107-97-1 | Sarcosine

Packsize	Purity	Availability	Price	Discounted Price
25g	97%	in stock	$8.00	$5.00
100g	97%	in stock	$15.00	$10.00
500g	97%	in stock	$45.00	$31.00

Description

• Catalog Number: AB78911
• Chemical Name: Sarcosine
• CAS Number: 107-97-1
• Molecular Formula: C3H7NO2
• Molecular Weight: 89.09318
• MDL Number: MFCD00004279
• SMILES: CNCC(=O)O
• NSC Number: 118114

Computed Properties

• Complexity: 52.8
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 6
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: -2.8

Upstream Synthesis Route

Sarcosine, also known as N-methylglycine, serves as a versatile compound in chemical synthesis due to its unique properties. As a derivative of glycine, it is used as a methyl donor in various reactions, making it a valuable intermediate in organic synthesis. Sarcosine is particularly utilized in the production of specialty chemicals, pharmaceuticals, and agrochemicals. Its ability to undergo various chemical transformations, such as N-methylation and N-demethylation, expands its potential applications in the synthesis of complex molecules. Additionally, Sarcosine can act as a stabilizing agent in certain reactions, improving yields and selectivity. Its role as a building block in peptide synthesis further showcases its significance in the field of chemical synthesis. This compound plays a crucial role in the development of innovative materials and biologically active compounds, making it an essential component in modern chemical processes.

Literature

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  Toxicology and applied pharmacology 20121201

• Serum sarcosine increases the accuracy of prostate cancer detection in patients with total serum PSA less than 4.0 ng/ml.

  The Prostate 20121101

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• Mutations in the sarcosine dehydrogenase gene in patients with sarcosinemia.

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• Use of crude extract of lentil plant (Lens culinaris Medikus) in peroxidase-based analyses: fast kinetic determination of hydrogen peroxide and sarcosine in urine.

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• Kinetics of the reversible reaction of CO2(aq) and HCO3(-) with sarcosine salt in aqueous solution.

  The journal of physical chemistry. A 20121025

• Glycine transporter type 2 (GlyT2) inhibitor ameliorates bladder overactivity and nociceptive behavior in rats.

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• Pharmacological induction of ischemic tolerance in hippocampal slices by sarcosine preconditioning.

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• Characterization of the neuropsychological phenotype of glycine N-methyltransferase-/- mice and evaluation of its responses to clozapine and sarcosine treatments.

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• Deuterium kinetic isotope effects in heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96: the anionic form of the substrate in the enzyme-substrate complex is a reactive species.

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  The Journal of biological chemistry 20110218

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• Methyl 3-(4-fluoro-phen-yl)-1-methyl-1,2,3,3a,4,9b-hexa-hydro-chromeno[4,3-b]pyrrole-3a-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20110201

• 4,9-Dioxa-1,3(1,2)-dibenzena-2(4,5)-1,3-oxazolidinacyclononaphane.

  Acta crystallographica. Section E, Structure reports online 20110201

• SLC36A4 (hPAT4) is a high affinity amino acid transporter when expressed in Xenopus laevis oocytes.

  The Journal of biological chemistry 20110128

• Inhibition of Cell Growth and Cellular Protein, DNA and RNA Synthesis in Human Hepatoma (HepG2) Cells by Ethanol Extract of Abnormal Savda Munziq of Traditional Uighur Medicine.

  Evidence-based complementary and alternative medicine : eCAM 20110101

• Thermodynamic and kinetic consequences of substituting glycine at different positions in a Pro-Hyp-Gly repeat collagen model peptide.

  Biopolymers 20110101

• Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2).

  Biochimica et biophysica acta 20110101

• Analogs of the CLV3 peptide: synthesis and structure-activity relationships focused on proline residues.

  Plant & cell physiology 20110101

• metaP-server: a web-based metabolomics data analysis tool.

  Journal of biomedicine & biotechnology 20110101

• Structural characterization of a lipopeptide antibiotic A54145E(Asn3Asp9) produced by a genetically engineered strain of Streptomyces fradiae.

  The Journal of antibiotics 20110101

• Peptoid conformational free energy landscapes from implicit-solvent molecular simulations in AMBER.

  Biopolymers 20110101

• GNMT expression increases hepatic folate contents and folate-dependent methionine synthase-mediated homocysteine remethylation.

  Molecular medicine (Cambridge, Mass.) 20110101

• Heterologous expression, purification and characterization of nitrilase from Aspergillus niger K10.

  BMC biotechnology 20110101

• Deciphering squamous cell carcinoma using multidimensional genomic approaches.

  Journal of skin cancer 20110101

• Whole-genome analysis reveals that active heat shock factor binding sites are mostly associated with non-heat shock genes in Drosophila melanogaster.

  PloS one 20110101

• Metastasis: new perspectives on an old problem.

  Molecular cancer 20110101

• Glycine transporter-1: a new potential therapeutic target for schizophrenia.

  Current pharmaceutical design 20110101

• Widespread, focal copy number variations (CNV) and whole chromosome aneuploidies in Trypanosoma cruzi strains revealed by array comparative genomic hybridization.

  BMC genomics 20110101

• Therapeutic approaches to delay the onset of Alzheimer's disease.

  Journal of aging research 20110101

• Changes in whole blood gene expression in obese subjects with type 2 diabetes following bariatric surgery: a pilot study.

  PloS one 20110101

• False positive seroreactivity to brucellosis in tuberculosis patients: a prevalence study.

  International journal of general medicine 20110101

• [L-carnitine treatment and fish odor syndrome: an unwaited adverse effect].

  Revue neurologique 20110101

• Laboratory and lysimeter studies of glyphosate and aminomethylphosphonic acid in a sand and a clay soil.

  Journal of environmental quality 20110101

• GC/MS based metabolomics: development of a data mining system for metabolite identification by using soft independent modeling of class analogy (SIMCA).

  BMC bioinformatics 20110101

• Pharmacotherapy for treatment-resistant schizophrenia.

  Neuropsychiatric disease and treatment 20110101

• [Alternative tests to PSA for prostate cancer diagnosis].

  Urologia 20110101

• Characters of homogentisate oxygenase gene mutation and high clonality of the natural pigment-producing Vibrio cholerae strains.

  BMC microbiology 20110101

• Identification of metabolites in the normal ovary and their transformation in primary and metastatic ovarian cancer.

  PloS one 20110101

• Novel insights into the diversity of catabolic metabolism from ten haloarchaeal genomes.

  PloS one 20110101

• Biological responses to perfluorododecanoic acid exposure in rat kidneys as determined by integrated proteomic and metabonomic studies.

  PloS one 20110101

• Genetic diversity and antimicrobial resistance of Escherichia coli from human and animal sources uncovers multiple resistances from human sources.

  PloS one 20110101

• Comparative genome analysis and genome-guided physiological analysis of Roseobacter litoralis.

  BMC genomics 20110101

• Pharmacological characterization of [³H]CHIBA-3007 binding to glycine transporter 1 in the rat brain.

  PloS one 20110101

• Plasma lipids and betaine are related in an acute coronary syndrome cohort.

  PloS one 20110101

• Thrombospondin-1: multiple paths to inflammation.

  Mediators of inflammation 20110101

• Bioinformatic and genetic association analysis of microRNA target sites in one-carbon metabolism genes.

  PloS one 20110101

• Liver Metabolic Alterations and Changes in Host Intercompartmental Metabolic Correlation during Progression of Malaria.

  Journal of parasitology research 20110101

• Metabolomic profiling reveals a role for androgen in activating amino acid metabolism and methylation in prostate cancer cells.

  PloS one 20110101

• Genomic species are ecological species as revealed by comparative genomics in Agrobacterium tumefaciens.

  Genome biology and evolution 20110101

• A Comparative Study of the Outer Membrane Proteome from an Atypical and a Typical Enteropathogenic Escherichia coli.

  The open microbiology journal 20110101

• NADPH oxidase: a target for the modulation of the excessive oxidase damage induced by overtraining in rat neutrophils.

  International journal of biological sciences 20110101

• Serum methionine metabolites are risk factors for metastatic prostate cancer progression.

  PloS one 20110101

• Metabolomic profile of hepatitis C virus-infected hepatocytes.

  PloS one 20110101

• Systematic spatial bias in DNA microarray hybridization is caused by probe spot position-dependent variability in lateral diffusion.

  PloS one 20110101

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  Breast cancer research : BCR 20110101

• Iron restriction induces preferential down-regulation of H(2)-consuming over H(2)-evolving reactions during fermentative growth of Escherichia coli.

  BMC microbiology 20110101

• One carbon metabolism in SAR11 pelagic marine bacteria.

  PloS one 20110101

• Characterization and regulation of the osmolyte betaine synthesizing enzymes GSMT and SDMT from halophilic methanogen Methanohalophilus portucalensis.

  PloS one 20110101

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  PloS one 20110101

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  PloS one 20110101

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  BMC structural biology 20110101

• Lysine 92 amino acid residue of USP46, a gene associated with 'behavioral despair' in mice, influences the deubiquitinating enzyme activity.

  PloS one 20110101

• Genotypic and phenotypic properties of cattle-associated Campylobacter and their implications to public health in the USA.

  PloS one 20110101

• GLUT 5 is not over-expressed in breast cancer cells and patient breast cancer tissues.

  PloS one 20110101

• Hepatic mitochondrial dysfunction in Friedreich ataxia.

  BMC neurology 20110101

• Folate network genetic variation, plasma homocysteine, and global genomic methylation content: a genetic association study.

  BMC medical genetics 20110101

• DNA Binding and Antitumor Activity of α-Diimineplatinum(II) and Palladium(II) Dithiocarbamate Complexes.

  Bioinorganic chemistry and applications 20110101

• Potential biomarkers in mouse myocardium of doxorubicin-induced cardiomyopathy: a metabonomic method and its application.

  PloS one 20110101

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  BMC bioinformatics 20110101

• Gut microbiota of healthy and malnourished children in bangladesh.

  Frontiers in microbiology 20110101

• Establishment of reference range of plasma amino acids for younger Chinese children by reverse phase HPLC.

  Journal of pediatric endocrinology & metabolism : JPEM 20110101

• Effect of a vitamin/mineral supplement on children and adults with autism.

  BMC pediatrics 20110101

• Engineering genetically encoded nanosensors for real-time in vivo measurements of citrate concentrations.

  PloS one 20110101

• Protective effects of polysaccharides from soybean meal against X-ray radiation induced damage in mouse spleen lymphocytes.

  International journal of molecular sciences 20110101

• Molecular preservation by extraction and fixation, mPREF: a method for small molecule biomarker analysis and histology on exactly the same tissue.

  BMC clinical pathology 20110101

• The discovery of putative urine markers for the specific detection of prostate tumor by integrative mining of public genomic profiles.

  PloS one 20110101

• Estimates of DNA damage by the comet assay in the direct-developing frog Eleutherodactylus johnstonei (Anura, Eleutherodactylidae).

  Genetics and molecular biology 20110101

• Defining the plant peroxisomal proteome: from Arabidopsis to rice.

  Frontiers in plant science 20110101

• One-chip biosensor for simultaneous disease marker/calibration substance measurement in human urine by electrochemical surface plasmon resonance method.

  Biosensors & bioelectronics 20101215

• Quantification of acetylcholine, choline, betaine, and dimethylglycine in human plasma and urine using stable-isotope dilution ultra performance liquid chromatography-tandem mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101215

• Ethylene glycol monomethyl ether-induced toxicity is mediated through the inhibition of flavoprotein dehydrogenase enzyme family.

  Toxicological sciences : an official journal of the Society of Toxicology 20101201

• Dietary N,N-dimethylglycine supplementation improves nutrient digestibility and attenuates pulmonary hypertension syndrome in broilers.

  Journal of animal physiology and animal nutrition 20101201

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  Neurochemical research 20101201

• Glycine transporter (GlyT1) inhibitors with reduced residence time increase prepulse inhibition without inducing hyperlocomotion in DBA/2 mice.

  Biochemical pharmacology 20101101

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  Fish & shellfish immunology 20101101

• Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours. Eur Urol 2010;58:12-8.

  European urology 20101101

• In vitro evaluation of liposomes containing bio-enhancers for the oral delivery of macromolecules.

  European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20101101

• 5-[(E)-Benzyl-idene]-2-hy-droxy-10-methyl-8-phenyl-3,10-diazahexa-cyclo-[10.7.1.1.0.0.0]henicosa-1(19),12(20),13,15,17-pentaen-6-one ethanol 0.25-solvate 0.6-hydrate.

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• 3'-Hy-droxy-methyl-1'-methyl-3'-nitro-4'-(o-tol-yl)spiro-[indoline-3,2'-pyrrolidin]-2-one.

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• 3'-Benzoyl-1'-methyl-4'-phenyl-spiro[acenaphthyl-ene-1(2H),2'-pyrrolidin]-2-one.

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  Biosensors & bioelectronics 20101015

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  Bioinformatics (Oxford, England) 20101015

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  Proceedings of the Japan Academy. Series B, Physical and biological sciences 20101008

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  Molecular genetics and metabolism 20101001

• Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment.

  Molecular genetics and metabolism 20101001

• Channeling and conformational changes in the heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96.

  Journal of biochemistry 20101001

• Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours. Eur Urol 2010;58:12-8.

  European urology 20101001

• N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn.

  British journal of pharmacology 20101001

• Methyl 3-[(1H-benzimidazol-1-yl)meth-yl]-1-methyl-4-(4-methyl-phen-yl)-2'-oxopyrrolidine-2-spiro-3'-1-benzimidazole-3-carboxyl-ate.

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  Journal of combinatorial chemistry 20100913

• Mapping the subcellular proteome of Shewanella oneidensis MR-1 using sarkosyl-based fractionation and LC-MS/MS protein identification.

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• Re: Florian Jentzmik, Carsten Stephan, Kurt Miller, et al. Sarcosine in urine after digital rectal examination fails as a marker in prostate cancer detection and identification of aggressive tumours. Eur Urol 2010;58:12-8.

  European urology 20100901

• PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells.

  American journal of physiology. Gastrointestinal and liver physiology 20100901

• Vanadocene complexes of amino acids containing secondary amino group: the first evidence of O,O-bonded carboxylic group to vanadocene(IV) moiety.

  Journal of inorganic biochemistry 20100901

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  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20100901

• A-Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance--part 12.

  British journal of sports medicine 20100901

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  Dialogues in clinical neuroscience 20100901

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• 5-[(E)-2-Bromo-benzyl-idene]-8-(2-bromo-phen-yl)-2-hy-droxy-10-methyl-3,10-di-aza-hexa-cyclo-[10.7.1.1.0.0.0]henicosa-1(20),12,14,16,18-pentaen-6-one.

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  Standards in genomic sciences 20100830

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• A medicinal chemist's guide to molecular interactions.

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• Mutation-dependent polymorphism of Cu,Zn-superoxide dismutase aggregates in the familial form of amyotrophic lateral sclerosis.

  The Journal of biological chemistry 20100716

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• Molecular basis of the waxy endosperm starch phenotype in broomcorn millet (Panicum miliaceum L.).

  Molecular biology and evolution 20100701

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  European urology 20100701

• Separation of isomers L-alanine and sarcosine in urine by electrospray ionization and tandem differential mobility analysis-mass spectrometry.

  Journal of the American Society for Mass Spectrometry 20100701

• Microbial community analysis of fresh and old microbial biofilms on Bayon temple sandstone of Angkor Thom, Cambodia.

  Microbial ecology 20100701

• 16-[(E)-Benzyl-idene]-13-hy-droxy-4-methyl-2-phenyl-4,14-diaza-penta-cyclo-[12.3.1.0.0.0]octa-deca-7(12),8,10-triene-6,17-dione.

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  Aquatic toxicology (Amsterdam, Netherlands) 20100610

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  Comparative biochemistry and physiology. Part D, Genomics & proteomics 20100601

• 2-Hydr-oxy-16-[(E)-4-hydr-oxy-3-methoxy-benzyl-idene]-13-(4-hydr-oxy-3-methoxy-phen-yl)-11-methyl-1,11-diaza-penta-cyclo-[12.3.1.0.0.0]octa-deca-3(8),4,6-triene-9,15-dione.

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• Blockade of glycine transporter (GlyT) 2, but not GlyT1, ameliorates dynamic and static mechanical allodynia in mice with herpetic or postherpetic pain.

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• Sodium hydroxymethylglycinate.

  Dermatitis : contact, atopic, occupational, drug 20100101

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• The specification of glycinergic neurons and the role of glycinergic transmission in development.

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  BMC cancer 20100101

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• A comprehensive platform for quality control of botanical drugs (PhytomicsQC): a case study of Huangqin Tang (HQT) and PHY906.

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  Current microbiology 20090901

• Prefrontal cortex and spinal cord mediated anti-neuropathy and analgesia induced by sarcosine, a glycine-T1 transporter inhibitor.

  Pain 20090901

• Regioselective intramolecular nucleophilic addition of alcohols to C60: one-step formation of a cis-1 bicyclic-fused fullerene.

  The Journal of organic chemistry 20090821

• Augmentation of fear extinction by infusion of glycine transporter blockers into the amygdala.

  Molecular pharmacology 20090801

• Preliminary X-ray analysis of twinned crystals of sarcosine dimethylglycine methyltransferase from Halorhodospira halochoris.

  Acta crystallographica. Section F, Structural biology and crystallization communications 20090801

• Expressions of uroplakins in the mouse urinary bladder with cyclophosphamide-induced cystitis.

  Journal of Korean medical science 20090801

• Beyond PSA: will future biomarker tests be better?

  Mayo Clinic health letter (English ed.) 20090801

• Methyl 1-methyl-3-p-tolyl-1,2,3,3a,4,11c-hexa-hydro-benzo[f]chromeno[4,3-b]pyrrole-3a-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20090801

• 1'-Methyl-2,2''-dioxoindoline-3-spiro-2'-pyrrolidine-3'-spiro-3''-indoline-4',4'-di-carbonitrile.

  Acta crystallographica. Section E, Structure reports online 20090801

• Methyl 3-(4-bromo-phen-yl)-1-methyl-1,2,3,3a,4,9b-hexa-hydro-benzo[f]chromeno[4,3-b]pyrrole-3a-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20090801

• SAM levels, gene expression of SAM synthetase, methionine synthase and ACC oxidase, and ethylene emission from N. suaveolens flowers.

  Plant molecular biology 20090701

• Thiotaurine and hypotaurine contents in hydrothermal-vent polychaetes without thiotrophic endosymbionts: correlation With sulfide exposure.

  Journal of experimental zoology. Part A, Ecological genetics and physiology 20090701

• The glycine transport inhibitor sarcosine is an NMDA receptor co-agonist that differs from glycine.

  The Journal of physiology 20090701

• An atom economic synthesis and antitubercular evaluation of novel spiro-cyclohexanones.

  Bioorganic & medicinal chemistry letters 20090701

• Glycine transport inhibitors for the treatment of schizophrenia: symptom and disease modification.

  Current opinion in drug discovery & development 20090701

• Organic analysis of peridotite rocks from the Ashadze and Logatchev hydrothermal sites.

  International journal of molecular sciences 20090701

• 4'-(4-Methoxy-phen-yl)-1,1',1''-trimethyl-dispiro-[indoline-3,2'-pyrrolidine-3',3''-pyrrolidine]-2,2'',5''-trione.

  Acta crystallographica. Section E, Structure reports online 20090701

• An internal reaction chamber in dimethylglycine oxidase provides efficient protection from exposure to toxic formaldehyde.

  The Journal of biological chemistry 20090626

• Pulmonary gene delivery of hybrid vector, lipopolyplex containing N-lauroylsarcosine, via the systemic route.

  Journal of controlled release : official journal of the Controlled Release Society 20090619

• Formation of specific dipolar microenvironments complementary to dipolar betaine dye by nonionic peptide lipids in nonpolar medium.

  Organic & biomolecular chemistry 20090607

• Effects of N, N-dimethylglycine on the development of in vitro produced bovine embryos.

  The Journal of reproduction and development 20090601

• A review of select recent patents on novel nanocarriers.

  Recent patents on drug delivery & formulation 20090601

• Methyl 5-ferrocenyl-5a-hydr-oxy-1-methyl-10-oxo-2,3,3a,4,5a,10-hexa-hydro-1H-indeno[1,2:2',3']furo[3',4'-b]pyrrole-3a-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20090601

• 2,10-Dihydr-oxy-13-methyl-13-aza-tetra-cyclo-[9.3.1.0.0]penta-deca-3(8),4,6-triene-9,15-dione.

  Acta crystallographica. Section E, Structure reports online 20090601

• Initial characterization of Pf62, a novel protein of Plasmodium falciparum identified by immunoscreening.

  Parasitology research 20090501

• Plasma and urine betaine and dimethylglycine variation in healthy young male subjects.

  Clinical biochemistry 20090501

• Catalytic and redox properties of glycine oxidase from Bacillus subtilis.

  Biochimie 20090501

• Acid-base interaction of probes at silica surface. Microcalorimetry and adsorption.

  Journal of colloid and interface science 20090501

• Fullerene isoniazid conjugate--a tuberculostat with increased lipophilicity: synthesis and evaluation of antimycobacterial activity.

  Chemical biology & drug design 20090501

• Folate, Cobalamin, Cysteine, Homocysteine, and Arsenic Metabolism among Children in Bangladesh.

  Environmental health perspectives 20090501

• Methyl 3-[ferrocen-yl(hydr-oxy)meth-yl]-1-methyl-2'-oxospiro-[pyrrolidine-2,3'-indoline]-3-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20090501

• Methyl 1-methyl-3-phenyl-1,2,3,3a,4,9b-hexa-hydro-benzo[f]chromeno[4,3-b]pyrrole-3a-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20090501

• 13-Hydr-oxy-4,16-dimethyl-4,16-diaza-penta-cyclo-[12.3.1.0.0.0]octa-deca-7(12),8,10-triene-6,18-dione.

  Acta crystallographica. Section E, Structure reports online 20090501

• Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats.

  Biochemical and biophysical research communications 20090417

• Osmolyte counteracts urea-induced denaturation of alpha-chymotrypsin.

  The journal of physical chemistry. B 20090416

• Effect of a carboxyl group on the chemiluminescent reaction of tris(2,2'-bipyridine)ruthenium(III) with aliphatic amines.

  Talanta 20090415

• Lipophilic prodrugs of amino acids and vitamin E as osmolytes for the compensation of hyperosmotic stress in human keratinocytes.

  Experimental dermatology 20090401

• (64)Cu-labeled CB-TE2A and diamsar-conjugated RGD peptide analogs for targeting angiogenesis: comparison of their biological activity.

  Nuclear medicine and biology 20090401

• A biomarker validation study of prenatal chlorpyrifos exposure within an inner-city cohort during pregnancy.

  Environmental health perspectives 20090401

• [Analysis of the metabolome suggests a major potential role of sarcosine in the progression of cancer of the prostate].

  Bulletin du cancer 20090401

• Transition metal complexes of short multihistidine peptides.

  Dalton transactions (Cambridge, England : 2003) 20090321

• Promising marker found for deadly prostate cancer.

  JAMA 20090311

• Regioselective synthesis and antimicrobial screening of novel ketocarbazolodispiropyrrolidine derivatives.

  European journal of medicinal chemistry 20090301

• Regioselective synthesis and stereochemical structure of anti-tumor active dispiro[3H-indole-3,2'-pyrrolidine-3',3''-piperidine]-2(1H),4''-diones.

  European journal of medicinal chemistry 20090301

• Slow glycinergic transmission mediated by transmitter pooling.

  Nature neuroscience 20090301

• Identification of non-flagellar genes involved in swarm cell differentiation using a Bacillus thuringiensis mini-Tn10 mutant library.

  Microbiology (Reading, England) 20090301

• Evaluation of procedures for outer membrane isolation from Campylobacter jejuni.

  Microbiology (Reading, England) 20090301

• Glycine transporter blockade ameliorates motor ataxia in a mouse model of spinocerebellar atrophy.

  Journal of pharmacological sciences 20090301

• [Elevated serum creatinine without discernible kidney disease].

  Deutsche medizinische Wochenschrift (1946) 20090301

• H-bond-assisted regioselective (cis-1) intramolecular nucleophilic addition of the hydroxyl group to [60]fullerene.

  The Journal of organic chemistry 20090220

• Biomarkers. Metabolite in urine may point to high-risk prostate cancer.

  Science (New York, N.Y.) 20090213

• Diagnostics: The prostate-cancer metabolome.

  Nature 20090212

• Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

  Nature 20090212

• A fluorescence study of human serum albumin binding sites modification by hypochlorite.

  Journal of photochemistry and photobiology. B, Biology 20090209

• Discovery of sarcosine dimethylglycine methyltransferase from Galdieria sulphuraria.

  Proteins 20090201

• Mutant mice with reduced NMDA-NR1 glycine affinity or lack of D-amino acid oxidase function exhibit altered anxiety-like behaviors.

  Pharmacology, biochemistry, and behavior 20090201

• rac-(4R,17S,18R,26R)-Ethyl 4'-methoxy-carbonyl-5''-(4-methoxy-phen-yl)-1'-methyl-2,3''-dioxo-2'',3''-dihydro-indoline-3-spiro-2'-pyrrolidine-3'-spiro-2''-thia-zolo[3,2-a]pyrimidine-6''-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20090201

• Regioselective synthesis of dispiro[1H-indene-2,3'-pyrrolidine-2',3''-[3H]indole]-1,2''(1''H)-diones of potential anti-tumor properties.

  European journal of medicinal chemistry 20090101

• Nitrogen substituent polarity influences dithiocarbamate-mediated lipid oxidation, nerve copper accumulation, and myelin injury.

  Chemical research in toxicology 20090101

• A study on the differential protein profiles in liver cells of heat stress rats with and without turpentine treatment.

  Proteome science 20090101

• Glycine receptor in rat hippocampal and spinal cord neurons as a molecular target for rapid actions of 17-beta-estradiol.

  Molecular pain 20090101

• The contribution of polystyrene nanospheres towards the crystallization of proteins.

  PloS one 20090101

• Inter- and intra-individual variations of urinary endogenous metabolites in healthy male college students using (1)H NMR spectroscopy.

  Clinical chemistry and laboratory medicine 20090101

• Comparative expression pathway analysis of human and canine mammary tumors.

  BMC genomics 20090101

• Comparative metagenomics of Daphnia symbionts.

  BMC genomics 20090101

• Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level.

  PloS one 20090101

• Personal phenotypes to go with personal genomes.

  Molecular systems biology 20090101

• Metabolomic analysis of human vitreous humor differentiates ocular inflammatory disease.

  Molecular vision 20090101

• Synaptically evoked glutamate transporter currents in Spinal Dorsal Horn Astrocytes.

  Molecular pain 20090101

• The glycine transport inhibitor sarcosine is an inhibitory glycine receptor agonist.

  Neuropharmacology 20090101

• Brucella microti: the genome sequence of an emerging pathogen.

  BMC genomics 20090101

• FAD binding in glycine oxidase from Bacillus subtilis.

  Biochimie 20090101

• Computational analysis of gene expression space associated with metastatic cancer.

  BMC bioinformatics 20090101

• Immunopurification of pathological prion protein aggregates.

  PloS one 20090101

• Oxidative stress-induced cell cycle blockage and a protease-independent programmed cell death in microaerophilic Giardia lamblia.

  Drug design, development and therapy 20090101

• Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease.

  PloS one 20090101

• Sodium hydroxymethylglycinate: a potential formaldehyde-releasing preservative in child products.

  Dermatitis : contact, atopic, occupational, drug 20090101

• Stabilization of quinapril by incorporating hydrogen bonding interactions.

  Indian journal of pharmaceutical sciences 20090101

• Phylogenetic analyses and detection of viridans streptococci based on sequences and denaturing gradient gel electrophoresis of the rod shape-determining protein gene.

  Journal of oral microbiology 20090101

• Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity.

  Dalton transactions (Cambridge, England : 2003) 20081221

• Inhibitors of GlyT1 affect glycine transport via discrete binding sites.

  Molecular pharmacology 20081201

• Molecular basis of dimethylglycine dehydrogenase deficiency associated with pathogenic variant H109R.

  Journal of inherited metabolic disease 20081201

• Design of potent GlyT1 inhibitors: in vitro and in vivo profiles.

  Current opinion in molecular therapeutics 20081201

• Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain.

  Neuroscience letters 20081121

• Glycine-mediated changes of onset reliability at a mammalian central synapse.

  Neuroscience 20081119

• Functional expression of the glycine transporter 1 on bullfrog retinal cones.

  Neuroreport 20081119

• Optimisation of chemical protein cleavage for erythropoietin semi-synthesis using native chemical ligation.

  Organic & biomolecular chemistry 20081107

• Expression of NR1, NR2A and NR2B NMDA receptor subunits is not altered in the genetically-inbred Balb/c mouse strain with heightened behavioral sensitivity to MK-801, a noncompetitive NMDA receptor antagonist.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20081101

• Structural insight on the activity of type 1 angiotensin II peptide antagonists using MD simulations.

  The journal of physical chemistry. B 20081030

• Crystal structure of the deglycating enzyme fructosamine oxidase (amadoriase II).

  The Journal of biological chemistry 20081003

• Mice with reduced NMDA receptor glycine affinity model some of the negative and cognitive symptoms of schizophrenia.

  Psychopharmacology 20081001

• Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs. cortical brain areas.

  Neuropharmacology 20081001

• Rescue of hippocampal LTP and learning deficits in a rat model of psychosis by inhibition of glycine transporter-1 (GlyT1).

  The European journal of neuroscience 20081001

• Discovery of antimycobacterial spiro-piperidin-4-ones: an atom economic, stereoselective synthesis, and biological intervention.

  Journal of medicinal chemistry 20080925

• The transglutaminase activating metalloprotease inhibitor from Streptomyces mobaraensis is a glutamine and lysine donor substrate of the intrinsic transglutaminase.

  FEBS letters 20080903

• Identification of the oxygen activation site in monomeric sarcosine oxidase: role of Lys265 in catalysis.

  Biochemistry 20080902

• Expression analysis of the BFN1 nuclease gene promoter during senescence, abscission, and programmed cell death-related processes.

  Journal of experimental botany 20080901

• Improvement of impaired albumin binding capacity in acute-on-chronic liver failure by albumin dialysis.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080901

• The phosphatidylinositol 3-kinase inhibitor LY 294002 inhibits GlyT1-mediated glycine uptake.

  Brain research 20080828

• Cytoplasmic expression of mouse prion protein causes severe toxicity in Caenorhabditis elegans.

  Biochemical and biophysical research communications 20080808

• PRAME expression and clinical outcome of breast cancer.

  British journal of cancer 20080805

• Permeabilization of baker's yeast with N-lauroyl sarcosine.

  Journal of industrial microbiology & biotechnology 20080801

• Spinal antiallodynia action of glycine transporter inhibitors in neuropathic pain models in mice.

  The Journal of pharmacology and experimental therapeutics 20080801

• Crystal structures of the conserved tRNA-modifying enzyme GidA: implications for its interaction with MnmE and substrate.

  Journal of molecular biology 20080711

• Acetylation of H4 suppresses the repressive effects of the N-termini of histones H3/H4 and facilitates the formation of positively coiled DNA.

  Biochemistry 20080708

• Mechanisms by which late coronary reperfusion mitigates postinfarction cardiac remodeling.

  Circulation research 20080703

• New insights into the open artery hypothesis.

  Circulation research 20080703

• [Synthesis and spectral properties of novel C60 derivative/Ag nanocomposites].

  Guang pu xue yu guang pu fen xi = Guang pu 20080701

• Effect of poly(D, L-lactic acid) nanoparticles as triptolide carrier on abating rats renal toxicity by NMR-based metabolic analysis.

  Journal of nanoscience and nanotechnology 20080701

• Thymidylate synthase, thymidine phosphorylase and orotate phosphoribosyl transferase levels as predictive factors of chemotherapy in oral squamous cell carcinoma.

  Acta histochemica et cytochemica 20080627

• Discovery of synergistic permeation enhancers for oral drug delivery.

  Journal of controlled release : official journal of the Controlled Release Society 20080604

• Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the glycine transporter-1 inhibitor NFPS and D-serine.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20080601

• The X-ray structure of N-methyltryptophan oxidase reveals the structural determinants of substrate specificity.

  Proteins 20080601

• Glycinergic nerve endings in hippocampus and spinal cord release glycine by different mechanisms in response to identical depolarizing stimuli.

  Journal of neurochemistry 20080601

• (4S)-4-(3,4-Dichloro-phen-yl)-1'-methyl-4'-phenyl-3,4-dihydronaphthalene-2-spiro-3'-pyrrolidine-2'-spiro-1''-acenaphthyl-ene-1,2''(2H,1''H)-dione.

  Acta crystallographica. Section E, Structure reports online 20080601

• Proline-rich proteins--deriving a basis for residue-based selectivity in polyphenolic binding.

  Organic & biomolecular chemistry 20080507

• Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy.

  Neuromuscular disorders : NMD 20080501

• Glycine transporter inhibitors as a potential therapeutic strategy for chronic pain with memory impairment.

  Anesthesiology 20080501

• Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant.

  Acta crystallographica. Section D, Biological crystallography 20080501

• Parasite burden and CD36-mediated sequestration are determinants of acute lung injury in an experimental malaria model.

  PLoS pathogens 20080501

• Pyromellitic acid-sarcosine (1/2).

  Acta crystallographica. Section E, Structure reports online 20080501

• Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase.

  The Journal of biological chemistry 20080404

• Synthesis, properties and photodynamic inactivation of Escherichia coli by novel cationic fullerene C60 derivatives.

  European journal of medicinal chemistry 20080401

• Development of fructosyl amine oxidase specific to fructosyl valine by site-directed mutagenesis.

  Protein engineering, design & selection : PEDS 20080401

• Heavy metal bioavailability and chelate mobilization efficiency in an assisted phytoextraction process.

  Environmental geochemistry and health 20080401

• Proteomic analysis of the sarcosine-insoluble outer membrane fraction of Flavobacterium columnare.

  Journal of fish diseases 20080401

• (3aS,9bR)-Methyl 1-methyl-3-phenyl-1,2,3,3a,4,9b-hexa-hydro-chromeno[4,3-b]pyrrole-3a-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20080401

• Synergistic enhancement of skin permeability by N-lauroylsarcosine and ethanol.

  International journal of pharmaceutics 20080320

• Singular efficacy of trimethylamine N-oxide to counter protein destabilization in ice.

  Biochemistry 20080318

• Adsorption of alpha amino acids at the water/goethite interface.

  Journal of colloid and interface science 20080315

• Krp1 (Sarcosin) promotes lateral fusion of myofibril assembly intermediates in cultured mouse cardiomyocytes.

  Experimental cell research 20080310

• Arginine 49 is a bifunctional residue important in catalysis and biosynthesis of monomeric sarcosine oxidase: a context-sensitive model for the electrostatic impact of arginine to lysine mutations.

  Biochemistry 20080304

• Characterization and structural modeling of a novel thermostable glycine oxidase from Geobacillus kaustophilus HTA426.

  Proteins 20080301

• Discovery and characterization of a putrescine oxidase from Rhodococcus erythropolis NCIMB 11540.

  Applied microbiology and biotechnology 20080301

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20080301

• Novel highly potent mu-opioid receptor antagonist based on endomorphin-2 structure.

  Bioorganic & medicinal chemistry letters 20080215

• Glycine uptake regulates hippocampal network activity via glycine receptor-mediated tonic inhibition.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080201

• Potentiation of the NMDA receptor in the treatment of schizophrenia: focused on the glycine site.

  European archives of psychiatry and clinical neuroscience 20080201

• Evaluation of nutritional and genetic determinants of total homocysteine, methylmalonic acid and S-adenosylmethionine/S-adenosylhomocysteine values in Brazilian childbearing-age women.

  Clinica chimica acta; international journal of clinical chemistry 20080201

• A large scale analysis of protein-protein interactions in the nitrogen-fixing bacterium Mesorhizobium loti.

  DNA research : an international journal for rapid publication of reports on genes and genomes 20080201

• Ethyl 3'-cyano-1'-methyl-2-oxo-4'-phenylspiro-[acenaphthene-1,2'-pyrrolidine]-3'-carboxyl-ate.

  Acta crystallographica. Section E, Structure reports online 20080201

• Covalent flavinylation of monomeric sarcosine oxidase: identification of a residue essential for holoenzyme biosynthesis.

  Biochemistry 20080129

• The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080116

• D-Serine and a glycine transporter inhibitor improve MK-801-induced cognitive deficits in a novel object recognition test in rats.

  Behavioural brain research 20080110

• Sarcosine (N-methylglycine) treatment for acute schizophrenia: a randomized, double-blind study.

  Biological psychiatry 20080101

• Development of an efficient protocol of RNA isolation from recalcitrant tree tissues.

  Molecular biotechnology 20080101

• Near-infrared fluorescent labeled peptosome for application to cancer imaging.

  Bioconjugate chemistry 20080101

• Pedein A and B: production, isolation, structure elucidation and biological properties of new antifungal cyclopeptides from Chondromyces pediculatus (Myxobacteria).

  The Journal of antibiotics 20080101

• Development of structure-lipid bilayer permeability relationships for peptide-like small organic molecules.

  Molecular pharmaceutics 20080101

• A mathematical model of glutathione metabolism.

  Theoretical biology & medical modelling 20080101

• Compatible solute influence on nucleic acids: many questions but few answers.

  Saline systems 20080101

• Genome-wide analysis of alternative promoters of human genes using a custom promoter tiling array.

  BMC genomics 20080101

• An optimized chloroplast DNA extraction protocol for grasses (Poaceae) proves suitable for whole plastid genome sequencing and SNP detection.

  PloS one 20080101

• Predicted mouse peroxisome-targeted proteins and their actual subcellular locations.

  BMC bioinformatics 20080101

• Rat Urinary Bladder Carcinogenesis by Dual-Acting PPARalpha + gamma Agonists.

  PPAR research 20080101

• Chronic experimental diabetes accelerates urinary elimination of deprenyl and its metabolites.

  The open medicinal chemistry journal 20080101

• (3aRS,9bSR)-3-(4-Chloro-phen-yl)-1-methyl-1,2,3,3a,4,9b-hexa-hydro-chromeno[4,3-b]pyrrole-3a-carbonitrile.

  Acta crystallographica. Section E, Structure reports online 20080101

• 1'-Methyl-4'-(1-naphth-yl)-3''-(1-naphthyl-methyl-ene)acenaphthene-1-spiro-2'-pyrrolidine-3'-spiro-1''-cyclo-hexane-2,2''-dione.

  Acta crystallographica. Section E, Structure reports online 20080101

• 5''-(4-Chloro-benzyl-idene)-1',1''-dimethyl-3'-phenyl-acenaphthene-1-spiro-2'-pyrrolidine-3'-spiro-3''-pyridine-2,4''-dione.

  Acta crystallographica. Section E, Structure reports online 20080101

• Testing the paradigm that the denaturing effect of urea on protein stability is offset by methylamines at the physiological concentration ratio of 2:1 (urea:methylamines).

  Biochimica et biophysica acta 20071201

• The salt-induced ABC transporter Ota of the methanogenic archaeon Methanosarcina mazei Gö1 is a glycine betaine transporter.

  FEMS microbiology letters 20071201

• [Antinociceptive effects of glycine transporter inhibitors in neuropathic pain models in mice].

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20071201

• The association of betaine, homocysteine and related metabolites with cognitive function in Dutch elderly people.

  The British journal of nutrition 20071101

• Glycine oxidase from Bacillus subtilis: role of histidine 244 and methionine 261.

  Biochimie 20071101

• Sex differences in the control of plasma concentrations and urinary excretion of glycine betaine in patients attending a lipid disorders clinic.

  Clinical biochemistry 20071101

• Exploration of intraclonal adaptation mechanisms of Pseudomonas brassicacearum facing cadmium toxicity.

  Environmental microbiology 20071101

• The contribution of the NMDA receptor glycine site to rhythm generation during fictive swimming in Xenopus laevis tadpoles.

  The European journal of neuroscience 20071101

• Structural and ligand-binding properties of serum albumin species interacting with a biomembrane interface.

  Journal of pharmaceutical sciences 20071101

• Functional analysis of genes encoding putative oxidoreductases in Aspergillus oryzae, which are similar to fungal fructosyl-amino acid oxidase.

  Journal of bioscience and bioengineering 20071101

• Photodegradation of glyphosate in the ferrioxalate system.

  Journal of hazardous materials 20070905

• Can the interaction density be measured? The example of the non-standard amino acid sarcosine.

  Acta crystallographica. Section A, Foundations of crystallography 20070901

• Thermodynamic characterization of the osmolyte effect on protein stability and the effect of GdnHCl on the protein denatured state.

  The journal of physical chemistry. B 20070802

• Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits.

  The Journal of pharmacology and experimental therapeutics 20070801

• DNA induces folding in alpha-synuclein: understanding the mechanism using chaperone property of osmolytes.

  Archives of biochemistry and biophysics 20070801

• Chemical chaperone rescue of mutant human cystathionine beta-synthase.

  Molecular genetics and metabolism 20070801

• Light chain C-terminal region reinforces the stability of clathrin heavy chain trimers.

  Traffic (Copenhagen, Denmark) 20070801

• A non-Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast.

  Molecular cell 20070706

• Folding and unfolding of helix-turn-helix motifs in the gas phase.

  Journal of the American Society for Mass Spectrometry 20070701

• Expedited, chemically enhanced sperm cell recovery from cotton swabs for rape kit analysis.

  Journal of forensic sciences 20070701

• [Biochemistry and structural biology of microbial enzymes and their medical applications].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070701

• Real-time measurement of free Ca2+ changes in CNS myelin by two-photon microscopy.

  Nature medicine 20070701

• Insights into the mechanism of flavoprotein-catalyzed amine oxidation from nitrogen isotope effects on the reaction of N-methyltryptophan oxidase.

  Biochemistry 20070626

• Kinetic studies on the role of Lys-171 and Lys-358 in the beta subunit of sarcosine oxidase from Corynebacterium sp. U-96.

  Journal of biochemistry 20070601

• Glycine-induced long-term synaptic potentiation is mediated by the glycine transporter GLYT1.

  Neuropharmacology 20070601

• YaeT-independent multimerization and outer membrane association of secretin PulD.

  Molecular microbiology 20070601

• Influence of electronic and steric effects on stability constants and electrochemical reversibility of divalent ion complexes with glycine and sarcosine. A glass electrode potentiometric, sampled direct current polarographic, virtual potentiometric, and molecular modelling study.

  Analytica chimica acta 20070508

• Synergistic effects of chemical enhancers on skin permeability: a case study of sodium lauroylsarcosinate and sorbitan monolaurate.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070501

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20070501

• Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells.

  American journal of physiology. Gastrointestinal and liver physiology 20070401

• High-affinity glycine and glutamate transport in pig forebrain white and gray matter: a quantitative study.

  Neurochemistry international 20070401

• Mechanistic aspects and redox properties of hyperthermophilic L-proline dehydrogenase from Pyrococcus furiosus related to dimethylglycine dehydrogenase/oxidase.

  The FEBS journal 20070401

• Signature-based small molecule screening identifies cytosine arabinoside as an EWS/FLI modulator in Ewing sarcoma.

  PLoS medicine 20070401

• Demonstration of functional dipeptide transport with expression of PEPT2 in guinea pig cardiomyocytes.

  Pflugers Archiv : European journal of physiology 20070301

• Amperometric biosensor for the determination of creatine.

  Analytical and bioanalytical chemistry 20070301

• Natural approaches to epilepsy.

  Alternative medicine review : a journal of clinical therapeutic 20070301

• 5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase.

  The Journal of biological chemistry 20070209

• Mixed osmolytes: the degree to which one osmolyte affects the protein stabilizing ability of another.

  Protein science : a publication of the Protein Society 20070201

• Glycine- and sarcosine-based models of vanadate-dependent haloperoxidases in sulfoxygenation reactions.

  Inorganic chemistry 20070108

• The organic osmolytes betaine and proline are transported by a shared system in early preimplantation mouse embryos.

  Journal of cellular physiology 20070101

• Characterization of oxysterols by electrospray ionization tandem mass spectrometry after one-step derivatization with dimethylglycine.

  Rapid communications in mass spectrometry : RCM 20070101

• Endogenous phospholipid metabolite containing topical product inhibits ultraviolet light-induced inflammation and DNA damage in human skin.

  Skin pharmacology and physiology 20070101

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20070101

• Microarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell line.

  Molecular vision 20070101

• Iron-independent specific protein expression pattern in the liver of HFE-deficient mice.

  The international journal of biochemistry & cell biology 20070101

• High-level production of bacillus subtilis glycine oxidase by fed-batch cultivation of recombinant Escherichia coli Rosetta (DE3).

  Biotechnology progress 20070101

• Immunomodulation of murine collagen-induced arthritis by N, N-dimethylglycine and a preparation of Perna canaliculus.

  BMC complementary and alternative medicine 20070101

• Investigation of laser-microdissected inclusion bodies.

  Methods in cell biology 20070101

• Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations.

  BMC genomics 20070101

• Genomic expression during human myelopoiesis.

  BMC genomics 20070101

• Genomic analysis reveals the major driving forces of bacterial life in the rhizosphere.

  Genome biology 20070101

• Application of the transfer model to understand how naturally occurring osmolytes affect protein stability.

  Methods in enzymology 20070101

• Conformational behavior of N-acylamino acid oil and N-acylamino acid surfactant in aqueous solution.

  Journal of oleo science 20070101

• Quantitative profiling of folate and one-carbon metabolism in large-scale epidemiological studies by mass spectrometry.

  Clinical chemistry and laboratory medicine 20070101

• Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana.

  BMC systems biology 20070101

• Catalysis in glycine N-methyltransferase: testing the electrostatic stabilization and compression hypothesis.

  Biochemistry 20061219

• Increasing the frequency of spontaneous rhythmic activity disrupts pool-specific axon fasciculation and pathfinding of embryonic spinal motoneurons.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20061206

• Expression and characterization of a thermostable sarcosine oxidase (SOX) from Bacillus sp. in Escherichia coli.

  Applied microbiology and biotechnology 20061201

• Active site analysis of fructosyl amine oxidase using homology modeling and site-directed mutagenesis.

  Biotechnology letters 20061201

• Effects of substrate and potassium on the betaine-synthesizing enzyme glycine sarcosine dimethylglycine N-methyltransferase from a halophilic methanoarchaeon Methanohalophilus portucalensis.

  Research in microbiology 20061201

• Systematic identification of the subproteome of Escherichia coli cell envelope reveals the interaction network of membrane proteins and membrane-associated peripheral proteins.

  Journal of proteome research 20061201

• Substance use disorders and Schizophrenia: a question of shared glutamatergic mechanisms.

  Neurotoxicity research 20061201

• Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo.

  Neuroscience research 20061101

• Structure-dependent photoinduced electron transfer in fullerodendrimers with light-harvesting oligophenylenevinylene terminals.

  Chemistry, an Asian journal 20061020

• Identification of a stable flavin-thiolate adduct in heterotetrameric sarcosine oxidase.

  Journal of molecular biology 20060929

• Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to clozapine for the treatment of schizophrenia.

  Biological psychiatry 20060915

• Tektin interactions and a model for molecular functions.

  Experimental cell research 20060910

• New 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr.

  Organic & biomolecular chemistry 20060907

• Pharmacological properties of glycine uptake in the developing rat retina.

  Neurochemistry international 20060901

• Designing amino acid residues with single-conformations.

  Protein engineering, design & selection : PEDS 20060901

• Mechanism of antibacterial action of a synthetic peptide with an Ala-peptoid residue based on the scorpion-derived antimicrobial peptide IsCT.

  Biotechnology letters 20060901

• Role of the covalent flavin linkage in monomeric sarcosine oxidase.

  Biochemistry 20060808

• Effect of ethylene glycol, urea, and N-methylated glycines on DNA thermal stability: the role of DNA base pair composition and hydration.

  Biochemistry 20060808

• Inhibition of the glycine transporter GlyT-1 potentiates the effect of risperidone, but not clozapine, on glutamatergic transmission in the rat medial prefrontal cortex.

  Synapse (New York, N.Y.) 20060801

• A report of two families with sarcosinaemia in Hong Kong and revisiting the pathogenetic potential of hypersarcosinaemia.

  Annals of the Academy of Medicine, Singapore 20060801

• Heterotetrameric sarcosine oxidase: structure of a diflavin metalloenzyme at 1.85 A resolution.

  Journal of molecular biology 20060728

• Mild and nonracemizing conditions for Ullmann-type diaryl ether formation between aryl iodides and tyrosine derivatives.

  The Journal of organic chemistry 20060707

• Critical factors influencing prion inactivation by sodium hydroxide.

  Vox sanguinis 20060701

• Degradation of glyphosate in soil and its effect on fungal population.

  Journal of environmental science & engineering 20060701

• Design and synthesis of novel sulfonamide-containing bradykinin hB2 receptor antagonists. 1. Synthesis and SAR of alpha,alpha-dimethylglycine sulfonamides.

  Journal of medicinal chemistry 20060615

• Nanosized rigid pi-conjugated molecular heterojunctions with multi[60]fullerenes: facile synthesis and photophysical properties.

  The Journal of organic chemistry 20060609

• Transactivation of rat apical sodium-dependent bile acid transporter and increased bile acid transport by 1alpha,25-dihydroxyvitamin D3 via the vitamin D receptor.

  Molecular pharmacology 20060601

• Use of sodium lauroyl sarcosinate in a high-sensitivity protein assay by resonance light scattering technique.

  Journal of biomolecular screening 20060601

• A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme.

  Transgenic research 20060601

• Modulatory effects of d-serine and sarcosine on NMDA receptor-mediated neurotransmission are apparent after stress in the genetically inbred BALB/c mouse strain.

  Brain research bulletin 20060531

• Functionalisation of carbon nanohorns.

  Chemical communications (Cambridge, England) 20060528

• GABAergic and glycinergic inhibitory mechanisms in the lamprey respiratory control.

  Brain research 20060523

• Spectral and kinetic characterization of the michaelis charge transfer complex in monomeric sarcosine oxidase.

  Biochemistry 20060516

• The paradoxical thermodynamic basis for the interaction of ethylene glycol, glycine, and sarcosine chains with bovine carbonic anhydrase II: an unexpected manifestation of enthalpy/entropy compensation.

  Journal of the American Chemical Society 20060503

• Osmolyte-induced protein folding free energy changes.

  Proteins 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Adding sarcosine, but not D-serine, to risperidone improves symptoms in people with acute phase schizophrenia.

  Evidence-based mental health 20060501

• Organic substances in xylem sap delivered to above-ground organs by the roots.

  Journal of plant research 20060501

• Gateways to clinical trials.

  Methods and findings in experimental and clinical pharmacology 20060501

• Liquid-crystalline fullerodendrimers which display columnar phases.

  Organic letters 20060427

• Radiosensitivity in breast cancer assessed by the Comet and micronucleus assays.

  British journal of cancer 20060424

• Health effects in fish of long-term exposure to effluents from wastewater treatment works.

  Environmental health perspectives 20060401

• Stabilization of charge-separated states in phthalocyanine-fullerene ensembles through supramolecular donor-acceptor interactions.

  Journal of the American Chemical Society 20060329

• Sensitivity to detergents and plasmid curing in Enterococcus faecalis.

  Journal of industrial microbiology & biotechnology 20060301

• Sarcosine based indandione hGlyT1 inhibitors.

  Bioorganic & medicinal chemistry letters 20060301

• The accumulation of methylamine counteracting solutes in elasmobranchs with differing levels of urea: a comparison of marine and freshwater species.

  The Journal of experimental biology 20060301

• Is the glycine site half saturated or half unsaturated? Effects of glutamatergic drugs in schizophrenia patients.

  Current opinion in psychiatry 20060301

• D-alanine added to antipsychotics for the treatment of schizophrenia.

  Biological psychiatry 20060201

• Application of electron spin resonance spin-trapping technique for evaluation of substrates and inhibitors of nitric oxide synthase.

  Analytical biochemistry 20060201

• Analysis of the Pasteurella multocida outer membrane sub-proteome and its response to the in vivo environment of the natural host.

  Proteomics 20060201

• Glutamate-based therapeutic approaches: inhibitors of glycine transport.

  Current opinion in pharmacology 20060201

• Treatment for mitochondrial disorders.

  The Cochrane database of systematic reviews 20060125

• Purification and antigenicity of two recombinant forms of Boophilus microplus yolk pro-cathepsin expressed in inclusion bodies.

  Protein expression and purification 20060101

• Development of a novel high-throughput assay for the investigation of GlyT-1b neurotransmitter transporter function.

  Combinatorial chemistry & high throughput screening 20060101

• [Novel diflavin-containing dehydrogenase family: FAD, FMN and ATP-containing L-proline dehydrogenase].

  Seikagaku. The Journal of Japanese Biochemical Society 20060101

• An amperometric enzyme electrode for creatine determination prepared by the immobilization of creatinase and sarcosine oxidase in poly(vinylferrocenium).

  Artificial cells, blood substitutes, and immobilization biotechnology 20060101

• Glycine transporter type-1 and its inhibitors.

  Current medicinal chemistry 20060101

• Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia.

  Current topics in medicinal chemistry 20060101

• Maximization of production of his-tagged glycine oxidase and its M261 mutant proteins.

  Biotechnology progress 20060101

• Clustering of Pseudomonas aeruginosa transcriptomes from planktonic cultures, developing and mature biofilms reveals distinct expression profiles.

  BMC genomics 20060101

• Determination of creatine in commercial creatine powder with new potentiometric and amperometric biosensors.

  Artificial cells, blood substitutes, and immobilization biotechnology 20060101

• A method for high-throughput gene expression signature analysis.

  Genome biology 20060101

• Simultaneous detection of creatine and creatinine using a sequential injection analysis/biosensor system.

  Preparative biochemistry & biotechnology 20060101

• Progress in the preparation and testing of glycine transporter type-1 (GlyT1) inhibitors.

  Current topics in medicinal chemistry 20060101

• Rare neurodevelopmental abnormalities of sarcosinemia may involve glycinergic stimulation of a primed N-methyl-d-aspartate receptor.

  Clinical neuropharmacology 20060101

• Simultaneous host and parasite expression profiling identifies tissue-specific transcriptional programs associated with susceptibility or resistance to experimental cerebral malaria.

  BMC genomics 20060101

• In silico experimentation with a model of hepatic mitochondrial folate metabolism.

  Theoretical biology & medical modelling 20060101

• Ionization of zwitterionic amine substrates bound to monomeric sarcosine oxidase.

  Biochemistry 20051227

• Electron propagator theory study of N-/O-methylglycine conformers.

  The Journal of chemical physics 20051222

• Redox cycling of iron complexes of N-(dithiocarboxy)sarcosine and N-methyl-D-glucamine dithiocarbamate.

  Free radical biology & medicine 20051215

• Oxidative degradation of glyphosate and aminomethylphosphonate by manganese oxide.

  Environmental science & technology 20051201

• Structure of the sodium borohydride-reduced N-(cyclopropyl)glycine adduct of the flavoenzyme monomeric sarcosine oxidase.

  Biochemistry 20051129

• Synergistic fungicidal activity of Cu(2+) and allicin, an allyl sulfur compound from garlic, and its relation to the role of alkyl hydroperoxide reductase 1 as a cell surface defense in Saccharomyces cerevisiae.

  Toxicology 20051115

• Poly(N-acryloylsarcosine methyl ester) protein-resistant surfaces.

  The journal of physical chemistry. B 20051110

• Transmembrane domains 1 and 3 of the glycine transporter GLYT1 contain structural determinants of N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)-propyl]sarcosine specificity.

  Neuropharmacology 20051101

• Mixed complexes of Pt(II) and Pd(II) with ethylsarcosinedithiocarbamate and 2-/3-picoline as antitumor agents.

  Journal of inorganic biochemistry 20051101

• Sarcosine or D-serine add-on treatment for acute exacerbation of schizophrenia: a randomized, double-blind, placebo-controlled study.

  Archives of general psychiatry 20051101

• Peroxisomal proteomics, a new tool for risk assessment of peroxisome proliferating pollutants in the marine environment.

  Proteomics 20051001

• Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization.

  Cell research 20051001

• Reactivities of quinone-free DsbB from Escherichia coli.

  The Journal of biological chemistry 20050923

• Crystal structure of a novel FAD-, FMN-, and ATP-containing L-proline dehydrogenase complex from Pyrococcus horikoshii.

  The Journal of biological chemistry 20050902

• Cloning, expression and crystallization of heterotetrameric sarcosine oxidase from Pseudomonas maltophilia.

  Protein expression and purification 20050901

• Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism.

  Pharmaceutical research 20050901

• TMAO and other organic osmolytes in the muscles of amphipods (Crustacea) from shallow and deep water of Lake Baikal.

  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20050901

• Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

  The Journal of biological chemistry 20050826

• Sexual dimorphism in urinary metabolite profiles of Han Wistar rats revealed by nuclear-magnetic-resonance-based metabonomics.

  Analytical biochemistry 20050815

• Gas-phase structure of N,N-dimethylglycine.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20050812

• Inhibitors of GlyT1 and GlyT2 differentially modulate inhibitory transmission.

  Neuroreport 20050801

• Crystal structure of heterotetrameric sarcosine oxidase from Corynebacterium sp. U-96.

  Biochemical and biophysical research communications 20050729

• Microheterogeneous solvation for aminolysis reactions in AOT-based water-in-oil microemulsions.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20050718

• The zebrafish shocked gene encodes a glycine transporter and is essential for the function of early neural circuits in the CNS.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713

• Amino acid promoted CuI-catalyzed C-N bond formation between aryl halides and amines or N-containing heterocycles.

  The Journal of organic chemistry 20050624

• Bile acid induces hydrophobicity-dependent membrane alterations.

  Biochimica et biophysica acta 20050615

• Biochemical and transcriptomic analyses of two bovine skeletal muscles in Charolais bulls divergently selected for muscle growth.

  Meat science 20050601

• Comprehensive assignment of mass spectral signatures from individual Bacillus atrophaeus spores in matrix-free laser desorption/ionization bioaerosol mass spectrometry.

  Analytical chemistry 20050515

• Biosynthesis of covalently bound flavin: isolation and in vitro flavinylation of the monomeric sarcosine oxidase apoprotein.

  Biochemistry 20050503

• Ampicillin/penicillin-binding protein interactions as a model drug-target system to optimize affinity pull-down and mass spectrometric strategies for target and pathway identification.

  Proteomics 20050501

• Corynebacterium sp. U-96 contains a cluster of genes of enzymes for the catabolism of sarcosine to pyruvate.

  Bioscience, biotechnology, and biochemistry 20050501

• Methyl transfer in glycine N-methyltransferase. A theoretical study.

  The journal of physical chemistry. B 20050428

• Binding mode and transcriptional activation potential of high affinity ligands for the CBP KIX domain.

  Journal of the American Chemical Society 20050406

• Modulation of striatal dopamine release by glycine transport inhibitors.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050401

• Cyclization-activated prodrugs. Synthesis, reactivity and toxicity of dipeptide esters of paracetamol.

  Bioorganic & medicinal chemistry letters 20050315

• Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino.

  The Journal of biological chemistry 20050311

• Synthesis, characterization, and comparative in vitro cytotoxicity studies of platinum(II), palladium(II), and gold(III) methylsarcosinedithiocarbamate complexes.

  Journal of medicinal chemistry 20050310

• Inhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action.

  Molecular psychiatry 20050301

• pH and kinetic isotope effects on sarcosine oxidation by N-methyltryptophan oxidase.

  Biochemistry 20050301

• Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.

  Analytical chemistry 20050301

• High-throughput solution-based medicinal library screening against human serum albumin.

  Analytical chemistry 20050301

• Occupational allergic contact dermatitis to sodium lauroyl sarcosinate in the liquid soap.

  Contact dermatitis 20050301

• Characterization of strychnine-sensitive glycine receptor in the intact frog retina: modulation by protein kinases.

  Neurochemical research 20050301

• A stable three-enzyme creatinine biosensor. 1. Impact of structure, function and environment on PEGylated and immobilized sarcosine oxidase.

  Acta biomaterialia 20050301

• Betaine and folate status as cooperative determinants of plasma homocysteine in humans.

  Arteriosclerosis, thrombosis, and vascular biology 20050201

• Efficient release from promoter-proximal stall sites requires transcript cleavage factor TFIIS.

  Molecular cell 20050107

• Homocysteine, glycine betaine, and N,N-dimethylglycine in patients attending a lipid clinic.

  Metabolism: clinical and experimental 20050101

• 3H-L-histidine and 65Zn(2+) are cotransported by a dipeptide transport system in intestine of lobster Homarus americanus.

  The Journal of experimental biology 20050101

• Enteric-coated cholylsarcosine microgranules for the treatment of short bowel syndrome.

  The Journal of pharmacy and pharmacology 20050101

• Substrate specificity and functional characterisation of the H+/amino acid transporter rat PAT2 (Slc36a2).

  British journal of pharmacology 20050101

• hPEPT1 affinity and translocation of selected Gln-Sar and Glu-Sar dipeptide derivatives.

  Molecular pharmaceutics 20050101

• A systematic search for new mammalian noncoding RNAs indicates little conserved intergenic transcription.

  BMC genomics 20050101

• Force measurement for antigen-antibody interaction by atomic force microscopy using a photograft-polymer spacer.

  Biomacromolecules 20050101

• Organic compatible solutes of halotolerant and halophilic microorganisms.

  Saline systems 20050101

• Proteomic analysis of the sarcosine-insoluble outer membrane fraction of Pseudomonas aeruginosa responding to ampicilin, kanamycin, and tetracycline resistance.

  Journal of proteome research 20050101

• Species-related differences in blastocyst quality are associated with differences in relative mRNA transcription.

  Molecular reproduction and development 20041201

• Novel ruthenium complex K2[Ru(dmgly)Cl4].2H2O is toxic to C6 astrocytoma cell line, but not to primary rat astrocytes.

  Journal of inorganic biochemistry 20041201

• Chemical aspects of amine oxidation by flavoprotein enzymes.

  Natural product reports 20041201

• A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.

  European journal of biochemistry 20041201

• Uncovering the basis for nonideal behavior of biological molecules.

  Biochemistry 20041116

• Integration of a flow-type chemiluminescence detector on a glass electrophoresis chip.

  Talanta 20041115

• Bergmann glial GlyT1 mediates glycine uptake and release in mouse cerebellar slices.

  The Journal of physiology 20041101

• Dimethylglycine supplementation does not affect plasma homocysteine concentrations in pre-dialysis chronic renal failure patients.

  Clinical biochemistry 20041101

• Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats.

  The Journal of nutritional biochemistry 20041101

• An isatin-beta-thiosemicarbazone-resistant vaccinia virus containing a mutation in the second largest subunit of the viral RNA polymerase is defective in transcription elongation.

  The Journal of biological chemistry 20041022

• The trimethylammonium headgroup of choline is a major determinant for substrate binding and specificity in choline oxidase.

  Archives of biochemistry and biophysics 20041015

• Thymidylate synthase predictive power is overcome by irinotecan combination therapy with S-1 for gastric cancer.

  British journal of cancer 20041004

• Blockade of glycine transporter-1 (GLYT-1) potentiates NMDA receptor-mediated synaptic transmission in hypoglossal motorneurons.

  Journal of neurophysiology 20041001

• Over-expression in Escherichia coli, functional characterization and refolding of rat dimethylglycine dehydrogenase.

  Protein expression and purification 20041001

• Proteomic analysis of the sarcosine-insoluble outer membrane fraction of the bacterial pathogen Bartonella henselae.

  Proteomics 20041001

• Spinnokinetic analyses of blood disposition and biliary excretion of nitric oxide (NO)-Fe(II)-N-(dithiocarboxy)sarcosine complex in rats: BCM-ESR and BEM-ESR studies.

  Free radical research 20041001

• Osmolytes induce structure in an early intermediate on the folding pathway of barstar.

  The Journal of biological chemistry 20040924

• Sustained antiproliferative mechanisms by RB24, a targeted precursor of multiple inhibitors of epidermal growth factor receptor and a DNA alkylating agent in the A431 epidermal carcinoma of the vulva cell line.

  British journal of cancer 20040913

• Iodo-controlled selective formation of pyrrolidino[60]fullerene and aziridino[60]fullerene from the reaction between C6) and amino acid esters.

  The Journal of organic chemistry 20040820

• Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins.

  Journal of neurochemistry 20040801

• Study in vitro and in vivo of nociceptin/orphanin FQ(1-13)NH2 analogues substituting N-Me-Gly for Gly2 or Gly3.

  Peptides 20040801

• Low pKa lysine residues at the active site of sarcosine oxidase from Corynebacterium sp. U-96.

  Biochemical and biophysical research communications 20040730

• Structure-function correlation in glycine oxidase from Bacillus subtilis.

  The Journal of biological chemistry 20040709

• Annular alpha-synuclein species from purified multiple system atrophy inclusions.

  Journal of neurochemistry 20040701

• Conjugated bile acid replacement therapy in short bowel syndrome patients with a residual colon.

  Zeitschrift fur Gastroenterologie 20040701

• Interactions of enzymes and a lectin with a chitin-based graft copolymer having polysarcosine side chains.

  Macromolecular bioscience 20040625

• New insights into protein S-nitrosylation. Mitochondria as a model system.

  The Journal of biological chemistry 20040611

• Electrochemical charging of a fullerene-functionalized self-assembled monolayer on au(111).

  The Journal of organic chemistry 20040611

• Glycine transporter type 1 blockade changes NMDA receptor-mediated responses and LTP in hippocampal CA1 pyramidal cells by altering extracellular glycine levels.

  The Journal of physiology 20040601

• Characterization of glycine N-methyltransferase from rabbit liver.

  Biochemistry and cell biology = Biochimie et biologie cellulaire 20040601

• Mutational and structural-based analyses of the osmolyte effect on protein stability.

  Journal of biochemistry 20040601

• Dissecting the catalytic mechanism of betaine-homocysteine S-methyltransferase by use of intrinsic tryptophan fluorescence and site-directed mutagenesis.

  Biochemistry 20040511

• Characterization and metabolic function of a peroxisomal sarcosine and pipecolate oxidase from Arabidopsis.

  The Journal of biological chemistry 20040423

• Mammalian electron transferring flavoprotein.flavoprotein dehydrogenase complexes observed by microelectrospray ionization-mass spectrometry and surface plasmon resonance.

  The Journal of biological chemistry 20040402

• The osmoprotectants glycine and its methyl derivatives prevent the thermal inactivation of protective antigen of Bacillus anthracis.

  Biochemical and biophysical research communications 20040402

• The interaction of human serum albumin with a novel antidiabetic agent--SU-118.

  Journal of pharmaceutical sciences 20040401

• Glycine transporter I inhibitor, N-methylglycine (sarcosine), added to antipsychotics for the treatment of schizophrenia.

  Biological psychiatry 20040301

• Influence of hemodialysis membrane permeability on serum levels of advanced glycation end products (AGEs) and homocysteine metabolites.

  Clinical nephrology 20040301

• Immune response induced by N-lauroylsarcosine extracted outer-membrane proteins of an isolate of Edwardsiella ictaluri in channel catfish.

  Fish & shellfish immunology 20040301

• Additive transfer free energies of the peptide backbone unit that are independent of the model compound and the choice of concentration scale.

  Biochemistry 20040210

• Reversal of phencyclidine-induced dopaminergic dysregulation by N-methyl-D-aspartate receptor/glycine-site agonists.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040201

• Betaine as a determinant of postmethionine load total plasma homocysteine before and after B-vitamin supplementation.

  Arteriosclerosis, thrombosis, and vascular biology 20040201

• Extraction of heavy metals from soils using biodegradable chelating agents.

  Environmental science & technology 20040201

• Pharmacological properties of glycine transport in the frog retina.

  Neurochemical research 20040101

• pB264, a small, mobilizable, temperature sensitive plasmid from Rhodococcus.

  BMC microbiology 20040101

• SUPFAM: a database of sequence superfamilies of protein domains.

  BMC bioinformatics 20040101

• System-based proteomic analysis of the interferon response in human liver cells.

  Genome biology 20040101

• Epidemiological and serological survey of brucellosis in Mongolia by ELISA using sarcosine extracts.

  Microbiology and immunology 20040101

• The functional landscape of mouse gene expression.

  Journal of biology 20040101

• Synthesis of non-immunosuppressive cyclophilin-Binding cyclosporin A derivatives as potential anti-HIV-1 drugs.

  Bioorganic & medicinal chemistry letters 20031215

• A strategy for identification and quantification of detergents frequently used in the purification of membrane proteins.

  Analytical biochemistry 20031215

• A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055.

  Journal of medicinal chemistry 20031204

• A single arginine residue is required for the interaction of the electron transferring flavoprotein (ETF) with three of its dehydrogenase partners.

  Molecular and cellular biochemistry 20031201

• Enzymatic activity and stability of D-fructose dehydrogenase and sarcosine dehydrogenase immobilized onto giant vesicles.

  Biotechnology and bioengineering 20031120

• Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition.

  Neuron 20031113

• Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1.

  The Journal of biological chemistry 20031107

• Effects of endogenous agonists, glycine and D-serine, on in vivo specific binding of [11C]L-703,717, a PET radioligand for the glycine-binding site of NMDA receptors.

  Synapse (New York, N.Y.) 20031101

• Relative messenger RNA abundance in bovine oocytes collected in vitro or in vivo before and 20 hr after the preovulatory luteinizing hormone surge.

  Molecular reproduction and development 20031101

• In vivo characterization of changes in glycine levels induced by GlyT1 inhibitors.

  Annals of the New York Academy of Sciences 20031101

• Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.

  Neuron 20031030

• N,N-dimethyl glycine-promoted Ullmann coupling reaction of phenols and aryl halides.

  Organic letters 20031016

• Temporal divergence in the pattern of messenger RNA expression in bovine embryos cultured from the zygote to blastocyst stage in vitro or in vivo.

  Biology of reproduction 20031001

• Pharmacology and expression analysis of glycine transporter GlyT1 with [3H]-(N-[3-(4'-fluorophenyl)-3-(4'phenylphenoxy)propyl])sarcosine.

  Neuropharmacology 20031001

• Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity.

  Analytical biochemistry 20031001

• Persistence of adhesive properties in Vibrio cholerae after long-term exposure to sea water.

  Environmental microbiology 20031001

• Synthesis of phosphorothioate oligonucleotides with stereodefined phosphorothioate linkages.

  Current protocols in nucleic acid chemistry 20031001

• Design of N-substituted peptomer ligands for EVH1 domains.

  The Journal of biological chemistry 20030919

• Quantitative recovery of immunoreactive proteins from clinical samples following RNA and DNA isolation.

  BioTechniques 20030901

• Simultaneous determination of creatine and creatinine using amperometric biosensors.

  Talanta 20030829

• The glycine transporter type 1 inhibitor N-[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20030820

• Radiosensitivity of human tumour cells is correlated with the induction but not with the repair of DNA double-strand breaks.

  British journal of cancer 20030804

• Catalytic mechanism of glycine N-methyltransferase.

  Biochemistry 20030722

• Osmolyte effects on kinetics of FKBP12 C22A folding coupled with prolyl isomerization.

  Journal of molecular biology 20030718

• Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes.

  The Biochemical journal 20030715

• Mild method for Ullmann coupling reaction of amines and aryl halides.

  Organic letters 20030710

• Liquid chromatographic determination of hydroxyproline in tissue samples.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030705

• Enzyme-linked immunosorbent assay to differentiate the antibody responses of animals infected with Brucella species from those of animals infected with Yersinia enterocolitica O9.

  Clinical and diagnostic laboratory immunology 20030701

• New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly.

  Journal of cell science 20030601

• Sarcosine-maleic acid (1:1) crystal: structure, 13C NMR and vibrational properties, protonation character.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030601

• Optimized conventional synthesis of 'RGD' and 'RGDS' peptides and their sarcosine mimics as integrin GP IIb/IIIa antagonists.

  Amino acids 20030601

• Degradation, cyclic adenosine monophosphate production, insulin secretion, and glycemic effects of two novel N-terminal Ala2-substituted analogs of glucose-dependent insulinotropic polypeptide with preserved biological activity in vivo.

  Metabolism: clinical and experimental 20030601

• [3H]-(R)-NPTS, a radioligand for the type 1 glycine transporter.

  Bioorganic & medicinal chemistry letters 20030407

• Modeling anhydrous and aqua copper(II) amino acid complexes: a new molecular mechanics force field parametrization based on quantum chemical studies and experimental crystal data.

  Inorganic chemistry 20030407

• Kinetic mechanisms of glycine oxidase from Bacillus subtilis.

  European journal of biochemistry 20030401

• Role of EphA4 and EphrinB3 in local neuronal circuits that control walking.

  Science (New York, N.Y.) 20030321

• Structural and mechanistic studies on ThiO, a glycine oxidase essential for thiamin biosynthesis in Bacillus subtilis.

  Biochemistry 20030318

• Oral bile acids reduce bacterial overgrowth, bacterial translocation, and endotoxemia in cirrhotic rats.

  Hepatology (Baltimore, Md.) 20030301

• The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study.

  Pharmacology, biochemistry, and behavior 20030301

• Molecular recognition in the gas phase ligand switching reactions of the proton bound dimer of sarcosine and glycylglycine.

  Organic & biomolecular chemistry 20030221

• A hydrophobicity scale for the lipid bilayer barrier domain from peptide permeabilities: nonadditivities in residue contributions.

  Biochemistry 20030218

• Isolation and functional characterization of N-methyltransferases that catalyze betaine synthesis from glycine in a halotolerant photosynthetic organism Aphanothece halophytica.

  The Journal of biological chemistry 20030214

• Synthesis, antimicrobial and antifungal activity of a new class of spiro pyrrolidines.

  Bioorganic & medicinal chemistry 20030206

• Tautomeric rearrangement of a dihydroflavin bound to monomeric sarcosine oxidase or N-methyltryptophan oxidase.

  Biochemistry 20030204

• Determination of choline, betaine, and dimethylglycine in plasma by a high-throughput method based on normal-phase chromatography-tandem mass spectrometry.

  Clinical chemistry 20030201

• Glycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo.

  Journal of neurophysiology 20030201

• Microfabricated electrophoresis chip for bioassay of renal markers.

  Analytical chemistry 20030201

• Pt(II) and Pd(II) derivatives of ter-butylsarcosinedithiocarbamate. Synthesis, chemical and biological characterization and in vitro nephrotoxicity.

  Journal of inorganic biochemistry 20030115

• Conjugated bile acid replacement therapy reduces urinary oxalate excretion in short bowel syndrome.

  American journal of kidney diseases : the official journal of the National Kidney Foundation 20030101

• The effect of short-term dimethylglycine treatment on oxygen consumption in cytochrome oxidase deficiency: a double-blind randomized crossover clinical trial.

  The Journal of pediatrics 20030101

• Pharmacokinetics of oral betaine in healthy subjects and patients with homocystinuria.

  British journal of clinical pharmacology 20030101

• Substrate recognition by the mammalian proton-dependent amino acid transporter PAT1.

  Molecular membrane biology 20030101

• Isolation of cosmid and BAC DNA from E. coli.

  Methods in molecular biology (Clifton, N.J.) 20030101

• Molecular phylogeny of the kelch-repeat superfamily reveals an expansion of BTB/kelch proteins in animals.

  BMC bioinformatics 20030101

• Glycine N -methyltransferase deficiency: a new patient with a novel mutation.

  Journal of inherited metabolic disease 20030101

• Homocystinuria due to cystathionine beta-synthase deficiency: novel biochemical findings and treatment efficacy.

  Journal of inherited metabolic disease 20030101

• Polar residue tagging of transmembrane peptides.

  Biopolymers 20030101

• Molecular characterization of NikD, a new flavoenzyme important in the biosynthesis of nikkomycin antibiotics.

  Biochemistry 20021231

• Efficacy of macromolecular crowding in forcing proteins to fold.

  Biophysical chemistry 20021210

• Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility.

  Journal of neurochemistry 20021201

• Simultaneous horizontal gene transfer of a gene coding for ribosomal protein l27 and operational genes in Arthrobacter sp.

  Journal of molecular evolution 20021201

• Hydrophobicity and helicity of membrane-interactive peptides containing peptoid residues.

  Biopolymers 20021115

• Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20021101

• Glycine receptors and transporters on bullfrog retinal Müller cells.

  Neuroreport 20020916

• Promoter escape by RNA polymerase II.

  Biochimica et biophysica acta 20020913

• Iron (III) induces aggregation of hyperphosphorylated tau and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease.

  Journal of neurochemistry 20020901

• Synthesis, characterization and in vitro cytotoxicity of new organotin(IV) derivatives of N-methylglycine.

  Journal of inorganic biochemistry 20020815

• Monomeric sarcosine oxidase: evidence for an ionizable group in the E.S complex.

  Biochemistry 20020806

• Monomeric sarcosine oxidase: role of histidine 269 in catalysis.

  Biochemistry 20020806

• Elevated plasma total homocysteine in severe methionine adenosyltransferase I/III deficiency.

  Metabolism: clinical and experimental 20020801

• Argyrins, immunosuppressive cyclic peptides from myxobacteria. II. Structure elucidation and stereochemistry.

  The Journal of antibiotics 20020801

• A new conceptual framework for enzyme catalysis. Hydrogen tunnelling coupled to enzyme dynamics in flavoprotein and quinoprotein enzymes.

  European journal of biochemistry 20020701

• Assay of the concentration and (13)C isotopic enrichment of propionyl-CoA, methylmalonyl-CoA, and succinyl-CoA by gas chromatography-mass spectrometry.

  Analytical biochemistry 20020601

• Peptoid residues and beta-turn formation.

  Journal of peptide science : an official publication of the European Peptide Society 20020601

• Mechanistic aspects of the covalent flavoprotein dimethylglycine oxidase of Arthrobacter globiformis studied by stopped-flow spectrophotometry.

  Biochemistry 20020409

• An unexpected Diels-Alder reaction on the fullerene core rather than an expected 1,3-dipolar cycloaddition.

  Chemical communications (Cambridge, England) 20020407

• Late-onset frontotemporal dementia with a novel exon 1 (Arg5His) tau gene mutation.

  Annals of neurology 20020401

• Detergent extract from chlamydial elementary bodies used as antigen for enzyme-linked immunosorbent assay.

  Diagnostic microbiology and infectious disease 20020401

• Proteome analysis of hepatocellular carcinoma.

  Biochemical and biophysical research communications 20020308

• Glycine oxidase from Bacillus subtilis. Characterization of a new flavoprotein.

  The Journal of biological chemistry 20020301

• Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism.

  American journal of physiology. Cell physiology 20020301

• Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure.

  Kidney international 20020301

• Analysis of differential messenger RNA expression between bovine blastocysts produced in different culture systems: implications for blastocyst quality.

  Biology of reproduction 20020301

• Overexpression of a recombinant wild-type and His-tagged Bacillus subtilis glycine oxidase in Escherichia coli.

  European journal of biochemistry 20020301

• Beta-alanine and taurine as endogenous agonists at glycine receptors in rat hippocampus in vitro.

  The Journal of physiology 20020215

• Synthesis of new beta-substituted meso-tetraphenylporphyrins via 1,3-dipolar cycloaddition reactions. 1.

  The Journal of organic chemistry 20020208

• Single crystal EPR studies on Mn(II)-doped sarcosine cadmium chloride and sarcosine cadmium bromide: study of zero-field splitting tensor in iso-structural complexes.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020201

• Polyols induce ATP-independent folding of GroEL-bound bacterial glutamine synthetase.

  Archives of biochemistry and biophysics 20020115

• Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism.

  Human genetics 20020101

• Cofactors in sarcosine oxidase from Corynebacterium sp. U-96.

  Journal of protein chemistry 20020101

• Biosensors and flow-through system for the determination of creatinine in hemodialysate.

  Analytical and bioanalytical chemistry 20020101

• Ion conductors derived from biogenic amines, bile acids, and amino acids.

  Bioconjugate chemistry 20020101

• Lysosomotropic N,N- dimethyl alpha-aminoacid N-alkyl esters and their quaternary ammonium salts as plasma membrane and mitochondrial ATPases inhibitors.

  Cellular & molecular biology letters 20020101

• The Gd(3+) complex of a fatty acid analogue of DOTP binds to multiple albumin sites with variable water relaxivities.

  Inorganic chemistry 20011217

• Ultrastructural and biochemical localization of N-RAP at the interface between myofibrils and intercalated disks in the mouse heart.

  Biochemistry 20011211

• Kinetic and mechanistic characterization of NMDA receptor antagonism by replacement and truncation variants of the conantokin peptides.

  Neuropharmacology 20011201

• ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter.

  Molecular pharmacology 20011201

• N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport.

  British journal of pharmacology 20011201

• B-subunit of phosphate-specific transporter from Mycobacterium tuberculosis is a thermostable ATPase.

  The Journal of biological chemistry 20011130

• Decrease of elevated N,N-dimethylglycine and N-methylglycine in human immunodeficiency virus infection during short-term highly active antiretroviral therapy.

  Metabolism: clinical and experimental 20011101

• Conformational change, aggregation and fibril formation induced by detergent treatments of cellular prion protein.

  Journal of neurochemistry 20011101

• Osmolytes as modulators of conformational changes in serpins.

  Biological chemistry 20011101

• Amperometric creatinine biosensor for hemodialysis patients.

  Clinica chimica acta; international journal of clinical chemistry 20011001

• Expression profiling of cardiac genes in human hypertrophic cardiomyopathy: insight into the pathogenesis of phenotypes.

  Journal of the American College of Cardiology 20011001

• Single-cell gel (comet) assay detects primary DNA damage in nonneoplastic urothelial cells of smokers and ex-smokers.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20010901

• Synthesis and spectroscopic characterization of protected N-phosphonomethylglycine dipeptides.

  Journal of peptide science : an official publication of the European Peptide Society 20010901

• Investigations into biochemical changes due to diurnal variation and estrus cycle in female rats using high-resolution (1)H NMR spectroscopy of urine and pattern recognition.

  Analytical biochemistry 20010815

• Osmolytes stabilize ribonuclease S by stabilizing its fragments S protein and S peptide to compact folding-competent states.

  The Journal of biological chemistry 20010803

• Purification and kinetic properties of betaine-homocysteine methyltransferase from Aphanothece halophytica.

  Current microbiology 20010801

• Intracellular re-routing of prion protein prevents propagation of PrP(Sc) and delays onset of prion disease.

  The EMBO journal 20010801

• Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia.

  Journal of inherited metabolic disease 20010801

• Homocysteine metabolism in children with Down syndrome: in vitro modulation.

  American journal of human genetics 20010701

• Pharmacological assessment of the role of the glycine transporter GlyT-1 in mediating high-affinity glycine uptake by rat cerebral cortex and cerebellum synaptosomes.

  Neuropharmacology 20010701

• Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations.

  Kidney international 20010601

• Organization of the genes involved in dimethylglycine and sarcosine degradation in Arthrobacter spp.: implications for glycine betaine catabolism.

  European journal of biochemistry 20010601

• Discovery of the factor Xa inhibitor, ZK 807834 (CI-1031).

  Current topics in medicinal chemistry 20010601

• Organization of the multiple coenzymes and subunits and role of the covalent flavin link in the complex heterotetrameric sarcosine oxidase.

  Biochemistry 20010508

• Cloning of dimethylglycine dehydrogenase and a new human inborn error of metabolism, dimethylglycine dehydrogenase deficiency.

  American journal of human genetics 20010401

• Conformation of cationic N,N-dimethylglycine in dimethylglycinium trifluoroacetate.

  Acta crystallographica. Section C, Crystal structure communications 20010401

• N-[tris(hydroxymethyl)methyl]glycine(tricine).

  Acta crystallographica. Section C, Crystal structure communications 20010401

• Glycine is taken up through GLYT1 and GLYT2 transporters into mouse spinal cord axon terminals and causes vesicular and carrier-mediated release of its proposed co-transmitter GABA.

  Journal of neurochemistry 20010301

• Effectiveness of N,N-dimethylglycine in autism and pervasive developmental disorder.

  Journal of child neurology 20010301

• Co-localization of alpha-synuclein and phosphorylated tau in neuronal and glial cytoplasmic inclusions in a patient with multiple system atrophy of long duration.

  Acta neuropathologica 20010301

• Analysis of alcohols, as dimethylglycine esters, by electrospray ionization tandem mass spectrometry.

  Journal of mass spectrometry : JMS 20010301

• Creatine as nutritional supplementation and medicinal product.

  The Journal of sports medicine and physical fitness 20010301

• Characterization of the FAD-containing N-methyltryptophan oxidase from Escherichia coli.

  Biochemistry 20010206

• N-methyltryptophan oxidase from Escherichia coli: reaction kinetics with N-methyl amino acid and carbinolamine substrates.

  Biochemistry 20010206

• Glycine supply to human enterocytes mediated by high-affinity basolateral GLYT1.

  Gastroenterology 20010201

• Distinct isoforms of tau aggregated in neurons and glial cells in brains of patients with Pick's disease, corticobasal degeneration and progressive supranuclear palsy.

  Acta neuropathologica 20010201

• 5-Aminolaevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line.

  Photochemistry and photobiology 20010201

• ICE bioassay. Isolating in vivo complexes of enzyme to DNA.

  Methods in molecular biology (Clifton, N.J.) 20010101

• Raman spectroscopy in magnetic fluids.

  Biomolecular engineering 20010101

• Final report on the safety assessment of Cocoyl Sarcosine, Lauroyl Sarcosine, Myristoyl Sarcosine, Oleoyl Sarcosine, Stearoyl Sarcosine, Sodium Cocoyl Sarcosinate, Sodium Lauroyl Sarcosinate, Sodium Myristoyl Sarcosinate, Ammonium Cocoyl Sarcosinate, and Ammonium Lauroyl Sarcosinate.

  International journal of toxicology 20010101

• Analysis of amino acids as formamidene butyl esters by electrospray ionization tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20010101

• L-Pipecolic acid oxidase, a human enzyme essential for the degradation of L-pipecolic acid, is most similar to the monomeric sarcosine oxidases.

  The Biochemical journal 20000201

• Dual effects of lisinopril on puromycin aminonucleoside nephrosis in unilaterally nephrectomized rats.

  Japanese journal of pharmacology 19970401

• Cloning and functional expression of a mammalian gene for a peroxisomal sarcosine oxidase.

  The Journal of biological chemistry 19970307

• NMR and X-ray crystallographic studies on cyclic tetrapeptide, cyclo (D-Phe-Pro-Sar-Gly).

  International journal of peptide and protein research 19960701

• Betaine:homocysteine methyltransferase from rat liver: purification and inhibition by a boronic acid substrate analog.

  Archives of biochemistry and biophysics 19920101

• Effects of cellular copper content on copper uptake and metallothionein and ceruloplasmin mRNA levels in mouse hepatocytes.

  The Journal of nutrition 19901101

• Demonstration of human, rye grass pollen extract-specific, helper and suppressor stimulating activity of modified allergens by effects on in vitro hapten-specific antibody production.

  International archives of allergy and applied immunology 19890101