1044870-39-4 | 2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$16.00	$11.00
5mg	95%	in stock	$22.00	$15.00
10mg	95%	in stock	$28.00	$19.00
50mg	95%	in stock	$63.00	$44.00
100mg	95%	in stock	$114.00	$80.00
250mg	95%	in stock	$170.00	$119.00
1g	95%	in stock	$463.00	$324.00
5g	95%	in stock	$1,878.00	$1,315.00

Description

• Catalog Number: AB60832
• Chemical Name: 2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one
• CAS Number: 1044870-39-4
• Molecular Formula: C20H22N2O5
• Molecular Weight: 370.3991
• MDL Number: MFCD18633270
• SMILES: OCCOc1c(C)cc(cc1C)c1nc2cc(OC)cc(c2c(=O)[nH]1)OC

Computed Properties

• Complexity: 543
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 2.3

Upstream Synthesis Route

RVX-208, also known as apabetalone, is a compound that has gained recognition in the field of chemical synthesis for its unique capabilities. This compound has shown significant potential in catalyzing various chemical reactions, making it a valuable tool for synthetic chemists.One of the key applications of RVX-208 in chemical synthesis is as a versatile catalyst in organic reactions. Its structure allows it to effectively facilitate transformations such as C-C bond formations, oxidation reactions, and rearrangements. This makes RVX-208 particularly useful in the development of new drugs, agrochemicals, and other specialty chemicals.Moreover, RVX-208 has shown promise in promoting environmentally friendly practices in chemical synthesis. By enabling efficient and selective reactions, it can help reduce the formation of unwanted byproducts and minimize waste generation. This aligns with the growing emphasis on sustainability and green chemistry principles in the modern chemical industry.In addition to its catalytic properties, RVX-208 has demonstrated good compatibility with a wide range of substrates and reaction conditions. This flexibility makes it a valuable asset for researchers and synthetic chemists working on diverse projects that require precise control over reaction outcomes.Overall, RVX-208 represents a powerful tool in the toolbox of synthetic chemists, offering a promising avenue for the development of novel compounds and the advancement of synthetic methodologies. Its versatility, efficiency, and eco-friendly characteristics make it a standout candidate for application in various chemical synthesis processes.

Literature

• A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice.

  Atherosclerosis 20140901

• RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.

  Proceedings of the National Academy of Sciences of the United States of America 20131203

• RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist.

  PloS one 20130101

• ApoA-I induction as a potential cardioprotective strategy: rationale for the SUSTAIN and ASSURE studies.

  Cardiovascular drugs and therapy 20120401

• RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.

  Journal of the American College of Cardiology 20100608

• RVX-208, a stimulator of apolipoprotein AI gene expression for the treatment of cardiovascular diseases.

  Current opinion in investigational drugs (London, England : 2000) 20100301