1072946-45-2 | 4-(Aminomethyl)-3-fluorophenylboronic acid, HCl

Packsize	Purity	Availability	Price	Discounted Price
100mg	97%	in stock	$50.00	$35.00
250mg	97%	in stock	$73.00	$51.00
1g	97%	in stock	$185.00	$129.00
5g	97%	in stock	$640.00	$448.00
10g	97%	in stock	$1,149.00	$804.00
25g	97%	in stock	$2,344.00	$1,641.00

Description

• Catalog Number: AE10414
• Chemical Name: 4-(Aminomethyl)-3-fluorophenylboronic acid, HCl
• CAS Number: 1072946-45-2
• Molecular Formula: C7H10BClFNO2
• Molecular Weight: 205.4222
• MDL Number: MFCD11053810
• SMILES: NCc1ccc(cc1F)B(O)O.Cl

Computed Properties

• Complexity: 147
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 4
• Rotatable Bond Count: 2

Upstream Synthesis Route

The (4-(Aminomethyl)-3-fluorophenyl)boronic acid hydrochloride is a versatile chemical reagent commonly used in chemical synthesis for the formation of carbon-carbon and carbon-heteroatom bonds. Due to its unique structure and properties, this compound serves as a valuable building block in the preparation of various pharmaceutical intermediates, agrochemicals, and materials.In organic synthesis, (4-(Aminomethyl)-3-fluorophenyl)boronic acid hydrochloride is frequently employed in Suzuki-Miyaura cross-coupling reactions to construct aryl-aryl or aryl-heteroaryl linkages. This methodology allows for the efficient and selective formation of C-C bonds under mild reaction conditions, making it an essential tool in drug discovery and development. Additionally, the boronic acid functionality in the molecule enables selective transformations through boronate ester formation, facilitating the synthesis of complex molecules with high stereochemical control.Furthermore, the presence of the fluorine atom in the phenyl ring confers unique properties to the compound, such as altered reactivity and pharmacokinetic profiles in drug design. By incorporating fluorine-containing building blocks like (4-(Aminomethyl)-3-fluorophenyl)boronic acid hydrochloride into molecular structures, chemists can modulate the physicochemical properties of bioactive compounds, enhancing their potency, selectivity, and metabolic stability.Overall, the (4-(Aminomethyl)-3-fluorophenyl)boronic acid hydrochloride plays a pivotal role in modern organic synthesis, enabling chemists to access diverse chemical space and accelerate the discovery of novel therapeutic agents and functional materials.