure makes it a valuable building block in the creation of various pharmaceuticals, agrochemicals, and fine chemicals.One of the key uses of 4'-(Methylsulfonyl)acetophenone is as a starting material for the synthesis of different sulfur-containing compounds. By utilizing the methylsulfonyl group, chemists can introduce sulfur atoms into the molecular structure, leading to the formation of compounds with diverse properties and functionalities. This compound serves as a key intermediate in the preparation of sulfonamide derivatives, which are important in medicinal chemistry.Additionally, 4'-(Methylsulfonyl)acetophenone is employed in the synthesis of chiral ligands and catalysts. Its presence in the molecular structure can impart specific stereochemical properties, making it useful in asymmetric synthesis and catalysis. This compound plays a crucial role in the development of new methodologies for organic transformations and the production of enantiomerically pure compounds.Furthermore, 4'-(Methylsulfonyl)acetophenone can be utilized as a masking group for carbonyl compounds in organic synthesis. The methylsulfonyl moiety can protect a carbonyl functionality from unwanted reactions, allowing selective modifications in multi-step synthetic sequences. This property makes it a valuable tool in the construction of complex organic molecules and natural product synthesis.Overall, the versatility and reactivity of 4'-(Methylsulfonyl)acetophenone make it a valuable reagent in chemical synthesis, enabling the preparation of diverse functionalized compounds with applications across various fields of chemistry.

Literature

• Rational determination of transfer free energies of small drugs across the water-oil interface.

  Journal of medicinal chemistry 20020103