10465-78-8 | Diamide

Packsize	Purity	Availability	Price	Discounted Price
1g	95%	in stock	$16.00	$11.00
10g	95%	in stock	$20.00	$14.00
25g	95%	in stock	$39.00	$27.00
50g	95%	in stock	$74.00	$52.00
100g	95%	in stock	$142.00	$99.00

Description

• Catalog Number: AB76658
• Chemical Name: Diamide
• CAS Number: 10465-78-8
• Molecular Formula: C6H12N4O2
• Molecular Weight: 172.1851
• MDL Number: MFCD00008318
• SMILES: CN(C(=O)/N=N/C(=O)N(C)C)C
• NSC Number: 143013

Computed Properties

• Complexity: 188
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 2
• XLogP3: 0.2

Literature

• Mitochondrial Thioredoxin System as a Modulator of Cyclophilin D Redox State.

  Scientific reports 20160101

• Modulation of the expression of ryanodine receptor mRNA from Plutella xylostella as a result of diamide insecticide application.

  Gene 20121215

• Dipole relaxation in erythrocyte membrane: involvement of spectrin skeleton.

  Bioelectrochemistry (Amsterdam, Netherlands) 20121201

• Sterol analogues with diamide side chains interfere with the intracellular localization of viral glycoproteins.

  Biochemical and biophysical research communications 20121012

• Short synthesis of diamide-linked sucrose macrocycles.

  Organic letters 20120817

• Synthesis and insecticidal activities of novel anthranilic diamides containing acylthiourea and acylurea.

  Journal of agricultural and food chemistry 20120808

• Protein S-glutathionylation enhances Ca2+-induced Ca2+ release via the IP3 receptor in cultured aortic endothelial cells.

  The Journal of physiology 20120801

• Chemical radioprotection and radiosensitization of Mammalian cells growing in vitro. 1973.

  Radiation research 20120801

• Delineation of the molecular mechanism for disulfide stress-induced aluminium toxicity.

  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20120601

• Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides.

  Bioorganic & medicinal chemistry letters 20120601

• Novel diamide insecticides: sulfoximines, sulfonimidamides and other new sulfonimidoyl derivatives.

  Bioorganic & medicinal chemistry letters 20120601

• p38(MAPK) and ERK1/2 dictate cell death/survival response to different pro-oxidant stimuli via p53 and Nrf2 in neuroblastoma cells SH-SY5Y.

  Biochemical pharmacology 20120515

• Gliotoxin effects on fungal growth: mechanisms and exploitation.

  Fungal genetics and biology : FG & B 20120401

• Characterization of a putative thioredoxin peroxidase prx1 of Candida albicans.

  Molecules and cells 20120331

• Plastidic phosphoglycerate kinase from Phaeodactylum tricornutum: on the critical role of cysteine residues for the enzyme function.

  Protist 20120301

• Glutathione is required by Rhizobium etli for glutamine utilization and symbiotic effectiveness.

  Molecular plant-microbe interactions : MPMI 20120301

• Genetic basis of hidden phenotypic variation revealed by increased translational readthrough in yeast.

  PLoS genetics 20120301

• Reversible heterochiral aggregation/dissociation of bis(2-hydroxyphenyl)diamides driven by UV/Vis irradiation.

  Angewandte Chemie (International ed. in English) 20120227

• A synthetic lipid A mimetic modulates human TLR4 activity.

  ChemMedChem 20120206

• Synthesis and biochemical analysis of 2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoro-N-hydroxy-octanediamides as inhibitors of human histone deacetylases.

  Bioorganic & medicinal chemistry 20120115

• SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production.

  Biochemical and biophysical research communications 20120106

• Baseline susceptibilities of B- and Q-biotype Bemisia tabaci to anthranilic diamides in Arizona.

  Pest management science 20120101

• Oxidant-mediated modification of the cellular thiols is sufficient for arginase activation in cultured cells.

  Molecular and cellular biochemistry 20120101

• Successful long-term preservation of rat sperm by freeze-drying.

  PloS one 20120101

• Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.

  Science (New York, N.Y.) 20111202

• IκBα glutathionylation and reduced histone H3 phosphorylation inhibit eotaxin and RANTES.

  The European respiratory journal 20111201

• Fe (III) complexes of a bis-benzimidazolyl diamide ligand: spectral and catalytic studies.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111201

• Dimerization of human 5-lipoxygenase.

  Biological chemistry 20111201

• The Rho kinase inhibitor Y-27632 increases erythrocyte deformability and low oxygen tension-induced ATP release.

  American journal of physiology. Heart and circulatory physiology 20111101

• Pyridinium-based symmetrical diamides as chemosensors in visual sensing of citrate through indicator displacement assay (IDA) and gel formation.

  Organic & biomolecular chemistry 20111007

• Differential oxidant tolerance determined by the key transcription factor Yap1 is controlled by levels of the Yap1-binding protein, Ybp1.

  The Journal of biological chemistry 20110930

• Basis for half-site ligand binding in yeast NAD(+)-specific isocitrate dehydrogenase.

  Biochemistry 20110927

• Regulation of chaperone gene expression by heat shock transcription factor in Saccharomyces cerevisiae: importance in normal cell growth, stress resistance, and longevity.

  FEBS letters 20110902

• A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities.

  European journal of medicinal chemistry 20110901

• Synthesis, spectral and catalytic activity of some manganese(II) bis-benzimidazole diamide complexes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901

• Lopinavir shows greater specificity than zinc finger ejecting compounds as a potential treatment for human papillomavirus-related lesions.

  Antiviral research 20110801

• Enantiopure cyclic O-substituted phenylphosphonothioic acid: synthesis and chirality-recognition ability.

  Chirality 20110701

• An antioxidant screening assay based on oxidant-induced growth arrest in Saccharomyces cerevisiae.

  FEMS yeast research 20110601

• Diamide amino-imidazoles: a novel series of γ-secretase inhibitors for the treatment of Alzheimer's disease.

  Bioorganic & medicinal chemistry letters 20110501

• Involvement of riboflavin kinase expression in cellular sensitivity against cisplatin.

  International journal of oncology 20110401

• Clusterin (apolipoprotein J), a molecular chaperone that facilitates degradation of the copper-ATPases ATP7A and ATP7B.

  The Journal of biological chemistry 20110325

• Imaging in real-time with FRET the redox response of tumorigenic cells to glutathione perturbations in a microscale flow.

  Integrative biology : quantitative biosciences from nano to macro 20110301

• Oxidative stress response and virulence factors in Candida glabrata clinical isolates.

  Folia microbiologica 20110301

• Cooperative binding and stabilization of the medicinal pigment curcumin by diamide linked γ-cyclodextrin dimers: a spectroscopic characterization.

  The journal of physical chemistry. B 20110210

• Transmetalation reactions of a scandium complex supported by a ferrocene diamide ligand.

  Inorganic chemistry 20110207

• Effect of protein S-glutathionylation on Ca2+ homeostasis in cultured aortic endothelial cells.

  American journal of physiology. Heart and circulatory physiology 20110201

• Synthesis and spectral studies of copper complexes using a N-octylated bis benzimidazole diamide ligand.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110201

• Strategies to enhance signal intensity with paramagnetic fluorine-labelled lanthanide complexes as probes for 19F magnetic resonance.

  Dalton transactions (Cambridge, England : 2003) 20110128

• Construction and analyses of tetrameric forms of yeast NAD+-specific isocitrate dehydrogenase.

  Biochemistry 20110118

• Modulation of membrane-bound glutathione transferase activity by phospholipids including cardiolipin.

  Biological & pharmaceutical bulletin 20110101

• Different reactive oxygen species lead to distinct changes of cellular metal ions in the eukaryotic model organism Saccharomyces cerevisiae.

  International journal of molecular sciences 20110101

• Mechanism of catalytic cyclohydroamination by zirconium salicyloxazoline complexes.

  Journal of the American Chemical Society 20101103

• Importance of ligand bioactive conformation in the discovery of potent indole-diamide inhibitors of the hepatitis C virus NS5B.

  Journal of the American Chemical Society 20101103

• Synthesis, gastroprotective effect and cytotoxicity of new amino acid diterpene monoamides and diamides.

  Molecules (Basel, Switzerland) 20101021

• Reactions of aromatic N-heterocycles with d0fn-metal alkyl complexes supported by chelating diamide ligands.

  Accounts of chemical research 20101019

• Thiol-oxidation reduces the release of amylase induced by β-adrenergic receptor activation in rat parotid acinar cells.

  Biomedical research (Tokyo, Japan) 20101001

• A novel PVC-membrane optical sensor for highly sensitive and selective determination of UO2(2+) ion based on a recently synthesized benzo-substituted macrocyclic diamide and dibenzoylmethane.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100915

• The redox state of the glutathione/glutathione disulfide couple mediates intracellular arginase activation in HCT-116 colon cancer cells.

  Digestive diseases and sciences 20100901

• The redox-sensing regulator YodB senses quinones and diamide via a thiol-disulfide switch in Bacillus subtilis.

  Proteomics 20100901

• Diamide decreases deformability of rabbit erythrocytes and attenuates low oxygen tension-induced ATP release.

  Experimental biology and medicine (Maywood, N.J.) 20100901

• Peroxiredoxin-2 expression is increased in beta-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress.

  Free radical biology & medicine 20100801

• The dynamic behavior of chemically 'stiffened' red blood cells in microchannel flows.

  Microvascular research 20100701

• Inactivation of Ca2+/calmodulin-dependent protein kinase I by S-glutathionylation of the active-site cysteine residue.

  FEBS letters 20100603

• The sigmaR regulon of Streptomyces coelicolor A32 reveals a key role in protein quality control during disulphide stress.

  Microbiology (Reading, England) 20100601

• Solvent-dependent self-discrimination of bis(2-hydroxyphenyl)diamides.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20100503

• Synthesis and bradykinin inhibitory activity of novel non-peptide compounds, and evaluation of in vivo analgesic activity.

  Bioorganic & medicinal chemistry 20100315

• Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity.

  Archiv der Pharmazie 20100301

• Synthesis and characterization of long-chain tartaric acid diamides as novel ceramide-like compounds.

  Molecules (Basel, Switzerland) 20100205

• The control of S-thiolation by cysteine via gamma-glutamyltranspeptidase and thiol exchanges in erythrocytes and plasma of diamide-treated rats.

  Toxicology and applied pharmacology 20100201

• Regulation of vascular smooth muscle cell bioenergetic function by protein glutathiolation.

  Biochimica et biophysica acta 20100201

• Synthesis and structure-activity relationships of novel furazan-3,4-diamide analogs as potent anti-cancer agents.

  Bioorganic & medicinal chemistry letters 20100201

• Discovery of benzimidazole-diamide finger loop (Thumb Pocket I) allosteric inhibitors of HCV NS5B polymerase: Implementing parallel synthesis for rapid linker optimization.

  Bioorganic & medicinal chemistry letters 20100101

• In cystic fibrosis homozygotes and heterozygotes, neutrophil apoptosis is delayed and modulated by diamide or roscovitine: evidence for an innate neutrophil disturbance.

  Journal of innate immunity 20100101

• RNA polymerase mapping during stress responses reveals widespread nonproductive transcription in yeast.

  Genome biology 20100101

• Lead-selective poly(vinyl chloride) electrodes based on some synthesized benzo-substituted macrocyclic diamides.

  Journal of hazardous materials 20091215

• The Saccharomyces cerevisiae YMR315W gene encodes an NADP(H)-specific oxidoreductase regulated by the transcription factor Stb5p in response to NADPH limitation.

  New biotechnology 20091031

• Synthesis and SAR of alkanediamide-linked bisbenzamidines with anti-trypanosomal and anti-pneumocystis activity.

  Bioorganic & medicinal chemistry letters 20091015

• On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences.

  Journal of medicinal chemistry 20090924

• Ineffective GSH regeneration enhances G6PD-knockdown Hep G2 cell sensitivity to diamide-induced oxidative damage.

  Free radical biology & medicine 20090901

• Oxidative stress induces a reversible flux of cysteine from tissues to blood in vivo in the rat.

  The FEBS journal 20090901

• Network of hydrogen bonds in Pro-Ala-Pro and Pro-Phe-Pro diamides: a first principles study of Ala-->Phe point mutation in proline environment.

  The Journal of chemical physics 20090721

• The role of cytosolic proteins in the insertion of tail-anchored proteins into phospholipid bilayers.

  Journal of cell science 20090715

• Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.

  Toxicology and applied pharmacology 20090615

• Two cys or not two cys? That is the question; alternative oxidase in the thermogenic plant sacred Lotus.

  Plant physiology 20090601

• One-pot syntheses of dissymmetric diamides based on the chemistry of cyclic monothioanhydrides. Scope and limitations and application to the synthesis of glycodipeptides.

  The Journal of organic chemistry 20090515

• FKBP12.6 binding of ryanodine receptors carrying mutations associated with arrhythmogenic cardiac disease.

  The Biochemical journal 20090415

• Crystal structures and spectroscopic properties of ester amide and diamide of squaric acid with prolinamide.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090401

• Oxidized and poorly glycosylated band 3 is selectively phosphorylated by Syk kinase to form large membrane clusters in normal and G6PD-deficient red blood cells.

  The Biochemical journal 20090301

• Protein kinase A regulates production of virulence determinants by the entomopathogenic fungus, Metarhizium anisopliae.

  Fungal genetics and biology : FG & B 20090301

• Escherichia coli O157 : H7 glutamate- and arginine-dependent acid-resistance systems protect against oxidative stress during extreme acid challenge.

  Microbiology (Reading, England) 20090301

• 5-S-GAD, a novel radical scavenging compound, prevents lens opacity development.

  Free radical biology & medicine 20090215

• Gamma-glutamyl transferase in the cell wall participates in extracellular glutathione salvage from the root apoplast.

  The New phytologist 20090101

• The thiol-oxidizing agent diamide reduces isoproterenol-stimulated amylase release in rat parotid acinar cells.

  The journal of medical investigation : JMI 20090101

• Glutathione oxidation as a trigger of mitochondrial depolarization and oscillation in intact hearts.

  Journal of molecular and cellular cardiology 20081101

• Effect of glycyrrhetinic acid on membrane band 3 in human erythrocytes.

  Archives of biochemistry and biophysics 20081101

• Novel function of glutathione transferase in rat liver mitochondrial membrane: role for cytochrome c release from mitochondria.

  Toxicology and applied pharmacology 20081001

• Complex I within oxidatively stressed bovine heart mitochondria is glutathionylated on Cys-531 and Cys-704 of the 75-kDa subunit: potential role of CYS residues in decreasing oxidative damage.

  The Journal of biological chemistry 20080905

• Regulation of the catalytic activity and structure of human thioredoxin 1 via oxidation and S-nitrosylation of cysteine residues.

  The Journal of biological chemistry 20080808

• Ultraviolet-A irradiation but not ultraviolet-B or infrared-A irradiation leads to a disturbed zinc homeostasis in cells.

  Free radical biology & medicine 20080701

• The mitogen-activated protein kinase MpkA of Aspergillus fumigatus regulates cell wall signaling and oxidative stress response.

  Fungal genetics and biology : FG & B 20080501

• S-glutathionylation of metallothioneins by nitrosative/oxidative stress.

  Experimental gerontology 20080501

• Evidence for transcriptional and post-translational regulation of sucrose synthase in pea nodules by the cellular redox state.

  Molecular plant-microbe interactions : MPMI 20080501

• The mechanism of ureido-pyrimidinone:2,7-diamido-naphthyridine complexation and the presence of kinetically controlled pathways in multicomponent hydrogen-bonded systems.

  Journal of the American Chemical Society 20080423

• Novel C2-symmetric macrocycles bearing diamide-diester groups: synthesis and enantiomeric recognition for primary alkyl ammonium salts.

  The Journal of organic chemistry 20080404

• Regulation of quinone detoxification by the thiol stress sensing DUF24/MarR-like repressor, YodB in Bacillus subtilis.

  Molecular microbiology 20080301

• Proteomic signatures uncover thiol-specific electrophile resistance mechanisms in Bacillus subtilis.

  Expert review of proteomics 20080201

• Chiral mono and diamide derivatives of calix[4]arene for enantiomeric recognition of chiral amines.

  Chirality 20080101

• Double affinity amplification of galectin-ligand interactions through arginine-arene interactions: synthetic, thermodynamic, and computational studies with aromatic diamido thiodigalactosides.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20080101

• Methods for the study of redox-mediated changes in p53 structure and function.

  Methods in molecular biology (Clifton, N.J.) 20080101

• Pyruvate-sensitive AOX exists as a non-covalently associated dimer in the homeothermic spadix of the skunk cabbage, Symplocarpus renifolius.

  FEBS letters 20071222

• Targeted disruption of the glutaredoxin 1 gene does not sensitize adult mice to tissue injury induced by ischemia/reperfusion and hyperoxia.

  Free radical biology & medicine 20071101

• Thiazole-diamides as potent gamma-secretase inhibitors.

  Bioorganic & medicinal chemistry letters 20071015

• Quantifying the intrinsic effects of two point mutation models of proline-proline diamino acid diamide: a first-principle computational study.

  The journal of physical chemistry. B 20071004

• S-cysteinylation is a general mechanism for thiol protection of Bacillus subtilis proteins after oxidative stress.

  The Journal of biological chemistry 20070907

• Novel use of the fluorescent dye 5-(and-6)-chloromethyl SNARF-1 acetate for the measurement of intracellular glutathione in leukemic cells and primary lymphocytes.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20070901

• Role of heat shock transcription factor in Saccharomyces cerevisiae oxidative stress response.

  Eukaryotic cell 20070801

• Human p53 is inhibited by glutathionylation of cysteines present in the proximal DNA-binding domain during oxidative stress.

  Biochemistry 20070703

• Cross-linked SecA dimers are not functional in protein translocation.

  FEBS letters 20070612

• On the cytotoxicity and status of oxidative stress of two novel synthesized tri-aza macrocyclic diamides as studied in the V79 cell lines.

  Bioorganic & medicinal chemistry 20070515

• Redox sensitivity of the ryanodine receptor interaction with FK506-binding protein.

  The Journal of biological chemistry 20070309

• Synthesis, spectral and oxidase studies of a new diamide copper(II) complex with pendant benzimidazolyl groups.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070201

• Mitochondrial recycling of ascorbic acid as a mechanism for regenerating cellular ascorbate.

  BioFactors (Oxford, England) 20070101

• Dynamic monitoring of glutathione in erythrocytes, without a separation step, in the presence of an oxidant insult.

  Analytical chemistry 20061215

• Mitochondrial thioredoxin in regulation of oxidant-induced cell death.

  FEBS letters 20061211

• Effect of beta-O-glucosylation on L-Ser and L-Thr diamides: a bias toward alpha-helical conformations.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20061016

• Redox regulation of human OGG1 activity in response to cellular oxidative stress.

  Molecular and cellular biology 20061001

• Transcriptional activation of dehalorespiration. Identification of redox-active cysteines regulating dimerization and DNA binding.

  The Journal of biological chemistry 20060908

• Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis.

  Free radical biology & medicine 20060815

• Use of microchip-based hydrodynamic focusing to measure the deformation-induced release of ATP from erythrocytes.

  The Analyst 20060801

• Combining the enantioselectivities of L-valine diamide and permethylated beta-cyclodextrin in one gas chromatographic chiral stationary phase.

  Analytical chemistry 20060715

• Reducing and oxidizing agents sensitize heat-activated vanilloid receptor (TRPV1) current.

  Molecular pharmacology 20060701

• Oxidized forms of glutathione in peripheral blood as biomarkers of oxidative stress.

  Clinical chemistry 20060701

• Use of tert-butylbenzoylated tartardiamide chiral stationary phase for the enantiomeric resolution of acidic compounds by nano-liquid chromatography.

  Journal of separation science 20060701

• Diamide stress induces a metallothionein BmtA through a repressor BxmR and is modulated by Zn-inducible BmtA in the cyanobacterium Oscillatoria brevis.

  Toxicology letters 20060601

• An altered oxidant defense system in red blood cells affects their ability to release nitric oxide-stimulating ATP.

  Molecular bioSystems 20060601

• Accumulation of deoxynivalenol and its 15-acetylated form is significantly modulated by oxidative stress in liquid cultures of Fusarium graminearum.

  FEMS microbiology letters 20060501

• Catalytic asymmetric desymmetrization of meso-diamide derivatives through enantioselective N-allylation with a chiral pi-allyl Pd catalyst: improvement and reversal of the enantioselectivity.

  The Journal of organic chemistry 20060317

• Cadmium-induced astroglial death proceeds via glutathione depletion.

  Journal of neuroscience research 20060201

• Regulation of plant alternative oxidase activity: a tale of two cysteines.

  Biochimica et biophysica acta 20060201

• Phthalic acid diamides activate ryanodine-sensitive Ca2+ release channels in insects.

  Cell calcium 20060101

• Membrane skeletal protein S-glutathionylation and hemolysis in human red blood cells.

  Blood cells, molecules & diseases 20060101

• Triose phosphate isomerase deficiency is caused by altered dimerization--not catalytic inactivity--of the mutant enzymes.

  PloS one 20060101

• Enhanced oxidative stress by L-ascorbic acid within cells challenged by hydrogen peroxide.

  Journal of nutritional science and vitaminology 20051201

• Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex.

  The Journal of biological chemistry 20051125

• A novel thiol oxidation-based mechanism for adriamycin-induced cell injury in human macrophages.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20051101

• Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat-TAR interactions: squaryldiamide as a new potential bioisostere of unsubstituted guanidine.

  Bioorganic & medicinal chemistry letters 20051001

• Fluorescence thiol modification assay: oxidatively modified proteins in Bacillus subtilis.

  Molecular microbiology 20051001

• Peptide and peptidomimetic chiral selectors in liquid chromatography.

  Journal of separation science 20051001

• Synthesis and structure of diamido ether uranium(IV) and thorium(IV) halide 'ate' complexes and their conversion to salt-free bis(alkyl) complexes.

  Dalton transactions (Cambridge, England : 2003) 20050921

• Effector-induced Syk-mediated phosphorylation in human erythrocytes.

  Biochimica et biophysica acta 20050815

• Decreased susceptibility of differentiated PC12 cells to oxidative challenge: relationship to cellular redox and expression of apoptotic protease activator factor-1.

  Cell death and differentiation 20050801

• Biphasic lindane-induced oxidation of glutathione and inhibition of gap junctions in myometrial cells.

  Toxicological sciences : an official journal of the Society of Toxicology 20050801

• Selective modifiers of glutathione prevent restoration of photorelaxations in mouse gastric fundus.

  Fundamental & clinical pharmacology 20050801

• Tautomerism and 1H, 13C and 15N NMR spectral assignments of some nitro derivatives of malonic acid diamide.

  Magnetic resonance in chemistry : MRC 20050701

• Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs.

  The Journal of biological chemistry 20050624

• Cytosolic NADH redox and thiol oxidation regulate pulmonary arterial force through ERK MAP kinase.

  American journal of physiology. Lung cellular and molecular physiology 20050601

• S-glutathionylation in human platelets by a thiol-disulfide exchange-independent mechanism.

  Free radical biology & medicine 20050601

• Identification by site-directed mutagenesis and chemical modification of three vicinal cysteine residues in rat mitochondrial carnitine/acylcarnitine transporter.

  The Journal of biological chemistry 20050520

• Redox regulation of the transcriptional repressor Bach1.

  Free radical biology & medicine 20050515

• Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

  The Journal of biological chemistry 20050513

• Bacillus subtilis paraquat resistance is directed by sigmaM, an extracytoplasmic function sigma factor, and is conferred by YqjL and BcrC.

  Journal of bacteriology 20050501

• 'Zn-link': a metal-sharing interface that organizes the quaternary structure and catalytic site of the endoribonuclease, RNase E.

  Biochemistry 20050329

• First principle computational study on the full conformational space of L-proline diamides.

  The journal of physical chemistry. A 20050324

• Regulation of mitochondrial NADP+-dependent isocitrate dehydrogenase activity by glutathionylation.

  The Journal of biological chemistry 20050318

• Elementary supramolecular chemistry in the gas phase: ligand exchange reactions of proton-bound clusters of aliphatic amides and diamides with amines.

  Physical chemistry chemical physics : PCCP 20050307

• Role of mitochondrial permeability transition pore in coated-platelet formation.

  Arteriosclerosis, thrombosis, and vascular biology 20050201

• Sensitivities of the alternative respiratory components of potato tuber mitochondria to thiol reagents and Ca2+.

  Plant physiology and biochemistry : PPB 20050101

• Band 3 tyr-phosphorylation in normal and glucose-6-phospate dehydrogenase-deficient human erythrocytes.

  Molecular membrane biology 20050101

• Comparison of gene expression signatures of diamide, H2O2 and menadione exposed Aspergillus nidulans cultures--linking genome-wide transcriptional changes to cellular physiology.

  BMC genomics 20050101

• Spatial activities and induction of glutamate-cysteine ligase (GCL) in the postimplantation rat embryo and visceral yolk sac.

  Toxicological sciences : an official journal of the Society of Toxicology 20041001

• Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis.

  Cell death and differentiation 20040801

• Interaction of selenium compounds with zinc finger proteins involved in DNA repair.

  European journal of biochemistry 20040801

• Thiol oxidation-mediated cell death in Aplysia cultured sensory neurons.

  Brain research 20040508

• Glycogenolysis is directed towards ascorbate synthesis by glutathione conjugation.

  Biochemical and biophysical research communications 20040423

• Oxidative stress inhibits ionomycin-mediated cell death in cortical neurons.

  Journal of neuroscience research 20040401

• YBP1 and its homologue YBP2/YBH1 influence oxidative-stress tolerance by nonidentical mechanisms in Saccharomyces cerevisiae.

  Eukaryotic cell 20040401

• Regulation of annexin A2 by reversible glutathionylation.

  The Journal of biological chemistry 20040227

• Effect of reducing and oxidizing agents and pH on malt endoproteolytic activities and brewing mashes.

  Journal of agricultural and food chemistry 20031203

• Tolerance of the mouse sperm nuclei to freeze-drying depends on their disulfide status.

  Biology of reproduction 20031201

• Expression of the trxA gene for thioredoxin 1 in Rhodobacter sphaeroides during oxidative stress.

  Archives of microbiology 20031201

• Actin S-glutathionylation: evidence against a thiol-disulphide exchange mechanism.

  Free radical biology & medicine 20031115

• Induction of apoptosis without redox catastrophe by thioredoxin-inhibitory compounds.

  Biochemical pharmacology 20031101

• Rapid stimulation of free glucuronate formation by non-glucuronidable xenobiotics in isolated rat hepatocytes.

  The Journal of biological chemistry 20030919

• The thioltransferase (glutaredoxin) 1 gene of fission yeast is regulated by Atf1 and Pap1.

  Molecules and cells 20030831

• Protective roles of mitochondrial manganese-containing superoxide dismutase against various stresses in Candida albicans.

  Yeast (Chichester, England) 20030801

• Post-treatment with a novel PARG inhibitor reduces infarct in cerebral ischemia in the rat.

  Brain research 20030718

• Hydrogen peroxide inhibits insulin signaling in vascular smooth muscle cells.

  Experimental biology and medicine (Maywood, N.J.) 20030701

• [Redox-dependent changes in structure and function of hHSF1].

  Sheng wu hua xue yu sheng wu wu li xue bao Acta biochimica et biophysica Sinica 20030601

• Thiols are main determinants of total antioxidant capacity of cellular homogenates.

  Free radical research 20030501

• Reversible inactivation of alpha-ketoglutarate dehydrogenase in response to alterations in the mitochondrial glutathione status.

  Biochemistry 20030415

• Aluminium-responsive genes in sugarcane: identification and analysis of expression under oxidative stress.

  Journal of experimental botany 20030401

• Differential inhibitory action of two azoic compounds against arenaviruses.

  International journal of antimicrobial agents 20030401

• Identification and characterization of a diamide sensitive mutant of Mycobacterium smegmatis.

  FEMS microbiology letters 20030328

• Failure to increase glucose consumption through the pentose-phosphate pathway results in the death of glucose-6-phosphate dehydrogenase gene-deleted mouse embryonic stem cells subjected to oxidative stress.

  The Biochemical journal 20030315

• The cytokine macrophage migration inhibitory factor reduces pro-oxidative stress-induced apoptosis.

  Journal of immunology (Baltimore, Md. : 1950) 20030315

• Use of diamide-acridine orange fluorescence staining to detect aberrant protamination of human-ejaculated sperm nuclei.

  Fertility and sterility 20030301

• MRP1-transfected cells do not show increased resistance against oxidative stress.

  Free radical research 20030201

• Visualization of the compartmentalization of glutathione and protein-glutathione mixed disulfides in cultured cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030101

• Effects of internal hydrogen bonds between amide groups: protonation of alicyclic diamides.

  European journal of mass spectrometry (Chichester, England) 20030101

• Dopamine biosynthesis is regulated by S-glutathionylation. Potential mechanism of tyrosine hydroxylast inhibition during oxidative stress.

  The Journal of biological chemistry 20021213

• Dual effect of oxidative stress on NF-kappakB activation in HeLa cells.

  Experimental & molecular medicine 20021130

• Regulation of cAMP-dependent protein kinase activity by glutathionylation.

  The Journal of biological chemistry 20021108

• Bcl-xL interrupts oxidative activation of neutral sphingomyelinase.

  FEBS letters 20021023

• Ab initio conformational space study of model compounds of O-glycosides of serine diamide.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20021018

• Role of critical thiol groups on the matrix surface of the adenine nucleotide translocase in the mechanism of the mitochondrial permeability transition pore.

  The Biochemical journal 20021015

• A putative role for S-nitrosoglutathione as the source of nitric oxide in photorelaxation of the mouse gastric fundus.

  European journal of pharmacology 20020830

• Role of the extracytoplasmic-function sigma factor sigma(H) in Mycobacterium tuberculosis global gene expression.

  Molecular microbiology 20020701

• Role of acetyl-coenzyme A synthetase in leaves of Arabidopsis thaliana.

  Archives of biochemistry and biophysics 20020615

• Modeling apoptotic chromatin condensation in normal cell nuclei. Requirement for intranuclear mobility and actin involvement.

  The Journal of biological chemistry 20020614

• Apoptosis in mitotic competent undifferentiated cells is induced by cellular redox imbalance independent of reactive oxygen species production.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020601

• Oxidative stress mediates cell surface expression of SS-A/Ro antigen on keratinocytes.

  Free radical biology & medicine 20020515

• Novel diamide-based inhibitors of IMPDH.

  Bioorganic & medicinal chemistry letters 20020506

• [The role of thiol oxidants in inhibition of pancreatic exocrine secretory function and glutathione].

  Zhonghua nei ke za zhi 20020501

• [Diamide and cyclosporin A enhanced arsenic trioxide-induced apoptosis in NB4 cells].

  Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20020501

• Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

  The Journal of biological chemistry 20020419

• Protein glutathionylation: coupling and uncoupling of glutathione to protein thiol groups in lymphocytes under oxidative stress and HIV infection.

  Molecular immunology 20020201

• Glutathione might exert an important function in caerulein-stimulated amylase release in isolated rat pancreatic acini.

  Pancreas 20020101

• Modulation of ICl(Ca) in vascular smooth muscle cells by oxidizing and cysteine-reactive reagents.

  Pflugers Archiv : European journal of physiology 20020101

• Cystathionine pathway-dependent cytotoxicities of diethyl maleate and diamide in rat and human hepatoma-derived cell cultures.

  Alternatives to laboratory animals : ATLA 20020101

• [Effect of diamide on protein oxidation and physico-chemical properties of lipids in erythrocyte membranes].

  Biofizika 20020101

• GSH depletion, K-Cl cotransport, and regulatory volume decrease in high-K/high-GSH dog red blood cells.

  American journal of physiology. Cell physiology 20011201

• The influence of oxidation of membrane thiol groups on lysosomal proton permeability.

  The Biochemical journal 20011201

• In vitro phagocytosis of carrier mouse red blood cells is increased by Band 3 cross-linking or diamide treatment.

  Biotechnology and applied biochemistry 20011201

• Oxidative stress impairs nuclear proteins binding to the insulin responsive element in the GLUT4 promoter.

  Diabetologia 20011201

• Differential in vitro and in vivo behavior of mouse ascorbate/Fe3+ and diamide oxidized erythrocytes.

  Bioscience reports 20011201

• p38 MAP kinase mediates stress-induced leukotriene synthesis in a human B-lymphocyte cell line.

  Journal of leukocyte biology 20011101

• Induction of mild intracellular redox imbalance inhibits proliferation of CaCo-2 cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011001

• Diamide derivatives and cycloartanes from the leaves of Aglaia elliptica.

  Chemical & pharmaceutical bulletin 20010901

• Inhibition of protein tyrosine phosphatases suppresses P-selectin exocytosis in activated human platelets.

  Biochemical and biophysical research communications 20010824

• Contrasting effects of thiol-modulating agents on endothelial NO bioactivity.

  American journal of physiology. Cell physiology 20010801

• Redox regulation of the DNA repair function of the human AP endonuclease Ape1/ref-1.

  Antioxidants & redox signaling 20010801

• Disulfide bonds stabilize JC virus capsid-like structure by protecting calcium ions from chelation.

  FEBS letters 20010706

• Resolution, detection, and characterization of redox conformers of human HSF1.

  The Journal of biological chemistry 20010629

• Determination of C4-C14 carboxylic acids by capillary zone electrophoresis. Application to the identification of diamide degradation products and partitioning studies.

  Journal of chromatography. A 20010622

• Influence of oxidation and crosslinking on oxygen binding properties of mouse erythrocytes.

  Cell biochemistry and function 20010601

• Selective disruption of cadherin/catenin complexes by oxidative stress in precision-cut mouse liver slices.

  Toxicological sciences : an official journal of the Society of Toxicology 20010601

• Cellular titration of apoptosis with steady state concentrations of H(2)O(2): submicromolar levels of H(2)O(2) induce apoptosis through Fenton chemistry independent of the cellular thiol state.

  Free radical biology & medicine 20010501

• Responses of thiols to an oxidant challenge: differences between blood and tissues in the rat.

  Chemico-biological interactions 20010314

• Different metabolizing ability of thiol reactants in human and rat blood: biochemical and pharmacological implications.

  The Journal of biological chemistry 20010309

• Multiple Yap1p-binding sites mediate induction of the yeast major facilitator FLR1 gene in response to drugs, oxidants, and alkylating agents.

  The Journal of biological chemistry 20010112

• Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20010105

• Cytotoxic constituents from leaves of Aglaia elliptifolia.

  Journal of natural products 20010101

• NF kappa b signaling in posthypoxic endothelial cells: relevance to E-selectin expression and neutrophil adhesion.

  Journal of vascular research 20010101

• Thiol-oxidizing agent diamide and acidic pH enhance lipid peroxidation of rat heart mitochondria and cardiolipin-cytochrome c complex.

  IUBMB life 20010101

• Aggregation and sedimentation of mixtures of erythrocytes with different properties.

  Clinical hemorheology and microcirculation 20010101

• Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes.

  The Journal of biological chemistry 19990618

• Redox regulation of manganese superoxide dismutase.

  The American journal of physiology 19960701

• Thiol modulation of TNF alpha and IL-1 induced MnSOD gene expression and activation of NF-kappa B.

  Molecular and cellular biochemistry 19950705