1074-79-9 | Ac-DL-Pro-OH

Packsize	Purity	Availability	Price	Discounted Price
1g	97%	in stock	$6.00	$4.00
5g	97%	in stock	$13.00	$9.00
25g	97%	in stock	$56.00	$39.00
100g	98%	in stock	$147.00	$103.00
500g	98%	in stock	$511.00	$358.00

Description

• Catalog Number: AD79127
• Chemical Name: Ac-DL-Pro-OH
• CAS Number: 1074-79-9
• Molecular Formula: C7H11NO3
• Molecular Weight: 157.1671
• MDL Number: MFCD02678612
• SMILES: CC(=O)N1CCCC1C(=O)O
• NSC Number: 280718

Computed Properties

• Complexity: 190
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 11
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 1
• Undefined Atom Stereocenter Count: 1
• XLogP3: -0.7

Upstream Synthesis Route

1-Acetylpyrrolidine-2-carboxylic acid, also known as $name$, is a valuable compound widely used in chemical synthesis for its versatility and reactivity. In organic chemistry, this compound serves as a key building block in the creation of various pharmaceuticals, agrochemicals, and fine chemicals. Its unique structure and functional groups make it a crucial intermediate in the synthesis of complex organic molecules.One of the primary applications of 1-Acetylpyrrolidine-2-carboxylic acid is as a starting material for the synthesis of heterocyclic compounds. These compounds play a vital role in drug discovery and development, as many biologically active molecules contain heterocyclic motifs. By incorporating 1-Acetylpyrrolidine-2-carboxylic acid into the synthesis of these compounds, chemists can access a diverse array of structures with potential medicinal properties.Furthermore, 1-Acetylpyrrolidine-2-carboxylic acid can be utilized in the preparation of chiral compounds. Asymmetric synthesis, a method to selectively produce enantiomerically pure molecules, is crucial in pharmaceutical chemistry, where drug efficacy often depends on the stereochemistry of the molecules. The presence of a chiral center in 1-Acetylpyrrolidine-2-carboxylic acid makes it an important starting material for the synthesis of chiral building blocks and pharmaceutical intermediates.Overall, the application of 1-Acetylpyrrolidine-2-carboxylic acid in chemical synthesis underscores its significance in the field of organic chemistry, particularly in the development of new pharmaceuticals and biologically active compounds.

Literature

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  The journal of physical chemistry. B 20111215

• The influence of the peptide bond on the conformation of amino acids: a theoretical and FT-IR matrix-isolation study of N-acetylproline.

  Biophysical chemistry 20111201

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  The Journal of chemical physics 20110921

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Quantum mechanical and NMR studies of ring puckering and cis/trans-rotameric interconversion in prolines and hydroxyprolines.

  The journal of physical chemistry. A 20091008

• Modeling the solvation of peptides. The case of (s)-N-acetylproline amide in liquid water.

  The journal of physical chemistry. B 20080320

• Structure of N-acetylproline amide in liquid water: experimentally measured and numerically simulated infrared and vibrational circular dichroism spectra.

  The journal of physical chemistry. B 20060928

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

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  Journal of the American Chemical Society 20050223

• Synergistic binding of ligands to angiotensin-converting enzyme.

  The Journal of biological chemistry 19880325