1077-28-7 | 5-(1,2-dithiolan-3-yl)pentanoic acid

Packsize	Purity	Availability	Price	Discounted Price
5g	98%	in stock	$8.00	$5.00
25g	98%	in stock	$15.00	$10.00
100g	98%	in stock	$22.00	$15.00
500g	98%	in stock	$82.00	$57.00

Description

• Catalog Number: AB52215
• Chemical Name: 5-(1,2-dithiolan-3-yl)pentanoic acid
• CAS Number: 1077-28-7
• Molecular Formula: C8H14O2S2
• Molecular Weight: 206.3256
• MDL Number: MFCD00005474
• SMILES: OC(=O)CCCCC1SSCC1

Computed Properties

• Complexity: 150
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 5
• Undefined Atom Stereocenter Count: 1
• XLogP3: 1.7

Literature

• α-Lipoic acid inhibits testicular and epididymal oxidative damage and improves fertility efficacy in arsenic-intoxicated rats.

  Journal of biochemical and molecular toxicology 20180201

• Cytoprotection of lipoic acid against toxicity induced by saxitoxin in hippocampal cell line HT-22 through in silico modeling and in vitro assays.

  Toxicology 20180115

• Biocorona formation on gold nanoparticles modulates human proximal tubule kidney cell uptake, cytotoxicity and gene expression.

  Toxicology in vitro : an international journal published in association with BIBRA 20170801

• Lipoic acid and Calligonum comosumon attenuate aroclor 1260-induced testicular toxicity in adult rats.

  Environmental toxicology 20170401

• Zinc deficiency affects the STAT1/3 signaling pathways in part through redox-mediated mechanisms.

  Redox biology 20170401

• Alpha-lipoic acid reduces methylmercury-induced neuronal injury in rat cerebral cortex via antioxidation pathways.

  Environmental toxicology 20170301

• α-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis.

  The Journal of toxicological sciences 20170101

• Role of Cyt-C/caspases-9,3, Bax/Bcl-2 and the FAS death receptor pathway in apoptosis induced by zinc oxide nanoparticles in human aortic endothelial cells and the protective effect by alpha-lipoic acid.

  Chemico-biological interactions 20161025

• Cardioprotective effects of lipoic acid, quercetin and resveratrol on oxidative stress related to thyroid hormone alterations in long-term obesity.

  The Journal of nutritional biochemistry 20160701

• Alpha lipoic acid supplementation attenuates reactive oxygen species in hypothalamic paraventricular nucleus and sympathoexcitation in high salt-induced hypertension.

  Toxicology letters 20160122

• Co-administration of α-lipoic acid and cyclosporine aggravates colon ulceration of acetic acid-induced ulcerative colitis via facilitation of NO/COX-2/miR-210 cascade.

  Toxicology and applied pharmacology 20151101

• Alpha-lipoic acid protects against cadmium-induced hepatotoxicity via calcium signalling and gap junctional intercellular communication in rat hepatocytes.

  The Journal of toxicological sciences 20150801

• Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo.

  Antioxidants & redox signaling 20141120

• α-Lipoic acid (α-LA) inhibits the transcriptional activity of interferon regulatory factor 1 (IRF-1) via SUMOylation.

  Toxicology in vitro : an international journal published in association with BIBRA 20141001

• Modulatory effects of curcumin, silybin-phytosome and alpha-R-lipoic acid against thioacetamide-induced liver cirrhosis in rats.

  Chemico-biological interactions 20140605

• α-Lipoic acid protects mitochondrial enzymes and attenuates lipopolysaccharide-induced hypothermia in mice.

  Free radical biology & medicine 20140601

• Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling.

  Chemico-biological interactions 20140225

• Arsenic trioxide induces unfolded protein response in vascular endothelial cells.

  Archives of toxicology 20140201

• Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.

  Biochemistry 20131223

• Investigations on the metabolic stability of cytosolic phospholipase A2α inhibitors with 1-indolylpropan-2-one structure.

  Chemico-biological interactions 20131125

• Lipoic acid mitigates bisphenol A-induced testicular mitochondrial toxicity in rats.

  Toxicology and industrial health 20131101

• Lipoic acid protects C6 cells against ammonia exposure through Na⁺-K⁺-Cl⁻ co-transporter and PKC pathway.

  Toxicology in vitro : an international journal published in association with BIBRA 20131001

• Small molecule activators of the Nrf2-HO-1 antioxidant axis modulate heme metabolism and inflammation in BV2 microglia cells.

  Pharmacological research 20131001

• Inhibitory effect of α-lipoic acid on thioacetamide-induced tumor promotion through suppression of inflammatory cell responses in a two-stage hepatocarcinogenesis model in rats.

  Chemico-biological interactions 20130925

• Lipoic acid prevents Cr(6+) induced cell transformation and the associated genomic dysregulation.

  Environmental toxicology and pharmacology 20130701

• α-Lipoic acid protects against arsenic trioxide-induced acute QT prolongation in anesthetized guinea pigs.

  European journal of pharmacology 20130405

• Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed rats.

  European journal of nutrition 20130301

• Impact of dihydrolipoic acid on mouse embryonic stem cells and related regulatory mechanisms.

  Environmental toxicology 20130201

• Cytoprotective effect of alpha-lipoic acid on paraquat-exposed human bronchial epithelial cells via activation of nuclear factor erythroid related factor-2 pathway.

  Biological & pharmaceutical bulletin 20130101

• Interaction of 9,10-phenanthraquinone with dithiol causes oxidative modification of Cu,Zn-superoxide dismutase (SOD) through redox cycling.

  The Journal of toxicological sciences 20130101

• Lipoic acid administration prevents nonalcoholic steatosis linked to long-term high-fat feeding by modulating mitochondrial function.

  The Journal of nutritional biochemistry 20121201

• Impact of gold nanoparticle coating on redox homeostasis.

  International journal of pharmaceutics 20121115

• Neuroprotection of lipoic acid treatment promotes angiogenesis and reduces the glial scar formation after brain injury.

  Neuroscience 20121108

• α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats.

  Liver international : official journal of the International Association for the Study of the Liver 20121101

• Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.

  Journal of lipid research 20121101

• Alpha-lipoic acid induces sodium iodide symporter expression in TPC-1 thyroid cancer cell line.

  Nuclear medicine and biology 20121101

• Alpha-lipoic acid pre- and post-treatments provide protection against in vitro ischemia-reperfusion injury in cerebral endothelial cells via Akt/mTOR signaling.

  Brain research 20121030

• Preparation, characterization and efficacy evaluation of synthetic biocompatible polymers linking natural antioxidants.

  Molecules (Basel, Switzerland) 20121026

• Alpha-lipoic acid induces adipose triglyceride lipase expression and decreases intracellular lipid accumulation in HepG2 cells.

  European journal of pharmacology 20121005

• Photoinduced phase transfer of luminescent quantum dots to polar and aqueous media.

  Journal of the American Chemical Society 20121003

• Determination of lipoic acid, Trolox methyl ether and tocopherols in human plasma by liquid-chromatography and ion-trap tandem mass spectrometry.

  Biomedical chromatography : BMC 20121001

• Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3.

  Obesity (Silver Spring, Md.) 20121001

• The protective effect of alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose.

  Biochemical pharmacology 20121001

• Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia.

  Cellular and molecular neurobiology 20121001

• α-Lipoic acid ameliorates impaired glucose uptake in LYRM1 overexpressing 3T3-L1 adipocytes through the IRS-1/Akt signaling pathway.

  Journal of bioenergetics and biomembranes 20121001

• A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy.

  European journal of endocrinology 20121001

• Dietary supplementation with N-acetyl cysteine, α-tocopherol and α-lipoic acid reduces the extent of oxidative stress and proinflammatory state in aged rat brain.

  Biogerontology 20121001

• Sodium butyrate potentiates carbon tetrachloride-induced acute liver injury in mice.

  Toxicology mechanisms and methods 20121001

• Xenobiotics and autoimmunity: does acetaminophen cause primary biliary cirrhosis?

  Trends in molecular medicine 20121001

• Studies on synthesis and activation mechanism of mitomycin dimers connected by 1,2-dithiolane and diol linkers.

  Bioorganic & medicinal chemistry 20121001

• Neuroprotective effect of alpha-lipoic acid on hydrostatic pressure-induced damage of retinal ganglion cells in vitro.

  Neuroscience letters 20120920

• Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20120901

• Polychlorinated biphenyl quinone metabolites lead to oxidative stress in HepG2 cells and the protective role of dihydrolipoic acid.

  Toxicology in vitro : an international journal published in association with BIBRA 20120901

• Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study.

  Pharmacological research 20120901

• Vascular function and the role of oxidative stress in heart failure, heart transplant, and beyond.

  Hypertension (Dallas, Tex. : 1979) 20120901

• Recent patents and developments in glaucoma biomarkers.

  Recent patents on endocrine, metabolic & immune drug discovery 20120901

• Reduction-responsive disassemblable core-cross-linked micelles based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)-lipoic acid conjugates for triggered intracellular anticancer drug release.

  Biomacromolecules 20120813

• Screening of well-established drugs targeting cancer metabolism: reproducibility of the efficacy of a highly effective drug combination in mice.

  Investigational new drugs 20120801

• Therapeutic effect of alpha lipoic acid combined with praziquantel on liver fibrosis induced by Schistosoma mansoni challenged mice.

  Parasitology research 20120801

• Lipoic acid metabolism of Plasmodium--a suitable drug target.

  Current pharmaceutical design 20120801

• High-fat diets impair spatial learning of mice in the Y-maze paradigm: ameliorative potential of α-lipoic acid.

  Journal of medicinal food 20120801

• Direct enantioseparation of lipoic acid in dietary supplements by capillary electrophoresis using trimethyl-β-cyclodextrin as a chiral selector.

  Electrophoresis 20120801

• Microwave-assisted rapid synthesis of luminescent gold nanoclusters for sensing Hg2+ in living cells using fluorescence imaging.

  Nanoscale 20120721

• Syntheses and characterization of lisinopril-coated gold nanoparticles as highly stable targeted CT contrast agents in cardiovascular diseases.

  Langmuir : the ACS journal of surfaces and colloids 20120717

• Determination of lipoic acid by flow-injection and high-performance liquid chromatography with chemiluminescence detection.

  Talanta 20120715

• Combination pharmacotherapy for the treatment of neuropathic pain in adults.

  The Cochrane database of systematic reviews 20120711

• Identification and functional expression of the mitochondrial pyruvate carrier.

  Science (New York, N.Y.) 20120706

• Evaluation of the antioxidative capability of commonly used antioxidants in dermocosmetics by in vivo detection of protein carbonylation in human stratum corneum.

  Journal of photochemistry and photobiology. B, Biology 20120702

• The effects of gold nanoparticles in wound healing with antioxidant epigallocatechin gallate and α-lipoic acid.

  Nanomedicine : nanotechnology, biology, and medicine 20120701

• Quantum-chemical investigation of the structure and the antioxidant properties of α-lipoic acid and its metabolites.

  Journal of molecular modeling 20120701

• Antioxidants for Alzheimer disease: a randomized clinical trial with cerebrospinal fluid biomarker measures.

  Archives of neurology 20120701

• Alfa-lipoic acid protects testosterone secretion pathway and sperm quality against 4-tert-octylphenol induced reproductive toxicity.

  Ecotoxicology and environmental safety 20120701

• Development of a simple and high-throughput method for detecting aflatoxins production in culture media.

  Letters in applied microbiology 20120701

• Alpha-lipoic acid reduces peridural fibrosis after laminectomy of lumbar vertebrae in rabbits.

  Acta neurochirurgica 20120701

• Antioxidants and endothelial dysfunction in young and elderly people: is flow-mediated dilation useful to assess acute effects?

  Hypertension (Dallas, Tex. : 1979) 20120701

• A cost effective complement to managing the vitamin D deficient and anemic dialysis patient in the bundled world.

  Nephrology news & issues 20120701

• Lipoic acid prevents steroid-induced osteonecrosis in rabbits.

  Rheumatology international 20120601

• Effects of α-lipoic acid, vitamins E and C upon the heat stress in Japanese quails.

  Journal of animal physiology and animal nutrition 20120601

• The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study.

  Journal of cardiovascular pharmacology and therapeutics 20120601

• α-Lipoic acid prevents mild portal endotoxaemia-induced hepatic inflammation and β cell dysfunction.

  European journal of clinical investigation 20120601

• Alpha-lipoic acid attenuates atherosclerotic lesions and inhibits proliferation of vascular smooth muscle cells through targeting of the Ras/MEK/ERK signaling pathway.

  Molecular biology reports 20120601

• α-Lipoic acid regulates lipid metabolism through induction of sirtuin 1 (SIRT1) and activation of AMP-activated protein kinase.

  Diabetologia 20120601

• Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways.

  Archives of toxicology 20120601

• The role of natural killer (NK) and NK T cells in the loss of tolerance in murine primary biliary cirrhosis.

  Clinical and experimental immunology 20120601

• Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response.

  Biochimica et biophysica acta 20120601

• α-Lipoic acid protects 3T3-L1 adipocytes from NYGGF4 (PID1) overexpression-induced insulin resistance through increasing phosphorylation of IRS-1 and Akt.

  Journal of bioenergetics and biomembranes 20120601

• Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk.

  Journal of dietary supplements 20120601

• α-lipoic acid inhibits high glucose-induced apoptosis in HIT-T15 cells.

  Development, growth & differentiation 20120601

• Ameliorating effect of DL-α-lipoic acid against cisplatin-induced nephrotoxicity and cardiotoxicity in experimental animals.

  Drug discoveries & therapeutics 20120601

• New α-lipoic acid derivative, DHL-HisZn, ameliorates renal ischemia-reperfusion injury in rats.

  The Journal of surgical research 20120515

• Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.

  The Journal of organic chemistry 20120504

• Effect of α-lipoic acid on sperm quality, reproductive tract measures in thinner exposed rats.

  Andrologia 20120501

• Treatment for mitochondrial disorders.

  The Cochrane database of systematic reviews 20120418

• Site-specific protein modification using lipoic acid ligase and bis-aryl hydrazone formation.

  Chembiochem : a European journal of chemical biology 20120416

• Comparing intracellular stability and targeting of sulfobetaine quantum dots with other surface chemistries in live cells.

  Small (Weinheim an der Bergstrasse, Germany) 20120410

• On the pH-dependent quenching of quantum dot photoluminescence by redox active dopamine.

  Journal of the American Chemical Society 20120404

• General oxidative stress during doxorubicin-induced cardiotoxicity in rats: absence of cardioprotection and low antioxidant efficiency of alpha-lipoic acid.

  Biochimie 20120401

• Randomized trials for the treatment of burning mouth syndrome: an evidence-based review of the literature.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20120401

• alpha-lipoic acid prevents the induction of iNOS gene expression through destabilization of its mRNA in proinflammatory cytokine-stimulated hepatocytes.

  Digestive diseases and sciences 20120401

• UPEI-100, a conjugate of lipoic acid and apocynin, mediates neuroprotection in a rat model of ischemia/reperfusion.

  American journal of physiology. Regulatory, integrative and comparative physiology 20120401

• Acute reversal of endothelial dysfunction in the elderly after antioxidant consumption.

  Hypertension (Dallas, Tex. : 1979) 20120401

• α-Lipoic acid increases tolerance of cardiomyoblasts to glucose/glucose oxidase-induced injury via ROS-dependent ERK1/2 activation.

  Biochimica et biophysica acta 20120401

• Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress.

  The Journal of biological chemistry 20120323

• ROS-mediated lipopolysaccharide-induced apoptosis in INS-1 cells by modulation of Bcl-2 and Bax.

  Cellular and molecular biology (Noisy-le-Grand, France) 20120323

• Colloidal stability of gold nanoparticles modified with thiol compounds: bioconjugation and application in cancer cell imaging.

  Langmuir : the ACS journal of surfaces and colloids 20120306

• Alpha lipoic acid protects heart against myocardial ischemia-reperfusion injury through a mechanism involving aldehyde dehydrogenase 2 activation.

  European journal of pharmacology 20120305

• Effects of alpha-lipoic acid supplementation on inflammation, oxidative stress, and serum lipid profile levels in patients with end-stage renal disease on hemodialysis.

  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20120301

• Protective effects of curcumin, α-lipoic acid, and N-acetylcysteine against carbon tetrachloride-induced liver fibrosis in rats.

  Journal of physiology and biochemistry 20120301

• Oxidative stress in preretinopathic diabetes subjects and antioxidants.

  Diabetes technology & therapeutics 20120301

• R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles.

  American journal of physiology. Regulatory, integrative and comparative physiology 20120301

• Changes in expression profiles of antioxidant enzymes in diabetic rat kidneys.

  Diabetes/metabolism research and reviews 20120301

• Mitochondrial lipoic acid scavenging is essential for Plasmodium berghei liver stage development.

  Cellular microbiology 20120301

• Reactive oxygen species are required for the hypothalamic osmoregulatory response.

  Endocrinology 20120301

• Lipoic acid attenuates high-fat-diet-induced oxidative stress and B-cell-related immune depression.

  Nutrition (Burbank, Los Angeles County, Calif.) 20120301

• Antiproliferative effects of a new α-lipoic acid derivative, DHL-HisZnNa, in HT29 human colon cancer cells in vitro.

  Expert opinion on therapeutic targets 20120301

• Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy.

  Drugs in R&D 20120301

• [Alpha lipoic acid affect the function of EPCs incubated by high-glucose].

  Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120301

• Effects of coenzyme Q10 and α-lipoic acid supplementation in fructose fed rats.

  Journal of clinical biochemistry and nutrition 20120301

• Poly(ethylene glycol)-based multidentate oligomers for biocompatible semiconductor and gold nanocrystals.

  Langmuir : the ACS journal of surfaces and colloids 20120207

• Anionic functionalized gold nanoparticle continuous full filling separations: importance of sample concentration.

  Analytical chemistry 20120207

• Adding a combination of hydroxycitrate and lipoic acid (METABLOC™) to chemotherapy improves effectiveness against tumor development: experimental results and case report.

  Investigational new drugs 20120201

• α-Lipoic acid attenuates vascular calcification via reversal of mitochondrial function and restoration of Gas6/Axl/Akt survival pathway.

  Journal of cellular and molecular medicine 20120201

• Effects of oxidized cooking oil and α-lipoic acid on blood antioxidants: enzyme activities and lipid peroxidation in rats fed a high-fat diet.

  Biological trace element research 20120201

• Role of AMP-activated protein kinase in α-lipoic acid-induced vasodilatation in spontaneously hypertensive rats.

  American journal of hypertension 20120201

• Mixed SAMs and MALDI-ToF MS: preparation of N-glycosylamine derivative and thioctic acid methyl ester bearing 1,2-dithiolane groups and detection of enzymatic reaction on Au.

  Bioorganic chemistry 20120201

• A comparative assessment of α-lipoic acid N-phenylamides as non-steroidal androgen receptor antagonists both on and off gold nanoparticles.

  Bioorganic chemistry 20120201

• Effect of α-lipoic acid on platelet reactivity in type 1 diabetic patients.

  Diabetes care 20120201

• The effect of alpha lipoic acid on the developmental competence of mouse isolated preantral follicles.

  Journal of assisted reproduction and genetics 20120201

• α-Lipoic acid, diabetic neuropathy, and Nathan's prophecy.

  Angiology 20120201

• Induction of ER Stress-Mediated Apoptosis by α-Lipoic Acid in A549 Cell Lines.

  The Korean journal of thoracic and cardiovascular surgery 20120201

• Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis.

  Marine drugs 20120201

• Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice.

  Life sciences 20120130

• Gold nanoparticles as a label-free probe for the detection of amyloidogenic protein.

  Talanta 20120130

• Bioorganic synthesis, characterization and antioxidant activity of esters of natural phenolics and α-lipoic acid.

  Journal of biotechnology 20120120

• Co-administration of apocynin with lipoic acid enhances neuroprotection in a rat model of ischemia/reperfusion.

  Neuroscience letters 20120117

• Reaction characteristics of andrographolide and its analogue AL-1 with GSH, as a simple chemical simulation of NF-κB inhibition.

  Molecules (Basel, Switzerland) 20120112

• α-Lipoic acid, a scavenging agent for H₂O₂, reduces ethanol-stimulated locomotion in mice.

  Psychopharmacology 20120101

• Effect of lipoic acid on expression of angiogenic factors in diabetic rat retina.

  Clinical & experimental ophthalmology 20120101

• Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.

  Experimental neurology 20120101

• Acetyl-L-carnitine and α-lipoic acid affect rotenone-induced damage in nigral dopaminergic neurons of rat brain, implication for Parkinson's disease therapy.

  Pharmacology, biochemistry, and behavior 20120101

• Insufficient endogenous redox buffer capacity may underlie neuronal vulnerability to cerebral ischemia and reperfusion.

  Journal of neuroscience research 20120101

• Evaluation of protective and curative role of α-lipoic acid and selenium in gentamicin-induced nephrotoxicity in rabbits.

  Pakistan journal of pharmaceutical sciences 20120101

• Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin.

  Photochemistry and photobiology 20120101

• A new model for raf kinase inhibitory protein induced chemotherapeutic resistance.

  PloS one 20120101

• Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study.

  Asia Pacific journal of clinical nutrition 20120101

• Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo.

  PloS one 20120101

• Alleviative effects of α-lipoic acid supplementation on acute heat stress-induced thermal panting and the level of plasma nonesterified fatty acids in hypothyroid broiler chickens.

  British poultry science 20120101

• Dihydrolipoic acid induces cytotoxicity in mouse blastocysts through apoptosis processes.

  International journal of molecular sciences 20120101

• Improvement of genetic stability in lymphocytes from Fanconi anemia patients through the combined effect of α-lipoic acid and N-acetylcysteine.

  Orphanet journal of rare diseases 20120101

• Enhancement of lipid stability of broiler breast meat and meat products fed on alpha lipoic acid and alpha tocopherol acetate supplemented feed.

  Lipids in health and disease 20120101

• A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells.

  Oxidative medicine and cellular longevity 20120101

• Effect of (R)-α-lipoic acid supplementation on serum lipids and antioxidative ability in patients with age-related macular degeneration.

  Annals of nutrition & metabolism 20120101

• Oxidative stress in 5/6 nephrectomized rat model: effect of alpha-lipoic acid.

  Renal failure 20120101

• TGF-β(2)- and H(2)O(2)-induced biological changes in optic nerve head astrocytes are reduced by the antioxidant alpha-lipoic acid.

  Ophthalmic research 20120101

• Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid.

  Cardiovascular diabetology 20120101

• Effect of alpha-lipoic acid on memory, oxidation, and lifespan in SAMP8 mice.

  Journal of Alzheimer's disease : JAD 20120101

• Effects of heat treatment on structural modification and in vivo antioxidant capacity of soy protein.

  Nutrition (Burbank, Los Angeles County, Calif.) 20120101

• Assessment of a standardized ROS production profile in humans by electron paramagnetic resonance.

  Oxidative medicine and cellular longevity 20120101

• Restoration of dioxin-induced damage to fetal steroidogenesis and gonadotropin formation by maternal co-treatment with α-lipoic acid.

  PloS one 20120101

• L-2-Oxothiazolidine-4-carboxylic acid or α-lipoic acid attenuates airway remodeling: involvement of nuclear factor-κB (NF-κB), nuclear factor erythroid 2p45-related factor-2 (Nrf2), and hypoxia-inducible factor (HIF).

  International journal of molecular sciences 20120101

• Alfa-lipoic acid controls tumor growth and modulates hepatic redox state in Ehrlich-ascites-carcinoma-bearing mice.

  TheScientificWorldJournal 20120101

• Protective effects of glutathione and lipoic acid against cadmium-induced oxidative stress in rat's kidney.

  Renal failure 20120101

• Lipoic acid modified low molecular weight polyethylenimine mediates nontoxic and highly potent in vitro gene transfection.

  Molecular pharmaceutics 20111205

• Biodegradable microspheres loaded with an anti-Parkinson prodrug: an in vivo pharmacokinetic study.

  Molecular pharmaceutics 20111205

• Dietary alpha lipoic acid supplementation prevents synovial inflammation and bone destruction in collagen-induced arthritic mice.

  Rheumatology international 20111201

• Palladium-α-lipoic acid complex attenuates alloxan-induced hyperglycemia and enhances the declined blood antioxidant status in diabetic rats.

  Journal of diabetes 20111201

• Intervention of mitochondrial dysfunction-oxidative stress-dependent apoptosis as a possible neuroprotective mechanism of α-lipoic acid against rotenone-induced parkinsonism and L-dopa toxicity.

  Neuroscience research 20111201

• α-Lipoic acid (LA) enantiomers protect SH-SY5Y cells against glutathione depletion.

  Neurochemistry international 20111201

• Direct analysis of carbohydrates in animal plasma by ion chromatography coupled with mass spectrometry and pulsed amperometric detection for use as a non-invasive diagnostic tool.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111201

• Formation of dopamine quinone-DNA adducts and their potential role in the etiology of Parkinson's disease.

  IUBMB life 20111201

• Suppression of high pacing-induced ANP secretion by antioxidants in isolated rat atria.

  Peptides 20111201

• Single dose bioavailability and pharmacokinetic study of a innovative formulation of α-lipoic acid (ALA600) in healthy volunteers.

  Minerva medica 20111201

• Neuronal and vascular oxidative stress in Alzheimer's disease.

  Current neuropharmacology 20111201

• Reversibly crosslinked poly(vinyl alcohol) nanoparticles for triggered release of doxorubicin.

  Journal of controlled release : official journal of the Controlled Release Society 20111130

• Thermosensitive dendrimer formulation for drug delivery at physiologically relevant temperatures.

  Chemical communications (Cambridge, England) 20111128

• A fatal mitochondrial disease is associated with defective NFU1 function in the maturation of a subset of mitochondrial Fe-S proteins.

  American journal of human genetics 20111111

• Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide.

  The Biochemical journal 20111101

• Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity.

  Journal of autoimmunity 20111101

• Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo.

  Journal of molecular medicine (Berlin, Germany) 20111101

• Mapping the lipoylation site of Arabidopsis thaliana plastidial dihydrolipoamide S-acetyltransferase using mass spectrometry and site-directed mutagenesis.

  Plant physiology and biochemistry : PPB 20111101

• Alpha-lipoic acid protects against myocardial ischemia/reperfusion injury via multiple target effects.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101

• Lipoic acid attenuates innate immune infiltration and activation in the visceral adipose tissue of obese insulin resistant mice.

  Lipids 20111101

• Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.

  European journal of medicinal chemistry 20111101

• Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid.

  Investigative ophthalmology & visual science 20111101

• Dihydrolipoyl histidinate zinc complex, a new antioxidant, attenuates hepatic ischemia-reperfusion injury in rats.

  Journal of gastroenterology and hepatology 20111101

• Multitarget-directed ligands: innovative chemical probes and therapeutic tools against Alzheimer's disease.

  Current topics in medicinal chemistry 20111101

• Antioxidant composition causes antiexsudorific effect in the model of chronic venous insufficiency.

  Bulletin of experimental biology and medicine 20111101

• Protective effect of acetyl-l-carnitine and α-lipoic acid against the acute toxicity of diepoxybutane to human lymphocytes.

  Toxicology 20111028

• Signaling of hypochlorous acid by selective deprotection of dithiane. [corrected].

  Organic & biomolecular chemistry 20111021

• Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

  Chemical research in toxicology 20111017

• A simple, label-free AuNPs-based colorimetric ultrasensitive detection of nerve agents and highly toxic organophosphate pesticide.

  Biosensors & bioelectronics 20111015

• The effect of uremic toxin cyanate (OCN–) on anaerobic sulfur metabolism and prooxidative processes in the rat kidney: a protective role of lipoate.

  Human & experimental toxicology 20111001

• Short-term oral α-lipoic acid does not prevent lipid-induced dysregulation of glucose homeostasis in obese and overweight nondiabetic men.

  American journal of physiology. Endocrinology and metabolism 20111001

• Abrogation of cisplatin-induced nephrotoxicity in mice by alpha lipoic acid through ameliorating oxidative stress and enhancing gene expression of antioxidant enzymes.

  European journal of pharmacology 20111001

• Effects of a new synthetic butyrylcholinesterase inhibitor, HBU-39, on cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus in a scopolamine-induced amnesia animal model.

  Neurochemistry international 20111001

• Design, synthesis and evaluation of PEGylated lipoic acid derivatives with functionality as potent anti-melanogenic agents.

  European journal of medicinal chemistry 20111001

• Reversible human serum albumin binding of lipocrine: a circular dichroism study.

  Chirality 20111001

• Impact of α-lipoic acid on liver peroxisome proliferator-activated receptor-α, vascular remodeling, and oxidative stress in insulin-resistant rats.

  Canadian journal of physiology and pharmacology 20111001

• Lipoic acid and moderate swimming improves the estrous cycle and oxidative stress in Wistar rats.

  Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 20111001

• Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction.

  Liver international : official journal of the International Association for the Study of the Liver 20111001

• [The influence of lipoic acid on total protein concentration in the liver and spleen tissue in rats during lipopolysaccharide-induced oxidative stress].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20111001

• Effects of α-lipoic acid and L-carnosine supplementation on antioxidant activities and lipid profiles in rats.

  Nutrition research and practice 20111001

• A novel piezoelectric immunosensor for the detection of malarial Plasmodium falciparum histidine rich protein-2 antigen.

  Talanta 20110930

• Protection against genotoxic damages following whole body gamma radiation exposure in mice by lipoic acid.

  Mutation research 20110918

• Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model.

  Brain research 20110915

• A complex lipoate utilization pathway in Listeria monocytogenes.

  The Journal of biological chemistry 20110909

• Does laryngopharyngeal reflux cause intraoral burning sensations? A preliminary study.

  European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery 20110901

• Effects of lipoic acid on apelin in 3T3-L1 adipocytes and in high-fat fed rats.

  Journal of physiology and biochemistry 20110901

• Reciprocal effects of α-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats.

  Menopause (New York, N.Y.) 20110901

• The effect of antioxidants on the response of the rabbit urinary bladder to in vitro ischemia/reperfusion.

  Molecular and cellular biochemistry 20110901

• Immunomodulatory effect of DL-α-lipoic acid in aged rats.

  Experimental gerontology 20110901

• Chemoprotection of lipoic acid against microcystin-induced toxicosis in common carp (Cyprinus carpio, Cyprinidae).

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20110901

• Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trial.

  Diabetes care 20110901

• Insulin autoimmune syndrome induced by α-lipoic acid in a Caucasian woman: case report.

  Diabetes care 20110901

• [Role of lipoic acid in health and disease].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20110901

• Beneficial effects of alpha lipoic acid on cerulein-induced experimental acute pancreatitis in rats.

  Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES 20110901

• Lipoic acid alters amino acid neurotransmitters content in rat hippocampus after pilocarpine-induced seizures.

  Fundamental & clinical pharmacology 20110801

• Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: a randomized, double-blind, placebo controlled trial.

  Medicina oral, patologia oral y cirugia bucal 20110801

• α-Lipoic acid normalizes nociceptive neuronal activity at the spinal cord of diabetic rats.

  Diabetes, obesity & metabolism 20110801

• Surface-engineered quantum dots for the labeling of hydrophobic microdomains in bacterial biofilms.

  Biomaterials 20110801

• 1,3-Dinitrobenzene-induced metabolic impairment through selective inactivation of the pyruvate dehydrogenase complex.

  Toxicological sciences : an official journal of the Society of Toxicology 20110801

• Quantification and morphometry of myenteric neurones in the jejunum of Holtzman rats (Rattus norvegicus).

  Anatomia, histologia, embryologia 20110801

• Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects.

  Obesity (Silver Spring, Md.) 20110801

• Stable dye-labelled oligonucleotide-nanoparticle conjugates for nucleic acid detection.

  Nanoscale 20110801

• Photochemical stability of lipoic acid and its impact on skin ageing.

  Free radical research 20110801

• Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation.

  American journal of medical genetics. Part A 20110801

• Nanoencapsulation improves the in vitro antioxidant activity of lipoic acid.

  Journal of biomedical nanotechnology 20110801

• Continuous-flow reactor-based synthesis of carbohydrate and dihydrolipoic acid-capped quantum dots.

  Nature protocols 20110728

• Multifunctional surface modification of gold-stabilized nanoparticles by bioorthogonal reactions.

  Journal of the American Chemical Society 20110727

• Effects of lipoic acid, caffeic acid and a synthesized lipoyl-caffeic conjugate on human hepatoma cell lines.

  Molecules (Basel, Switzerland) 20110727

• Single-molecule colocalization studies shed light on the idea of fully emitting versus dark single quantum dots.

  Small (Weinheim an der Bergstrasse, Germany) 20110718

• A deficit in zinc availability can cause alterations in tubulin thiol redox status in cultured neurons and in the developing fetal rat brain.

  Free radical biology & medicine 20110715

• Electrochemical analysis of HIV-1 reverse transcriptase serum level: exploiting protein binding to a functionalized nanostructured surface.

  Talanta 20110715

• Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.

  Journal of medicinal chemistry 20110714

• Lipid stability and antioxidant profile of microsomal fraction of broiler meat enriched with α-lipoic acid and α-tocopherol acetate.

  Journal of agricultural and food chemistry 20110713

• Lipoic acid stimulates cAMP production via G protein-coupled receptor-dependent and -independent mechanisms.

  The Journal of nutritional biochemistry 20110701

• Lipoic acid inhibits leptin secretion and Sp1 activity in adipocytes.

  Molecular nutrition & food research 20110701

• The effect of the uremic toxin cyanate (CNO⁻) on anaerobic cysteine metabolism and oxidative processes in the rat liver: a protective effect of lipoate.

  Toxicology mechanisms and methods 20110701

• Synthesis and biological evaluations of novel apocynin analogues.

  European journal of medicinal chemistry 20110701

• Selective binding of carbamate pesticides by self-assembled monolayers of calix[4]arene lipoic acid: wettability and impedance dual-signal response.

  Organic letters 20110701

• Thioctic acid-induced acute cholestatic hepatitis.

  The Annals of pharmacotherapy 20110701

• Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy.

  Annals of neurology 20110701

• Salt-mediated self-assembly of thioctic acid on gold nanoparticles.

  ACS nano 20110628

• Multifunctional compact zwitterionic ligands for preparing robust biocompatible semiconductor quantum dots and gold nanoparticles.

  Journal of the American Chemical Society 20110622

• Simultaneous determination of lipoic acid (LA) and dihydrolipoic acid (DHLA) in human plasma using high-performance liquid chromatography coupled with electrochemical detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110615

• Neuropharmacological effects of lipoic acid and ubiquinone on the mRNA level of interleukin-1β and acetylcholinesterase activity in rat hippocampus after seizures.

  Fundamental & clinical pharmacology 20110601

• Effect of alpha lipoic acid on cardiac autonomic dysfunction and platelet reactivity in type 1 diabetes: rationale and design of the AUTOnomic function and platelet REACTivity trial (AUTO-REACT protocol).

  Diabetes research and clinical practice 20110601

• Antioxidant supplementation reduces skeletal muscle mitochondrial biogenesis.

  Medicine and science in sports and exercise 20110601

• Testicular oxidative damage and role of combined antioxidant supplementation in experimental diabetic rats.

  Journal of physiology and biochemistry 20110601

• Alpha-lipoic acid inhibits endoplasmic reticulum stress-induced cell death through PI3K/Akt signaling pathway in FRTL5 thyroid cells.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110601

• Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients.

  Saudi medical journal 20110601

• A new strategy improves assembly efficiency of DNA mono-modified gold nanoparticles.

  Chemical communications (Cambridge, England) 20110528

• Preparation and characterization of poly(lactic-co-glycolic acid) microspheres loaded with a labile antiparkinson prodrug.

  International journal of pharmaceutics 20110516

• Effects of combination tocopherols and alpha lipoic acid therapy on oxidative stress and inflammatory biomarkers in chronic kidney disease.

  Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 20110501

• Essential role of ERK activation in neurite outgrowth induced by α-lipoic acid.

  Biochimica et biophysica acta 20110501

• The effects of lipoic acid and α-tocopherol supplementation on the lipid profile and insulin sensitivity of patients with type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled trial.

  Diabetes research and clinical practice 20110501

• The α-lipoic acid derivative sodium zinc dihydrolipoylhistidinate reduces chemotherapy-induced alopecia in a rat model: a pilot study.

  Surgery today 20110501

• Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages.

  Chemico-biological interactions 20110425

• Inhibitory effect of α-lipoic acid on platelet aggregation is mediated by PPARs.

  Journal of agricultural and food chemistry 20110413

• Effects of lipoic acid on antiapoptotic genes in control and ethanol-treated fetal rhombencephalic neurons.

  Brain research 20110406

• Hybrid lipoic acid derivatives to attack prion disease on multiple fronts.

  ChemMedChem 20110404

• Neuropharmacological effects of lipoic acid and ubiquinone on δ-aminolevulinic dehydratase, Na(+) , K(+) -ATPase, and Mg(2+) -ATPase activities in rat hippocampus after pilocarpine-induced seizures.

  Fundamental & clinical pharmacology 20110401

• Antipsychotic-induced DRD2 upregulation and its prevention by α-lipoic acid in SH-SY5Y neuroblastoma cells.

  Synapse (New York, N.Y.) 20110401

• Cellular mechanisms by which lipoic acid confers protection during the early stages of cerebral ischemia: a possible role for calcium.

  Neuroscience research 20110401

• Lipoic acid decreases inflammation and confers neuroprotection in experimental autoimmune optic neuritis.

  Journal of neuroimmunology 20110401

• α-lipoic acid can improve endothelial dysfunction in subjects with impaired fasting glucose.

  Metabolism: clinical and experimental 20110401

• A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis.

  Molecular microbiology 20110401

• A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.

  Molecular microbiology 20110401

• Lipoic acid increases the expression of genes involved in bone formation in mice fed a high-fat diet.

  Nutrition research (New York, N.Y.) 20110401

• [Extract of Ginkgo biloba and alpha-lipoic acid attenuate advanced glycation end products accumulation and RAGE expression in diabetic nephropathy rats].

  Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110401

• α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β.

  Toxicology 20110328

• Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors.

  Free radical biology & medicine 20110315

• Protein-protein interactions in assembly of lipoic acid on the 2-oxoacid dehydrogenases of aerobic metabolism.

  The Journal of biological chemistry 20110311

• Carbonic anhydrase activators: gold nanoparticles coated with derivatized histamine, histidine, and carnosine show enhanced activatory effects on several mammalian isoforms.

  Journal of medicinal chemistry 20110310

• Differential effects of coenzyme Q10 and α-lipoic acid on two models of in vitro oxidative damage to the rabbit urinary bladder.

  International urology and nephrology 20110301

• Protective, antioxidative and antiapoptotic effects of 2-methoxy-6-acetyl-7-methyljuglone from Polygonum cuspidatum in PC12 cells.

  Planta medica 20110301

• Evidence that α-lipoic acid inhibits NF-κB activation independent of its antioxidant function.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110301

• A combination of melatonin and alpha lipoic acid has greater cardioprotective effect than either of them singly against cadmium-induced oxidative damage.

  Cardiovascular toxicology 20110301

• Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase-cGMP-protein kinase G signalling pathway.

  British journal of pharmacology 20110301

• Protective role of exogenous α-lipoic acid (ALA) on hippocampal antioxidant status and memory function in rat pups exposed to sodium arsenite during the early post-natal period.

  Toxicology mechanisms and methods 20110301

• New lipoic acid derivative drug sodium zinc dihydrolipoylhistidinate prevents cardiac dysfunction in an isolated perfused rat heart model.

  Critical care medicine 20110301

• Antioxidants in the treatment of diabetes.

  Current diabetes reviews 20110301

• The effects of thrombin and cytokines upon the biomechanics and remodeling of isolated amnion membrane, in vitro.

  Placenta 20110301

• Effects of intragastric fructose and dextrose on mesenteric microvascular inflammation and postprandial hyperemia in the rat.

  JPEN. Journal of parenteral and enteral nutrition 20110301

• Antioxidative effects of N-acetylcysteine, lipoic acid, taurine, and curcumin in the muscle of Cyprinus carpio L. exposed to cadmium.

  Arhiv za higijenu rada i toksikologiju 20110301

• Alleviation of lindane induced toxicity in testis of Swiss mice (Mus musculus) by combined treatment with vitamin C, vitamin E and alpha-lipoic acid.

  Indian journal of experimental biology 20110301

• [The effect of oral alpha-lipoic acid in overweight/obese individuals on brachial-ankle pulse wave velocity and supine blood pressure: a randomized, crossover, double-blind, placebo-controlled trial].

  Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 20110301

• Lipoic acid protects against reperfusion injury in the early stages of cerebral ischemia.

  Brain research 20110223

• Chronic pretreatment with acetyl-L-carnitine and ±DL-α-lipoic acid protects against acute glutamate-induced neurotoxicity in rat brain by altering mitochondrial function.

  Neurotoxicity research 20110201

• Dyslipidemic high-fat diet affects adversely bone metabolism in mice associated with impaired antioxidant capacity.

  Nutrition (Burbank, Los Angeles County, Calif.) 20110201

• Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110201

• The contributions of antioxidant activity of lipoic acid in reducing neurogenerative progression of Parkinson's disease: a review.

  The International journal of neuroscience 20110201

• α-Lipoic acid suppresses the development of DNFB-induced atopic dermatitis-like symptoms in NC/Nga mice.

  Experimental dermatology 20110201

• Alpha-lipoic acid rebalances redox and immune-testicular milieu in septic rats.

  Chemico-biological interactions 20110201

• Oxidative stress: key player in gastrointestinal complications of diabetes.

  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20110201

• Protective role of lipoic acid on methotrexate induced intestinal damage in rabbit model.

  Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 20110201

• Water-soluble semiconductor nanocrystals cap exchanged with metalated ligands.

  ACS nano 20110125

• Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies.

  European journal of pharmacology 20110110

• Surprising substrate versatility in SLC5A6: Na+-coupled I- transport by the human Na+/multivitamin transporter (hSMVT).

  The Journal of biological chemistry 20110107

• Role of lipoic acid on insulin resistance and leptin in experimentally diabetic rats.

  Journal of diabetes and its complications 20110101

• Alpha-lipoic acid protects against potassium cyanide-induced seizures and mortality.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20110101

• α-Lipoic acid protects diabetic apolipoprotein E-deficient mice from nephropathy.

  Journal of diabetes and its complications 20110101

• Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110101

• (R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria.

  Pharmacological research 20110101

• Inhibition of aldehyde dehydrogenase 2 by oxidative stress is associated with cardiac dysfunction in diabetic rats.

  Molecular medicine (Cambridge, Mass.) 20110101

• Modulatory effects of lipoic acid and selenium against cadmium-induced biochemical alterations in testicular steroidogenesis.

  Journal of biochemical and molecular toxicology 20110101

• The autoimmunity of primary biliary cirrhosis and the clonal selection theory.

  Immunology and cell biology 20110101

• α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1.

  Free radical biology & medicine 20110101

• Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures.

  Pharmacology, biochemistry, and behavior 20110101

• α-Lipoic acid has anti-inflammatory and anti-oxidative properties: an experimental study in rats with carrageenan-induced acute and cotton pellet-induced chronic inflammations.

  The British journal of nutrition 20110101

• Differential efficiency of simvastatin and lipoic acid treatments on Bothrops jararaca envenomation-induced acute kidney injury in mice.

  Toxicon : official journal of the International Society on Toxinology 20110101

• Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells.

  European journal of medicinal chemistry 20110101

• Anti-oxidative effect of lipoic Acid in spinal cord ischemia/reperfusion.

  Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20110101

• Effects of alpha-lipoic Acid on body weight in obese subjects.

  The American journal of medicine 20110101

• Effects of lipoic acid on proliferation and apoptosis of liver cells in rats with metabolic stress.

  Bulletin of experimental biology and medicine 20110101

• Effect of pro- and antioxidants on insulin sensitivity and glucose tolerance.

  Bulletin of experimental biology and medicine 20110101

• Protective effect of α-lipoic acid against arsenic trioxide-induced acute cardiac toxicity in rats.

  Journal of pharmacological sciences 20110101

• [Tiolepta (thioctic acid) in the treatment of vibration disease].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• The aqueous solubility and thermal stability of α-lipoic acid are enhanced by cyclodextrin.

  Bioscience, biotechnology, and biochemistry 20110101

• [Neuroprotective effects of lipoic acid and superoxide dismutase in the rat model of cerebral ischemia].

  Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20110101

• Alpha lipoic acid treatment improved endothelium-dependent relaxation in diabetic rat aorta.

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20110101

• Lipoic acid effects on glutamate and taurine concentrations in rat hippocampus after pilocarpine-induced seizures.

  Arquivos de neuro-psiquiatria 20110101

• [Decrease in tumorigenic activity of murine hepatoma cells after treatment with antioxidants and melatonin].

  Tsitologiia 20110101

• The effect of alpha-lipoic acid in the prevention of peritoneal adhesions.

  The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 20110101

• [Cerebroprotective effect of 3-oxypyridine and succinic acid derivatives in acute phase of alloxan-induced diabetes mellitus in rats].

  Eksperimental'naia i klinicheskaia farmakologiia 20110101

• Alpha-lipoic acid for the prevention of diabetic macular edema.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20110101

• Comparison of antioxidant effectiveness of lipoic acid and dihydrolipoic acid.

  Journal of biochemical and molecular toxicology 20110101

• Antioxidant therapy: current status and future prospects.

  Current medicinal chemistry 20110101

• [Influence of alpha-lipoic acid on liver glutathione system of healthy and Ehrlich ascites carcinoma transplanted mice].

  Biomeditsinskaia khimiia 20110101

• Update on the management of diabetic polyneuropathies.

  Diabetes, metabolic syndrome and obesity : targets and therapy 20110101

• [Oxidative homeostasis and functional parameters of rats at high altitudes with alpha-lipoic acid correction].

  Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine 20110101

• Dietary and behavioral interventions protect against age related activation of caspase cascades in the canine brain.

  PloS one 20110101

• Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy.

  Therapeutics and clinical risk management 20110101

• Mechanisms pertaining to arsenic toxicity.

  Toxicology international 20110101

• Vitamin A palmitate and α-lipoic acid stability in o/w emulsions for cosmetic application.

  Journal of cosmetic science 20110101

• Lipoic acid - biological activity and therapeutic potential.

  Pharmacological reports : PR 20110101

• Combined treatment with antioxidants and immunosuppressants on cytokine release by human peripheral blood mononuclear cells - chemically injured keratocyte reaction.

  Molecular vision 20110101

• Fatty acids and gene expression responses to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes.

  Neuro endocrinology letters 20110101

• Effect of α-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance.

  Lipids in health and disease 20110101

• Diabetes and alpha lipoic Acid.

  Frontiers in pharmacology 20110101

• Oxygen/ozone as a medical gas mixture. A critical evaluation of the various methods clarifies positive and negative aspects.

  Medical gas research 20110101

• Validation of a phase-mass characterization concept and interface for acoustic biosensors.

  Sensors (Basel, Switzerland) 20110101

• Protective effect of α-lipoic acid on oxidized low density lipoprotein-induced human umbilical vein endothelial cell injury.

  Pharmacological reports : PR 20110101

• The effects of alpha lipoic acid on cerebral vasospasm following experimental subarachnoid hemorrhage in the rabbit.

  Turkish neurosurgery 20110101

• Dietary lipoic acid influences antioxidant capability and oxidative status of broilers.

  International journal of molecular sciences 20110101

• [Comparative study of alpha-lipoic acid and mexidol effects on affective status, cognitive functions and quality of life in diabetes mellitus patients].

  Eksperimental'naia i klinicheskaia farmakologiia 20110101

• Simple HPLC evaluation of lipoamidase activity in tissue using a newly synthesized fluorescent substrate, dansyl-α-lipoyllysine.

  Journal of nutritional science and vitaminology 20110101

• [Antihypoxic effect of 3-hydroxypyridine and succinic acid derivatives and their nootropic action in alloxan diabetes].

  Eksperimental'naia i klinicheskaia farmakologiia 20110101

• [A search for new markers of oxidative stress in brain ischemia for the optimization of treatment approaches].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• [Thioctic (alpha-lipoic) acid-spectrum of clinical use].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101

• [Application of alpha-lipoic acid in clinical practice].

  Likars'ka sprava 20110101

• Reverse-phase liquid chromatographic determination of α-lipoic acid in dietary supplements using a boron-doped diamond electrode.

  Journal of chromatography. A 20101203

• Alpha-lipoic acid does not alter stress protein response to acute exercise in diabetic brain.

  Cell biochemistry and function 20101202

• Effects of oxidized cooking oil and α-lipoic acid on liver antioxidants: enzyme activities and lipid peroxidation in rats fed a high fat diet.

  Biological trace element research 20101201

• Is it time to reassess alpha lipoic acid and niacinamide therapy in schizophrenia?

  Medical hypotheses 20101201

• Alpha-lipoic acid modulates GFAP, vimentin, nestin, cyclin D1 and MAP-kinase expression in astroglial cell cultures.

  Neurochemical research 20101201

• [Effects of α-lipoic acid and vitamin C on oxidative stress in rat exposed to chronic arsenic toxicity].

  Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20101201

• Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases.

  Biochemistry 20101123

• Neuroprotective role of lipoic acid against acute toxicity of N-acetylaspartic acid.

  Molecular and cellular biochemistry 20101101

• The construction, fouling and enzymatic cleaning of a textile dye surface.

  Journal of colloid and interface science 20101101

• α-Lipoic acid prevents neointimal hyperplasia via induction of p38 mitogen-activated protein kinase/Nur77-mediated apoptosis of vascular smooth muscle cells and accelerates postinjury reendothelialization.

  Arteriosclerosis, thrombosis, and vascular biology 20101101

• Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

  Bioorganic & medicinal chemistry letters 20101101

• Effect of antioxidants on mitochondrial function in HIV-1-related lipoatrophy: a pilot study.

  AIDS research and human retroviruses 20101101

• Pharmacokinetics of orally administered DL-α-lipoic acid in dogs.

  American journal of veterinary research 20101101

• Structure Effect on Antioxidant Activity of Catecholamines toward Singlet Oxygen and Other Reactive Oxygen Species in vitro.

  Journal of clinical biochemistry and nutrition 20101101

• [Biochemical changes in cavernosal tissue caused by single sided cavernosal nerve resection and the effects of alpha lipoic acid on these changes].

  Actas urologicas espanolas 20101101

• A mimic of the pyruvate dehydrogenase complex.

  Bioorganic & medicinal chemistry letters 20101015

• Determination of lipoic acid in human plasma by HPLC-ECD using liquid-liquid and solid-phase extraction: Method development, validation and optimization of experimental parameters.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101015

• Alpha-lipoic acid improves endothelial dysfunction in patients with subclinical hypothyroidism.

  Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20101001

• Evaluation of anti-oxidant treatments in an in vitro model of alkaptonuric ochronosis.

  Rheumatology (Oxford, England) 20101001

• α-Lipoic acid induces collagen biosynthesis involving prolyl hydroxylase expression via activation of TGF-β-Smad signaling in human dermal fibroblasts.

  Connective tissue research 20101001

• Evaluation of protective effects of the alpha lipoic acid after spinal cord injury: an animal study.

  Injury 20101001

• Alpha-lipoic acid inhibits thrombin-induced fetal membrane weakening in vitro.

  Placenta 20101001

• Pharmacokinetics of lipoyl vildagliptin, a novel dipeptidyl peptidase IV inhibitor after oral administration in rats.

  Xenobiotica; the fate of foreign compounds in biological systems 20101001

• Comparative effects of α lipoic acid and melatonin on cisplatin-induced neurotoxicity.

  The International journal of neuroscience 20101001

• Neuroprotective effects of alpha-lipoic acid in experimental spinal cord injury in rats.

  The journal of spinal cord medicine 20101001

• Role of pyruvate dehydrogenase kinase 4 in regulation of blood glucose levels.

  Korean diabetes journal 20101001

• Effect of pentoxifylline and/or alpha lipoic acid on experimentally induced acute pancreatitis.

  European journal of pharmacology 20100925

• [Efficacy and safety of high-dose α-lipoic acid in the treatment of diabetic polyneuropathy].

  Zhonghua yi xue za zhi 20100921

• Augmentation of cholinesterases and ATPase activities in the cerebellum and pons-medulla oblongata, by a combination of antioxidants (resveratrol, ascorbic acid, alpha-lipoic acid and vitamin E), in acutely lindane intoxicated mice.

  Journal of the neurological sciences 20100915

• Lipoic acid effects on renal function, aminopeptidase activities and oxidative stress in Crotalus durissus terrificus envenomation in mice.

  Toxicon : official journal of the International Society on Toxinology 20100901

• Anti-apoptotic and neuroprotective effects of α-lipoic acid on spinal cord ischemia-reperfusion injury in rabbits.

  Acta neurochirurgica 20100901

• The natural antioxidant alpha-lipoic acid induces p27(Kip1)-dependent cell cycle arrest and apoptosis in MCF-7 human breast cancer cells.

  European journal of pharmacology 20100901

• Different therapeutic strategies for burning mouth syndrome: preliminary data.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20100901

• Effects of DHLA-capped CdSe/ZnS quantum dots on the fibrillation of human serum albumin.

  The journal of physical chemistry. B 20100826

• Antiplatelet activity of alpha-lipoic acid.

  Journal of agricultural and food chemistry 20100811

• Alpha-lipoic acid activates dimethylarginine dimethylaminohydrolase in cultured endothelial cells.

  Biochemical and biophysical research communications 20100806

• Amino-functionalized single-chain bolalipids: synthesis and aggregation behavior of new basic building blocks.

  Biophysical chemistry 20100801

• Improved functionality of antibody-colloidal gold conjugates with the aid of lipoamide-grafted N-[tris(hydroxymethyl)methyl]acrylamide polymers.

  Journal of colloid and interface science 20100801

• Study of alpha-lipoic acid penetration in the human aqueous after topical administration.

  Clinical & experimental ophthalmology 20100801

• A stable and controllable Prussian blue layer electrodeposited on self-assembled monolayers for constructing highly sensitive glucose biosensor.

  The Analyst 20100801

• Radioprotection by alpha-lipoic acid palladium complex formulation (POLY-MVA) in mice.

  Cancer biotherapy & radiopharmaceuticals 20100801

• Protective roles of alpha-lipoic acid in rat model of mitochondrial DNA4834bp deletion in inner ear.

  Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20100801

• Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation.

  Annals of the New York Academy of Sciences 20100801

• Lipoic acid increases glutathione peroxidase, Na+, K+-ATPase and acetylcholinesterase activities in rat hippocampus after pilocarpine-induced seizures?

  Arquivos de neuro-psiquiatria 20100801

• Lipoic acid nanoparticles: effect of polymeric stabilizer on appetite suppression.

  Die Pharmazie 20100801

• [Complex approach to the treatment of the diskal hernia of lumbosacral spine].

  Voenno-meditsinskii zhurnal 20100801

• alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice.

  Metabolism: clinical and experimental 20100701

• Lipoic acid and redox status in barley plants subjected to salinity and elevated CO2.

  Physiologia plantarum 20100701

• Effect of POLY-MVA, a palladium alpha-lipoic acid complex formulation against declined mitochondrial antioxidant status in the myocardium of aged rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100701

• Role of oxidative stress and nitric oxide in the protective effects of alpha-lipoic acid and aminoguanidine against isoniazid-rifampicin-induced hepatotoxicity in rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100701

• Protective effect of lipoic acid against methotrexate-induced oxidative stress in liver mitochondria.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100701

• alpha-Lipoic acid alters post-translational modifications and protects the chaperone activity of lens alpha-crystallin in naphthalene-induced cataract.

  Current eye research 20100701

• Lipoic acid effects on monoaminergic system after pilocarpine-induced seizures.

  Neuroscience letters 20100625

• [Pathomechanism of diabetic neuropathy: background of the pathogenesis-oriented therapy].

  Orvosi hetilap 20100613

• Inflammation and apoptosis in aortic tissues of aged type II diabetes: amelioration with alpha-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism.

  Life sciences 20100605

• Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice.

  Clinical nutrition (Edinburgh, Scotland) 20100601

• Electrical behavior of stored erythrocytes after exposure to gamma radiation and the role of alpha-lipoic acid as radioprotector.

  Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20100601

• Multi-tasking with single platform dendrimers for targeting sub-cellular microenvironments.

  Chemistry (Weinheim an der Bergstrasse, Germany) 20100601

• Inhibition of lindane-induced toxicity using alpha-lipoic acid and vitamin E in the brain of Mus musculus.

  Protoplasma 20100601

• The effects of lipoic acid on soybean beta-conglycinin-induced anaphylactic reactions in a rat model.

  Archives of animal nutrition 20100601

• Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes.

  International journal of sport nutrition and exercise metabolism 20100601

• Alterations on monoamines concentration in rat hippocampus produced by lipoic acid.

  Arquivos de neuro-psiquiatria 20100601

• alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells.

  Nutrition research (New York, N.Y.) 20100601

• Lipoic acid prevents oxidative stress in vitro and in vivo by an acute hyperphenylalaninemia chemically-induced in rat brain.

  Journal of the neurological sciences 20100515

• Synthesis and anticancer evaluation of alpha-lipoic acid derivatives.

  Bioorganic & medicinal chemistry letters 20100515

• Alpha-lipoic acid as a potential target for the treatment of lung injury caused by cecal ligation and puncture-induced sepsis model in rats.

  Shock (Augusta, Ga.) 20100501

• Dietary fructose accelerates the development of diabetes in UCD-T2DM rats: amelioration by the antioxidant, alpha-lipoic acid.

  American journal of physiology. Regulatory, integrative and comparative physiology 20100501

• Sulforaphane and alpha-lipoic acid upregulate the expression of the pi class of glutathione S-transferase through c-jun and Nrf2 activation.

  The Journal of nutrition 20100501

• A combination of alpha lipoic acid and calcium hydroxycitrate is efficient against mouse cancer models: preliminary results.

  Oncology reports 20100501

• Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity.

  British journal of pharmacology 20100501

• Complementary and alternative medicine for the treatment of multiple sclerosis.

  Expert review of clinical immunology 20100501

• Protective effects of irbesartan and alpha lipoic acid in STZ-induced diabetic nephropathy in rats.

  Renal failure 20100501

• Managing diabetic peripheral neuropathic pain in primary care.

  The Journal of family practice 20100501

• Lipoic acid: an immunomodulator that attenuates glycinin-induced anaphylactic reactions in a rat model.

  Journal of agricultural and food chemistry 20100428

• Small and stable sulfobetaine zwitterionic quantum dots for functional live-cell imaging.

  Journal of the American Chemical Society 20100407

• Lipoic acid alters delta-aminolevulinic dehydratase, glutathione peroxidase and Na+,K+-ATPase activities and glutathione-reduced levels in rat hippocampus after pilocarpine-induced seizures.

  Cellular and molecular neurobiology 20100401

• A new method for the detection and characterization of alpha-lipoic acid mixed disulphides.

  Free radical research 20100401

• Pharmacokinetic study of lipoic acid in multiple sclerosis: comparing mice and human pharmacokinetic parameters.

  Multiple sclerosis (Houndmills, Basingstoke, England) 20100401

• Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes?

  The Netherlands journal of medicine 20100401

• [Effects of alpha lipoic acid on hypothalamus-pituitary-adrenal axis in rats].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100401

• Global conformational change associated with the two-step reaction catalyzed by Escherichia coli lipoate-protein ligase A.

  The Journal of biological chemistry 20100326

• Lipoic acid glyco-conjugates, a new class of agents for controlling nonspecific adsorption of blood serum at biointerfaces for biosensor and biomedical applications.

  Langmuir : the ACS journal of surfaces and colloids 20100316

• Mutated glutathione S-transferase in combination with reduced glutathione shows a synergistic effect in ameliorating oxidative stress and airway inflammation.

  Free radical biology & medicine 20100315

• Alpha-lipoic acid inhibits hepatic PAI-1 expression and fibrosis by inhibiting the TGF-beta signaling pathway.

  Biochemical and biophysical research communications 20100312

• Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .

  Biochemistry 20100302

• Alpha lipoic acid alleviates oxidative stress and preserves blood brain permeability in rats with subarachnoid hemorrhage.

  Neurochemical research 20100301

• Effect of antioxidants on airway smooth muscle contraction: action of lipoic acid and some of its novel derivatives on guinea pig tracheal smooth muscle.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100301

• Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain.

  Pharmacology, biochemistry, and behavior 20100301

• Effect of endogenous and synthetic antioxidants on hydrogen peroxide-induced guinea-pig colon contraction.

  Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20100301

• The combination of exercise training and alpha-lipoic acid treatment has therapeutic effects on the pathogenic phenotypes of Alzheimer's disease in NSE/APPsw-transgenic mice.

  International journal of molecular medicine 20100301

• Ibuprofen and lipoic acid diamides as potential codrugs with neuroprotective activity.

  Archiv der Pharmazie 20100301

• Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome.

  Journal of diabetes science and technology 20100301

• Neuropathy in a rat model of mild diabetes induced by multiple low doses of streptozotocin: effects of the antioxidant stobadine in comparison with a high-dose alpha-lipoic acid treatment.

  General physiology and biophysics 20100301

• Polyvalent display and packing of peptides and proteins on semiconductor quantum dots: predicted versus experimental results.

  Small (Weinheim an der Bergstrasse, Germany) 20100222

• Homocysteine-lowering therapy or antioxidant therapy for bone loss in Parkinson's disease.

  Movement disorders : official journal of the Movement Disorder Society 20100215

• A sensitive LC/MS/MS bioanalysis assay of orally administered lipoic acid in rat blood and brain tissue.

  Journal of pharmaceutical and biomedical analysis 20100205

• Prevention of high-fat diet-induced muscular lipid accumulation in rats by alpha lipoic acid is not mediated by AMPK activation.

  Journal of lipid research 20100201

• Thioctic acid protects against carrageenan-induced acute inflammation in rats by reduction in oxidative stress, downregulation of COX-2 mRNA and enhancement of IL-10 mRNA.

  Fundamental & clinical pharmacology 20100201

• Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men.

  American journal of physiology. Heart and circulatory physiology 20100201

• Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial.

  European journal of clinical investigation 20100201

• Pathological, biochemical and haematological investigations on the protective effect of alpha-lipoic acid in experimental aflatoxin toxicosis in chicks.

  British poultry science 20100201

• [Effect of alpha-lipoic acid on hearing functions after cerebral concussion].

  Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20100201

• Ameliorative effect of a combination of vitamin E, vitamin C, alpha-lipoic acid and stilbene resveratrol on lindane induced toxicity in mice olfactory lobe and cerebrum.

  Indian journal of experimental biology 20100201

• Lipoic acid effects on established atherosclerosis.

  Life sciences 20100116

• Mitochondrial DNA haplogroups influence the therapeutic response to riboflavin in migraineurs.

  Neurology 20100112

• [Treatment of neuropathies].

  Orvosi hetilap 20100110

• Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: A study in rat intestine.

  Chemico-biological interactions 20100105

• Lipoic Acid increases hippocampal choline acetyltransferase and acetylcholinesterase activities and improvement memory in epileptic rats.

  Neurochemical research 20100101

• ACS67, a hydrogen sulfide-releasing derivative of latanoprost acid, attenuates retinal ischemia and oxidative stress to RGC-5 cells in culture.

  Investigative ophthalmology & visual science 20100101

• Effects of lipoic acid on oxidative stress in rat striatum after pilocarpine-induced seizures.

  Neurochemistry international 20100101

• The use of mitochondrial nutrients to improve the outcome of infertility treatment in older patients.

  Fertility and sterility 20100101

• The role of zinc in the modulation of neuronal proliferation and apoptosis.

  Neurotoxicity research 20100101

• Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism.

  Neurotoxicology 20100101

• Treatment with alpha-lipoic acid reduces asymmetric dimethylarginine in patients with type 2 diabetes mellitus.

  Translational research : the journal of laboratory and clinical medicine 20100101

• Nitric oxide and thioredoxin type 1 modulate the activity of caspase 8 in HepG2 cells.

  Biochemical and biophysical research communications 20100101

• Assessing the reductive capacity of cells by measuring the recycling of ascorbic and lipoic acids.

  Methods in molecular biology (Clifton, N.J.) 20100101

• Antioxidant therapy in human endocrine disorders.

  Medical science monitor : international medical journal of experimental and clinical research 20100101

• Antioxidants and skin care: the essentials.

  Plastic and reconstructive surgery 20100101

• Design and synthesis of antioxidant alpha-lipoic acid hybrids.

  Methods in molecular biology (Clifton, N.J.) 20100101

• Mitochondrial fatty acid synthesis and respiration.

  Biochimica et biophysica acta 20100101

• Alpha-lipoic acid supplementation: a tool for obesity therapy?

  Current pharmaceutical design 20100101

• Combined R-alpha-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson's disease.

  Journal of cellular and molecular medicine 20100101

• Optimal micronutrients delay mitochondrial decay and age-associated diseases.

  Mechanisms of ageing and development 20100101

• [Alpha-lipoic acid triggers elimination of cells with abnormal nuclei in human carcinoma epidermoid cell line].

  Tsitologiia 20100101

• Effects of duodenal redox status on calcium absorption and related genes expression in high-fat diet-fed mice.

  Nutrition (Burbank, Los Angeles County, Calif.) 20100101

• Improving the effect of incubation and oxidative stress on thawed spermatozoa from red deer by using different antioxidant treatments.

  Reproduction, fertility, and development 20100101

• Physiological and histopathological investigations on the effects of alpha-lipoic acid in rats exposed to malathion.

  Journal of biomedicine & biotechnology 20100101

• Metabolic pathways in the apicoplast of apicomplexa.

  International review of cell and molecular biology 20100101

• Cytoprotective effects of DL-alpha-lipoic acid or squalene on cyclophosphamide-induced oxidative injury: an experimental study on rat myocardium, testicles and urinary bladder.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100101

• Effects of epigallocatechin gallate, L-ascorbic acid, alpha-tocopherol, and dihydrolipoic acid on the formation of deoxyguanosine adducts derived from lipid peroxidation.

  Nutrition and cancer 20100101

• Inborn errors of energy metabolism associated with myopathies.

  Journal of biomedicine & biotechnology 20100101

• Comparative proteome analysis of splenic lymphocytes in long-term high-fat diet and dietary supplement with lipoic acid mice.

  Cellular immunology 20100101

• Ibuprofen and lipoic acid diamide as co-drug with neuroprotective activity: pharmacological properties and effects in beta-amyloid (1-40) infused Alzheimer's disease rat model.

  International journal of immunopathology and pharmacology 20100101

• [Atrial fibrillation in patients with type 2 diabetes mellitus: specific features of development and antirecurrence therapy].

  Kardiologiia 20100101

• [Pharmacologic therapy in peripheral diabetic polyneuropathy].

  Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20100101

• Redox homeostasis of albumin in relation to alpha-lipoic acid and dihydrolipoic acid.

  Oxidative medicine and cellular longevity 20100101

• Lipoic acid attenuates inflammation via cAMP and protein kinase A signaling.

  PloS one 20100101

• Vitamin C, resveratrol and lipoic acid actions on isolated rat liver mitochondria: all antioxidants but different.

  Redox report : communications in free radical research 20100101

• Formulation of a medical food cocktail for Alzheimer's disease: beneficial effects on cognition and neuropathology in a mouse model of the disease.

  PloS one 20100101

• Probucol attenuates cyclophosphamide-induced oxidative apoptosis, p53 and Bax signal expression in rat cardiac tissues.

  Oxidative medicine and cellular longevity 20100101

• Stimulation of suicidal erythrocyte death by α-lipoic acid.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20100101

• Glycoxidative stress and cardiovascular complications in experimentally-induced diabetes: effects of antioxidant treatment.

  The open cardiovascular medicine journal 20100101

• [Expression and catalytic properties NADP-isocitrate dehydrogenase from the rat liver under normal conditions and following administration of tumor necrosis factor-alpha or thioctic acid].

  Biomeditsinskaia khimiia 20100101

• Efficacy of alpha lipoic acid in adjunct with intralesional steroids and hyaluronidase in the management of oral submucous fibrosis.

  Journal of cancer research and therapeutics 20100101

• [Long-term effect of 3-week intravenous alpha-lipoic acid administration in symptomatic diabetic polyneutropathy with clinical manifestations].

  Terapevticheskii arkhiv 20100101

• Colorimetric assay for determination of lead (II) based on its incorporation into gold nanoparticles during their synthesis.

  Sensors (Basel, Switzerland) 20100101

• Aryl diazonium for biomolecules immobilization onto SPRi chips.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20091221

• Nonparametric non-inferiority analyses in the three-arm design with active control and placebo.

  Statistics in medicine 20091220

• Modulatory role of lipoic acid on lipopolysaccharide-induced oxidative stress in adult rat Sertoli cells in vitro.

  Chemico-biological interactions 20091210

• Toward a rational design of multitarget-directed antioxidants: merging memoquin and lipoic acid molecular frameworks.

  Journal of medicinal chemistry 20091210

• alpha-Lipoic acid supplementation enhances heat shock protein production and decreases post exercise lactic acid concentrations in exercised standardbred trotters.

  Research in veterinary science 20091201

• A current update on the use of alpha lipoic acid in the management of type 2 diabetes mellitus.

  Endocrine, metabolic & immune disorders drug targets 20091201

• Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles.

  Experimental gerontology 20091201

• Effect of alpha lipoic acid in a porcine in-stent restenosis model.

  Journal of cardiology 20091201

• Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases.

  Integrative cancer therapies 20091201

• [Comparison of the antioxidants lipoic acid pharmacokinetics in inner ear between intravenous and intratympanic administration in guinea pigs.].

  Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20091201

• Yeast display evolution of a kinetically efficient 13-amino acid substrate for lipoic acid ligase.

  Journal of the American Chemical Society 20091118

• Probing the relative stability of thiolate- and dithiolate-protected Au monolayer-protected clusters.

  Langmuir : the ACS journal of surfaces and colloids 20091117

• Attenuation of myocardial apoptosis by alpha-lipoic acid through suppression of mitochondrial oxidative stress to reduce diabetic cardiomyopathy.

  Chinese medical journal 20091105

• Nitric oxide and dihydrolipoic acid modulate the activity of caspase 3 in HepG2 cells.

  FEBS letters 20091103

• 17beta-hydroxysteroid dehydrogenase type 8 and carbonyl reductase type 4 assemble as a ketoacyl reductase of human mitochondrial FAS.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091101

• Cytoprotection against Cr(6+)-induced DNA damage by alpha-lipoic acid: implications in reducing occupational cancer risk.

  Mutagenesis 20091101

• Antioxidants and aging: NMR-based evidence of improved skeletal muscle perfusion and energetics.

  American journal of physiology. Heart and circulatory physiology 20091101

• Improved efficacy of appetite suppression by lipoic acid particles prepared by nanocomminution.

  Drug development and industrial pharmacy 20091101

• Painful diabetic neuropathy: advantage of novel drugs over old drugs?

  Diabetes care 20091101

• Antioxidant properties of an endogenous thiol: Alpha-lipoic acid, useful in the prevention of cardiovascular diseases.

  Journal of cardiovascular pharmacology 20091101

• Effects of sulphur-containing compounds on plasma redox status in muscle-damaging exercise.

  The Chinese journal of physiology 20091031

• Liquid chromatographic determination of polythiols based on pre-column excimer fluorescence derivatization and its application to alpha-lipoic acid analysis.

  Journal of chromatography. A 20091030

• Lipoic acid effects on lipid peroxidation level, superoxide dismutase activity and monoamines concentration in rat hippocampus.

  Neuroscience letters 20091023

• Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine.

  Free radical biology & medicine 20091015

• Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat.

  Biogerontology 20091001

• Alpha-lipoic acid attenuates cisplatin-induced acute kidney injury in mice by suppressing renal inflammation.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20091001

• Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential.

  Biochimica et biophysica acta 20091001

• The essential mycobacterial genes, fabG1 and fabG4, encode 3-oxoacyl-thioester reductases that are functional in yeast mitochondrial fatty acid synthase type 2.

  Molecular genetics and genomics : MGG 20091001

• Therapy and outcome of suspected alpha lipoic acid toxicity in two dogs.

  Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) 20091001

• [Expressions of NOS isoforms in the cavernous tissues of diabetic rat models].

  Zhonghua nan ke xue = National journal of andrology 20091001

• A love affair with vitamins.

  The Journal of biological chemistry 20090925

• Sequential injection system for phospholipase A2 activity evaluation: studies on liposomes using an environment-sensitive fluorescent probe.

  Talanta 20090915

• alpha-Lipoic acid prevents cisplatin-induced acute kidney injury in rats.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090901

• Design and synthesis of novel neuroprotective 1,2-dithiolane/chroman hybrids.

  Bioorganic & medicinal chemistry 20090901

• Lipoic acid synthesis and attachment in yeast mitochondria.

  The Journal of biological chemistry 20090828

• The effect of acetyl-L-carnitine and R-alpha-lipoic acid treatment in ApoE4 mouse as a model of human Alzheimer's disease.

  Journal of the neurological sciences 20090815

• Radioprotective effect of DL-alpha-lipoic acid on mice skin fibroblasts.

  Cell biology and toxicology 20090801

• Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A.

  Biogerontology 20090801

• Palladium alpha-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I-IV in the heart of aged rats.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801

• alpha-Lipoic acid modulates thiol antioxidant defenses and attenuates exercise-induced oxidative stress in standardbred trotters.

  Free radical research 20090801

• Gene expression profiling of aging in multiple mouse strains: identification of aging biomarkers and impact of dietary antioxidants.

  Aging cell 20090801

• Electron transfer mediators and other metabolites and cofactors in the treatment of mitochondrial dysfunction.

  Nutrition reviews 20090801

• Mechanism of alpha-lipoic acid-induced apoptosis of lung cancer cells.

  Annals of the New York Academy of Sciences 20090801

• Direct electron transfer to a metalloenzyme redox center coordinated to a monolayer-protected cluster.

  Journal of the American Chemical Society 20090729

• Molecular mechanisms of lipoic acid modulation of T-type calcium channels in pain pathway.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20090729

• No selenium required: reactions catalyzed by mammalian thioredoxin reductase that are independent of a selenocysteine residue.

  Biochemistry 20090707

• Small-molecule targeting of the mitochondrial compartment with an endogenously cleaved reversible tag.

  Chembiochem : a European journal of chemical biology 20090706

• Gene expressions of Mn-SOD and GPx-1 in streptozotocin-induced diabetes: effect of antioxidants.

  Molecular and cellular biochemistry 20090701

• Synthesis and evaluation of the antioxidant and anti-inflammatory activity of novel coumarin-3-aminoamides and their alpha-lipoic acid adducts.

  European journal of medicinal chemistry 20090701

• High-sensitivity analysis of naturally occurring sugar chains, using a novel fluorescent linker molecule.

  Journal of biochemistry 20090701

• Alpha-lipoic acid and frataxin: a new indication for an old antioxidant?

  Experimental neurology 20090701

• Effect of alpha lipoic acid on the tardive dyskinesia and oxidative stress induced by haloperidol in rats.

  Journal of neural transmission (Vienna, Austria : 1996) 20090701

• The protective effect of alpha lipoic acid against traumatic brain injury in rats.

  Free radical research 20090701

• Environmental toxicants inhibit neuronal Jak tyrosine kinase by mitochondrial disruption.

  Neurotoxicology 20090701

• [The comparison of alpha-lipoic acid, melatonin, vitamin C and trolox effectiveness in decreasing DNA stand brakes and increasing plasma antioxidant power].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20090701

• Oral co-administration of α-lipoic acid, quercetin and captopril prevents gallium arsenide toxicity in rats.

  Environmental toxicology and pharmacology 20090701

• The effect of lipoic acid on macro and trace metal levels in living tissues exposed to oxidative stress.

  Anti-cancer agents in medicinal chemistry 20090601

• Assessment of the antioxidant effectiveness of alpha-lipoic acid in healthy men exposed to muscle-damaging exercise.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090601

• A piezoelectric immunosensor for the determination of pesticide residues and metabolites in fruit juices.

  Talanta 20090515

• (R)-lipo-diaza-18-crown-6 self-assembled monolayer as a selective serotonin receptor.

  Analytical chemistry 20090515

• The evaluation of effects of lipoic acid on the lipid peroxidation, nitrite formation and antioxidant enzymes in the hippocampus of rats after pilocarpine-induced seizures.

  Neuroscience letters 20090515

• Organocatalysts immobilised onto gold nanoparticles: application in the asymmetric reduction of imines with trichlorosilane.

  Organic & biomolecular chemistry 20090507

• Lack of efficacy of alpha-lipoic acid in burning mouth syndrome: a double-blind, randomized, placebo-controlled study.

  European journal of pain (London, England) 20090501

• Kinetic resolution of alpha-lipoic acid via enzymatic differentiation of a remote stereocenter.

  Journal of industrial microbiology & biotechnology 20090501

• Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion.

  Archives of biochemistry and biophysics 20090501

• Chaperone-aided expression of LipA and LplA followed by the increase in alpha-lipoic acid production.

  Applied microbiology and biotechnology 20090501

• Oral antioxidant supplementation does not prevent acute mountain sickness: double blind, randomized placebo-controlled trial.

  QJM : monthly journal of the Association of Physicians 20090501

• Effects of alpha-lipoic acid on transforming growth factor beta1-p38 mitogen-activated protein kinase-fibronectin pathway in diabetic nephropathy.

  Metabolism: clinical and experimental 20090501

• Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid.

  Journal of neurochemistry 20090501

• Amperometric sensor for hydrogen peroxide based on immobilized cytochrome c on binary self-assembled monolayers.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20090501

• Down-regulation of mitochondrial acyl carrier protein in mammalian cells compromises protein lipoylation and respiratory complex I and results in cell death.

  The Journal of biological chemistry 20090424

• Metabolic interactions of AGE inhibitor pyridoxamine and antioxidant alpha-lipoic acid following 22 weeks of treatment in obese Zucker rats.

  Life sciences 20090410

• Mitochondrial fatty acid synthesis type II: more than just fatty acids.

  The Journal of biological chemistry 20090403

• Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine.

  Neurochemical research 20090401

• Plasmodium falciparum: organelle-specific acquisition of lipoic acid.

  The international journal of biochemistry & cell biology 20090401

• Protective effect of sulfhydryl-containing antioxidants against ischemia/reperfusion injury of prepubertal rat intestine.

  Journal of gastroenterology and hepatology 20090401

• Chronic lipoic acid treatment worsens energy imbalances in streptozotocin-induced diabetic rats.

  Diabetes & metabolism 20090401

• Alpha-lipoic acid inhibits tumor necrosis factor-induced remodeling and weakening of human fetal membranes.

  Biology of reproduction 20090401

• Influence of anchoring ligands and particle size on the colloidal stability and in vivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice.

  Biomaterials 20090401

• Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20090401

• Alpha-lipoic acid modifies oxidative stress parameters in sickle cell trait subjects and sickle cell patients.

  Clinical nutrition (Edinburgh, Scotland) 20090401

• Probing and preventing quantum dot-induced cytotoxicity with multimodal alpha-lipoic acid in multiple dimensions of the peripheral nervous system.

  Nanomedicine (London, England) 20090401

• Prophylaxis with alpha-lipoic acid against lipopolysaccharide-induced brain injury in rats.

  Archivum immunologiae et therapiae experimentalis 20090401

• [Effects of sustained-release alpha-lipoic acid tablet on blood lipid, blood sugar and insulin in hyperlipidemic New Zealand rabbits].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20090401

• Protective effect of lipoic acid against acrolein-induced cytotoxicity in IMR-90 human fibroblasts.

  Journal of nutritional science and vitaminology 20090401

• Lipoic acid-palladium complex interaction with DNA, voltammetric and AFM characterization.

  Talanta 20090315

• Preparation and characterization of antioxidant nanospheres from multiple alpha-lipoic acid-containing compounds.

  Bioorganic & medicinal chemistry letters 20090315

• Effect of Ganoderma lucidum on the activities of mitochondrial dehydrogenases and complex I and II of electron transport chain in the brain of aged rats.

  Experimental gerontology 20090301

• Alpha-lipoic acid potently inhibits peroxynitrite-mediated DNA strand breakage and hydroxyl radical formation: implications for the neuroprotective effects of alpha-lipoic acid.

  Molecular and cellular biochemistry 20090301

• Alpha lipoic acid in burning mouth syndrome--a randomized double-blind placebo-controlled trial.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20090301

• Alpha-lipoic acid reduces congenital malformations in the offspring of diabetic mice.

  Diabetes/metabolism research and reviews 20090301

• Physicochemical characteristics, cytotoxicity, and antioxidant activity of three lipid nanoparticulate formulations of alpha-lipoic acid.

  AAPS PharmSciTech 20090301

• Effect of alpha-lipoic acid on LPS-induced oxidative stress in the heart.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20090301

• [Burning mouth syndrome and alpha-lipoic acid].

  Actas dermo-sifiliograficas 20090301

• [Progress in the research on multi-target-directed drugs against Alzheimer's disease].

  Yao xue xue bao = Acta pharmaceutica Sinica 20090301

• Lipoic acid prevents body weight gain induced by a high fat diet in rats: effects on intestinal sugar transport.

  Journal of physiology and biochemistry 20090301

• Stabilizing effects of eicosapentaenoic acid on Kv1.5 channel protein expressed in mammalian cells.

  European journal of pharmacology 20090214

• Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats.

  Journal of cellular and molecular medicine 20090201

• HMOX1 and NQO1 genes are upregulated in response to contact sensitizers in dendritic cells and THP-1 cell line: role of the Keap1/Nrf2 pathway.

  Toxicological sciences : an official journal of the Society of Toxicology 20090201

• Alpha-lipoic acid improves acetic acid-induced gastric ulcer healing in rats.

  Inflammation 20090201

• Ethacrynic and alpha-lipoic acids inhibit vaccinia virus late gene expression.

  Antiviral research 20090201

• Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.

  Free radical research 20090201

• Effects of antioxidant supplements intervention on the level of plasma inflammatory molecules and disease severity of rheumatoid arthritis patients.

  Journal of the American College of Nutrition 20090201

• Distribution study of orally administered lipoic acid in rat brain tissues.

  Brain research 20090128

• The evaluation of effect of alpha-lipoic acid and vitamin E on the lipid peroxidation, gamma-amino butyric acid and serotonin level in the brain of mice (Mus musculus) acutely intoxicated with lindane.

  Journal of the neurological sciences 20090115

• Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatients.

  Journal of diabetes and its complications 20090101

• Radical scavengers for elderly patients with age-related hearing loss.

  Acta oto-laryngologica 20090101

• Effect of alpha-lipoic acid on visual evoked potentials in rats exposed to sulfite.

  Neurotoxicology and teratology 20090101

• The 'rejuvenatory' impact of lipoic acid on mitochondrial function in aging rats may reflect induction and activation of PPAR-gamma coactivator-1alpha.

  Medical hypotheses 20090101

• Role of NADPH-cytochrome P450 reductase and cytochrome-b5/NADH-b5 reductase in variability of CYP3A activity in human liver microsomes.

  Drug metabolism and disposition: the biological fate of chemicals 20090101

• Antioxidant properties of alpha-lipoic acid: effects on red blood membrane permeability and adaptation of isolated rat heart to reversible ischemia.

  Molecular and cellular biochemistry 20090101

• Mice with heterozygous deficiency of lipoic acid synthase have an increased sensitivity to lipopolysaccharide-induced tissue injury.

  Journal of leukocyte biology 20090101

• Efficacy of alpha lipoic acid in burning mouth syndrome: a randomized, placebo-treatment study.

  Journal of oral rehabilitation 20090101

• Drug-induced insulin autoimmune syndrome.

  Diabetes research and clinical practice 20090101

• The comparison of antioxidant and hematological properties of N-acetylcysteine and alpha-lipoic acid in physically active males.

  Physiological research 20090101

• Dihydro-alpha-lipoic acid has more potent cytotoxicity than alpha-lipoic acid.

  In vitro cellular & developmental biology. Animal 20090101

• Dietary supplementation with a combination of alpha-lipoic acid, acetyl-L-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance.

  Nutrition research (New York, N.Y.) 20090101

• MTDL design strategy in the context of Alzheimer's disease: from lipocrine to memoquin and beyond.

  Current pharmaceutical design 20090101

• Effect of alpha lipoic acid on oxidative stress and vascular wall of diabetic rats.

  Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 20090101

• Polyethylene glycol-based bidentate ligands to enhance quantum dot and gold nanoparticle stability in biological media.

  Nature protocols 20090101

• Multifunctional ligands based on dihydrolipoic acid and polyethylene glycol to promote biocompatibility of quantum dots.

  Nature protocols 20090101

• Glucosamine/chondroitin/primorine combination therapy for osteoarthritis.

  Drugs of today (Barcelona, Spain : 1998) 20090101

• Effects of alpha-lipoic acid administration on plasma glucose levels, total malondialdehyde values and withdrawal signs in rats treated with morphine or morphine plus naloxone.

  Arzneimittel-Forschung 20090101

• Dose-related cytoprotective effect of alpha-lipoic acid on hydrogen peroxide-induced oxidative stress to pancreatic beta cells.

  Free radical research 20090101

• Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival.

  PloS one 20090101

• Treatment of carpal tunnel syndrome with alpha-lipoic acid.

  European review for medical and pharmacological sciences 20090101

• [Effect of alpha-lipoic acid on the sensitivity of transformed fibroblasts to lysis by natural killer cells. Comparison with NAC action].

  Tsitologiia 20090101

• Hypoglycemic and beta cell protective effects of andrographolide analogue for diabetes treatment.

  Journal of translational medicine 20090101

• Evaluation of lenticular antioxidant and redox system components in the lenses of acetyl-L-carnitine treatment in BSO-induced glutathione deprivation.

  Molecular vision 20090101

• Alpha-lipoic acid attenuates cisplatin-induced tubulointerstitial injuries through inhibition of mitochondrial bax translocation in rats.

  Nephron. Experimental nephrology 20090101

• Caenorhabditis elegans F09E10.3 encodes a putative 3-oxoacyl-thioester reductase of mitochondrial type 2 fatty acid synthase FASII that is functional in yeast.

  Journal of biomedicine & biotechnology 20090101

• Immobilization of a naphthalene diimide-DNA complex on the gold through dithiolane moieties.

  Nucleic acids symposium series (2004) 20090101

• Lipoic acid attenuates high fat diet-induced chronic oxidative stress and immunosuppression in mice jejunum: a microarray analysis.

  Cellular immunology 20090101

• [Present-day possibilities of correcting impaired autoregulation of the cerebral circulation].

  Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20090101

• Impact of therapy with alpha-lipoic acid (ALA) on the oxidative stress in the controlled NIDDM: a possible preventive way against the organ dysfunction?

  Archives of gerontology and geriatrics 20090101

• The use of alpha-lipoic acid (ALA), gamma linolenic acid (GLA) and rehabilitation in the treatment of back pain: effect on health-related quality of life.

  International journal of immunopathology and pharmacology 20090101

• Multifunctional lipoic acid conjugates.

  Current medicinal chemistry 20090101

• [Structural and functional condition of the left ventricle in patients with type 2 diabetes mellitus complicated with diabetic autonomic neuropathy].

  Likars'ka sprava 20090101

• Clinical applications of alpha-lipoic acid in the management of neurological disorders besides carpal tunnel syndrome.

  European review for medical and pharmacological sciences 20090101

• Prevention of selenite-induced cataractogenesis by rutin in Wistar rats.

  Molecular vision 20090101

• Modulation of cytochrome P450 enzyme system by selected flavonoids.

  Neuro endocrinology letters 20090101

• [Correction of disordered cerebral blood flow autoregulation in atherosclerosis].

  Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery 20090101

• [Effect of alpha-lipoic acid on fibroblasts 3T3 and 3T3-SV40. Comparison with N-acetylcysteine action].

  Tsitologiia 20090101

• Short interfering RNA against transient receptor potential vanilloid 1 attenuates cisplatin-induced hearing loss in the rat.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20081203

• Alpha lipoic acid possess dual antioxidant and lipid lowering properties in atherosclerotic-induced New Zealand White rabbit.

  Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20081201

• Dietary supplementation with N-acetylcysteine, alpha-tocopherol and alpha-lipoic acid prevents age related decline in Na(+),K (+)-ATPase activity and associated peroxidative damage in rat brain synaptosomes.

  Biogerontology 20081201

• Alpha-lipoic acid prevents mitochondrial damage and neurotoxicity in experimental chemotherapy neuropathy.

  Experimental neurology 20081201

• Dihydrolipoic acid inhibits tetrachlorohydroquinone-induced tumor promotion through prevention of oxidative damage.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20081201

• Xenobiotic incorporation into pyruvate dehydrogenase complex can occur via the exogenous lipoylation pathway.

  Hepatology (Baltimore, Md.) 20081201

• Management of painful diabetic neuropathy.

  Expert opinion on pharmacotherapy 20081201

• Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E.

  International journal of cosmetic science 20081201

• Electrochemical immunosensor for detection of celiac disease toxic gliadin in foodstuff.

  Analytical chemistry 20081201

• Mutated glutathione-S-transferase reduced airway inflammation by limiting oxidative stress and Th2 response.

  Free radical biology & medicine 20081115

• Investigation of the drug-drug interaction between alpha-lipoic acid and valproate via mitochondrial beta-oxidation.

  Pharmaceutical research 20081101

• The beneficial effect of coenzyme Q10 and lipoic acid on obstructive bladder dysfunction in the rabbit.

  The Journal of urology 20081101

• Alpha-lipoic acid attenuates hemorrhagic shock-induced apoptotic signaling and vascular hyperpermeability.

  Shock (Augusta, Ga.) 20081101

• Intestinal tumour chemoprevention with the antioxidant lipoic acid stimulates the growth of breast cancer.

  European journal of cancer (Oxford, England : 1990) 20081101

• Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways.

  Hepatology (Baltimore, Md.) 20081101

• Alpha-lipoic acid supplementation and diabetes.

  Nutrition reviews 20081101

• Pharmacokinetics of different formulations of tioctic (alpha-lipoic) acid in healthy volunteers.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20081101

• The role of alpha-lipoic acid in diabetic polyneuropathy treatment.

  Bosnian journal of basic medical sciences 20081101

• Influence of alpha lipoic acid on antioxidant status in D-galactosamine-induced hepatic injury.

  Toxicology and industrial health 20081101

• Optimization of octanoic acid and sulfur donor concentrations for lipoic acid production by Pseudomonas reptilivora.

  Biotechnology letters 20081001

• A computational investigation of sulfur-containing heterocyclic components from the anal sac secretions of Mustela species.

  Journal of molecular modeling 20081001

• Oral benfotiamine plus alpha-lipoic acid normalises complication-causing pathways in type 1 diabetes.

  Diabetologia 20081001

• Interactions of the advanced glycation end product inhibitor pyridoxamine and the antioxidant alpha-lipoic acid on insulin resistance in the obese Zucker rat.

  Metabolism: clinical and experimental 20081001

• Control of cellular redox status and upregulation of quinone reductase NQO1 via Nrf2 activation by alpha-lipoic acid in human leukemia HL-60 cells.

  International journal of oncology 20081001

• [Thermodynamically controlled deracemization utilizing inclusion complexation].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20081001

• Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20081001

• Drugs for the treatment of diabetes complications. Zycose: a new player in the field?

  Drugs of today (Barcelona, Spain : 1998) 20081001

• Neuropharmacology.

  Indian journal of pharmacology 20081001

• The role of lipoic acid in prevention of nitroglycerin tolerance.

  European journal of pharmacology 20080904

• Alpha-lipoic acid treatment of 31 patients with sore, burning mouth.

  Oral diseases 20080901

• Opposite effects of alpha-lipoic acid on antioxidation and long-term potentiation in control and chronically lead-exposed rats.

  Naunyn-Schmiedeberg's archives of pharmacology 20080901

• Modulation of antioxidant and detoxification responses mediated by lipoic acid in the fish Corydoras paleatus (Callychthyidae).

  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080901

• Experimental determination of quantum dot size distributions, ligand packing densities, and bioconjugation using analytical ultracentrifugation.

  Nano letters 20080901

• Lipid lowering effect of antioxidant alpha-lipoic Acid in experimental atherosclerosis.

  Journal of clinical biochemistry and nutrition 20080901

• The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by alpha-lipoic acid.

  Free radical research 20080901

• [Effect of lipoic acid on gene expression related to oxidative stress, lipid and glucose metabolism of mice fed with high fat diet].

  Wei sheng yan jiu = Journal of hygiene research 20080901

• Lipoic acid rescues DBA mice from early-onset age-related hearing impairment.

  Neuroreport 20080827

• Lipoic acid stimulates cAMP production via the EP2 and EP4 prostanoid receptors and inhibits IFN gamma synthesis and cellular cytotoxicity in NK cells.

  Journal of neuroimmunology 20080813

• Antioxidant effects of methionine, alpha-lipoic acid, N-acetylcysteine and homocysteine on lead-induced oxidative stress to erythrocytes in rats.

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080801

• Plasma malondialdehyde levels and opiate withdrawal signs observed in rats treated with morphine plus naloxone: effects of alpha-lipoic acid administration.

  Fundamental & clinical pharmacology 20080801

• A study of the antioxidant effect of alpha lipoic acids on sperm quality.

  Clinics (Sao Paulo, Brazil) 20080801

• A 41-year-old man with polyarthritis and severe autonomic neuropathy.

  Therapeutics and clinical risk management 20080801

• Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats.

  The British journal of nutrition 20080701

• Protective effects of R-alpha-lipoic acid and acetyl-L-carnitine in MIN6 and isolated rat islet cells chronically exposed to oleic acid.

  Journal of cellular biochemistry 20080701

• Effect of co-enzyme Q10 and alpha-lipoic acid on response of rabbit urinary bladder to repetitive stimulation and in vitro ischemia.

  Urology 20080701

• Label-free detection of antibody-antigen interactions on (R)-lipo-diaza-18-crown-6 self-assembled monolayer modified gold electrodes.

  Analytical chemistry 20080701

• Synthesis and anti-melanogenic effects of lipoic acid-polyethylene glycol ester.

  The Journal of pharmacy and pharmacology 20080701

• Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols.

  Bioconjugate chemistry 20080701

• Synthesis and anticancer properties of water-soluble zinc ionophores.

  Cancer research 20080701

• Early lipoic acid intake protects retina of diabetic mice.

  Free radical research 20080701

• Selective and sensitive determination of lipoyllysine (protein-bound alpha-lipoic acid) in biological specimens by high-performance liquid chromatography with fluorescence detection.

  Analytica chimica acta 20080623

• Chitosan microspheres for encapsulation of alpha-lipoic acid.

  International journal of pharmaceutics 20080605

• The effect of oral alpha-lipoic acid on oxidative stress in adolescents with type 1 diabetes mellitus.

  Pediatric diabetes 20080601

• Binding of lipoic acid induces conformational change and appearance of a new binding site in methylglyoxal modified serum albumin.

  The protein journal 20080601

• Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: a microarray analysis.

  Nutrition (Burbank, Los Angeles County, Calif.) 20080601

• Efficacy of DL-alpha lipoic acid against systemic inflammation-induced mice: antioxidant defense system.

  Molecular and cellular biochemistry 20080601

• Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity.

  IUBMB life 20080601

• Synthesis of new antioxidant conjugates and their in vitro hydrolysis with Stratum corneum enzymes.

  International journal of cosmetic science 20080601

• Dietary lipoic acid supplementation can mimic or block the effect of dietary restriction on life span.

  Mechanisms of ageing and development 20080601

• Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders?

  Expert opinion on investigational drugs 20080601

• Ability of alpha-lipoic acid to reverse the diabetic cystopathy in a rat model.

  Acta pharmacologica Sinica 20080601

• Lipoic acid: a novel therapeutic approach for multiple sclerosis and other chronic inflammatory diseases of the CNS.

  Endocrine, metabolic & immune disorders drug targets 20080601

• Phase II enzyme induction by alpha-lipoic acid through phosphatidylinositol 3-kinase-dependent C/EBPs activation.

  Xenobiotica; the fate of foreign compounds in biological systems 20080601

• [An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases].

  Annales de cardiologie et d'angeiologie 20080601

• Beneficial effect of alpha-lipoic acid on lipopolysaccharide-induced oxidative stress in bronchoalveolar lavage fluid.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20080601

• Coenzyme Q(10) and alpha-lipoic acid supplementation in diabetic rats: conduction velocity distributions.

  Methods and findings in experimental and clinical pharmacology 20080601

• The combination of alpha-lipoic acid supplementation and aerobic exercise inhibits lipid peroxidation in rat skeletal muscles.

  Nutrition research (New York, N.Y.) 20080601

• Alpha-lipoic acid induces apoptosis in hepatoma cells via the PTEN/Akt pathway.

  FEBS letters 20080528

• Electrochemical characterization of pore formation by bacterial protein toxins on hybrid supported membranes.

  Langmuir : the ACS journal of surfaces and colloids 20080520

• Increased biomass yield of Lactococcus lactis during energetically limited growth and respiratory conditions.

  Biotechnology and applied biochemistry 20080501

• Potent upregulation of glutathione and NAD(P)H:quinone oxidoreductase 1 by alpha-lipoic acid in human neuroblastoma SH-SY5Y cells: protection against neurotoxicant-elicited cytotoxicity.

  Neurochemical research 20080501

• The antioxidant alpha-lipoic acid improves endothelial dysfunction induced by acute hyperglycaemia during OGTT in impaired glucose tolerance.

  Clinical endocrinology 20080501

• Treatment of experimental autoimmune encephalomyelitis with alpha lipoic acid and associative conditioning.

  Brain, behavior, and immunity 20080501

• High glucose-induced NF-kappaB activation occurs via tyrosine phosphorylation of IkappaBalpha in human glomerular endothelial cells: involvement of Syk tyrosine kinase.

  American journal of physiology. Renal physiology 20080501

• [Estimation of protective effect of lipoic acid in the brain of rats during lipopolysaccharide-induced oxidative stress].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20080501

• Alpha-lipoic acid suppresses 6-hydroxydopamine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1.

  Brain research 20080424

• Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties.

  Bioorganic & medicinal chemistry 20080415

• Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons.

  Brain research 20080414

• Is dihydrolipoic acid among the reductive activators of parasite CysHis proteases?

  Experimental parasitology 20080401

• Inhibitory effects of short-term administration of DL-alpha-lipoic acid on oxidative vulnerability induced by Abeta amyloid fibrils (25-35) in mice.

  Molecular and cellular biochemistry 20080401

• Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction.

  Free radical biology & medicine 20080401

• Lipoic acid significantly restores, in rats, the age-related decline in vasomotion.

  British journal of pharmacology 20080401

• A preliminary investigation of alpha-lipoic acid treatment of antipsychotic drug-induced weight gain in patients with schizophrenia.

  Journal of clinical psychopharmacology 20080401

• Lipoic acid supplementation and endothelial function.

  British journal of pharmacology 20080401

• Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection.

  The Journal of infectious diseases 20080315

• Memory impairment, oxidative damage and apoptosis induced by space radiation: ameliorative potential of alpha-lipoic acid.

  Behavioural brain research 20080305

• The 3-hydroxyacyl-ACP dehydratase of mitochondrial fatty acid synthesis in Trypanosoma brucei.

  FEBS letters 20080305

• Effects of alpha-lipoic acid on endothelial function in aged diabetic and high-fat fed rats.

  British journal of pharmacology 20080301

• Alpha-lipoic acid protects against renal ischaemia-reperfusion injury in rats.

  Clinical and experimental pharmacology & physiology 20080301

• Lipoic acid ameliorates oxidative stress and renal injury in alloxan diabetic rabbits.

  Biochimie 20080301

• Restoration of blood total glutathione status and lymphocyte function following alpha-lipoic acid supplementation in patients with HIV infection.

  Journal of alternative and complementary medicine (New York, N.Y.) 20080301

• Effect of the antioxidant alpha-lipoic acid on apoptosis in human umbilical vein endothelial cells induced by high glucose.

  Clinical and experimental medicine 20080301

• Postmitotic tissue selenium and manganese levels in alpha-lipoic acid-supplemented aged rats.

  Chemico-biological interactions 20080215

• Novel lipoate-selective membrane sensor for the flow injection determination of alpha-lipoic acid in pharmaceutical preparations and urine.

  Talanta 20080215

• Diabetic neuropathy: new strategies for treatment.

  Diabetes, obesity & metabolism 20080201

• Genetic and pharmacologic manipulation of oxidative stress after neonatal hypoxia-ischemia.

  International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20080201

• Participation of chlorobiumquinone in the transplasma membrane electron transport system of Leishmania donovani promastigote: effect of near-ultraviolet light on the redox reaction of plasma membrane.

  Biochimica et biophysica acta 20080201

• Effect of vitamin C and lipoic acid on streptozotocin-induced diabetes gene expression: mRNA and protein expressions of Cu-Zn SOD and catalase.

  Molecular and cellular biochemistry 20080201

• alpha-Lipoic acid and ascorbate prevent LDL oxidation and oxidant stress in endothelial cells.

  Molecular and cellular biochemistry 20080201

• Alpha lipoic acid attenuates microvascular endothelial cell hyperpermeability by inhibiting the intrinsic apoptotic signaling.

  American journal of surgery 20080201

• Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

  Antioxidants & redox signaling 20080201

• Alpha-lipoic acid inhibits TNF-alpha induced NF-kappa B activation through blocking of MEKK1-MKK4-IKK signaling cascades.

  International immunopharmacology 20080201

• The significance of Nrf2 pathway in (photo)-oxidative stress response in melanocytes and keratinocytes of the human epidermis.

  Pigment cell & melanoma research 20080201

• Protective effect of lipoic acid against methylglyoxal-induced oxidative stress in LLC-PK(1) cells.

  Journal of nutritional science and vitaminology 20080201

• Dietary alpha-lipoic acid supplementation inhibits atherosclerotic lesion development in apolipoprotein E-deficient and apolipoprotein E/low-density lipoprotein receptor-deficient mice.

  Circulation 20080122

• The potential protective role of alpha-lipoic acid against acetaminophen-induced hepatic and renal damage.

  Toxicology 20080120

• Design and synthesis of cellulose derivatives with antioxidant activity.

  Macromolecular bioscience 20080109

• Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid.

  Biochemistry 20080108

• Insulin signaling and the heat shock response modulate protein homeostasis in the Caenorhabditis elegans intestine during infection.

  The Journal of biological chemistry 20080104

• Antioxidants modulate the IL-6 induced inhibition of negative acute-phase protein secretion in HepG2 cells.

  Cell biochemistry and function 20080101

• The effects and mechanisms of mitochondrial nutrient alpha-lipoic acid on improving age-associated mitochondrial and cognitive dysfunction: an overview.

  Neurochemical research 20080101

• Alpha-lipoic acid promotes the growth of rat hepatic pre-neoplastic lesions in the choline-deficient model.

  Carcinogenesis 20080101

• Vascular and neural dysfunction in Zucker diabetic fatty rats: a difficult condition to reverse.

  Diabetes, obesity & metabolism 20080101

• Antioxidant effect of alpha-lipoic acid against ethanol-induced gastric mucosal erosion in rats.

  Pharmacology 20080101

• R-alpha-lipoic acid and acetyl-L-carnitine complementarily promote mitochondrial biogenesis in murine 3T3-L1 adipocytes.

  Diabetologia 20080101

• Effects of alpha-lipoic acid on ischemia-reperfusion-induced renal dysfunction in rats.

  American journal of physiology. Renal physiology 20080101

• The effect of lipoic acid on antioxidant status and lipid peroxidation in rats exposed to chronic restraint stress.

  Physiological research 20080101

• alpha-Lipoic acid modulates extracellular matrix and angiogenesis gene expression in non-healing wounds treated with hyperbaric oxygen therapy.

  Molecular medicine (Cambridge, Mass.) 20080101

• Burning mouth syndrome and burning mouth in hypothyroidism: proposal for a diagnostic and therapeutic protocol.

  Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20080101

• The effect of alpha-lipoic acid on NOS dispersion in the lung of streptozotocin-induced diabetic rats.

  Journal of diabetes and its complications 20080101

• alpha-Lipoic acid: the potential for use in cancer therapy.

  Neoplasma 20080101

• Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts.

  Redox report : communications in free radical research 20080101

• Effects of lipoic acid on citrate content, aconitate hydratase activity, and oxidative status during myocardial ischemia in rats.

  Biochemistry. Biokhimiia 20080101

• [Implication of alpha-lipoic acid preparations in the treatment of diabetic neuropathy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• [Assessment of berlition effectiveness in ischemic stroke with CT perfusion imaging of the brain].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• Biological actions of lipoic acid associated with sulfane sulfur metabolism.

  Pharmacological reports : PR 20080101

• [Pharmacological significance of alpha lipoic acid in up to date treatment of diabetic neuropathy].

  Medicinski arhiv 20080101

• Regulation of cell cycle transition and induction of apoptosis in HL-60 leukemia cells by lipoic acid: role in cancer prevention and therapy.

  Journal of hematology & oncology 20080101

• [The free-radical processes and antioxidant therapy in brain ischemia].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• [Alpha-tocopherol and alpha-lipoic acid. An antioxidant synergy with potential for preventive medicine].

  Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20080101

• Thioctic acid and acetyl-L-carnitine in the treatment of sciatic pain caused by a herniated disc: a randomized, double-blind, comparative study.

  Clinical drug investigation 20080101

• The mitochondrial cocktail: rationale for combined nutraceutical therapy in mitochondrial cytopathies.

  Advanced drug delivery reviews 20080101

• [Effect of taurine and thioctacide on carbohydrate metabolism and the antioxydant system in rats with experimental diabetes].

  Eksperimental'naia i klinicheskaia farmakologiia 20080101

• Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.

  Advanced drug delivery reviews 20080101

• An engineered aryl azide ligase for site-specific mapping of protein-protein interactions through photo-cross-linking.

  Angewandte Chemie (International ed. in English) 20080101

• [The use of dipyridamole (curantyl) in combination with alpha-lipoic acid in the treatment of diabetic neuropathy with retinopathy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• [The blood glutathione system in cerebral vascular diseases and its treatment with alpha-lipoic acid].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101

• Pathogenesis of ganglion 'cell death' in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria.

  Progress in brain research 20080101

• Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine.

  Surgery today 20080101

• [Changes in matrix metalloproteinases activities in normal and transformed mouse fibroblasts under effect of antioxidants].

  Tsitologiia 20080101

• [Effect of alpha-lipoic acid and mexidol on neuro- and the affective status in patients at early stages of diabetic foot syndrome].

  Klinicheskaia meditsina 20080101

• Alpha--lipoic acid decreases DNA damage and oxidative stress induced by alcohol in the developing hippocampus and cerebellum of rat.

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20080101

• [Efficacy of using alpha-lipoic acid (berlition) in patients with nonalcoholic steatohepatitis].

  Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20080101

• Lipoic acid and 6-formylpterin reduce potentiation of noise-induced hearing loss by carbon monoxide: preliminary investigation.

  Journal of rehabilitation research and development 20080101

• Antioxidant systems and oxidative stress in the testes.

  Oxidative medicine and cellular longevity 20080101

• The effect of biothiol on UV irradiated alpha-lipoic acid.

  BioFactors (Oxford, England) 20080101

• Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: role of carnitine and lipoic acid.

  Free radical biology & medicine 20071215

• Interfacial activity of polymer-coated gold nanoparticles.

  Langmuir : the ACS journal of surfaces and colloids 20071204

• Antioxidants slow photoreceptor cell death in mouse models of retinitis pigmentosa.

  Journal of cellular physiology 20071201

• The effect of lipoic acid on lipid peroxidation and visual evoked potentials (VEPs) in rats exposed to chronic restraint stress.

  The International journal of neuroscience 20071201

• The protective effect of alpha-lipoic acid in experimental ovarian ischaemia-reperfusion injury.

  The Australian & New Zealand journal of obstetrics & gynaecology 20071201

• Effect of cysteine derivatives administration in healthy men exposed to intense resistance exercise by evaluation of pro-antioxidant ratio.

  The journal of physiological sciences : JPS 20071201

• Possible relevance of HLA-DRB1*0403 haplotype in insulin autoimmune syndrome induced by alpha-lipoic acid, used as a dietary supplement.

  Diabetes care 20071201

• Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes.

  Nature biotechnology 20071201

• Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum.

  PLoS pathogens 20071201

• The plasma pharmacokinetics of R-(+)-lipoic acid administered as sodium R-(+)-lipoate to healthy human subjects.

  Alternative medicine review : a journal of clinical therapeutic 20071201

• Antioxidant DL-alpha lipoic acid as an attenuator of adriamycin induced hepatotoxicity in rat model.

  Indian journal of experimental biology 20071201

• The bilberry blues.

  Alternative medicine review : a journal of clinical therapeutic 20071201

• alpha-Lipoic acid in dietary supplements: development and comparison of HPLC-CEAD and HPLC-ESI-MS methods.

  Journal of pharmaceutical and biomedical analysis 20071130

• Thiol supplementation inhibits metalloproteinase activity independent of glutathione status.

  Biochemical and biophysical research communications 20071123

• Carnitine and lipoate ameliorates lipofuscin accumulation and monoamine oxidase activity in aged rat heart.

  European journal of pharmacology 20071121

• Enhancing the stability and biological functionalities of quantum dots via compact multifunctional ligands.

  Journal of the American Chemical Society 20071114

• Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20071101

• Effects of zinc on SN56 cholinergic neuroblastoma cells.

  Journal of neurochemistry 20071101

• Targeted binding of PLA microparticles with lipid-PEG-tethered ligands.

  Biomaterials 20071101

• Protective effect of lipoic acid on oxidative and peroxidative damage in cyclosporine A-induced renal toxicity.

  International immunopharmacology 20071101

• Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats.

  Journal of gastroenterology and hepatology 20071101

• Antioxidants and narrow band-UVB in the treatment of vitiligo: a double-blind placebo controlled trial.

  Clinical and experimental dermatology 20071101

• Comparative crossover, randomized, open-label bioequivalence study on the bioequivalence of two formulations of thioctic acid in healthy volunteers.

  Clinical and experimental hypertension (New York, N.Y. : 1993) 20071101

• [Curative effect of alpha-lipoic acid on peripheral neuropathy in type 2 diabetes: a clinical study].

  Zhonghua yi xue za zhi 20071016

• Improvement of patient tolerance to dapsone: current and future developments.

  Dermatology online journal 20071013

• Enzymatic characterization of dihydrolipoamide dehydrogenase from Streptococcus pneumoniae harboring its own substrate.

  The Journal of biological chemistry 20071005

• S-allylcysteine scavenges singlet oxygen and hypochlorous acid and protects LLC-PK(1) cells of potassium dichromate-induced toxicity.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071001

• Therapeutic efficacy of DL-alpha-lipoic acid on cyclosporine A induced renal alterations.

  European journal of pharmacology 20071001

• Uptake and reduction of alpha-lipoic acid by human erythrocytes.

  Clinical biochemistry 20071001

• Ca2+/calmodulin-dependent protein kinase kinase is involved in AMP-activated protein kinase activation by alpha-lipoic acid in C2C12 myotubes.

  American journal of physiology. Cell physiology 20071001

• Protective effects of L-carnitine and alpha-lipoic acid in rats with adjuvant arthritis.

  Pharmacological research 20071001

• Impaired apparent ion demand in experimental diabetic retinopathy: correction by lipoic Acid.

  Investigative ophthalmology & visual science 20071001

• [Safety and structural analysis of polymers produced in manufacturing process of alpha-lipoic acid].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20071001

• Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells.

  Human molecular genetics 20070915

• Mitochondrial ageing and the beneficial role of alpha-lipoic acid.

  Neurochemical research 20070901

• The effect of alpha-lipoic acid on symptoms and skin blood flow in diabetic neuropathy.

  Diabetic medicine : a journal of the British Diabetic Association 20070901

• Alpha-lipoic acid increases cardiac glucose oxidation independent of AMP-activated protein kinase in isolated working rat hearts.

  Basic research in cardiology 20070901

• Cytochrome c oxidase rather than cytochrome c is a major determinant of mitochondrial respiratory capacity in skeletal muscle of aged rats: role of carnitine and lipoic acid.

  Rejuvenation research 20070901

• Comparative treatment of alpha-amanitin poisoning with N-acetylcysteine, benzylpenicillin, cimetidine, thioctic acid, and silybin in a murine model.

  Annals of emergency medicine 20070901

• R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1.

  American journal of physiology. Endocrinology and metabolism 20070901

• Alpha-lipoic acid and insulin autoimmune syndrome.

  Diabetes care 20070901

• An open-label 52-week clinical extension comparing duloxetine with routine care in patients with diabetic peripheral neuropathic pain.

  Pain medicine (Malden, Mass.) 20070901

• Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.

  Journal of Alzheimer's disease : JAD 20070901

• Protective effects of early treatment with lipoic acid in LPS-induced lung injury in rats.

  Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901

• Design and synthesis of 1,2-dithiolane derivatives and evaluation of their neuroprotective activity.

  Bioorganic & medicinal chemistry letters 20070801

• Recognition of the inner lipoyl-bearing domain of dihydrolipoyl transacetylase and of the blood glucose-lowering compound AZD7545 by pyruvate dehydrogenase kinase 2.

  Biochemistry 20070724

• Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model.

  World journal of gastroenterology 20070721

• Stable aqueous nanoparticle film assemblies with covalent and charged polymer linking networks.

  Langmuir : the ACS journal of surfaces and colloids 20070703

• Beneficial effect of DL-alpha-lipoic acid on cyclosporine A induced hyperlipidemic nephropathy in rats.

  Molecular and cellular biochemistry 20070701

• Activation of apoptosis signal regulating kinase 1 (ASK1) and translocation of death-associated protein, Daxx, in substantia nigra pars compacta in a mouse model of Parkinson's disease: protection by alpha-lipoic acid.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20070701

• Oxidative stress reduces renal dopamine D1 receptor-Gq/11alpha G protein-phospholipase C signaling involving G protein-coupled receptor kinase 2.

  American journal of physiology. Renal physiology 20070701

• Simultaneous determination of alpha-lipoic acid and its reduced form by high-performance liquid chromatography with fluorescence detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701

• CoCl2 induces protective events via the p38-MAPK signalling pathway and ANP in the perfused amphibian heart.

  The Journal of experimental biology 20070701

• Pharmacodynamic effects of orally administered dexlipotam on endothelial function in type 2-diabetic patients.

  International journal of clinical pharmacology and therapeutics 20070701

• Transepithelial transport of alpha-lipoic acid across human intestinal Caco-2 cell monolayers.

  Journal of agricultural and food chemistry 20070627

• Targeting lipoic acid to mitochondria: synthesis and characterization of a triphenylphosphonium-conjugated alpha-lipoyl derivative.

  Free radical biology & medicine 20070615

• Alpha-lipoic acid differently affects the reserpine-induced oxidative stress in the striatum and prefrontal cortex of rat brain.

  Neuroscience 20070608

• Unusual fluorescence enhancement of a novel carbazolyldiacetylene bound to gold nanoparticles.

  Langmuir : the ACS journal of surfaces and colloids 20070605

• Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid.

  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070601

• Dihydrolipoic acid inhibits skin tumor promotion through anti-inflammation and anti-oxidation.

  Biochemical pharmacology 20070601

• D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid.

  Biogerontology 20070601

• Therapeutic effects of alpha-lipoic acid on bleomycin-induced pulmonary fibrosis in rats.

  International journal of molecular medicine 20070601

• Protection from hepatic ischemia/reperfusion injury and improvement of liver regeneration by alpha-lipoic acid.

  Shock (Augusta, Ga.) 20070601

• Autophagocytosis of mitochondria is prominent in Alzheimer disease.

  Journal of neuropathology and experimental neurology 20070601

• Chelation therapy and vanadium: effect on reproductive organs in rats.

  Indian journal of experimental biology 20070601

• Effects of alpha-lipoic acid supplementation in peripheral arterial disease: a pilot study.

  Journal of alternative and complementary medicine (New York, N.Y.) 20070601

• Comparison of the total oxyradical scavenging capacity and oxygen radical absorbance capacity antioxidant assays.

  Journal of medicinal food 20070601

• Endothelial dysfunction in type 2 diabetes: effect of antioxidants.

  Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20070601

• The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury.

  Toxicology 20070520

• Design and synthesis of novel quinolinone-3-aminoamides and their alpha-lipoic acid adducts as antioxidant and anti-inflammatory agents.

  Journal of medicinal chemistry 20070517

• Biological assays and genomic analysis reveal lipoic acid modulation of endothelial cell behavior and gene expression.

  Carcinogenesis 20070501

• Efficacy of DL-alpha-lipoic acid on methanol induced free radical changes, protein oxidative damages and hsp70 expression in folate deficient rat nervous tissue.

  Chemico-biological interactions 20070501

• Effect of DL-alpha-lipoic acid on cyclophosphamide induced lysosomal changes in oxidative cardiotoxicity.

  Life sciences 20070501

• Fluorimetric determination of some sulfur containing compounds through complex formation with terbium (Tb+3) and uranium (U+3).

  Journal of fluorescence 20070501

• The role of plant mitochondria in the biosynthesis of coenzymes.

  Photosynthesis research 20070501

• Alpha-lipoic acid may improve symptomatic diabetic polyneuropathy.

  The neurologist 20070501

• Effect of alpha-lipoic acid supplementation on trace element levels in serum and in postmitotic tissue in aged rats.

  Medicinal chemistry (Shariqah (United Arab Emirates)) 20070501

• Arsenic and lead induced free radical generation and their reversibility following chelation.

  Cellular and molecular biology (Noisy-le-Grand, France) 20070415

• Traces of copper ions deplete glutathione in human hepatoma cell cultures with low cysteine content.

  Chemico-biological interactions 20070405

• Involvement of oxidants and AP-1 in angiotensin II-activated NFAT3 transcription factor.

  American journal of physiology. Cell physiology 20070401

• Alpha-lipoic Acid modulates heat shock factor-1 expression in streptozotocin-induced diabetic rat kidney.

  Antioxidants & redox signaling 20070401

• Histochemical staining and quantification of dihydrolipoamide dehydrogenase diaphorase activity using blue native PAGE.

  Electrophoresis 20070401

• Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease.

  Journal of clinical hypertension (Greenwich, Conn.) 20070401

• More light please.

  Journal of clinical hypertension (Greenwich, Conn.) 20070401

• [High-performance liquid chromatography for determining plasma alpha-lipoic acid in New Zealand rabbits].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070401

• Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review.

  Journal of environmental biology 20070401

• Lipoic acid stimulates cAMP production in T lymphocytes and NK cells.

  Biochemical and biophysical research communications 20070302

• Possible relevance of alpha lipoic acid contained in a health supplement in a case of insulin autoimmune syndrome.

  Diabetes research and clinical practice 20070301

• alpha-Lipoic acid attenuates x-irradiation-induced oxidative stress in mice.

  Cell biology and toxicology 20070301

• Is there a role for reactive oxygen species in arterial medial elastocalcinosis?

  Vascular pharmacology 20070301

• Mitogen-activated protein kinase upregulation reduces renal D1 receptor affinity and G-protein coupling in obese rats.

  Kidney international 20070301

• Modulating effects of a novel skin-lightening agent, alpha-lipoic acid derivative, on melanin production by the formation of DOPA conjugate products.

  Bioorganic & medicinal chemistry 20070301

• Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum.

  Molecular microbiology 20070301

• Alpha-lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome.

  Expert opinion on investigational drugs 20070301

• Continuous infusion of lipoic acid rapidly reduces plasma beta-hydroxybutyrate with elevation of non-esterified fatty acids in broiler chickens.

  The British journal of nutrition 20070301

• Alpha-lipoic acid as a directly binding activator of the insulin receptor: protection from hepatocyte apoptosis.

  Biochemistry 20070227

• Alpha-lipoic acid inhibits matrix metalloproteinase-9 expression by inhibiting NF-kappaB transcriptional activity.

  Experimental & molecular medicine 20070227

• Monolayer-protected gold nanoparticles by the self-assembly of micellar poly(ethylene oxide)-b-poly(epsilon-caprolactone) block copolymer.

  Langmuir : the ACS journal of surfaces and colloids 20070213

• Radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice: protective effect of alpha-lipoic acid.

  Behavioural brain research 20070212

• Chronic dietary alpha-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice.

  Neurobiology of aging 20070201

• S-adenosylmethionine and radical-based catalysis.

  Amino acids 20070201

• Beneficial effects of creatine, CoQ10, and lipoic acid in mitochondrial disorders.

  Muscle & nerve 20070201

• alpha-Lipoic acid and glutathione protect against the prooxidant activity of SOD/catalase mimetic manganese salen derivatives.

  Journal of inorganic biochemistry 20070201

• Mitigation of age-dependent oxidative damage to DNA in rat heart by carnitine and lipoic acid.

  Mechanisms of ageing and development 20070201

• Involvement of PI3K/PKG/ERK1/2 signaling pathways in cortical neurons to trigger protection by cotreatment of acetyl-L-carnitine and alpha-lipoic acid against HNE-mediated oxidative stress and neurotoxicity: implications for Alzheimer's disease.

  Free radical biology & medicine 20070201

• Extending the dynamic range of electrochemical sensors using multiple modified electrodes.

  Analytical and bioanalytical chemistry 20070201

• Effects of lipoic acid and dihydrolipoic acid on total erythrocytic thiols under conditions of restricted glucose in vitro.

  Basic & clinical pharmacology & toxicology 20070201

• Modulation of p38 mitogen-activated protein kinase cascade and metalloproteinase activity in diaphragm muscle in response to free radical scavenger administration in dystrophin-deficient Mdx mice.

  The American journal of pathology 20070201

• An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide.

  Experimental hematology 20070201

• [Burning mouth syndrome].

  Recenti progressi in medicina 20070201

• Lipoate-based imprinted self-assembled molecular thin films for biosensor applications.

  Biosensors & bioelectronics 20070115

• Role of reduced lipoic acid in the redox regulation of mitochondrial aldehyde dehydrogenase (ALDH-2) activity. Implications for mitochondrial oxidative stress and nitrate tolerance.

  The Journal of biological chemistry 20070105

• Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: effect of the anti-oxidant alpha-lipoic acid.

  Cell biochemistry and function 20070101

• Alpha-lipoic acid suppresses the development of collagen-induced arthritis and protects against bone destruction in mice.

  Rheumatology international 20070101

• Presynaptic mechanisms underlying the alpha-lipoic acid facilitation of glutamate exocytosis in rat cerebral cortex nerve terminals.

  Neurochemistry international 20070101

• Lipoic acid as a novel treatment for Alzheimer's disease and related dementias.

  Pharmacology & therapeutics 20070101

• Zinc and the cytoskeleton in the neuronal modulation of transcription factor NFAT.

  Journal of cellular physiology 20070101

• Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS.

  Neurochemistry international 20070101

• Protective effect of alpha-lipoic acid in experimental spermatic cord torsion.

  Nutrition (Burbank, Los Angeles County, Calif.) 20070101

• Should it be safer to use a redox couple, both with (R)-alpha-lipoic acid combined with (R)-dihydrolipoic acid for avoiding prooxidant action of alpha-lipoic acid?

  Medical hypotheses 20070101

• Increased ROS generation and p53 activation in alpha-lipoic acid-induced apoptosis of hepatoma cells.

  Apoptosis : an international journal on programmed cell death 20070101

• Acrolein, a toxicant in cigarette smoke, causes oxidative damage and mitochondrial dysfunction in RPE cells: protection by (R)-alpha-lipoic acid.

  Investigative ophthalmology & visual science 20070101

• Self-assembled monolayers with latent aldehydes for protein immobilization.

  Bioconjugate chemistry 20070101

• Effects of alpha-lipoic acid on the plasma levels of asymmetric dimethylarginine in diabetic end-stage renal disease patients on hemodialysis: a pilot study.

  American journal of nephrology 20070101

• Alpha-lipoic acid protects against hepatic ischemia-reperfusion injury in rats.

  Pharmacology 20070101

• Efficacy and safety of alpha-lipoic acid supplementation in the treatment of symptomatic diabetic neuropathy.

  The Diabetes educator 20070101

• Efficacy of alpha-lipoic acid against diabetic cataract in rat.

  Japanese journal of ophthalmology 20070101

• Insulin Autoimmune Syndrome possibly caused by alpha lipoic acid.

  Internal medicine (Tokyo, Japan) 20070101

• Diabetic painful neuropathy: current and future treatment options.

  Drugs 20070101

• A randomized double-blind placebo-controlled trial of thioctic acid in migraine prophylaxis.

  Headache 20070101

• Alpha-lipoic acid may be a clinically useful therapy in interstitial cystitis.

  Medical hypotheses 20070101

• The clinical application of metabolic therapy for cardiovascular disease.

  Heart, lung & circulation 20070101

• Hepatocellular injury of nonischemic liver tissue after selective clamping in rats--protective action by pharmacological pretreatment with lipoic acid.

  European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20070101

• [Thioctic acid action on glutathione-dependent antioxidant system functioning at toxic hepatitis of rats].

  Biomeditsinskaia khimiia 20070101

• [Liver cirrhosis and therapy issues].

  Likars'ka sprava 20070101

• Adjunctive care with nutritional, herbal, and homeopathic complementary and alternative medicine modalities in stroke treatment and rehabilitation.

  Topics in stroke rehabilitation 20070101

• The novel agent, alpha lipoic acid, can cause the development of insulin autoimmune syndrome.

  Internal medicine (Tokyo, Japan) 20070101

• Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis.

  Journal of neural transmission. Supplementum 20070101

• Effect of surface conjugation chemistry on the sensitivity of microcantilever sensors.

  Scanning 20070101

• Alpha-lipoic acid: an inhibitor of secretory phospholipase A2 with anti-inflammatory activity.

  Life sciences 20061214

• A synchronized substrate-gating mechanism revealed by cubic-core structure of the bovine branched-chain alpha-ketoacid dehydrogenase complex.

  The EMBO journal 20061213

• Long-term safety of alpha-lipoic acid (ALA) consumption: A 2-year study.

  Regulatory toxicology and pharmacology : RTP 20061201

• Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation.

  The Journal of pharmacology and experimental therapeutics 20061201

• Preliminary evidence on existence of transplasma membrane electron transport in Entamoeba histolytica trophozoites: a key mechanism for maintaining optimal redox balance.

  Journal of bioenergetics and biomembranes 20061201

• Paraquat-induced oxidative stress in drosophila melanogaster: effects of melatonin, glutathione, serotonin, minocycline, lipoic acid and ascorbic acid.

  Neurochemical research 20061201

• Bioavailability of selenium from the selenotrisulphide derivative of lipoic acid.

  Photodermatology, photoimmunology & photomedicine 20061201

• T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis.

  Journal of autoimmunity 20061201

• Effects of glutathione and N-acetyl cysteine on the antimycobacterial efficacy of isoniazid on Mycobacterium fortuitum in vitro.

  Journal of chemotherapy (Florence, Italy) 20061201

• [Beneficial actions of lipoic acid in cerebral cortex homogenates in rats during lipopolysaccharide-induced oxidative stress].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20061201

• Reduction of ischemia reperfusion injury after liver resection and hepatic inflow occlusion by alpha-lipoic acid in humans.

  World journal of gastroenterology 20061114

• Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells.

  DNA repair 20061108

• The effect of different antioxidants on glutathione turnover in human cell lines and their interaction with hydrogen peroxide.

  Chemico-biological interactions 20061107

• Interfacial pH and surface pKa of a thioctic acid self-assembled monolayer.

  Physical chemistry chemical physics : PCCP 20061107

• Alpha-lipoic acid inhibits fractalkine expression and prevents neointimal hyperplasia after balloon injury in rat carotid artery.

  Atherosclerosis 20061101

• Protective role of eicosapentaenoate-lipoate (EPA-LA) derivative in combating oxidative hepatocellular injury in hypercholesterolemic atherogenesis.

  Atherosclerosis 20061101

• Oral treatment with alpha-lipoic acid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial.

  Diabetes care 20061101

• Lipoic acid, a lead structure for multi-target-directed drugs for neurodegeneration.

  Mini reviews in medicinal chemistry 20061101

• Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans.

  Pharmacology, biochemistry, and behavior 20061101

• Doxorubicin-induced reactive oxygen species generation and intracellular Ca2+ increase are reciprocally modulated in rat cardiomyocytes.

  Experimental & molecular medicine 20061031

• Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes.

  Brain research 20061020

• Alpha-lipoic acid modulates ovarian surface epithelial cell growth.

  Gynecologic oncology 20061001

• Role of lipoic acid in reducing the oxidative stress induced by cyclosporine A.

  Clinica chimica acta; international journal of clinical chemistry 20061001

• Antioxidant down-regulates interleukin-18 expression in asthma.

  Molecular pharmacology 20061001

• Safety evaluation of alpha-lipoic acid (ALA).

  Regulatory toxicology and pharmacology : RTP 20061001

• Modulation of transcription factor NF-kappaB in Hodgkin's lymphoma cell lines: effect of (-)-epicatechin.

  Free radical research 20061001

• Biotin uptake by rabbit corneal epithelial cells: role of sodium-dependent multivitamin transporter (SMVT).

  Current eye research 20061001

• Synthesis, pulse radiolysis, and in vitro radioprotection studies of melatoninolipoamide, a novel conjugate of melatonin and alpha-lipoic acid.

  Bioorganic & medicinal chemistry 20060915

• Dietary antioxidants and behavioral enrichment enhance neutrophil phagocytosis in geriatric Beagles.

  Veterinary immunology and immunopathology 20060915

• Insight into the role of DL-alpha-lipoic acid against cyclophosphamide induced alterations in calcium sensitivity of cardiac myofilaments.

  Molecular and cellular biochemistry 20060901

• Effect of chronic restraint stress and alpha-lipoic acid on lipid peroxidation and antioxidant enzyme activities in rat peripheral organs.

  Pharmacological research 20060901

• Effects of lipoic acid and dihydrolipoic acid on 4-aminophenol-mediated erythrocytic toxicity in vitro.

  Basic & clinical pharmacology & toxicology 20060901

• alpha-lipoic acid corrects late-phase supernormal retinal oxygenation response in experimental diabetic retinopathy.

  Investigative ophthalmology & visual science 20060901

• Application of N-PLS calibration to the simultaneous determination of Cu(2+), Cd(2+) and Pb(2+) using peptide modified electrochemical sensors.

  The Analyst 20060901

• Alpha-lipoic acid. Monograph.

  Alternative medicine review : a journal of clinical therapeutic 20060901

• Effects of antioxidant supplementation and exercise training on erythrocyte antioxidant enzymes.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20060901

• Orthomolecular medicine: the therapeutic use of dietary supplements for anti-aging.

  Clinical interventions in aging 20060901

• A comparative study of capacitive immunosensors based on self-assembled monolayers formed from thiourea, thioctic acid, and 3-mercaptopropionic acid.

  Biosensors & bioelectronics 20060815

• Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.

  Journal of neuroscience research 20060815

• Lipoic acid affects cellular migration into the central nervous system and stabilizes blood-brain barrier integrity.

  Journal of immunology (Baltimore, Md. : 1950) 20060815

• Protective effect of DL-alpha-lipoic acid on cyclophosphamide induced hyperlipidemic cardiomyopathy.

  European journal of pharmacology 20060814

• Lipoyl synthase inserts sulfur atoms into an octanoyl substrate in a stepwise manner.

  Angewandte Chemie (International ed. in English) 20060804

• Modifications of the lipoamide-containing mitochondrial subproteome in a yeast mutant defective in cysteine desulfurase.

  Molecular & cellular proteomics : MCP 20060801

• RS-alpha-lipoic acid protects cholinergic cells against sodium nitroprusside and amyloid-beta neurotoxicity through restoration of acetyl-CoA level.

  Journal of neurochemistry 20060801

• alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein E-deficient mice fed high-fat/low-cholesterol diet.

  Diabetes 20060801

• Antioxidants reduce cone cell death in a model of retinitis pigmentosa.

  Proceedings of the National Academy of Sciences of the United States of America 20060725

• Modification of cyclophosphamide-induced clastogenesis and apoptosis in rats by alpha-lipoic acid.

  Mutation research 20060714

• Design and synthesis of the first generation of dithiolane thiazolidinedione- and phenylacetic acid-based PPARgamma agonists.

  Journal of medicinal chemistry 20060713

• Toxoplasma gondii scavenges host-derived lipoic acid despite its de novo synthesis in the apicoplast.

  The EMBO journal 20060712

• Oxidative renal injury and lipoprotein oxidation in hypercholesterolemic atherogenesis: Role of eicosapentaenoate-lipoate (EPA-LA) derivative.

  Prostaglandins, leukotrienes, and essential fatty acids 20060701

• alpha-lipoic acid regulates AMP-activated protein kinase and inhibits insulin secretion from beta cells.

  Diabetologia 20060701

• Expanding role of AMPK in endocrinology.

  Trends in endocrinology and metabolism: TEM 20060701

• Managing psychiatric disorders with antidiabetic agents: translational research and treatment opportunities.

  Expert opinion on pharmacotherapy 20060701

• Effect of dietary lipoic acid on metabolic hormones and acute-phase proteins during challenge with infectious bovine rhinotracheitis virus in cattle.

  American journal of veterinary research 20060701

• Contact dermatitis to alpha-lipoic acid in an anti-wrinkle cream.

  Contact dermatitis 20060701

• L-carnitine and alpha-lipoic acid improve age-associated decline in mitochondrial respiratory chain activity of rat heart muscle.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20060701

• Biofunctional ZnO nanorod arrays grown on flexible substrates.

  Langmuir : the ACS journal of surfaces and colloids 20060620

• Cellular disulfide-reducing capacity: an integrated measure of cell redox capacity.

  Biochemical and biophysical research communications 20060616

• Lipoic acid downmodulates CD4 from human T lymphocytes by dissociation of p56(Lck).

  Biochemical and biophysical research communications 20060609

• Oxidative stress-mediated macromolecular damage and dwindle in antioxidant status in aged rat brain regions: role of L-carnitine and DL-alpha-lipoic acid.

  Clinica chimica acta; international journal of clinical chemistry 20060601

• Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid.

  Journal of neuroscience research 20060601

• Lipoic acid inhibits expression of ICAM-1 and VCAM-1 by CNS endothelial cells and T cell migration into the spinal cord in experimental autoimmune encephalomyelitis.

  Journal of neuroimmunology 20060601

• Effects of dietary lipoic acid on plasma lipid, in vivo insulin sensitivity, metabolic response to corticosterone and in vitro lipolysis in broiler chickens.

  The British journal of nutrition 20060601

• [Estimation of the effect of lipoic acid in the rat's lung during lipopolysaccharide-induced oxidative stress].

  Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060601

• Preparation and characterization of polypeptide-stabilized gold nanoparticles.

  Journal of nanoscience and nanotechnology 20060601

• Alpha-lipoic acid prevents lipotoxic cardiomyopathy in acyl CoA-synthase transgenic mice.

  Biochemical and biophysical research communications 20060526

• Salubrious effects of lipoic acid against adriamycin-induced clastogenesis and apoptosis in Wistar rat bone marrow cells.

  Toxicology 20060515

• Expression of the kidney injury molecule 1 in the rat cochlea and induction by cisplatin.

  Neuroscience 20060512

• Protective effect of lipoic acid on cyclophosphamide-induced testicular toxicity.

  Clinica chimica acta; international journal of clinical chemistry 20060501

• Effect of R-(+)-alpha-lipoic acid on experimental diabetic retinopathy.

  Diabetologia 20060501

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• Lipoic acid supplementation prevents cyclosporine-induced hypertension and nephrotoxicity in spontaneously hypertensive rats.

  Journal of hypertension 20060501

• Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha.

  Free radical biology & medicine 20060501

• HIV-1 integrase inhibition of biscoumarin analogues.

  Chemical & pharmaceutical bulletin 20060501

• A phase II study with antioxidants, both in the diet and supplemented, pharmaconutritional support, progestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/cachexia and oxidative stress.

  Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20060501

• Evidence for covalent lipoyl adduction with dopaquinone following tyrosinase-catalyzed oxidation.

  Biochemical and biophysical research communications 20060428

• Alpha-tocopherol (vitamin E) induces rapid, nonsustained proliferation in cultured rat microglia.

  Glia 20060415

• Heme oxygenase-1 contributes to the cytoprotection of alpha-lipoic acid via activation of p44/42 mitogen-activated protein kinase in vascular smooth muscle cells.

  Free radical biology & medicine 20060415

• [The role of antioxidants in prevention].

  Orvosi hetilap 20060402

• Effect of lipid peroxides and antioxidants on glycation of hemoglobin: an in vitro study on human erythrocytes.

  Clinica chimica acta; international journal of clinical chemistry 20060401

• Mitochondrial membrane damage during aging process in rat heart: potential efficacy of L-carnitine and DL alpha lipoic acid.

  Mechanisms of ageing and development 20060401

• Protection against radiation-induced oxidative stress in cultured human epithelial cells by treatment with antioxidant agents.

  International journal of radiation oncology, biology, physics 20060401

• Modulation of cardiac and aortic peroxisome proliferator-activated receptor-gamma expression by oxidative stress in chronically glucose-fed rats.

  American journal of hypertension 20060401

• Vitamin E and alpha-lipoic acid supplementation increase bleeding tendency via an intrinsic coagulation pathway.

  Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 20060401

• Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process.

  Biogerontology 20060401

• Oxidative stress and DNA single strand breaks in skeletal muscle of aged rats: role of carnitine and lipoicacid.

  Biogerontology 20060401

• Modulatory role of lipoic acid on adriamycin-induced testicular injury.

  Chemico-biological interactions 20060325

• Alpha-lipoic acid exhibits anti-amyloidogenicity for beta-amyloid fibrils in vitro.

  Biochemical and biophysical research communications 20060324

• An NMDA receptor-dependent hydroxyl radical pathway in the rabbit hypothalamus may mediate lipopolysaccharide fever.

  Neuropharmacology 20060301

• The long-term survival of a patient with pancreatic cancer with metastases to the liver after treatment with the intravenous alpha-lipoic acid/low-dose naltrexone protocol.

  Integrative cancer therapies 20060301

• Size series of small indium arsenide-zinc selenide core-shell nanocrystals and their application to in vivo imaging.

  Journal of the American Chemical Society 20060301

• MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells.

  Diabetes 20060301

• Supply of R-alpha-lipoic acid and glutamine to casein-fed mice influences the number of B lymphocytes and tissue glutathione levels during endotoxemia.

  Wiener klinische Wochenschrift 20060301

• Structure of a putative lipoate protein ligase from Thermoplasma acidophilum and the mechanism of target selection for post-translational modification.

  Journal of molecular biology 20060224

• L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties.

  Journal of medicinal chemistry 20060223

• Protective effect of lipoic acid on micronuclei induction by cyclophosphamide.

  Archives of toxicology 20060201

• Synthesis and effects of 3-methylthiopropanoyl thiolesters of lipoic acid, methional metabolite mimics.

  Bioorganic chemistry 20060201

• Diabetic neuropathy.

  Postgraduate medical journal 20060201

• [Oxaliplatin neurotoxicity].

  Bulletin du cancer 20060201

• Chemoprotective effect of lipoic acid against cyclophosphamide-induced changes in the rat sperm.

  Toxicology 20060105

• Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat.

  Cell biochemistry and function 20060101

• Lipoic acid modulates adriamycin-induced testicular toxicity.

  Reproductive toxicology (Elmsford, N.Y.) 20060101

• Nutritional therapy improves function and complements corticosteroid intervention in mdx mice.

  Muscle & nerve 20060101

• Pro-oxidant actions of alpha-lipoic acid and dihydrolipoic acid.

  Medical hypotheses 20060101

• Preservation of pressure-induced cutaneous vasodilation by limiting oxidative stress in short-term diabetic mice.

  Cardiovascular research 20060101

• alpha-Lipoic acid and N-acetyl cysteine prevent zinc deficiency-induced activation of NF-kappaB and AP-1 transcription factors in human neuroblastoma IMR-32 cells.

  Free radical research 20060101

• Induction of heat shock proteins may combat insulin resistance.

  Medical hypotheses 20060101

• Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes.

  Free radical biology & medicine 20060101

• alpha-Lipoic acid inhibits inflammatory bone resorption by suppressing prostaglandin E2 synthesis.

  Journal of immunology (Baltimore, Md. : 1950) 20060101

• Preincubation of rat and human hepatocytes with cytoprotectants prior to cryopreservation can improve viability and function upon thawing.

  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20060101

• Decrease in NADPH-cytochrome P450 reductase activity of the human heart, Liver and lungs in the presence of alpha-lipoic acid.

  Annals of nutrition & metabolism 20060101

• Supplemental conditionally essential nutrients in cardiovascular disease therapy.

  The Journal of cardiovascular nursing 20060101

• Antioxidant supplementation enhances erythrocyte antioxidant status and attenuates cyclosporine-induced vascular dysfunction.

  American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20060101

• Alpha-tocopherol and alpha-lipoic acid enhance the erythrocyte antioxidant defence in cyclosporine A-treated rats.

  Basic & clinical pharmacology & toxicology 20060101

• Synthesis, characterization and biological activity of chemically modified insulin derivative with alpha lipoic acid.

  Protein and peptide letters 20060101

• Diabetes--a man made disease.

  Medical hypotheses 20060101

• Reduction in podocyte density as a pathologic feature in early diabetic nephropathy in rodents: prevention by lipoic acid treatment.

  BMC nephrology 20060101

• Synthesis and grafting of thioctic acid-PEG-folate conjugates onto Au nanoparticles for selective targeting of folate receptor-positive tumor cells.

  Bioconjugate chemistry 20060101

• Protective efficacy of alpha-lipoic acid on acetylcholinesterase activity in aged rat brain regions.

  Rejuvenation research 20060101

• An overdose of alpha lipoic acid may cause trace element deficiency in diabetes mellitus.

  Medical hypotheses 20060101

• Heat shock protein 60 response to exercise in diabetes: effects of alpha-lipoic acid supplementation.

  Journal of diabetes and its complications 20060101

• Protective effects of early administration of alpha-lipoic acid against lipopolysaccharide-induced plasma lipid peroxidation.

  Pharmacological reports : PR 20060101

• [Neurometabolic therapy of diabetic neuropathy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101

• [Pharmacological correction of energy metabolism disturbance in the inflammatory-dystrophic process in the periodontium].

  Eksperimental'naia i klinicheskaia farmakologiia 20060101

• Different protection mechanisms after pretreatment with glycine or alpha-lipoic acid in a rat model of warm hepatic ischemia.

  European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20060101

• Effect of antioxidant capacity on blood lipid metabolism and lipoprotein lipase activity of rats fed a high-fat diet.

  Nutrition (Burbank, Los Angeles County, Calif.) 20060101

• Clinical applications of lipoic acid in type II diabetes mellitus.

  Holistic nursing practice 20060101

• Improvement of insulin sensitivity in patients with type 2 diabetes mellitus after oral administration of alpha-lipoic acid.

  Hormones (Athens, Greece) 20060101

• [Efficacy of magnetotherapy in diabetic peripheral neuropathy in children].

  Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury 20060101

• Stimulation of membrane permeability transition by alpha-lipoic acid and its biochemical characteristics.

  Physiological chemistry and physics and medical NMR 20060101

• Combined efficacies of DL-alpha-lipoic acid and meso 2,3 dimercaptosuccinic acid against arsenic induced toxicity in antioxidant systems of rats.

  Toxicology letters 20051230

• The reaction of LipB, the octanoyl-[acyl carrier protein]:protein N-octanoyltransferase of lipoic acid synthesis, proceeds through an acyl-enzyme intermediate.

  Biochemistry 20051220

• The photochemistry of lipoic acid: photoionization and observation of a triplet excited state of a disulfide.

  Chemphyschem : a European journal of chemical physics and physical chemistry 20051209

• Tethered bilayer lipid membranes based on monolayers of thiolipids mixed with a complementary dilution molecule. 1. Incorporation of channel peptides.

  Langmuir : the ACS journal of surfaces and colloids 20051206

• Alpha-lipoic acid prevents endothelial dysfunction in obese rats via activation of AMP-activated protein kinase.

  Arteriosclerosis, thrombosis, and vascular biology 20051201

• Lipoic acid decreases exhaled nitric oxide concentrations in anesthetized endotoxemic rats.

  Vascular pharmacology 20051201

• Age-associated deficit of mitochondrial oxidative phosphorylation in skeletal muscle: role of carnitine and lipoic acid.

  Molecular and cellular biochemistry 20051201

• Thioredoxin and lipoic acid catalyze the denitrosation of low molecular weight and protein S-nitrosothiols.

  Journal of the American Chemical Society 20051116

• dl-alpha-lipoic acid ameliorates cyclophosphamide induced cardiac mitochondrial injury.

  Toxicology 20051105

• A prodrug of cysteine, L-2-oxothiazolidine-4-carboxylic acid, regulates vascular permeability by reducing vascular endothelial growth factor expression in asthma.

  Molecular pharmacology 20051101

• Thioredoxin and dihydrolipoic acid inhibit elastase activity in cystic fibrosis sputum.

  American journal of physiology. Lung cellular and molecular physiology 20051101

• Effect of dietary alpha-lipoic acid on growth, body composition, muscle pH, and AMP-activated protein kinase phosphorylation in mice.

  Journal of animal science 20051101

• Protective effects of different antioxidants and amrinone on vancomycin-induced nephrotoxicity.

  Basic & clinical pharmacology & toxicology 20051101

• Plasmodium falciparum possesses organelle-specific alpha-keto acid dehydrogenase complexes and lipoylation pathways.

  Biochemical Society transactions 20051101

• (R)-alpha-lipoic acid protects retinal pigment epithelial cells from oxidative damage.

  Investigative ophthalmology & visual science 20051101

• Glutathione turnover in human cell lines in the presence of agents with glutathione influencing potential with and without acivicin inhibition of gamma-glutamyltranspeptidase.

  Biochimica et biophysica acta 20051030

• Protective effect of alpha-lipoic acid in lipopolysaccharide-induced endothelial fractalkine expression.

  Circulation research 20051028

• Characterization of the redox components of transplasma membrane electron transport system from Leishmania donovani promastigotes.

  Biochimica et biophysica acta 20051010

• Efficacy of levo carnitine and alpha lipoic acid in ameliorating the decline in mitochondrial enzymes during aging.

  Clinical nutrition (Edinburgh, Scotland) 20051001

• Protective effect of lipoic acid on adriamycin-induced testicular toxicity.

  Clinica chimica acta; international journal of clinical chemistry 20051001

• Alpha-lipoic acid-induced heme oxygenase-1 expression is mediated by nuclear factor erythroid 2-related factor 2 and p38 mitogen-activated protein kinase in human monocytic cells.

  Arteriosclerosis, thrombosis, and vascular biology 20051001

• Efficient production of reactive oxygen species in neural precursor cells after exposure to 250 MeV protons.

  Radiation research 20051001

• Lipoic acid improves glucose utilisation and prevents protein glycation and AGE formation.

  Die Pharmazie 20051001

• Crystal structure of lipoate-protein ligase A from Escherichia coli. Determination of the lipoic acid-binding site.

  The Journal of biological chemistry 20050930

• Quantification of lipoic acid in plasma by high-performance liquid chromatography-electrospray ionization mass spectrometry.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925

• Effects of triple antioxidant combination (vitamin E, vitamin C and alpha-lipoic acid) with insulin on lipid and cholesterol levels and fatty acid composition of brain tissue in experimental diabetic and non-diabetic rats.

  Cell biology international 20050901

• Endogenous production of lipoic acid is essential for mouse development.

  Molecular and cellular biology 20050901

• A novel approach based on lipid nanoparticles (SLN) for topical delivery of alpha-lipoic acid.

  Journal of microencapsulation 20050901

• Alpha-lipoic acid protects against cholecystokinin-induced acute pancreatitis in rats.

  World journal of gastroenterology 20050821

• Effects of alpha-lipoic acid on kinin B1 and B2 receptor binding sites in the spinal cord of chronically angiotensin-treated rats.

  Peptides 20050801

• N-acetylcysteine decreases angiotensin II receptor binding in vascular smooth muscle cells.

  Journal of the American Society of Nephrology : JASN 20050801

• Pretreatment of diabetic rats with lipoic acid improves healing of subsequently-induced abrasion wounds.

  Archives of dermatological research 20050801

• Insulin, AGE and hypertension.

  Journal of hypertension 20050801

• Increases of spinal kinin receptor binding sites in two rat models of insulin resistance.

  Peptides 20050801

• Cytoprotective role of DL-alpha-lipoic acid in cyclophosphamide induced myocardial toxicity.

  Molecular and cellular biochemistry 20050801

• alpha-Lipoic acid supplementation inhibits oxidative damage, accelerating chronic wound healing in patients undergoing hyperbaric oxygen therapy.

  Biochemical and biophysical research communications 20050729

• Crystal structure of human dihydrolipoamide dehydrogenase: NAD+/NADH binding and the structural basis of disease-causing mutations.

  Journal of molecular biology 20050715

• Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic and dihydrolipoic acid.

  Free radical biology & medicine 20050715

• Thioctic acid amides: convenient tethers for achieving low nonspecific protein binding to carbohydrates presented on gold surfaces.

  Chemical communications (Cambridge, England) 20050714

• Alpha-lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle.

  Biochemical and biophysical research communications 20050708

• Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells.

  The Journal of biological chemistry 20050701

• Alpha-lipoic acid inhibits TNF-alpha-induced apoptosis in human bone marrow stromal cells.

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20050701

• Dietary lipoic acid supplementation attenuates hypertension in Dahl salt sensitive rats.

  Molecular and cellular biochemistry 20050701

• Elimination of high amounts of extracellular homocysteine in human cell lines.

  Clinica chimica acta; international journal of clinical chemistry 20050601

• Treatment for diabetic mononeuropathy with alpha-lipoic acid.

  International journal of clinical practice 20050601

• Alpha-lipoic acid suppresses osteoclastogenesis despite increasing the receptor activator of nuclear factor kappaB ligand/osteoprotegerin ratio in human bone marrow stromal cells.

  The Journal of endocrinology 20050601

• Effects of supplementation with alpha-lipoic acid on exercise-induced activation of coagulation.

  Metabolism: clinical and experimental 20050601

• Prevention of chromate induced oxidative stress by alpha-lipoic acid.

  Indian journal of experimental biology 20050601

• [Pathogenesis and progression of neuropathies in diabetic patients with endothelial dysfunction].

  Nihon rinsho. Japanese journal of clinical medicine 20050601

• Partial protection by lipoic acid against carboplantin-induced ototoxicity in rats.

  Biomedical and environmental sciences : BES 20050601

• Brain regional responses in antioxidant system to alpha-lipoic acid in arsenic intoxicated rat.

  Toxicology 20050515

• Arsenic trioxide (As(2)O(3)) induces apoptosis through activation of Bax in hematopoietic cells.

  Oncogene 20050505

• Lipoic acid prevents collagen abnormalities in tail tendon of high-fructose-fed rats.

  Diabetes, obesity & metabolism 20050501

• Gene expression profiling studies of aging in cardiac and skeletal muscles.

  Cardiovascular research 20050501

• Oxidative stress on mitochondrial antioxidant defense system in the aging process: role of DL-alpha-lipoic acid and L-carnitine.

  Clinica chimica acta; international journal of clinical chemistry 20050501

• Attenuation of serum lipid abnormalities and cardiac oxidative stress by eicosapentaenoate-lipoate (EPA-LA) derivative in experimental hypercholesterolemia.

  Clinica chimica acta; international journal of clinical chemistry 20050501

• Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis.

  Journal of autoimmunity 20050501

• Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines.

  Cancer research 20050501

• Evidence for a non-antioxidant, dose-dependent role of alpha -lipoic acid in caspase-3 and ERK2 activation in endothelial cells.

  Apoptosis : an international journal on programmed cell death 20050501

• The protective role of DL-alpha-lipoic acid in biogenic amines catabolism triggered by Abeta amyloid vaccination in mice.

  Brain research bulletin 20050430

• Pyruvate protects motor neurons expressing mutant superoxide dismutase 1 against copper toxicity.

  Neuroreport 20050425

• Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia.

  The EMBO journal 20050420

• Functionalization of thioctic acid-capped gold nanoparticles for specific immobilization of histidine-tagged proteins.

  Journal of the American Chemical Society 20050420

• Thermodynamics of the As(III)-thiol interaction: arsenite and monomethylarsenite complexes with glutathione, dihydrolipoic acid, and other thiol ligands.

  Inorganic chemistry 20050418

• Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain.

  The Journal of biological chemistry 20050401

• Short-term hyperglycemia produces oxidative damage and apoptosis in neurons.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050401

• Determination of ultrafast protein folding rates from loop formation dynamics.

  Journal of molecular biology 20050401

• Mechanisms of antioxidant and pro-oxidant effects of alpha-lipoic acid in the diabetic and nondiabetic kidney.

  Kidney international 20050401

• Lipoic acid in multiple sclerosis: a pilot study.

  Multiple sclerosis (Houndmills, Basingstoke, England) 20050401

• Mitigation of oxidative stress in cyclophosphamide-challenged hepatic tissue by DL-alpha-lipoic acid.

  Molecular and cellular biochemistry 20050401

• Immobilization of single-stranded DNA by self-assembled polymer on gold substrate for a DNA chip.

  Biotechnology and bioengineering 20050330

• Synthesis of compact multidentate ligands to prepare stable hydrophilic quantum dot fluorophores.

  Journal of the American Chemical Society 20050323

• Mechanistic investigations of lipoic acid biosynthesis in Escherichia coli: both sulfur atoms in lipoic acid are contributed by the same lipoyl synthase polypeptide.

  Journal of the American Chemical Society 20050309

• Pharmacokinetics of alpha-lipoic acid in subjects with severe kidney damage and end-stage renal disease.

  Journal of clinical pharmacology 20050301

• Bcl-2 in endothelial cells is increased by vitamin E and alpha-lipoic acid supplementation but not exercise training.

  Journal of molecular and cellular cardiology 20050301

• Syntheses of novel indole lipoic acid derivatives and their antioxidant effects on lipid peroxidation.

  Archiv der Pharmazie 20050301

• Arsenic intoxication-induced reduction of glutathione level and of the activity of related enzymes in rat brain regions: reversal by DL-alpha-lipoic acid.

  Archives of toxicology 20050301

• alpha-Lipoic acid induces apoptosis in human colon cancer cells by increasing mitochondrial respiration with a concomitant O2-*-generation.

  Apoptosis : an international journal on programmed cell death 20050301

• Inhibition of gelatinase B (matrix metalloproteinase-9) by dihydrolipoic acid.

  Canadian journal of physiology and pharmacology 20050301

• Effect of ethanol on the response of the rat urinary bladder to in vitro ischemia: protective effect of alpha-lipoic acid.

  Molecular and cellular biochemistry 20050301

• Oriented assembly of Au nanorods using biorecognition system.

  Chemical communications (Cambridge, England) 20050227

• Beneficial effects of DL-alpha-lipoic acid on cyclophosphamide-induced oxidative stress in mitochondrial fractions of rat testis.

  Chemico-biological interactions 20050227

• A pulsed potential waveform displaying enhanced detection capabilities towards sulfur-containing compounds at a gold working electrode.

  Journal of chromatography. A 20050225

• Peroxide-mediated desulfurization of phosphorothioate oligonucleotides and its prevention.

  Journal of pharmaceutical sciences 20050201

• Effects of antioxidant treatment on normal and diabetic rat retinal enzyme activities.

  Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20050201

• Effects of dietary antioxidant supplementation before and after oral acetaminophen challenge in cats.

  American journal of veterinary research 20050201

• The protective role of DL-alpha-lipoic acid in the oxidative vulnerability triggered by Abeta-amyloid vaccination in mice.

  Molecular and cellular biochemistry 20050201

• Rational approach to discover multipotent anti-Alzheimer drugs.

  Journal of medicinal chemistry 20050127

• Irbesartan and lipoic acid improve endothelial function and reduce markers of inflammation in the metabolic syndrome: results of the Irbesartan and Lipoic Acid in Endothelial Dysfunction (ISLAND) study.

  Circulation 20050125

• Protein oxidative damage in arsenic induced rat brain: influence of DL-alpha-lipoic acid.

  Toxicology letters 20050115

• Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds.

  Journal of medicinal chemistry 20050113

• alpha-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats.

  Biochemical and biophysical research communications 20050107

• Prevention of doxorubicin-induced acute cardiotoxicity by an experimental antioxidant compound.

  Journal of cardiovascular pharmacology 20050101

• Proteomic analysis of specific brain proteins in aged SAMP8 mice treated with alpha-lipoic acid: implications for aging and age-related neurodegenerative disorders.

  Neurochemistry international 20050101

• The protective effect of alpha-lipoic acid against oxidative damage in rabbit conjunctiva and cornea exposed to ultraviolet radiation.

  Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20050101

• [Functional state of the liver in patients with an acute destructive pancreatitis in the early postoperative period].

  Klinichna khirurhiia 20050101

• Effects of antioxidants coenzyme Q10 and lipoic acid on interleukin-1 beta-mediated inhibition of glucose-stimulated insulin release from cultured mouse pancreatic islets.

  Immunopharmacology and immunotoxicology 20050101

• Lipoic acid ameliorates adriamycin-induced testicular mitochondriopathy.

  Reproductive toxicology (Elmsford, N.Y.) 20050101

• Prooxidant activities of alpha-lipoic acid on oxidative protein damage in the aging rat heart muscle.

  Archives of gerontology and geriatrics 20050101

• Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex.

  Redox report : communications in free radical research 20050101

• [Treatment of Chagas disease with benznidazole and thioctic acid].

  Medicina 20050101

• Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice.

  Cardiovascular diabetology 20050101

• Complementary therapies for diabetes: the case for chromium, magnesium, and antioxidants.

  Archives of medical research 20050101

• [Regional anesthesia and timely treatment for neuropathy in patients with pyonecrotic forms of the diabetic foot].

  Anesteziologiia i reanimatologiia 20050101

• A randomized, double-blind, placebo-controlled study on the clinical efficacy of oral treatment with DermaVite on ageing symptoms of the skin.

  The Journal of international medical research 20050101

• The plasmodial apicoplast was retained under evolutionary selective pressure to assuage blood stage oxidative stress.

  Medical hypotheses 20050101

• Utilization of the insulin-signaling network in the metabolic actions of alpha-lipoic acid-reduction or oxidation?

  Antioxidants & redox signaling 20050101

• Plasma protein oxidation in aging rats after alpha-lipoic acid administration.

  Biogerontology 20050101

• Function, attachment and synthesis of lipoic acid in Escherichia coli.

  Advances in microbial physiology 20050101

• Lipoic acid - the drug of the future?

  Pharmacological reports : PR 20050101

• Effects of antioxidants on glutathione levels and clinical recovery from the malnutrition syndrome kwashiorkor--a pilot study.

  Redox report : communications in free radical research 20050101

• [Predictors of alpha-lipoic acid treatment efficacy in diabetic polyneuropathy of the lower limbs].

  Terapevticheskii arkhiv 20050101

• Cell culture modeling to test therapies against hyperglycemia-mediated oxidative stress and injury.

  Antioxidants & redox signaling 20050101

• The effects of alpha-lipoic acid on nitric oxide synthetase dispersion in penile function in streptozotocin-induced diabetic rats.

  International journal of tissue reactions 20050101

• A review of antioxidants and Alzheimer's disease.

  Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20050101

• [Lipoic acid: characteristics and therapeutic application].

  Postepy higieny i medycyny doswiadczalnej (Online) 20050101

• Synthesis and preliminary in vitro evaluation of 5'-O-esters of 2'-deoxyadenosine and 2-chloro-2'-deoxyadenosine with alpha-lipoic acid as potential prodrugs.

  Acta poloniae pharmaceutica 20050101

• Differential activity of lipoic acid enantiomers in cell culture.

  Journal of herbal pharmacotherapy 20050101

• Transdermal delivery of amino acids and antioxidants enhance collagen synthesis: in vivo and in vitro studies.

  Connective tissue research 20050101

• [Alpha-lipoic--dihydrolipoic acids--active bioantioxidant and bioregulatory system].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20050101

• Effect of alpha lipoic acid, melatonin and trans resveratrol on intracerebroventricular streptozotocin induced spatial memory deficit in rats.

  Indian journal of physiology and pharmacology 20050101

• Re-establishment of olfactory and taste functions.

  GMS current topics in otorhinolaryngology, head and neck surgery 20050101

• Protective effect of DL-alpha-lipoic acid on cyclophosphamide induced oxidative cardiac injury.

  Chemico-biological interactions 20041230

• [Evidence-based pharmacotherapy of neuropathic pain syndromes].

  MMW Fortschritte der Medizin 20041209

• Protective effect of DL-alpha-lipoic acid in cyclophosphamide induced oxidative injury in rat testis.

  Reproductive toxicology (Elmsford, N.Y.) 20041201

• Effect of long-term administration of alpha-lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats.

  Diabetes 20041201

• Prevention and treatment of macroangiopathy: focusing on oxidative stress.

  Diabetes research and clinical practice 20041201

• Alpha-lipoic acid, an anti-obesity agent?

  Expert opinion on investigational drugs 20041201

• Effects of lipoic acid and a reduced-calorie diet on skin flap survival in a rat model.

  Plastic and reconstructive surgery 20041201

• Remedial effect of DL-alpha-lipoic acid against adriamycin induced testicular lipid peroxidation.

  Molecular and cellular biochemistry 20041201

• Cardiac lipids and antioxidant status in high fructose rats and the effect of alpha-lipoic acid.

  Nutrition, metabolism, and cardiovascular diseases : NMCD 20041201

• Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit.

  Biochemistry 20041109

• Analysis of proteome and transcriptome of tumor necrosis factor alpha stimulated vascular smooth muscle cells with or without alpha lipoic acid.

  Proteomics 20041101

• Determination of lipoic acid in rat plasma by LC-MS/MS with electrospray ionization: assay development, validation and application to a pharamcokinetic study.

  Biomedical chromatography : BMC 20041101

• Alpha lipoic acid inhibits human T-cell migration: implications for multiple sclerosis.

  Journal of neuroscience research 20041101

• Burning mouth syndrome: the efficacy of lipoic acid on subgroups.

  Journal of the European Academy of Dermatology and Venereology : JEADV 20041101

• Alpha-lipoic acid is ineffective as a topical antioxidant for photoprotection of skin.

  The Journal of investigative dermatology 20041101

• Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose-fed rats.

  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20041101

• Antioxidant effects of sulfur-containing amino acids.

  Yonsei medical journal 20041031

• Determination of lipoic acid in dietary supplement preparations by capillary electrophoresis.

  Journal of biochemical and biophysical methods 20041029

• Pyruvate dehydrogenase kinase isoform 2 activity stimulated by speeding up the rate of dissociation of ADP.

  Biochemistry 20041026

• Inhibitory effect of lipoic acid on firefly luciferase bioluminescence.

  Biochemical and biophysical research communications 20041015

• A supramolecular approach to the selective detection of dopamine in the presence of ascorbate.

  Chemical communications (Cambridge, England) 20041007

• The effects of the antioxidant lipoic acid on beef longissimus bloom time.

  Journal of animal science 20041001

• R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase.

  Free radical research 20041001

• Synthesis of chroman analogues of lipoic acid and evaluation of their activity against reperfusion arrhythmias.

  Bioorganic & medicinal chemistry 20040915

• Interactions of exercise training and alpha-lipoic acid on insulin signaling in skeletal muscle of obese Zucker rats.

  American journal of physiology. Endocrinology and metabolism 20040901

• Regulation of ischemic cell death by the lipoic acid-palladium complex, Poly MVA, in gerbils.

  Experimental neurology 20040901

• Conformational stability and thermodynamic characterization of the lipoic acid bearing domain of human mitochondrial branched chain alpha-ketoacid dehydrogenase.

  Protein science : a publication of the Protein Society 20040901

• Alpha-lipoic acid does not acutely affect resistance and conduit artery function or oxidative stress in healthy men.

  British journal of clinical pharmacology 20040901

• Natural antioxidants and neurodegenerative diseases.

  Frontiers in bioscience : a journal and virtual library 20040901

• Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes.

  Biochemistry. Biokhimiia 20040901

• Attenuation of chloroquine-induced renal damage by alpha-lipoic acid: possible antioxidant mechanism.

  Renal failure 20040901

• Lipoic acid pretreatment attenuates ferric chloride-induced seizures in the rat.

  Brain research 20040806

• Alpha-Lipoic acid-based PPARgamma agonists for treating inflammatory skin diseases.

  Archives of dermatological research 20040801

• Pseudomonas aeruginosa-induced production of free radicals by IFNgamma plus TNFalpha-activated human endothelial cells: mechanism of host defense or of bacterial pathogenesis?

  Immunology and cell biology 20040801

• Effect of antioxidants and ACE inhibition on chemical modification of proteins and progression of nephropathy in the streptozotocin diabetic rat.

  Diabetologia 20040801

• alpha-Lipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma.

  The Journal of allergy and clinical immunology 20040801

• Alpha-lipoic acid mitigates insulin resistance in Goto-Kakizaki rats.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040801

• Cross-talk between thiamin diphosphate binding and phosphorylation loop conformation in human branched-chain alpha-keto acid decarboxylase/dehydrogenase.

  The Journal of biological chemistry 20040730

• [Evidence-based management of diabetic polyneuropathy. 'Burning feet' alarm signal].

  MMW Fortschritte der Medizin 20040708

• Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase.

  Nature medicine 20040701

• Effects of a medium chain triglyceride oil mixture and alpha-lipoic acid diet on body composition, antioxidant status, and plasma lipid levels in the Golden Syrian hamster.

  The Journal of nutritional biochemistry 20040701

• Cellular energy sensor balances the scales.

  Nature medicine 20040701

• Repression of oxidant-induced nuclear factor-kappaB activity mediates placental cytokine responses in gestational diabetes.

  The Journal of clinical endocrinology and metabolism 20040701

• L-carnitine and DL-alpha-lipoic acid reverse the age-related deficit in glutathione redox state in skeletal muscle and heart tissues.

  Mechanisms of ageing and development 20040701

• alpha-lipoic acid inhibits endotoxin-stimulated expression of iNOS and nitric oxide independent of the heat shock response in RAW 264.7 cells.

  Free radical research 20040701

• Immunochemical identification of coenzyme Q0-dihydrolipoamide adducts in the E2 components of the alpha-ketoglutarate and pyruvate dehydrogenase complexes partially explains the cellular toxicity of coenzyme Q0.

  The Journal of biological chemistry 20040625

• Selective modulation of antioxidant enzyme activities in host tissues during Rickettsia conorii infection.

  Microbial pathogenesis 20040601

• Lipoyl synthase requires two equivalents of S-adenosyl-L-methionine to synthesize one equivalent of lipoic acid.

  Biochemistry 20040601

• Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age.

  Annals of the New York Academy of Sciences 20040601

• Alpha-lipoic acid increases Na+K+ATPase activity and reduces lipofuscin accumulation in discrete brain regions of aged rats.

  Annals of the New York Academy of Sciences 20040601

• Delaying the mitochondrial decay of aging.

  Annals of the New York Academy of Sciences 20040601

• Effects of alpha-lipoic acid supplementation on maternal diabetes-induced growth retardation and congenital anomalies in rat fetuses.

  Molecular and cellular biochemistry 20040601

• HFA1 encoding an organelle-specific acetyl-CoA carboxylase controls mitochondrial fatty acid synthesis in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20040521

• Xenobiotic-induced loss of tolerance in rabbits to the mitochondrial autoantigen of primary biliary cirrhosis is reversible.

  Journal of immunology (Baltimore, Md. : 1950) 20040515

• Influence of alpha-lipoic acid on lipid peroxidation and antioxidant defence system in blood of insulin-resistant rats.

  Diabetes, obesity & metabolism 20040501

• Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs.

  Experimental gerontology 20040501

• Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress.

  Current medicinal chemistry 20040501

• [Toxicological aspects and health risks associated with hydroquinone in skin bleaching formula].

  Nederlands tijdschrift voor geneeskunde 20040417

• The impact of alpha-lipoic acid, coenzyme Q10 and caloric restriction on life span and gene expression patterns in mice.

  Free radical biology & medicine 20040415

• Therapeutic efficacy of lipoic acid in combination with dimercaptosuccinic acid against lead-induced renal tubular defects and on isolated brush-border enzyme activities.

  Chemico-biological interactions 20040415

• Antioxidative treatment reverses imbalances of nitric oxide synthase isoform expression and attenuates tissue-cGMP activation in diabetic rats.

  Biochemical and biophysical research communications 20040409

• Plasma C-reactive protein concentrations in active and passive smokers: influence of antioxidant supplementation.

  Journal of the American College of Nutrition 20040401

• Lipoic acid is 10 times more toxic in cats than reported in humans, dogs or rats.

  Journal of animal physiology and animal nutrition 20040401

• The role of lipoic acid in the regulation of the redox status of wheat irrigated with 20% sea water.

  Plant physiology and biochemistry : PPB 20040401

• Prevention and partial reversal of diabetes-induced changes in enteric nerves of the rat ileum by combined treatment with alpha-lipoic acid and evening primrose oil.

  Autonomic neuroscience : basic & clinical 20040331

• Lipoic acid protects efficiently only against a specific form of peroxynitrite-induced damage.

  The Journal of biological chemistry 20040312

• (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis.

  Archives of biochemistry and biophysics 20040301

• Alpha-lipoic acid is effective in prevention and treatment of experimental autoimmune encephalomyelitis.

  Journal of neuroimmunology 20040301

• Synthesis and characterization of new and potent alpha-lipoic acid derivatives.

  Bioorganic & medicinal chemistry 20040301

• Antioxidant supplementation normalizes elevated protein kinase C activity in the proximal tubules of old rats.

  Experimental biology and medicine (Maywood, N.J.) 20040301

• (r)-, but not (s)-alpha lipoic acid stimulates deficient brain pyruvate dehydrogenase complex in vascular dementia, but not in Alzheimer dementia.

  Journal of neural transmission (Vienna, Austria : 1996) 20040301

• Effect of lipoic acid on the oxidoreductive status of red blood cells in rats subject to oxidative stress by chronic administration of adriamycin.

  Human & experimental toxicology 20040301

• alpha-Lipoic acid ameliorates altered colonic contractility and intestinal transit in STZ-diabetic rats.

  Indian journal of experimental biology 20040301

• [Effects of DL-alpha-lipoic acid on the experimentally induced diabetic cataract in rats].

  [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20040301

• Complications & side effects. Supplements and CD4+ counts: study finds surprising results.

  TreatmentUpdate 20040301

• Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis.

  Plant physiology 20040201

• Effect of R(+)alpha-lipoic acid on pyruvate metabolism and fatty acid oxidation in rat hepatocytes.

  Metabolism: clinical and experimental 20040201

• Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a meta-analysis.

  Diabetic medicine : a journal of the British Diabetic Association 20040201

• Photoinduced interactions between oxidized and reduced lipoic acid and riboflavin (vitamin B2).

  Chemphyschem : a European journal of chemical physics and physical chemistry 20040123

• Antioxidants effectively prevent oxidation-induced protein damage in OLN 93 cells.

  Archives of biochemistry and biophysics 20040101

• Burning Mouth Syndrome: open trial of psychotherapy alone, medication with alpha-lipoic acid (thioctic acid), and combination therapy.

  Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal 20040101

• Combined efficacies of lipoic acid and 2,3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver.

  The Journal of nutritional biochemistry 20040101

• Protective effect of alpha-lipoic acid against chloroquine-induced hepatotoxicity in rats.

  Journal of applied toxicology : JAT 20040101

• Alpha lipoic acid for dementia.

  The Cochrane database of systematic reviews 20040101

• Oxidative stress and antioxidant supplementation in the management of diabetic cardiovascular disease.

  Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20040101

• Development of a sustained release dosage form for alpha-lipoic acid. I. Design and in vitro evaluation.

  Drug development and industrial pharmacy 20040101

• Development of a sustained release dosage form for alpha-lipoic acid. II. Evaluation in human volunteers.

  Drug development and industrial pharmacy 20040101

• [Possibilities and perspectives of berlition usage in the treatment of alcohol polyneuropathy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20040101

• Molecular and genetic mechanisms of floral control.

  The Plant cell 20040101

• [Treatment of Chagas disease with benznidazole and thioctic acid].

  Medicina 20040101

• Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes.

  Redox report : communications in free radical research 20040101

• Unraveling the pathway of lipoic acid biosynthesis.

  Chemistry & biology 20040101

• Clinical experience with thioctacid (thioctic acid) in the treatment of distal symmetric polyneuropathy in Korean diabetic patients.

  Journal of diabetes and its complications 20040101

• Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles.

  Veterinary therapeutics : research in applied veterinary medicine 20040101

• Effect of fidarestat and alpha-lipoic acid on diabetes-induced epineurial arteriole vascular dysfunction.

  Experimental diabesity research 20040101

• The effect of cytoprotective agents in platinum anticancer therapy.

  Metal ions in biological systems 20040101

• [Device laboratory and postmortem parallels in alcoholic hepatitis during combined therapy using thioctic (alpha-lipoic) acid].

  Klinicheskaia meditsina 20040101

• Effect of alpha-lipoic acid on lipid profile in rats fed a high-fructose diet.

  Experimental diabesity research 20040101

• Treatment of diabetic polyneuropathy with alpha-lipoic acid is evidence based.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 20040101

• Alpha-lipoic acid in the treatment of autonomic diabetic neuropathy (controlled, randomized, open-label study).

  Romanian journal of internal medicine = Revue roumaine de medecine interne 20040101

• Protective activity of hesperidin and lipoic acid against sodium arsenite acute toxicity in mice.

  Toxicologic pathology 20040101

• Stability study of lipoic acid in the presence of vitamins A and E in o/w emulsions for cosmetic application.

  Journal of cosmetic science 20040101

• Influence of treatment of diabetic rats with combinations of pycnogenol, beta-carotene, and alpha-lipoic acid on parameters of oxidative stress.

  Journal of biochemical and molecular toxicology 20040101

• The role of antioxidant micronutrients in the prevention of diabetic complications.

  Treatments in endocrinology 20040101

• Fructose diet-induced skin collagen abnormalities are prevented by lipoic acid.

  Experimental diabesity research 20040101

• Thioctic acid for patients with symptomatic diabetic polyneuropathy: a critical review.

  Treatments in endocrinology 20040101

• [Changes in antioxidant capacity of the guinea pig exposed to noise and the protective effect of alpha-lipoic acid against acoustic trauma].

  Sheng li xue bao : [Acta physiologica Sinica] 20031225

• Irwin C. Gunsalus, versatile and creative scientist.

  Biochemical and biophysical research communications 20031205

• Metabolism of vitamins in microbes and mammals.

  Biochemical and biophysical research communications 20031205

• Prophylaxis against lipopolysaccharide-induced liver injuries by lipoic acid in rats.

  Pharmacological research 20031201

• Oxidative stress in the pathogenesis of experimental mesangial proliferative glomerulonephritis.

  American journal of physiology. Renal physiology 20031201

• Effect of single and combined supply of glutamine, glycine, N-acetylcysteine, and R,S-alpha-lipoic acid on glutathione content of myelomonocytic cells.

  Clinical nutrition (Edinburgh, Scotland) 20031201

• Vascular endothelial dysfunction in aging: loss of Akt-dependent endothelial nitric oxide synthase phosphorylation and partial restoration by (R)-alpha-lipoic acid.

  Biochemical Society transactions 20031201

• Salt-induced hypertension in WKY rats: prevention by alpha-lipoic acid supplementation.

  Molecular and cellular biochemistry 20031201

• Prophylactic action of lipoic acid on oxidative stress and growth performance in broilers at risk of developing ascites syndrome.

  Avian pathology : journal of the W.V.P.A 20031201

• Assembly of the covalent linkage between lipoic acid and its cognate enzymes.

  Chemistry & biology 20031201

• Autoreactivity to lipoate and a conjugated form of lipoate in primary biliary cirrhosis.

  Gastroenterology 20031201

• Dihydrolipoic acid inhibits 15-lipoxygenase-dependent lipid peroxidation.

  Free radical biology & medicine 20031115

• Plasma kinetics, metabolism, and urinary excretion of alpha-lipoic acid following oral administration in healthy volunteers.

  Journal of clinical pharmacology 20031101

• Beta-cyclodextrin-based ferrocene-imprinted gold electrodes.

  Analytical chemistry 20031101

• Advanced glycation endproducts induce changes in glucose consumption, lactate production, and ATP levels in SH-SY5Y neuroblastoma cells by a redox-sensitive mechanism.

  Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20031101

• Alpha-lipoic acid treatment prevents the diabetes-induced attenuation of the afferent limb of the baroreceptor reflex in rats.

  Autonomic neuroscience : basic & clinical 20031031

• Induction of endogenous antioxidants and phase 2 enzymes by alpha-lipoic acid in rat cardiac H9C2 cells: protection against oxidative injury.

  Biochemical and biophysical research communications 20031024

• Listeria intracellular growth and virulence require host-derived lipoic acid.

  Science (New York, N.Y.) 20031017

• Alpha-lipoic acid preconditioning reduces ischemia-reperfusion injury of the rat liver via the PI3-kinase/Akt pathway.

  American journal of physiology. Gastrointestinal and liver physiology 20031001

• Glucose transporter type1 (GLUT-1) deficiency.

  Brain & development 20031001

• An alpha-lipoic acid-vitamin E mixture reduces post-embolism lipid peroxidation, cerebral infarction, and neurological deficit in rats.

  Neuroscience research 20031001

• Potent antioxidant improves diabetic nerve damage.

  Mayo Clinic women's healthsource 20031001

• Creatine monohydrate supplemented in swine finishing diets and fresh pork quality: III. Evaluating the cumulative effect of creatine monohydrate and alpha-lipoic acid.

  Journal of animal science 20031001

• Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity.

  Antioxidants & redox signaling 20031001

• Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin.

  The British journal of dermatology 20031001

• Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathways.

  The Journal of biological chemistry 20030912

• Alpha-lipoic acid decreases thiol reactivity of the insulin receptor and protein tyrosine phosphatase 1B in 3T3-L1 adipocytes.

  Biochemical pharmacology 20030901

• Free radical scavengers improve the impaired endothelium-dependent responses in aorta and kidneys of diabetic rabbits.

  Diabetes research and clinical practice 20030901

• Interactions of conjugated linoleic acid and lipoic acid on insulin action in the obese Zucker rat.

  Metabolism: clinical and experimental 20030901

• Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and lipids in aged rats.

  The journals of gerontology. Series A, Biological sciences and medical sciences 20030901

• A dual action of alpha-lipoic acid in the brain: an electrophysiological evaluation.

  Arquivos de neuro-psiquiatria 20030901

• Effect of alpha-lipoic acid combined with creatine monohydrate on human skeletal muscle creatine and phosphagen concentration.

  International journal of sport nutrition and exercise metabolism 20030901

• Lipoic acid restores antioxidant system in tissues of hyperinsulinaemic rats.

  The Indian journal of medical research 20030901

• Futile cycling of intermediates of fatty acid biosynthesis toward peroxisomal beta-oxidation in Saccharomyces cerevisiae.

  The Journal of biological chemistry 20030829

• Synthesis and antioxidant efficiency of a new amphiphilic spin-trap derived from PBN and lipoic acid.

  Bioorganic & medicinal chemistry letters 20030818

• Lipoic acid supplementation prevents angiotensin II-induced renal injury.

  Kidney international 20030801

• Experimental therapeutics in Huntington's disease: are models useful for therapeutic trials?

  Current opinion in neurology 20030801

• Effect of alpha lipoic acid on intracerebroventricular streptozotocin model of cognitive impairment in rats.

  European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20030801

• [Therapy of olfactory loss].

  Laryngo- rhino- otologie 20030801

• Lipoic acid as a potential first agent for protection from mycotoxins and treatment of mycotoxicosis.

  Archives of environmental health 20030801

• Copper toxicity, oxidative stress, and antioxidant nutrients.

  Toxicology 20030715

• Effects of alpha-lipoic acid on impaired gastric fundus innervation in diabetic rats.

  Free radical biology & medicine 20030715

• Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2.

  Biochemical and biophysical research communications 20030627

• Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor kappa B transcriptional activity.

  Cancer research 20030615

• Acute glucose deprivation leads to apoptosis in a cell model of acute diabetic neuropathy.

  Journal of the peripheral nervous system : JPNS 20030601

• Biological radical sulfur insertion reactions.

  Chemical reviews 20030601

• Evaluation of the effect of lipoic acid administered along with gentamicin in rats rendered bacteremic.

  Molecular and cellular biochemistry 20030601

• Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid.

  Journal of Alzheimer's disease : JAD 20030601

• Prevention of oxidant-induced cell death by lysosomotropic iron chelators.

  Free radical biology & medicine 20030515

• Melatonin, xanthurenic acid, resveratrol, EGCG, vitamin C and alpha-lipoic acid differentially reduce oxidative DNA damage induced by Fenton reagents: a study of their individual and synergistic actions.

  Journal of pineal research 20030501

• NAD(P)H oxidase activation by angiotensin II is dependent on p42/44 ERK-MAPK pathway activation in rat's vascular smooth muscle cells.

  Journal of hypertension 20030501

• IRS1 degradation and increased serine phosphorylation cannot predict the degree of metabolic insulin resistance induced by oxidative stress.

  Diabetologia 20030501

• Protective role of DLalpha-lipoic acid against adriamycin-induced cardiac lipid peroxidation.

  Human & experimental toxicology 20030501

• Physico-chemical properties and spectrophotometric determination of biologically active 1-alkyl-2-(2-pyridyl)pyridinium bromides.

  Die Pharmazie 20030501

• Prophylactic effect of lipoic acid against adriamycin-induced peroxidative damages in rat kidney.

  Renal failure 20030501

• Effects of alpha-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats.

  The Journal of nutritional biochemistry 20030501

• Protective effect of lipoic acid on adriamycin induced lipid peroxidation in rat kidney.

  Molecular and cellular biochemistry 20030501

• The influence of lipoic acid on adriamycin induced nephrotoxicity in rats.

  Molecular and cellular biochemistry 20030501

• Inhibition of oxygen radical formation by methylene blue, aspirin, or alpha-lipoic acid, prevents bacterial-lipopolysaccharide-induced fever.

  Molecular and cellular biochemistry 20030501

• The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats.

  Molecular and cellular biochemistry 20030501

• Radiation response of cells during altered protein thiol redox.

  Radiation research 20030401

• Glycated albumin increases oxidative stress, activates NF-kappa B and extracellular signal-regulated kinase (ERK), and stimulates ERK-dependent transforming growth factor-beta 1 production in macrophage RAW cells.

  The Journal of laboratory and clinical medicine 20030401

• Exercise training and antioxidants: relief from oxidative stress and insulin resistance.

  Exercise and sport sciences reviews 20030401

• Combined efficacies of lipoic acid and meso-2,3-dimercaptosuccinic acid on lead-induced erythrocyte membrane lipid peroxidation and antioxidant status in rats.

  Human & experimental toxicology 20030401

• Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells.

  Biochimica et biophysica acta 20030317

• [Polyneuropathy--therapy].

  Deutsche medizinische Wochenschrift (1946) 20030314

• Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines.

  Journal of cellular physiology 20030301

• The Escherichia coli lipB gene encodes lipoyl (octanoyl)-acyl carrier protein:protein transferase.

  Journal of bacteriology 20030301

• The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice.

  Journal of neurochemistry 20030301

• Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation.

  Diabetes 20030301

• The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial.

  Diabetes care 20030301

• Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production.

  American journal of hypertension 20030301

• 2-Oxo acid dehydrogenase complexes in redox regulation.

  European journal of biochemistry 20030301

• Graded sensitiveness of the various retinal neuron populations on the glyoxal-mediated formation of advanced glycation end products and ways of protection.

  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20030301

• Protective effect of green tea polyphenol (-)-epigallocatechin gallate and other antioxidants on lipid peroxidation in gerbil brain homogenates.

  Phytotherapy research : PTR 20030301

• Catalysis of diaphorase reactions by Mycobacterium tuberculosis lipoamide dehydrogenase occurs at the EH4 level.

  Biochemistry 20030225

• Photoprotection by antioxidants against UVB-radiation-induced damage in pig skin organ culture.

  Radiation research 20030201

• Amelioration of docetaxel/cisplatin induced polyneuropathy by alpha-lipoic acid.

  Annals of oncology : official journal of the European Society for Medical Oncology 20030201

• Alpha lipoic acid changes iron uptake and storage in lens epithelial cells.

  Experimental eye research 20030201

• Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y.

  Journal of Alzheimer's disease : JAD 20030201

• Early oxidative stress in the diabetic kidney: effect of DL-alpha-lipoic acid.

  Free radical biology & medicine 20030115

• Hemoprotein-mediated reduction of nitrated DNA bases in the presence of reducing agents.

  Free radical biology & medicine 20030115

• Reactive oxygen species are involved in the stimulation of the mitochondrial permeability transition by dihydrolipoate.

  Biochemical pharmacology 20030101

• The effectiveness of treatments of diabetic autonomic neuropathy is not the same in autonomic nerves supplying different organs.

  Diabetes 20030101

• Botanicals and dietary supplements in diabetic peripheral neuropathy.

  The Journal of the American Board of Family Practice 20030101

• Synthesis and pharmacological evaluation of new 1,2-dithiolane based antioxidants.

  European journal of medicinal chemistry 20030101

• [Lipoylation of the proteins having lipoic acid as a prosthetic group].

  Seikagaku. The Journal of Japanese Biochemical Society 20030101

• Preventing superoxide formation in epineurial arterioles of the sciatic nerve from diabetic rats restores endothelium-dependent vasodilation.

  Free radical research 20030101

• Bioenergetic approaches for neuroprotection in Parkinson's disease.

  Annals of neurology 20030101

• In vitro neuroprotection against oxidative stress by pre-treatment with a combination of dihydrolipoic acid and phenyl-butyl nitrones.

  Neurotoxicity research 20030101

• Vitamin C, glutathione, or lipoic acid did not decrease brain or kidney mercury in rats exposed to mercury vapor.

  Journal of toxicology. Clinical toxicology 20030101

• Lipoic acid: a multifunctional antioxidant.

  BioFactors (Oxford, England) 20030101

• Redox regulation of mitochondrial permeability transition: effects of uncoupler, lipoic acid and its positively charged analog LA-plus and selenium.

  BioFactors (Oxford, England) 20030101

• Cocaine, not morphine, causes the generation of reactive oxygen species and activation of NF-kappaB in transiently cotransfected heart cells.

  Cardiovascular toxicology 20030101

• Subcutaneous interleukin-2 in combination with medroxyprogesterone acetate and antioxidants in advanced cancer responders to previous chemotherapy: phase II study evaluating clinical, quality of life, and laboratory parameters.

  Journal of experimental therapeutics & oncology 20030101

• Protective effect of lipoic acid against hydrogen peroxide in yeast cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20030101

• Redox balance in patients with Down's syndrome before and after dietary supplementation with alpha-lipoic acid and L-cysteine.

  International journal of clinical pharmacology research 20030101

• Acrolein inhibits NADH-linked mitochondrial enzyme activity: implications for Alzheimer's disease.

  Neurotoxicity research 20030101

• ADP- and oligomycin-sensitive redox behavior of F0 b thiol in ATPsynthase depends on neighbored primary structure: investigations using 14-C-labeled alpha lipoic acid.

  BioFactors (Oxford, England) 20030101

• Histidine 407, a phantom residue in the E1 subunit of the Escherichia coli pyruvate dehydrogenase complex, activates reductive acetylation of lipoamide on the E2 subunit. An explanation for conservation of active sites between the E1 subunit and transketolase.

  Biochemistry 20021231

• The lipoamide dehydrogenase from Mycobacterium tuberculosis permits the direct observation of flavin intermediates in catalysis.

  Biochemistry 20021210

• Inhibition of LPS-induced nitric oxide and TNF-alpha production by alpha-lipoic acid in rat Kupffer cells and in RAW 264.7 murine macrophages.

  Immunology and cell biology 20021201

• Alpha-lipoic acid ameliorates myocardial toxicity induced by doxorubicin.

  Pharmacological research 20021201

• Capillary zone electrophoresis study of cyclodextrin--lipoic acid host-guest interaction.

  Electrophoresis 20021201

• Modulation of microphthalmia-associated transcription factor gene expression alters skin pigmentation.

  The Journal of investigative dermatology 20021201

• Mercury toxicity and antioxidants: Part 1: role of glutathione and alpha-lipoic acid in the treatment of mercury toxicity.

  Alternative medicine review : a journal of clinical therapeutic 20021201

• Idiopathic dysgeusia; an open trial of alpha lipoic acid (ALA) therapy.

  International journal of oral and maxillofacial surgery 20021201

• Neurochemical changes related to ageing in the rat brain and the effect of DL-alpha-lipoic acid.

  Experimental gerontology 20021201

• Effects of intraperitoneally administered lipoic acid, vitamin E, and linalool on the level of total lipid and fatty acids in guinea pig brain with oxidative stress induced by H2O2.

  Journal of biochemistry and molecular biology 20021130

• Alpha-lipoic acid protects the retina against ischemia-reperfusion.

  Neuropharmacology 20021101

• Lipoic acid in the treatment of smell dysfunction following viral infection of the upper respiratory tract.

  The Laryngoscope 20021101

• Folding kinetics of the lipoic acid-bearing domain of human mitochondrial branched chain alpha-ketoacid dehydrogenase complex.

  FEBS letters 20021023

• The C-terminal hinge region of lipoic acid-bearing domain of E2b is essential for domain interaction with branched-chain alpha-keto acid dehydrogenase kinase.

  The Journal of biological chemistry 20021004

• Interactions of lipoic acid radical cations with vitamins C and E analogue and hydroxycinnamic acid derivatives.

  Archives of biochemistry and biophysics 20021001

• Thioltransferase (glutaredoxin) mediates recovery of motor neurons from excitotoxic mitochondrial injury.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20021001

• Inactivation of the 2-oxo acid dehydrogenase complexes upon generation of intrinsic radical species.

  European journal of biochemistry 20021001

• Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy.

  Neurotoxicology 20021001

• Alpha lipoic acid inhibits T cell migration into the spinal cord and suppresses and treats experimental autoimmune encephalomyelitis.

  Journal of neuroimmunology 20021001

• Burning mouth syndrome (BMS): an open trial of comparative efficacy of alpha-lipoic acid (thioctic acid) with other therapies.

  Minerva stomatologica 20020901

• Lead induced oxidative damage and its response to combined administration of alpha-lipoic acid and succimers in rats.

  Toxicology 20020815

• Lipoyl dehydrogenase catalyzes reduction of nitrated DNA and protein adducts using dihydrolipoic acid or ubiquinol as the cofactor.

  Chemico-biological interactions 20020815

• Alpha-lipoic acid prevents ethanol-induced protein oxidation in mouse hippocampal HT22 cells.

  Neuroscience letters 20020809

• Glutaredoxins catalyze the reduction of glutathione by dihydrolipoamide with high efficiency.

  Biochemical and biophysical research communications 20020802

• Effective treatment of oxaliplatin-induced cumulative polyneuropathy with alpha-lipoic acid.

  Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020801

• Lipoic acid in combination with a chelator ameliorates lead-induced peroxidative damages in rat kidney.

  Archives of toxicology 20020801

• Cofactors of mitochondrial enzymes attenuate copper-induced death in vitro and in vivo.

  Annals of neurology 20020801

• Cathepsin B responsiveness to glutathione and lipoic acid redox.

  Antioxidants & redox signaling 20020801

• Inhibition of glucose production and stimulation of bile flow by R (+)-alpha-lipoic acid enantiomer in rat liver.

  Liver 20020801

• Uptake, recycling, and antioxidant actions of alpha-lipoic acid in endothelial cells.

  Free radical biology & medicine 20020701

• Antioxidant and prooxidant activities of alpha-lipoic acid and dihydrolipoic acid.

  Toxicology and applied pharmacology 20020701

• Synthesis of a rabbit polyclonal antibody to the human sodium-dependent multivitamin transporter.

  International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition 20020701

• Lipoic acid increases glutathione production and enhances the effect of mercury in human cell lines.

  Toxicology 20020614

• Novel lipoic acid analogues that inhibit nitric oxide synthase.

  Bioorganic & medicinal chemistry letters 20020603

• [Fatal Lepiota brunneoincarnata poisoning].

  Anales de medicina interna (Madrid, Spain : 1984) 20020601

• Effect of DL-alpha-lipoic acid on the status of lipid peroxidation and antioxidant enzymes in various brain regions of aged rats.

  Experimental gerontology 20020601

• The neuroprotective antioxidant alpha-lipoic acid induces detoxication enzymes in cultured astroglial cells.

  Free radical research 20020601

• Dihydrolipoic acid as an effective cofactor for peptide methionine sulfoxide reductase in enzymatic repair of oxidative damage to both lipid-free and lipid-bound apolipoprotein a-I.

  Antioxidants & redox signaling 20020601

• Solution structure and dynamics of the lipoic acid-bearing domain of human mitochondrial branched-chain alpha-keto acid dehydrogenase complex.

  The Journal of biological chemistry 20020503

• Arsenate reductase II. Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems.

  Chemical research in toxicology 20020501

• Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy.

  Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20020501

• The biosynthetic pathway for lipoic acid is present in plastids and mitochondria in Arabidopsis thaliana.

  FEBS letters 20020424

• High-performance liquid chromatographic assay for alpha-lipoic acid and five of its metabolites in human plasma and urine.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020405

• Synthesis of 1,2-dithiolane analogues of leucine for potential use in peptide chemistry.

  Organic letters 20020404

• Delaying brain mitochondrial decay and aging with mitochondrial antioxidants and metabolites.

  Annals of the New York Academy of Sciences 20020401

• Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.

  Annals of the New York Academy of Sciences 20020401

• Effect of alpha-lipoic acid on lipid peroxidation and anti-oxidant enzyme activities in diabetic rats.

  Clinical and experimental pharmacology & physiology 20020401

• Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT.

  Biochimica et biophysica acta 20020319

• Beneficial effects of alpha-lipoic acid plus vitamin E on neurological deficit, reactive gliosis and neuronal remodeling in the penumbra of the ischemic rat brain.

  Neuroscience letters 20020315

• Influence of controlled hypoxia and radical scavenging agents on erythropoietin and malondialdehyde concentrations in humans.

  Acta physiologica Scandinavica 20020301

• Protective effect of alpha-lipoic acid against ischaemic acute renal failure in rats.

  Clinical and experimental pharmacology & physiology 20020301

• Mitigation of free radical toxicity in hyperoxaluric condition by a novel derivative eicosapentaenoate-lipoate.

  Human & experimental toxicology 20020301

• Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.

  Science (New York, N.Y.) 20020208

• Dietary modulation of age-related changes in cerebral pro-oxidant status.

  Neurochemistry international 20020201

• Differential effects of the antioxidant alpha-lipoic acid on the proliferation of mitogen-stimulated peripheral blood lymphocytes and leukaemic T cells.

  Molecular immunology 20020201

• Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid.

  Hypertension (Dallas, Tex. : 1979) 20020201

• Sulfur in human nutrition and applications in medicine.

  Alternative medicine review : a journal of clinical therapeutic 20020201

• Antimitochondrial antibodies in primary biliary cirrhosis: the role of xenobiotics.

  Autoimmunity reviews 20020201

• Biocytin and biotin uptake into NB2a neuroblastoma and C6 astrocytoma cells.

  Brain research 20020125

• R-alpha-lipoic acid action on cell redox status, the insulin receptor, and glucose uptake in 3T3-L1 adipocytes.

  Archives of biochemistry and biophysics 20020115

• Exploring the interest of 1,2-dithiolane ring system in peptide chemistry. Synthesis of a chemotactic tripeptide and x-ray crystal structure of a 4-amino-1,2-dithiolane-4-carboxylic acid derivative.

  Bioorganic & medicinal chemistry 20020101

• Effects of exercise training and antioxidant R-ALA on glucose transport in insulin-sensitive rat skeletal muscle.

  Journal of applied physiology (Bethesda, Md. : 1985) 20020101

• Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: new insights into the reaction of peroxynitrite with thiols.

  Archives of biochemistry and biophysics 20020101

• Alpha-lipoic acid attenuates hyperglycemia and prevents glomerular mesangial matrix expansion in diabetes.

  Journal of the American Society of Nephrology : JASN 20020101

• Alpha-lipoic acid modulates NF-kappaB activity in human monocytic cells by direct interaction with DNA.

  Experimental gerontology 20020101

• N-acetylcysteine augments adenovirus-mediated gene expression in human endothelial cells by enhancing transgene transcription and virus entry.

  The journal of gene medicine 20020101

• Lipoic acid increases glucose uptake by skeletal muscles of obese-diabetic ob/ob mice.

  Diabetes, obesity & metabolism 20020101

• Elimination of *O(2)(-)/H(2)O(2) by alpha-lipoic acid mediates the recovery of basal EDRF/NO availability and the reversal of superoxide dismutase-induced relaxation in diabetic rat aorta.

  Diabetes, obesity & metabolism 20020101

• Natural products used for diabetes.

  Journal of the American Pharmaceutical Association (Washington,D.C. : 1996) 20020101

• Activation of choline acetyl transferase by dihydrolipoic acid.

  Molecular and cellular biochemistry 20020101

• [Immunomodulating effect of berlithione in clean-up workers of the Chernobyl nuclear plant accident].

  Likars'ka sprava 20020101

• Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid.

  Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101

• [Complex evaluation of treatment efficacy in diabetic encephalopathy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20020101

• Myeloperoxidase-dependent caspase-3 activation and apoptosis in HL-60 cells: protection by the antioxidants ascorbate and (dihydro)lipoic acid.

  Redox report : communications in free radical research 20020101

• Phase II study of subcutaneously administered interleukin-2 in combination with medroxyprogesterone acetate and antioxidant agents as maintenance treatment in advanced cancer responders to previous chemotherapy.

  Oncology reports 20020101

• [Biologic properties of lipoic acid].

  Postepy higieny i medycyny doswiadczalnej 20020101

• Effects of alpha lipoic acid, ascorbic acid-6-palmitate, and fish oil on the glutathione, malonaldehyde, and fatty acids levels in erythrocytes of streptozotocin induced diabetic male rats.

  Journal of cellular biochemistry 20020101

• Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status.

  Redox report : communications in free radical research 20020101

• Zinc availability from zinc lipoate and zinc sulfate in growing rats.

  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20020101

• Effects of certain micronutrients and melatonin on plasma lipid, lipid peroxidation, and homocysteine levels in rats.

  Archives of medical research 20020101

• Influence of lipoic acid on lipid metabolism and beta-adrenergic response to intravenous or oral administration of clenbuterol in broiler chickens.

  Reproduction, nutrition, development 20020101

• Diabetic neuropathy--choices of treatment.

  Romanian journal of internal medicine = Revue roumaine de medecine interne 20020101

• Safety of long-term feeding of dl-alpha-lipoic acid and its effect on reduced glutathione:oxidized glutathione ratios in beagles.

  Veterinary therapeutics : research in applied veterinary medicine 20020101

• Effect of DL-alpha-lipoic acid on glutathione metabolic enzymes in aged rats.

  Experimental gerontology 20011201

• Measurement of the length of the a helical section of a peptide directly using atomic force microscopy.

  Chemical & pharmaceutical bulletin 20011201

• Two ways to stimulate glutathione.

  Survival news (Atlanta, Ga.) 20011201

• Effect of DL-alpha-lipoic acid on mitochondrial enzymes in aged rats.

  Chemico-biological interactions 20011128

• Novel potent inhibitors of lipid peroxidation with protective effects against reperfusion arrhythmias.

  Journal of medicinal chemistry 20011122

• Sulfur-centered radical formation from the antioxidant dihydrolipoic acid.

  The Journal of biological chemistry 20011116

• Theoretical study of the conformation of the lipoamide arm in a mutant H protein.

  Proteins 20011115

• Restoration of glutathione levels in vascular smooth muscle cells exposed to high glucose conditions.

  Free radical biology & medicine 20011115

• Alpha-lipoic acid inhibits TNF-alpha-induced NF-kappaB activation and adhesion molecule expression in human aortic endothelial cells.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011101

• Anti-aging products, Part I. Can supplements rewind our body clocks?

  Harvard women's health watch 20011101

• Effect of selenolipoic acid on peroxynitrite-dependent inactivation of NADPH-cytochrome P450 reductase.

  Free radical research 20011101

• Energy, mood and behaviour: Part Two.

  Nursing times 20011101

• Lipoic acid improves survival in transgenic mouse models of Huntington's disease.

  Neuroreport 20011029

• Alpha-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway.

  Neuroscience letters 20011026

• Hypochlorous acid is a potent inhibitor of GST P1-1.

  Chemico-biological interactions 20011025

• A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes.

  The Journal of biological chemistry 20011019

• Aqueous leaching properties and environmental implications of cadmium, lead and zinc trimercaptotriazine (TMT) compounds.

  Water research 20011001

• Use of antioxidant nutrients in the prevention and treatment of type 2 diabetes.

  Journal of the American College of Nutrition 20011001

• Molecular aspects of lipoic acid in the prevention of diabetes complications.

  Nutrition (Burbank, Los Angeles County, Calif.) 20011001

• Immunoreactivity of organic mimeotopes of the E2 component of pyruvate dehydrogenase: connecting xenobiotics with primary biliary cirrhosis.

  Journal of immunology (Baltimore, Md. : 1950) 20010901

• Versatile cytoprotective activity of lipoic acid may reflect its ability to activate signalling intermediates that trigger the heat-shock and phase II responses.

  Medical hypotheses 20010901

• alpha-Lipoic acid prevents the development of glucose-induced insulin resistance in 3T3-L1 adipocytes and accelerates the decline in immunoreactive insulin during cell incubation.

  Metabolism: clinical and experimental 20010901

• Solution structure of the lipoyl domain of the chimeric dihydrolipoyl dehydrogenase P64K from Neisseria meningitidis.

  European journal of biochemistry 20010901

• Antioxidants attenuate early up regulation of retinal vascular endothelial growth factor in streptozotocin-diabetic rats.

  Diabetologia 20010901

• Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.

  The Journal of biological chemistry 20010803

• Effect of antioxidant treatment of streptozotocin-induced diabetic rats on endoneurial blood flow, motor nerve conduction velocity, and vascular reactivity of epineurial arterioles of the sciatic nerve.

  Diabetes 20010801

• The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat.

  Metabolism: clinical and experimental 20010801

• Amplification of antigen-antibody interactions based on biotin labeled protein-streptavidin network complex using impedance spectroscopy.

  Biosensors & bioelectronics 20010801

• Effects of alpha-lipoic acid on deoxycorticosterone acetate-salt-induced hypertension in rats.

  European journal of pharmacology 20010720

• Interactions of exercise training and lipoic acid on skeletal muscle glucose transport in obese Zucker rats.

  Journal of applied physiology (Bethesda, Md. : 1985) 20010701

• Beneficial effects of alpha-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress.

  Free radical biology & medicine 20010701

• Effect of alpha-lipoic acid on vascular responses and nociception in diabetic rats.

  Free radical biology & medicine 20010701

• Evidence for the extracellular reduction of alpha-lipoic acid by Leishmania donovani promastigotes: a transplasma membrane redox system.

  Biochimica et biophysica acta 20010606

• Effect of alpha-lipoic acid on the progression of endothelial cell damage and albuminuria in patients with diabetes mellitus: an exploratory study.

  Diabetes research and clinical practice 20010601

• New metabolic pathways of alpha-lipoic acid.

  Drug metabolism and disposition: the biological fate of chemicals 20010601

• The antihyperglycemic drug alpha-lipoic acid stimulates glucose uptake via both GLUT4 translocation and GLUT4 activation: potential role of p38 mitogen-activated protein kinase in GLUT4 activation.

  Diabetes 20010601

• Cytotoxicity of ascorbate, lipoic acid, and other antioxidants in hollow fibre in vitro tumours.

  British journal of cancer 20010601

• Do mammalian cells synthesize lipoic acid? Identification of a mouse cDNA encoding a lipoic acid synthase located in mitochondria.

  FEBS letters 20010601

• Electrocatalytic reduction of lipoic acid and electroenzymatic reduction of NAD(P)(+) for integrated dehydrogenase biosensors.

  Biosensors & bioelectronics 20010601

• Lipoic acid metabolism in Arabidopsis thaliana: cloning and characterization of a cDNA encoding lipoyltransferase.

  Plant & cell physiology 20010601

• The isolation and characterisation of a Saccharomyces cerevisiae gene (LIP2) involved in the attachment of lipoic acid groups to mitochondrial enzymes.

  FEMS microbiology letters 20010515

• Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state.

  European journal of clinical investigation 20010501

• Effects of vitamin E and alpha-lipoic acid on skeletal muscle contractile properties.

  Journal of applied physiology (Bethesda, Md. : 1985) 20010401

• Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

  Experimental neurology 20010401

• Efficacy of antioxidant therapies in transient focal ischemia in mice.

  Stroke 20010401

• Natural therapies for ocular disorders, part two: cataracts and glaucoma.

  Alternative medicine review : a journal of clinical therapeutic 20010401

• Oxidative stress participates in the breakdown of neuronal phenotype in experimental diabetic neuropathy.

  Diabetologia 20010401

• Schisandrin B modulates the ischemia-reperfusion induced changes in non-enzymatic antioxidant levels in isolated-perfused rat hearts.

  Molecular and cellular biochemistry 20010401

• Effects of vitamins and common drugs on reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rat microsomes.

  Archives of physiology and biochemistry 20010401

• Inhibitory effect of alpha-lipoic acid and its positively charged amide analogue on nitric oxide production in RAW 264.7 macrophages.

  Biochemical pharmacology 20010301

• Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20010301

• [Effect of alpha-lipoic acid on the apoptosis of PC12 cells induced by 6-hydroxydopamine].

  Shi yan sheng wu xue bao 20010301

• Antioxidant alpha-lipoic acid and protein turnover in insulin-resistant rat muscle.

  Free radical biology & medicine 20010215

• Reaction mechanism for mammalian pyruvate dehydrogenase using natural lipoyl domain substrates.

  Archives of biochemistry and biophysics 20010215

• Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by mircomolar concentrations of alpha-lipoic acid.

  Diabetes 20010201

• Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid.

  Oncogene 20010118

• Effects of dietary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus.

  Journal of the American Society of Nephrology : JASN 20010101

• Thiols can either enhance or suppress DNA damage induction by catecholestrogens.

  Free radical biology & medicine 20010101

• The effect of gamma-linolenic acid-alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats.

  Journal of the neurological sciences 20010101

• Biosynthesis of biotin and lipoic acid.

  Vitamins and hormones 20010101

• [Berlition R 300 oral -- alpha-lipoic acid preparation for the correction of body changes associated with high serum iron content].

  Meditsina truda i promyshlennaia ekologiia 20010101

• Activity of alpha-lipoic acid in the protection against oxidative stress in skin.

  Current problems in dermatology 20010101

• The antioxidant effect of DL-alpha-lipoic acid on copper-induced acute hepatitis in Long-Evans Cinnamon (LEC) rats.

  Free radical research 20010101

• Cataract development in diabetic sand rats treated with alpha-lipoic acid and its gamma-linolenic acid conjugate.

  Diabetes/metabolism research and reviews 20010101

• Diabetes-induced changes in retinal NAD-redox status: pharmacological modulation and implications for pathogenesis of diabetic retinopathy.

  Pharmacology 20010101

• Effects of age and dietary antioxidants on cerebral electron transport chain activity.

  Neurobiology of aging 20010101

• [Effect of alpha-lipoic acid preparations on bilirubin and transferrin levels and ferritin iron and transferrin iron content].

  Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20010101

• Radical mechanisms of S-adenosylmethionine-dependent enzymes.

  Advances in protein chemistry 20010101

• Corpus cavernosum dysfunction in diabetic rats: effects of combined alpha-lipoic acid and gamma-linolenic acid treatment.

  Diabetes/metabolism research and reviews 20010101

• [Efficiency of thioctacid in dyscirculatory encephalopathy].

  Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20010101

• Neuronal death in the rat hippocampus in experimental diabetes and cerebral ischaemia treated with antioxidants.

  Folia neuropathologica 20010101

• Alpha-lipoic acid and alpha-lipoamide prevent oxidant-induced lysosomal rupture and apoptosis.

  Redox report : communications in free radical research 20010101

• Lipoic acid confers protection against oxidative injury in non-neuronal and neuronal tissue.

  Nutritional neuroscience 20010101

• Hypochlorous acid-modified low-density lipoprotein inactivates the lysosomal protease cathepsin B: protection by ascorbic and lipoic acids.

  Redox report : communications in free radical research 20010101

• Update on thiol status and supplements in physical exercise.

  Canadian journal of applied physiology = Revue canadienne de physiologie appliquee 20010101

• Electrochemical sensing for the determination of activated cyclic AMP-dependent protein kinase.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20010101

• Attenuation of oxalate-induced nephrotoxicity by eicosapentaenoate-lipoate (EPA-LA) derivative in experimental rat model.

  Prostaglandins, leukotrienes, and essential fatty acids 20010101

• Escherichia coli LipA is a lipoyl synthase: in vitro biosynthesis of lipoylated pyruvate dehydrogenase complex from octanoyl-acyl carrier protein.

  Biochemistry 20001212

• Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions.

  Annual review of biochemistry 20000101

• Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization.

  The Journal of biological chemistry 19990521

• Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate.

  The Journal of biological chemistry 19980327

• One-electron reduction of chromium(VI) by alpha-lipoic acid and related hydroxyl radical generation, dG hydroxylation and nuclear transcription factor-kappaB activation.

  Archives of biochemistry and biophysics 19970215

• Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.

  Diabetes care 19950801

• The lipoic acid containing components of the 2-oxoacid dehydrogenase complexes mimic trifluoroacetylated proteins and are autoantigens associated with halothane hepatitis.

  Chemical research in toxicology 19950101

• Thiamine disulfide as a potent inhibitor of human immunodeficiency virus (type-1) production.

  Biochemical and biophysical research communications 19941130

• Identification of the dihydrolipoamide acetyltransferase subunit of the human pyruvate dehydrogenase complex as an autoantigen in halothane hepatitis. Molecular mimicry of trifluoroacetyl-lysine by lipoic acid.

  European journal of biochemistry 19940801

• [The neurohumoral systems of patients with ischemic heart disease and under emotional-pain stress: the means for their pharmacological regulation].

  Kardiologiia 19930101

• Lipid peroxidation of erythrocyte membrane induced by lipoamide dehydrogenase in the presence of ADP-Fe3+.

  Pharmacology & toxicology 19921001

• Alpha-lipoic acid is an effective inhibitor of human immuno-deficiency virus (HIV-1) replication.

  Klinische Wochenschrift 19911002

• Thioredoxin fragment 31-36 is reduced by dihydrolipoamide and reduces oxidized protein.

  Biochemical and biophysical research communications 19880115

• Crystalline alpha-lipoic acid; a catalytic agent associated with pyruvate dehydrogenase.

  Science (New York, N.Y.) 19510727