106685-40-9 | Adapalene

Packsize	Purity	Availability	Price	Discounted Price
100mg	95%	in stock	$8.00	$5.00
1g	95%	in stock	$72.00	$50.00
5g	95%	in stock	$308.00	$216.00
25g	95%	in stock	$1,044.00	$731.00

Description

• Catalog Number: AB50559
• Chemical Name: Adapalene
• CAS Number: 106685-40-9
• Molecular Formula: C28H28O3
• Molecular Weight: 412.5201
• MDL Number: MFCD03106112
• SMILES: COc1ccc(cc1C12CC3CC(C2)CC(C1)C3)c1ccc2c(c1)ccc(c2)C(=O)O

Computed Properties

• Complexity: 645
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 4
• XLogP3: 7.7

Literature

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  Microbes and infection 20140201

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  The Journal of dermatology 20120901

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  Journal of drugs in dermatology : JDD 20120801

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  The Journal of dermatological treatment 20120601

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  The Journal of dermatology 20120601

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  Journal of drugs in dermatology : JDD 20120601

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  International journal of clinical pharmacology and therapeutics 20120601

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  The Journal of clinical and aesthetic dermatology 20120501

• Lack of irritative potential of nadifloxacin 1% when combined with other topical anti-acne agents.

  Clinical and experimental dermatology 20120301

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  The Journal of dermatological treatment 20120201

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  Journal of medicinal chemistry 20120112

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  European journal of dermatology : EJD 20120101

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  Beilstein journal of organic chemistry 20120101

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  Indian journal of dermatology 20120101

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  Indian journal of dermatology, venereology and leprology 20120101

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  Investigative radiology 20110801

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  Journal of chromatographic science 20110101

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  Indian journal of dermatology 20110101

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  The Journal of dermatological treatment 20090101

• Drugs associated with more suicidal ideations are also associated with more suicide attempts.

  PloS one 20090101

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  Veterinary dermatology 20081201

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  European journal of dermatology : EJD 20050101

• Pseudoacne of the nasal crease in a patient with congenital deafness and pigmentary mosaicism.

  Pediatric dermatology 20050101

• A successful maintenance approach in inflammatory acne with adapalene gel 0.1% after an initial treatment in combination with clindamycin topical solution 1% or after monotherapy with clindamycin topical solution 1%.

  The Journal of dermatological treatment 20041201

• Topical retinoids in the management of acne: the best path to clear results.

  Cutis 20041001

• Meta-analysis of topical tazarotene in the treatment of mild to moderate acne.

  Cutis 20041001

• Skin tolerability and efficacy of combination therapy with hydrogen peroxide stabilized cream and adapalene gel in comparison with benzoyl peroxide cream and adapalene gel in common acne. A randomized, investigator-masked, controlled trial.

  The British journal of dermatology 20040801

• Topical tretinoin or adapalene in acne vulgaris: an overview.

  The Journal of dermatological treatment 20040701

• Potentiated anticancer effects on hepatoma cells by the retinoid adapalene.

  Cancer letters 20040510

• [The clinical observation of treating acne vulgaris with 'xiao cuo fang'].

  Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20040401

• An unusual late onset closed-comedone naevus: successful therapy with light cautery and a topical retinoid.

  The Journal of dermatological treatment 20040101

• Adapalene: a review of its use in the treatment of acne vulgaris.

  Drugs 20040101

• Phototoxic effects of topical azelaic acid, benzoyl peroxide and adapalene were not detected when applied immediately before UVB to normal skin.

  European journal of dermatology : EJD 20040101

• Topical agents used in the management of hyperpigmentation.

  Skin therapy letter 20040101

• Spotlight on adapalene in acne vulgaris.

  American journal of clinical dermatology 20040101

• Comparison of topical retinoids in the treatment of acne.

  Clinics in dermatology 20040101

• Facial tolerability of topical retinoid therapy.

  Journal of drugs in dermatology : JDD 20040101

• Cumulative irritancy potential of adapalene cream 0.1% compared with adapalene gel 0.1% and several tretinoin formulations.

  Cutis 20031201

• The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitro.

  International journal of cancer 20031110

• Clinical review: topical retinoids.

  Dermatology nursing 20031001

• A review of the use of combination therapies for the treatment of acne vulgaris.

  Journal of the American Academy of Dermatology 20030901

• Efficacy and tolerability of combined topical treatment of acne vulgaris with adapalene and clindamycin: a multicenter, randomized, investigator-blinded study.

  Journal of the American Academy of Dermatology 20030901

• Is combined oral and topical therapy better than oral therapy alone in patients with moderate to moderately severe acne vulgaris? A comparison of the efficacy and safety of lymecycline plus adapalene gel 0.1%, versus lymecycline plus gel vehicle.

  Journal of the American Academy of Dermatology 20030901

• Cumulative irritancy comparison of adapalene gel 0.1% versus other retinoid products when applied in combination with topical antimicrobial agents.

  Journal of the American Academy of Dermatology 20030901

• Single-blind and comparative clinical study of the efficacy and safety of benzoyl peroxide 4% gel (BID) and adapalene 0.1% Gel (QD) in the treatment of acne vulgaris for 11 weeks.

  The Journal of dermatological treatment 20030901

• Assessment of adapalene gel for the treatment of actinic keratoses and lentigines: a randomized trial.

  Journal of the American Academy of Dermatology 20030701

• Cumulative irritation comparison of adapalene gel and solution with 2 tazarotene gels and 3 tretinoin formulations.

  Cutis 20030701

• Retinoids: fascinating up-and-coming scenario.

  The Journal of dermatology 20030501

• 13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4: a mechanism for its anti-androgenic effects in sebaceous glands?

  Biochemical and biophysical research communications 20030328

• Management of acne.

  The Journal of family practice 20030101

• The rationale for using a topical retinoid for inflammatory acne.

  American journal of clinical dermatology 20030101

• Topical treatment in acne: current status and future aspects.

  Dermatology (Basel, Switzerland) 20030101

• Optimizing treatment with topical tazarotene.

  American journal of clinical dermatology 20030101

• Current concepts of the pathogenesis of acne: implications for drug treatment.

  Drugs 20030101

• Axillary granular parakeratosis.

  Journal of cutaneous medicine and surgery 20030101

• Safety and efficacy of adapalene gel 0.1% in acne vulgaris: results of a post-marketing surveillance study.

  Indian journal of dermatology, venereology and leprology 20030101

• Prospective study of depressive symptoms and quality of life in acne vulgaris patients treated with isotretinoin compared to antibiotic and topical therapy.

  The Australasian journal of dermatology 20021101

• Efficacy and cutaneous safety of adapalene in black patients versus white patients with acne vulgaris.

  Cutis 20021001

• Topical adapalene gel 0.1% vs. isotretinoin gel 0.05% in the treatment of acne vulgaris: a randomized open-label clinical trial.

  The British journal of dermatology 20020901

• Adapalene in the treatment of melasma: a preliminary report.

  The Journal of dermatology 20020801

• Perioral dermatitis successfully treated with topical adapalene.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20020301

• A multicenter, double-blind, randomized comparison study of the efficacy and tolerability of once-daily tazarotene 0.1% gel and adapalene 0.1% gel for the treatment of facial acne vulgaris.

  Cutis 20020201

• Comparison of the effects of tretinoin, adapalene and collagenase in an experimental model of wound healing.

  European journal of dermatology : EJD 20020101

• Epithelial malignancies in organ transplant patients: clinical presentation and new methods of treatment.

  Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20020101

• Randomised, controlled trial of the efficacy and safety of adapalene gel 0.1% and tretinoin cream 0.05% in patients with acne vulgaris.

  European journal of dermatology : EJD 20020101

• Potential anti-inflammatory effects of topical retinoids and retinoid analogues.

  Advances in therapy 20020101

• Randomized controlled trial of the tolerability, safety, and efficacy of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris.

  Cutis 20011001

• Randomized, controlled, bilateral (split-face) comparison trial of the tolerability and patient preference of adapalene gel 0.1% and tretinoin microsphere gel 0.1% for the treatment of acne vulgaris.

  Cutis 20011001

• Polarized light photography and videomicroscopy greatly enhance the capability of estimating the therapeuic response to a topical retinoid (adapalene) in acne vulgaris.

  Cutis 20011001

• Efficacy and tolerance of adapalene cream 0.1% compared with its cream vehicle for the treatment of acne vulgaris.

  Cutis 20011001

• Adapalene gel 0.1% is effective and well tolerated in acne patients in a dermatology practice setting.

  Cutis 20011001

• Adapalene gel 0.1% for topical treatment of acne vulgaris in African patients.

  Cutis 20011001

• Adapalene gel 0.1%: effective and well tolerated in the topical treatment of acne vulgaris in Chinese patients.

  Cutis 20011001

• Adapalene in clinical practice.

  Cutis 20011001

• Developments in topical retinoid therapy for acne.

  Seminars in cutaneous medicine and surgery 20010901

• A comparative trial of two retinoids commonly used in the treatment of acne vulgaris.

  The Journal of dermatological treatment 20010901

• Lipid analysis of follicular casts from cyanoacrylate strips as a new method for studying therapeutic effects of antiacne agents.

  The British journal of dermatology 20010701

• Synthesis, high-performance liquid chromatography-nuclear magnetic resonance characterization and pharmacokinetics in mice of CD271 glucuronide.

  Journal of chromatography. B, Biomedical sciences and applications 20010605

• Comparison of treatment of acne vulgaris with alternate-day applications of tazarotene 0.1% gel and once-daily applications of adapalene 0.1% gel: a randomized trial.

  Cutis 20010601

• Randomized facial tolerability studies comparing gel formulations of retinoids used to treat acne vulgaris.

  Cutis 20010601

• Are 2 combined antimicrobial mechanisms better than 1 for the treatment of acne vulgaris? Clinical and antimicrobial results of a topical combination product containing 1% clindamycin and 5% benzoyl peroxide. Introduction.

  Cutis 20010201

• Comparison of the cumulative irritation potential of adapalene gel and cream with that of erythromycin/tretinoin solution and gel and erythromycin/isotretinoin gel.

  Clinical therapeutics 20010201

• Acral Darier's disease successfully treated with adapalene.

  Acta dermato-venereologica 20010101

• The modern age of acne therapy: a review of current treatment options.

  The Mount Sinai journal of medicine, New York 20010101

• Retinoids--which dermatological indications will benefit in the near future?

  Skin pharmacology and applied skin physiology 20010101

• Current perspectives on the treatment of acne vulgaris and implications for future directions.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• New photographic techniques for clinical evaluation of acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• Pivotal clinical trials of adapalene in the treatment of acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• An update of recent clinical trials examining adapalene and acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• A comparison of adapalene gel 0.1% vs. tretinoin gel 0.025% in the treatment of acne vulgaris in China.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• Adapalene in the treatment of African patients.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• The integral role of topical and oral retinoids in the early treatment of acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

• Treatment of cervical intraepithelial neoplasia levels 2 and 3 with adapalene, a retinoid-related molecule.

  Journal of lower genital tract disease 20010101

• The role of specific retinoid receptors in sebocyte growth and differentiation in culture.

  The Journal of investigative dermatology 20000201

• Pharmacology of adapalene.

  The British journal of dermatology 19981001

• Adapalene 0.1% gel and adapalene 0.1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers.

  The British journal of dermatology 19981001

• A new concept of drug delivery for acne.

  Dermatology (Basel, Switzerland) 19980101

• Synthesis, structure-affinity relationships, and biological activities of ligands binding to retinoic acid receptor subtypes.

  Journal of medicinal chemistry 19951222

• Comparison of CD271 (adapalene) and all-trans retinoic acid in human skin: dissociation of epidermal effects and CRABP-II mRNA expression.

  The Journal of investigative dermatology 19930901