104678-13-9 | 2-(Methoxymethyl)piperidine

Packsize	Purity	Availability	Price	Discounted Price
250mg	96%	in stock	$106.00	$75.00
1g	96%	in stock	$275.00	$193.00
5g	96%	in stock	$775.00	$543.00
10g	96%	in stock	$1,148.00	$804.00

Description

• Catalog Number: AE08977
• Chemical Name: 2-(Methoxymethyl)piperidine
• CAS Number: 104678-13-9
• Molecular Formula: C7H15NO
• Molecular Weight: 129.2001
• MDL Number: MFCD02663567
• SMILES: COCC1CCCCN1

Computed Properties

• Complexity: 75.3
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 9
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• Undefined Atom Stereocenter Count: 1
• XLogP3: 0.6

Upstream Synthesis Route

2-(Methoxymethyl)piperidine, also known as MPM, is a versatile compound widely utilized in chemical synthesis. This compound serves as a valuable building block in the creation of complex organic molecules due to its unique reactivity and structural properties. In chemical synthesis, 2-(Methoxymethyl)piperidine is commonly used as a protecting group for amines, particularly in peptide and drug synthesis.By selectively masking the amine functional group with the methoxymethyl (MOM) moiety, 2-(Methoxymethyl)piperidine allows chemists to control the reactivity of the amine during various synthetic steps. This protection strategy helps prevent unwanted side reactions and allows for the manipulation of specific functional groups within a molecule. Furthermore, the MOM group can be efficiently cleaved under mild conditions, enabling the regeneration of the free amine for subsequent transformations.Overall, the strategic application of 2-(Methoxymethyl)piperidine as a protecting group in chemical synthesis enhances the efficiency and precision of organic reactions, making it an indispensable tool for synthetic chemists across diverse research fields.

Literature

• Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors.

  Nature chemical biology 20110701

• Diastereoselective synthesis of N-secondary alkyl 2-alkoxymethylpyrrolidines via sequential addition reactions of organolithium and -magnesium reagents to N-thioformyl 2-alkoxymethylpyrrolidines.

  The Journal of organic chemistry 20081205