103321-49-9 | Fmoc-Gly-Cl

Packsize	Purity	Availability	Price	Discounted Price
250mg	95%	in stock	$20.00	$14.00
1g	95%	in stock	$51.00	$36.00
5g	98%(GC)	in stock	$157.00	$110.00
25g	95%	in stock	$625.00	$438.00

Description

• Catalog Number: AD80643
• Chemical Name: Fmoc-Gly-Cl
• CAS Number: 103321-49-9
• Molecular Formula: C17H14ClNO3
• Molecular Weight: 315.7510
• MDL Number: MFCD00235814
• SMILES: ClC(=O)CNC(=O)OCC1c2ccccc2c2c1cccc2

Computed Properties

• Complexity: 406
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 22
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• XLogP3: 3.6

Upstream Synthesis Route

Fmoc-Gly-Cl, also known as Fmoc-Glycine Chloride, is a versatile reagent widely used in chemical synthesis for its ability to introduce a glycine moiety into peptide and organic molecule synthesis. As a chlorinated derivative of Fmoc-protected glycine, Fmoc-Gly-Cl serves as an important building block in solid-phase peptide synthesis (SPPS) and solution-phase synthesis.In SPPS, Fmoc-Gly-Cl is utilized in the stepwise assembly of peptides on a solid support, allowing for the controlled elongation of the peptide chain. By selectively deprotecting the N-terminal Fmoc group of the bound amino acid and coupling with Fmoc-Gly-Cl, the glycine residue is efficiently incorporated into the growing peptide chain. This strategic use of Fmoc-Gly-Cl enables the synthesis of complex peptides with precise control over sequence and length.Furthermore, Fmoc-Gly-Cl finds applications in solution-phase peptide synthesis, where it can be used to functionalize amino groups of various molecules for the synthesis of peptidomimetics and peptide conjugates. The chloride group on Fmoc-Gly-Cl can undergo nucleophilic substitution reactions to introduce glycine functionalities onto diverse chemical scaffolds, expanding the scope of its synthetic utility.Overall, Fmoc-Gly-Cl plays a crucial role in the synthesis of peptides and peptidomimetics by offering a straightforward and efficient method for incorporating glycine residues. Its compatibility with both solid-phase and solution-phase synthesis methods makes it a valuable tool for chemists and researchers working in the field of peptide chemistry and drug discovery.