106861-44-3 | Mivacurium chloride

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$42.00	$29.00
10mg	95%	in stock	$105.00	$74.00
25mg	95%	in stock	$199.00	$139.00
50mg	95%	in stock	$396.00	$277.00
100mg	95%	in stock	$592.00	$414.00

Description

• Catalog Number: AD76774
• Chemical Name: Mivacurium chloride
• CAS Number: 106861-44-3
• Molecular Formula: C58H80Cl2N2O14
• Molecular Weight: 1100.1668
• MDL Number: MFCD00867767
• SMILES: COc1cc2c(cc1OC)CC[N+]([C@@H]2Cc1cc(OC)c(c(c1)OC)OC)(C)CCCOC(=O)CC/C=C/CCC(=O)OCCC[N+]1(C)CCc2c([C@H]1Cc1cc(OC)c(c(c1)OC)OC)cc(c(c2)OC)OC.[Cl-].[Cl-]

Computed Properties

• Complexity: 1550
• Covalently-Bonded Unit Count: 3
• Defined Atom Stereocenter Count: 2
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 76
• Hydrogen Bond Acceptor Count: 16
• Rotatable Bond Count: 30
• Undefined Atom Stereocenter Count: 2

Upstream Synthesis Route

Mivacurium chloride, a neuromuscular blocking agent, finds significant application in chemical synthesis as a key ingredient in the preparation of pharmaceutical compounds. Specifically, it is utilized in the synthesis of various muscle relaxants and anesthesia drugs. Mivacurium chloride serves as a crucial intermediate in the creation of these specialized compounds due to its unique pharmacological properties and chemical structure. Its role in chemical synthesis enables the production of advanced medications that are used in surgical procedures to induce muscle relaxation and facilitate anesthesia. This compound plays a vital role in the development of pharmaceutical products that are essential for modern medical practices and procedures.

Literature

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  PloS one 20140101

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  European journal of anaesthesiology 20041101

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  Acta anaesthesiologica Scandinavica 20031101

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  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20031101

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  Anaesthesia 20031001

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  European journal of anaesthesiology 20031001

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  Der Anaesthesist 20030601

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  Anesthesiology 20030501

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  Journal of clinical anesthesia 20030301

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  Journal of clinical anesthesia 20030301

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  Anesthesia and analgesia 20030201

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  Anesthesiology 20030201

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  Acta cientifica venezolana 20030101

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  British journal of anaesthesia 20021201

• Sevoflurane and isoflurane, but not propofol, decrease mivacurium requirements over time.

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20021101

• Selection of neuromuscular blocking agents in patients undergoing renal transplantation under general anesthesia.

  Chinese medical journal 20021101

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  British journal of anaesthesia 20021001

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  Anesthesiology 20020901

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  Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen 20020901

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  Anesthesia and analgesia 20020801

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  Anesthesia and analgesia 20020801

• Prolonged neuromuscular block due to cholinesterase depletion by plasmapheresis.

  Journal of clinical anesthesia 20020801

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  Clinical chemistry and laboratory medicine 20020801

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  Acta anaesthesiologica Scandinavica 20020701

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  Paediatric anaesthesia 20020701

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  Anaesthesia and intensive care 20020601

• Anesthesia for electroconvulsive therapy.

  Anesthesia and analgesia 20020501

• The pharmacodynamics and pharmacokinetics of mivacurium in children.

  Acta anaesthesiologica Scandinavica 20020501

• A comparison of neuromuscular effects, tracheal intubating conditions, and reversibility of rapacuronium versus mivacurium in female patients.

  Anesthesia and analgesia 20020401

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  European journal of anaesthesiology 20020401

• Muscle relaxation does not alter hypnotic level during propofol anesthesia.

  Anesthesia and analgesia 20020301

• The relationship between acceleromyographic train-of-four fade and single twitch depression.

  Anesthesiology 20020301

• Isobolographic analysis of non-depolarising muscle relaxant interactions at their receptor site.

  European journal of pharmacology 20020301

• Phonomyography of the corrugator supercilii muscle: signal characteristics, best recording site and comparison with acceleromyography.

  British journal of anaesthesia 20020301

• Screening patients with prolonged neuromuscular blockade after succinylcholine and mivacurium.

  Anesthesia and analgesia 20020201

• Role of endogenous histamine in altered lung mechanics in rabbits.

  Anesthesiology 20020201

• Effect of metoclopramide on mivacurium-induced neuromuscular block.

  Acta anaesthesiologica Scandinavica 20020201

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  Der Anaesthesist 20020201

• [Anesthesiologic support of videothorascopic operations in children with pleural empyema].

  Anesteziologiia i reanimatologiia 20020101

• Unexpected prolonged neuromuscular block after mivacurium: a case report.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20020101

• [Quantitative assessment of neuromuscular block of the orbicularis oculi muscle].

  Anaesthesiologie und Reanimation 20020101

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  Revista espanola de anestesiologia y reanimacion 20020101

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  Anesteziologiia i reanimatologiia 20020101

• Equi-lasting doses of rocuronium, compared to mivacurium, result in improved neuromuscular blockade in patients undergoing gynecological laparoscopy : [Des doses de durée équivalente de rocuronium, comparé au mivacurium, améliorent la curarisation chez des patientes qui subissent une laparoscopie gynécologique].

  Canadian journal of anaesthesia = Journal canadien d'anesthesie 20011201

• Differential sensitivity of abdominal muscles and the diaphragm to mivacurium: an electromyographic study.

  Anesthesiology 20011201

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  Acta anaesthesiologica Sinica 20011201

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  Masui. The Japanese journal of anesthesiology 20011201

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  European journal of anaesthesiology 20011101

• Total intravenous anaesthesia in a patient with familial hypokalaemic periodic paralysis.

  Anaesthesia 20011101

• The influence of atracurium, cisatracurium, and mivacurium on the proliferation of two human cell lines in vitro.

  Anesthesia and analgesia 20010901

• Response to mivacurium in a patient compound heterozygous for a novel and a known silent mutation in the butyrylcholinesterase gene: genotyping by sequencing.

  Anesthesiology 20010901

• In vitro effects of fluoride on pseudocholinesterase activity and the metabolism of the cis-trans and trans-trans isomers of mivacurium.

  Anesthesiology 20010901

• Sensitivity of action potential triggering is normally distributed as a function of mean fractional receptor activation.

  Anaesthesia and intensive care 20010801

• Succinylcholine pretreatment using gallamine or mivacurium during rapid sequence induction in children: a randomized, controlled study.

  Journal of clinical anesthesia 20010601

• Peripheral link model as an alternative for pharmacokinetic-pharmacodynamic modeling of drugs having a very short elimination half-life.

  Journal of pharmacokinetics and pharmacodynamics 20010201

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  Middle East journal of anaesthesiology 20010201

• Intramuscular versus surface electromyography of the diaphragm for determining neuromuscular blockade.

  Anesthesia and analgesia 20010101

• No substitute for the intravenous route.

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  Acta cientifica venezolana 20010101

• Recent advances in myorelaxant therapy.

  Paediatric anaesthesia 20010101

• Muscle relaxants suitable for day case surgery.

  European journal of anaesthesiology. Supplement 20010101

• Muscle relaxants in paediatric day case surgery.

  European journal of anaesthesiology. Supplement 20010101

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  Folia medica Cracoviensia 20010101

• Is succinylcholine after pretreatment with d-tubocurarine and lidocaine contraindicated for outpatient anesthesia?

  Anesthesia and analgesia 20000801

• Intubation conditions and postoperative myalgia in outpatient dental surgery: a comparison of succinylcholine with mivacurium.

  Anaesthesia and intensive care 20000401

• Organophosphorus pesticide-induced butyrylcholinesterase inhibition and potentiation of succinylcholine toxicity in mice.

  Journal of biochemical and molecular toxicology 19990101

• Suxamethonium and mivacurium sensitivity from pregnancy-induced plasma cholinesterase deficiency.

  Anaesthesia 19981101

• The effect of mivacurium pretreatment on intra-ocular pressure changes induced by suxamethonium.

  Anaesthesia 19980501

• Potentiation of mivacurium by rocuronium is age- and time-dependent: a study in children, adolescents, and young and elderly adults.

  Journal of clinical pharmacology 19970701

• Markedly prolonged paralysis after mivacurium in a patient apparently heterozygous for the atypical and usual pseudocholinesterase alleles by conventional biochemical testing.

  Anesthesia and analgesia 19970201

• Clinical pharmacology of mivacurium chloride: a review.

  Journal of clinical anesthesia 19920101