10470-83-4 | Quinoline-5,8-dione

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$50.00	$35.00
250mg	97%	in stock	$85.00	$60.00
1g	97%	in stock	$232.00	$163.00

Description

• Catalog Number: AE11841
• Chemical Name: Quinoline-5,8-dione
• CAS Number: 10470-83-4
• Molecular Formula: C9H5NO2
• Molecular Weight: 159.1415
• MDL Number: MFCD04038780
• SMILES: O=C1C=CC(=O)c2c1nccc2
• NSC Number: 682996

Computed Properties

• Complexity: 257
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 3
• XLogP3: 0.7

Literature

• New quinoline-5,8-dione and hydroxynaphthoquinone derivatives inhibit a chloroquine resistant Plasmodium falciparum strain.

  European journal of medicinal chemistry 20120801

• Application of porous nickel-coated TiO₂ for the photocatalytic degradation of aqueous quinoline in an internal airlift loop reactor.

  International journal of environmental research and public health 20120201

• 7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel synthetic compound induces lung carcinoma cell death associated with inhibiting ERK and CDC2 phosphorylation via a p53-independent pathway.

  Cancer chemotherapy and pharmacology 20081001

• The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase.

  Organic & biomolecular chemistry 20080807

• Discovery of quinolinediones exhibiting a heat shock response and angiogenesis inhibition.

  Journal of medicinal chemistry 20080424

• Investigating the antiproliferative activity of quinoline-5,8-diones and styrylquinolinecarboxylic acids on tumor cell lines.

  Bioorganic & medicinal chemistry letters 20071115

• Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.

  Bioorganic & medicinal chemistry 20040801

• Antitumor agents. 3. Design, synthesis, and biological evaluation of new pyridoisoquinolindione and dihydrothienoquinolindione derivatives with potent cytotoxic activity.

  Journal of medicinal chemistry 20040212

• Synthesis and in vitro antitumor activity of novel ring D analogues of the marine pyridoacridine ascididemin: structure-activity relationship.

  Journal of medicinal chemistry 20020815

• Discovery and biological evaluation of a new family of potent inhibitors of the dual specificity protein phosphatase Cdc25.

  Journal of medicinal chemistry 20011122

• Synthesis of pyridino[2,3-f]indole-4,9-dione and 6,7-disubstituted quinoline-5,8-dione derivatives and evaluation on their cytotoxic activity.

  Bioorganic & medicinal chemistry 20011101

• Comparative study on biological activities of heterocyclic quinones and streptonigrin.

  The Journal of antibiotics 19870501