1072951-47-3 | 8-Trifluoromethylquinoline-6-boronic acid

Packsize	Purity	Availability	Price	Discounted Price
250mg	98%	in stock	$95.00	$67.00
1g	98%	in stock	$251.00	$176.00
5g	98%	in stock	$760.00	$532.00
10g	98%	in stock	$1,319.00	$923.00
25g	98%	in stock	$2,625.00	$1,837.00

Description

• Catalog Number: AD68729
• Chemical Name: 8-Trifluoromethylquinoline-6-boronic acid
• CAS Number: 1072951-47-3
• Molecular Formula: C10H7BF3NO2
• Molecular Weight: 240.9743
• MDL Number: MFCD11504852
• SMILES: OB(c1cc2cccnc2c(c1)C(F)(F)F)O

Computed Properties

• Complexity: 275
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 17
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1

Upstream Synthesis Route

The (8-(Trifluoromethyl)quinolin-6-yl)boronic acid is a valuable reagent in chemical synthesis, particularly in the field of organic chemistry. Its unique structure and properties make it a versatile tool for various synthetic applications. This compound is widely used as a boronic acid building block in the preparation of biologically active molecules and pharmaceutical intermediates.Its presence of a boronic acid functional group allows for the formation of stable boronate esters through Suzuki-Miyaura cross-coupling reactions with aryl halides or pseudohalides. This reaction is commonly employed in the synthesis of complex organic molecules, such as natural products, pharmaceuticals, and materials science.Additionally, the trifluoromethyl group on the quinoline ring imparts significant lipophilicity and steric effects, making it a valuable handle for altering the physicochemical properties of the target molecules. This property is often exploited to enhance the bioavailability and metabolic stability of drug candidates.Overall, the (8-(Trifluoromethyl)quinolin-6-yl)boronic acid serves as a key building block in the design and synthesis of novel chemical entities with potential applications in drug discovery, agrochemicals, and materials science. Its versatility and reactivity make it a valuable tool for organic chemists seeking to explore new avenues in chemical synthesis and molecular design.