1061353-68-1 | Pnd-1186

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$10.00	$7.00
2mg	98%	in stock	$14.00	$10.00
5mg	98%	in stock	$21.00	$15.00
10mg	98%	in stock	$31.00	$22.00
50mg	98%	in stock	$79.00	$55.00
250mg	98%	in stock	$202.00	$141.00

Description

• Catalog Number: AE11319
• Chemical Name: Pnd-1186
• CAS Number: 1061353-68-1
• Molecular Formula: C25H26F3N5O3
• Molecular Weight: 501.5008
• MDL Number: MFCD28125506
• SMILES: CNC(=O)c1ccccc1Nc1cc(ncc1C(F)(F)F)Nc1ccc(cc1OC)N1CCOCC1

Computed Properties

• Complexity: 709
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 36
• Hydrogen Bond Acceptor Count: 10
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 7
• XLogP3: 4.7

Literature

• FAK signaling in human cancer as a target for therapeutics.

  Pharmacology & therapeutics 20150201

• FAK Inhibition disrupts a β5 integrin signaling axis controlling anchorage-independent ovarian carcinoma growth.

  Molecular cancer therapeutics 20140801

• PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.

  Cancer biology & therapy 20100501

• Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.

  Cancer biology & therapy 20100501