10444-89-0 | 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$22.00	$15.00
1g	97%	in stock	$24.00	$17.00
5g	97%	in stock	$58.00	$41.00
10g	97%	in stock	$94.00	$66.00
25g	97%	in stock	$183.00	$129.00
100g	97%	in stock	$573.00	$402.00

Description

• Catalog Number: AB61144
• Chemical Name: 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole
• CAS Number: 10444-89-0
• Molecular Formula: C3H2F3N3S
• Molecular Weight: 169.1283
• MDL Number: MFCD00003109
• SMILES: FC(c1nnc(s1)N)(F)F
• NSC Number: 231655

Computed Properties

• Complexity: 127
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 10
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 1
• XLogP3: 0.9

Upstream Synthesis Route

5-(Trifluoromethyl)-1,3,4-thiadiazol-2-amine is a versatile compound widely used in chemical synthesis. Its unique molecular structure makes it an important building block for the synthesis of various biologically active molecules and pharmaceutical compounds. This compound is commonly employed as a reactive intermediate in the production of organic compounds due to its ability to undergo various chemical transformations. In particular, its trifluoromethyl group enhances the compound's reactivity and influences the properties of the final product. In organic synthesis, 5-(Trifluoromethyl)-1,3,4-thiadiazol-2-amine serves as a key component in the development of new drugs, agrochemicals, and materials with specialized properties. Its application extends to the creation of heterocyclic frameworks, which are essential structural motifs in many natural and synthetic compounds. Additionally, this compound plays a crucial role in the preparation of fluorinated organic molecules, which are valuable in medicinal chemistry and materials science.

Literature

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• 2-Amino-5-trifluoromethyl-1,3,4-thiadiazole and a redetermination of 2-amino-1,3,4-thiadiazole, both at 120 K: chains of edge-fused R(2)(2)(8) and R(4)(4)(10) rings, and sheets of R(2)(2)(8) and R(6)(6)(20) rings.

  Acta crystallographica. Section C, Crystal structure communications 20060101