1078-38-2 | Acetyl isoniazid

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$401.00	$281.00
250mg	98%	in stock	$867.00	$607.00
1g	98%	in stock	$2,344.00	$1,641.00

Description

• Catalog Number: AD67317
• Chemical Name: Acetyl isoniazid
• CAS Number: 1078-38-2
• Molecular Formula: C8H9N3O2
• Molecular Weight: 179.176
• MDL Number: MFCD00466330
• SMILES: O=C(c1ccncc1)NNC(=O)C

Computed Properties

• Complexity: 200
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 13
• Hydrogen Bond Acceptor Count: 3
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• XLogP3: -0.4

Literature

• Metabolism of isoniazid by neutrophil myeloperoxidase leads to isoniazid-NAD(+) adduct formation: A comparison of the reactivity of isoniazid with its known human metabolites.

  Biochemical pharmacology 20160415

• Pharmacometabonomic characterization of xenobiotic and endogenous metabolic phenotypes that account for inter-individual variation in isoniazid-induced toxicological response.

  Journal of proteome research 20120907

• Gene dose effect of NAT2 variants on the pharmacokinetics of isoniazid and acetylisoniazid in healthy Chinese subjects.

  Drug metabolism and drug interactions 20110101

• Pharmacogenetic & pharmacokinetic biomarker for efavirenz based ARV and rifampicin based anti-TB drug induced liver injury in TB-HIV infected patients.

  PloS one 20110101

• Evaluation of hepatoprotective activity of Cissus quadrangularis stem extract against isoniazid-induced liver damage in rats.

  Indian journal of pharmacology 20101201

• Is there any difference between acetylator phenotypes in tuberculosis patients and healthy subjects?

  European journal of clinical pharmacology 20100301

• [High-performance liquid chromatography for detecting the concentrations of isoniazid and acetylisoniazid in spinal tuberculosis].

  Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100201

• Simultaneous determination of isoniazid, pyrazinamide, rifampicin and acetylisoniazid in human plasma by high-performance liquid chromatography.

  Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20100101

• Estimating N-acetyltransferase metabolic activity and pharmacokinetic parameters of isoniazid from genotypes in Chinese subjects.

  Clinica chimica acta; international journal of clinical chemistry 20090701

• Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and Glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients.

  The Journal of toxicological sciences 20080501

• The effect of pyrazinamide and rifampicin on isoniazid metabolism in rats.

  Biopharmaceutics & drug disposition 20070901

• Low serum concentrations of anti-tuberculosis drugs and determinants of their serum levels.

  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20070901

• Quantification of isoniazid and acetylisoniazid in rat plasma and alveolar macrophages by liquid chromatography-tandem mass spectrometry with on-line extraction.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070301

• Simultaneous determination of first-line anti-tuberculosis drugs and their major metabolic ratios by liquid chromatography/tandem mass spectrometry.

  Rapid communications in mass spectrometry : RCM 20070101

• [Detection of mutation in NAT II gene as a method of determination of izoniazyd (INH) acetylation type in human population].

  Pneumonologia i alergologia polska 20070101

• Microsphere-based protease assays and screening application for lethal factor and factor Xa.

  Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

• The influence of NAT2 genotypes on the plasma concentration of isoniazid and acetylisoniazid in Chinese pulmonary tuberculosis patients.

  Clinica chimica acta; international journal of clinical chemistry 20060301

• Tuberculosis chemotherapy: current drug delivery approaches.

  Respiratory research 20060101

• Microparticle-based lung delivery of INH decreases INH metabolism and targets alveolar macrophages.

  Journal of controlled release : official journal of the Controlled Release Society 20051003

• Expression, purification, characterization and structure of Pseudomonas aeruginosa arylamine N-acetyltransferase.

  The Biochemical journal 20050115

• The effects of acute ethanol intake on isoniazid pharmacokinetics.

  European journal of clinical pharmacology 20041101

• Unchanged acetylation of isoniazid by alcohol intake.

  The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease 20041101

• Solid-phase extraction and HPTLC determination of isoniazid and acetylisoniazid in serum. Comparison with HPLC.

  Journal of chromatographic science 20040101

• Determination of the acetylator phenotype in Moroccan tuberculosis patients using isoniazid as metabolic probe.

  International journal of clinical pharmacology and therapeutics 20021201

• Determination of antitubercular drugs in urine and pharmaceuticals by LC using a gradient flow combined with programmed diode array photometric detection.

  Talanta 20020823

• A simplified method for detecting isoniazid compliance in patients receiving antituberculosis chemotherapy.

  Journal of clinical pharmacology 20020201

• Therapeutic isoniazid monitoring using a simple high-performance liquid chromatographic method with ultraviolet detection.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020105

• Increased urinary excretion of toxic hydrazino metabolites of isoniazid by slow acetylators. Effect of a slow-release preparation of isoniazid.

  European journal of clinical pharmacology 19870101

• Antituberculous compounds. 23. Alkyl- and acylisonicotinic acid hydrazides.

  Journal of medicinal chemistry 19651101