1038915-60-4 | (S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide

Packsize	Purity	Availability	Price	Discounted Price
5mg	98%	in stock	$25.00	$18.00
10mg	98%	in stock	$33.00	$23.00
100mg	98%	in stock	$97.00	$68.00
1g	98%	in stock	$915.00	$641.00

Description

• Catalog Number: AB51426
• Chemical Name: (S)-2-(4-(Piperidin-3-yl)phenyl)-2h-indazole-7-carboxamide
• CAS Number: 1038915-60-4
• Molecular Formula: C19H20N4O
• Molecular Weight: 320.3883
• MDL Number: MFCD17779309
• SMILES: NC(=O)c1cccc2c1nn(c2)c1ccc(cc1)[C@@H]1CCCNC1

Computed Properties

• Complexity: 449
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 24
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 2.2

Literature

• The Role of PARP Inhibitors in the Treatment of Gynecologic Malignancies.

  Frontiers in oncology 20130101

• Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors.

  Cancer research 20121101

• PARP inhibitors: its role in treatment of cancer.

  Chinese journal of cancer 20110701

• Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP.

  Journal of hematology & oncology 20110101

• Discovery of 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.

  Journal of medicinal chemistry 20091126

• Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

  The New England journal of medicine 20090709

• Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase.

  Nature 20050414

• Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy.

  Nature 20050414