107753-78-6 | Zafirlukast

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$16.00	$11.00
10mg	97%	in stock	$25.00	$18.00
50mg	97%	in stock	$65.00	$46.00
100mg	97%	in stock	$95.00	$67.00

Description

• Catalog Number: AD44325
• Chemical Name: Zafirlukast
• CAS Number: 107753-78-6
• Molecular Formula: C31H33N3O6S
• Molecular Weight: 575.6752
• MDL Number: MFCD00864775
• SMILES: COc1cc(ccc1Cc1cn(c2c1cc(cc2)NC(=O)OC1CCCC1)C)C(=O)NS(=O)(=O)c1ccccc1C

Computed Properties

• Complexity: 1010
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 41
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 9
• XLogP3: 5.5

Upstream Synthesis Route

Zafirlukast, a potent leukotriene receptor antagonist, finds a significant application in chemical synthesis as a building block for the creation of novel pharmaceutical compounds. This compound is commonly utilized in the development of drug candidates targeting inflammation, asthma, and related respiratory conditions. Its unique chemical structure provides a valuable starting material for the synthesis of various derivatives with enhanced pharmacological properties. Zafirlukast's role in chemical synthesis highlights its versatility and importance in the pharmaceutical industry.

Literature

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• Single-dose agents in the prevention of exercise-induced asthma: a descriptive review.

  Treatments in respiratory medicine 20040101

• Effect of the two different leukotriene receptor antagonists, montelukast and zafirlukast, on quality of life: a 12-week randomized study.

  Allergy and asthma proceedings 20040101

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• Structure-activity relationships of indole cytosolic phospholipase A(2)alpha inhibitors: substrate mimetics.

  Bioorganic & medicinal chemistry letters 20031215

• Generation and evaluation of a CYP2C9 heteroactivation pharmacophore.

  The Journal of pharmacology and experimental therapeutics 20031201

• Evaluating the prophylactic potential of zafirlukast against the toxic effects of acetic acid on the rat colon.

  Toxicology letters 20031101

• Interactions among three classes of mediators explain antigen-induced bronchoconstriction in the isolated perfused and ventilated guinea pig lung.

  The Journal of pharmacology and experimental therapeutics 20031001

• Acute renal failure and nephrotic syndrome associated with zafirlukast therapy.

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20031001

• Treatment of acquired cold urticaria with cetirizine and zafirlukast in combination.

  Journal of the American Academy of Dermatology 20031001

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  The American journal of medicine 20030901

• Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist.

  British journal of pharmacology 20030901

• The cysteinyl-leukotriene D4 induces cytosolic Ca2+ elevation and contraction of the human detrusor muscle.

  The Journal of urology 20030801

• Zafirlukast improves pulmonary function in patients with moderate persistent asthma receiving regular inhaled steroids: a prospective randomized control study.

  Chang Gung medical journal 20030801

• Asthma associated with worsening leg ulcer: a case of vasculitis in primary care.

  Southern medical journal 20030701

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  Pharmacological research 20030601

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  Revista clinica espanola 20030501

• Leukotriene antagonists.

  Clinics in liver disease 20030501

• Anti-leukotriene drugs in the prevention and treatment of hepatorenal syndrome.

  Prostaglandins, leukotrienes, and essential fatty acids 20030401

• The role of chemical mediators in eosinophil infiltration in allergic rhinitis in mice.

  International immunopharmacology 20030401

• Effects of leukotriene receptor antagonist on chronic obstructive [correction of obstractive] pulmonary disease induced pulmonary hypertension.

  Chinese medical journal 20030301

• A pilot study of zafirlukast as an anti-inflammatory agent in the treatment of adults with cystic fibrosis.

  Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society 20030301

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  Aesthetic surgery journal 20030301

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  Aesthetic surgery journal 20030301

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  Aesthetic surgery journal 20030301

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  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030201

• Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer.

  Molecular cancer 20030101

• Potential use of leukotriene inhibitors in treatment of psoriasis.

  Dermatology (Basel, Switzerland) 20030101

• Chronic urticaria: a role for newer immunomodulatory drugs?

  American journal of clinical dermatology 20030101

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  Drugs 20030101

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  Drug safety 20030101

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  Pulmonary pharmacology & therapeutics 20030101

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  Pulmonary pharmacology & therapeutics 20030101

• Effect of zafirlukast on methacholine and ultrasonically nebulized distilled water challenge in patients with mild asthma.

  Respiration; international review of thoracic diseases 20030101

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  American journal of respiratory medicine : drugs, devices, and other interventions 20030101

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  Drugs 20030101

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  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20021201

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  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021201

• Lipoxin, leukotriene, and PDGF receptors cross-talk to regulate mesangial cell proliferation.

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021101

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  Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 20021101

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  Bulletin of experimental biology and medicine 20021101

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  Journal of pharmaceutical and biomedical analysis 20021015

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  Pharmacotherapy 20020901

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  Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020601

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  The Journal of asthma : official journal of the Association for the Care of Asthma 20020601

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  Zhonghua yi xue za zhi 20020110

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  Drugs under experimental and clinical research 20020101

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  Pneumonologia i alergologia polska 20020101

• Severe liver injury associated with zafirlukast.

  Annals of internal medicine 20011120

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  Heart (British Cardiac Society) 20010901

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• Synergistic antiallergic activity of combined histamine H1- and cysteinyl leukotriene1-receptor blockade in human bronchus.

  Life sciences 20010511

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  Clinical therapeutics 20010501

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  European journal of clinical pharmacology 20010401

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  Journal of the Formosan Medical Association = Taiwan yi zhi 20010401

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  Expert opinion on pharmacotherapy 20010301

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  Pediatrics 20010201

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  Managed care interface 20010201

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  Internal medicine (Tokyo, Japan) 20010201

• One-year claims analysis comparing inhaled fluticasone propionate with zafirlukast for the treatment of asthma.

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  Expert opinion on pharmacotherapy 20010101

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  Allergologia et immunopathologia 20010101

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  BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 20010101

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  PharmacoEconomics 20010101

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  Respiratory research 20010101

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  The Cochrane database of systematic reviews 20010101

• Comparison of the bronchodilating effect of salmeterol and zafirlukast in combination with that of their use as single treatments in asthma and chronic obstructive pulmonary disease.

  Respiration; international review of thoracic diseases 20010101

• An open study to evaluate the safety and efficacy of zafirlukast ('Accolate') in patients with mild to moderate asthma in Ibadan, Nigeria.

  West African journal of medicine 20010101

• Zafirlukast versus budesonide on bronchial reactivity in subjects with mild-persistent asthma.

  International journal of immunopathology and pharmacology 20010101

• A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization.

  The Journal of biological chemistry 20001229

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  Annals of internal medicine 20001219

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  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20001101

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  Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20001001

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  Postgraduate medicine 20000915

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  Postgraduate medicine 20000915

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  Postgraduate medicine 20000915

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  The American journal of medicine 20000801

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  Thorax 20000601

• A kinetic binding study to evaluate the pharmacological profile of a specific leukotriene C(4) binding site not coupled to contraction in human lung parenchyma.

  Molecular pharmacology 20000601

• Recurrent panniculitis in a man with asthma receiving treatment with leukotriene-modifying agents.

  Mayo Clinic proceedings 20000601

• Effectiveness and tolerability of zafirlukast for the treatment of asthma in children.

  Clinical therapeutics 20000601

• Efficacy and duration of action of the antileukotriene zafirlukast on cold air-induced bronchoconstriction.

  The European respiratory journal 20000401

• Montelukast in the prophylaxis of migraine: a potential role for leukotriene modifiers.

  Headache 20000201

• Acute effects of antileukotrienes on sinonasal polyposis and sinusitis.

  Ear, nose, & throat journal 20000101

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  Pulmonary pharmacology & therapeutics 20000101

• Efficacy and safety of Zafirlukast ('Accolate') in the management of patients with mild-to-moderate asthma.

  West African journal of medicine 20000101

• Discovery of CP-199,330 and CP-199,331: two potent and orally efficacious cysteinyl LT1 receptor antagonists devoid of liver toxicity.

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  Molecular pharmacology 19990901

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  The Journal of asthma : official journal of the Association for the Care of Asthma 19990501

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  Chest 19990201

• Development of 2,2-dimethylchromanol cysteinyl LT1 receptor antagonists.

  Bioorganic & medicinal chemistry letters 19981215

• Zafirlukast improves asthma symptoms and quality of life in patients with moderate reversible airflow obstruction.

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• Severe neuromuscular complications possibly associated with amlodipine.

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  Chest 19980701

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  American journal of respiratory and critical care medicine 19980601

• Effects of the cysteinyl leukotriene receptor antagonists pranlukast and zafirlukast on tracheal mucus secretion in ovalbumin-sensitized guinea-pigs in vitro.

  British journal of pharmacology 19980601

• Inhibition of 5-lipoxygenase diminishes neurally evoked tachykinergic contraction of guinea pig isolated airway.

  The Journal of pharmacology and experimental therapeutics 19980501

• Failure of zafirlukast to prevent ibuprofen-induced anaphylaxis.

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 19980301

• Pharmacological characterization of the cysteinyl-leukotriene antagonists CGP 45715A (iralukast) and CGP 57698 in human airways in vitro.

  British journal of pharmacology 19980201

• The leukotriene receptor antagonist zafirlukast inhibits sulfur dioxide-induced bronchoconstriction in patients with asthma.

  American journal of respiratory and critical care medicine 19971201

• Combined antagonism of leukotrienes and histamine produces predominant inhibition of allergen-induced early and late phase airway obstruction in asthmatics.

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• Cysteinyl leukotrienes induce P-selectin expression in human endothelial cells via a non-CysLT1 receptor-mediated mechanism.

  The Journal of pharmacology and experimental therapeutics 19970501

• Eosinophil chemotaxis inhibited by 5-lipoxygenase blockade and leukotriene receptor antagonism.

  American journal of respiratory and critical care medicine 19970401

• Effectiveness of the leukotriene receptor antagonist zafirlukast for mild-to-moderate asthma. A randomized, double-blind, placebo-controlled trial.

  Annals of internal medicine 19970201

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  Clinical therapeutics 19970101

• The leukotriene D4-receptor antagonist, ICI 204,219, relieves symptoms of acute seasonal allergic rhinitis.

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• Leukotriene D4-induced increases in cytosolic calcium in THP-1 cells: dependence on extracellular calcium and inhibition with selective leukotriene D4 receptor antagonists.

  The Journal of pharmacology and experimental therapeutics 19940601

• The leukotriene-antagonist ICI-204,219 inhibits the early airway reaction to cumulative bronchial challenge with allergen in atopic asthmatics.

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  The American review of respiratory disease 19930601

• Potent leukotriene D4 receptor antagonist ICI 204,219 given by the inhaled route inhibits the early but not the late phase of allergen-induced bronchoconstriction.

  The American review of respiratory disease 19930601

• Characterization of the leukotriene D4 receptor in dimethylsulphoxide-differentiated U937 cells: comparison with the leukotriene D4 receptor in human lung and guinea-pig lung.

  European journal of pharmacology 19930215

• Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.

  Inflammation 19920601

• Role of leukotrienes in exercise-induced asthma. Inhibitory effect of ICI 204219, a potent leukotriene D4 receptor antagonist.

  The American review of respiratory disease 19920401

• Lung function improvement in asthma with a cysteinyl-leukotriene receptor antagonist.

  Lancet (London, England) 19910504

• Endogenously formed leukotriene C4 activates LTC4 receptors in guinea pig tracheal strips.

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