1044870-39-4 | 2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	in stock	$7.00	$5.00
5mg	99%	in stock	$11.00	$8.00
10mg	99%	in stock	$15.00	$11.00
50mg	99%	in stock	$41.00	$29.00
250mg	95%	in stock	$178.00	$124.00
1g	95%	in stock	$463.00	$324.00
5g	98%	in stock	$1,910.00	$1,337.00

Description

• Catalog Number: AB60832
• Chemical Name: 2-(4-(2-Hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3H)-one
• CAS Number: 1044870-39-4
• Molecular Formula: C20H22N2O5
• Molecular Weight: 370.3991
• MDL Number: MFCD18633270
• SMILES: OCCOc1c(C)cc(cc1C)c1nc2cc(OC)cc(c2c(=O)[nH]1)OC

Computed Properties

• Complexity: 543
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 27
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 6
• XLogP3: 2.3

Literature

• A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice.

  Atherosclerosis 20140901

• RVX-208, an inhibitor of BET transcriptional regulators with selectivity for the second bromodomain.

  Proceedings of the National Academy of Sciences of the United States of America 20131203

• RVX-208, an inducer of ApoA-I in humans, is a BET bromodomain antagonist.

  PloS one 20130101

• ApoA-I induction as a potential cardioprotective strategy: rationale for the SUSTAIN and ASSURE studies.

  Cardiovascular drugs and therapy 20120401

• RVX-208: a small molecule that increases apolipoprotein A-I and high-density lipoprotein cholesterol in vitro and in vivo.

  Journal of the American College of Cardiology 20100608

• RVX-208, a stimulator of apolipoprotein AI gene expression for the treatment of cardiovascular diseases.

  Current opinion in investigational drugs (London, England : 2000) 20100301