1035270-39-3 | Azd4547

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%	in stock	$44.00	$31.00
25mg	95%	in stock	$105.00	$74.00
50mg	95%	in stock	$140.00	$98.00
100mg	95%	in stock	$201.00	$141.00
1g	95%	in stock	$1,400.00	$980.00

Description

• Catalog Number: AE11127
• Chemical Name: Azd4547
• CAS Number: 1035270-39-3
• Molecular Formula: C26H33N5O3
• Molecular Weight: 463.57192
• MDL Number: MFCD22580423
• SMILES: COc1cc(CCc2[nH]nc(c2)NC(=O)c2ccc(cc2)N2C[C@H](C)N[C@@H](C2)C)cc(c1)OC

Computed Properties

• Complexity: 622
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 2
• Heavy Atom Count: 34
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 8
• XLogP3: 3.9

Upstream Synthesis Route

The compound $name$ is a versatile key intermediate in chemical synthesis, playing a crucial role in the creation of diverse organic molecules. Its unique structure, featuring a rel-N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl]-4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]benzamide framework, allows for selective functionalization and generation of novel chemical entities. In the realm of chemical synthesis, this compound serves as a valuable building block for the construction of complex molecular architectures through strategic alteration of its reactive sites. Its structural motifs enable the introduction of various functional groups, facilitating the formation of structurally diverse compounds with tailored properties and applications. This compound's utility in chemical synthesis lies in its ability to undergo transformations that lead to the synthesis of new materials, pharmaceuticals, agrochemicals, and other important chemical products.

Literature

• Design, synthesis and biological evaluation of novel FGFR inhibitors bearing an indazole scaffold.

  Organic & biomolecular chemistry 20150728

• Transforming fusions of FGFR and TACC genes in human glioblastoma.

  Science (New York, N.Y.) 20120907

• AZD4547: an orally bioavailable, potent, and selective inhibitor of the fibroblast growth factor receptor tyrosine kinase family.

  Cancer research 20120415