1073371-73-9 | 4-(Hydroxy(thiazol-2-yl)methyl)phenylboronic acid, pinacol ester

Packsize	Purity	Availability	Price	Discounted Price
1g	96%	in stock	$105.00	$74.00
5g	96%	in stock	$293.00	$205.00

Description

• Catalog Number: AE20048
• Chemical Name: 4-(Hydroxy(thiazol-2-yl)methyl)phenylboronic acid, pinacol ester
• CAS Number: 1073371-73-9
• Molecular Formula: C16H20BNO3S
• Molecular Weight: 317.2109
• MDL Number: MFCD09953504
• SMILES: OC(c1nccs1)c1ccc(cc1)B1OC(C(O1)(C)C)(C)C

Computed Properties

• Complexity: 383
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 22
• Hydrogen Bond Acceptor Count: 5
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 3
• Undefined Atom Stereocenter Count: 1

Upstream Synthesis Route

The compound (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(thiazol-2-yl)methanol, commonly referred to as $name$, is a versatile reagent that plays a crucial role in chemical synthesis. This compound is primarily utilized as a key building block in the development of various organic molecules due to its unique structural properties and reactivity.One of the key applications of $name$ in chemical synthesis is as a boronic ester reagent in Suzuki-Miyaura cross-coupling reactions. In this process, $name$ acts as a boron source that undergoes transmetallation with an organoboron compound in the presence of a palladium catalyst. This reaction allows for the formation of carbon-carbon bonds, enabling the synthesis of complex organic molecules with high selectivity and efficiency.Moreover, the thiazole moiety in $name$ confers additional functionality and diversity to the synthesized molecules, making it a valuable tool in medicinal chemistry and material science. The combination of boronic ester and thiazole functionalities in $name$ offers a wide range of synthetic possibilities, allowing chemists to access novel compounds with tailored properties and applications.Overall, the strategic incorporation of (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)(thiazol-2-yl)methanol in chemical synthesis enables the streamlined and efficient construction of complex molecules, making it an indispensable reagent in modern organic chemistry research.