108179-91-5 | SKF 83566 hydrobromide

Packsize	Purity	Availability	Price	Discounted Price
5mg	95%	in stock	$80.00	$56.00
10mg	95%	in stock	$123.00	$86.00
25mg	95%	in stock	$250.00	$175.00

Description

• Catalog Number: AB79005
• Chemical Name: SKF 83566 hydrobromide
• CAS Number: 108179-91-5
• Molecular Formula: C17H19Br2NO
• Molecular Weight: 413.1469
• MDL Number: MFCD04039787
• SMILES: CN1CCc2c(C(C1)c1ccccc1)cc(c(c2)Br)O.Br

Computed Properties

• Complexity: 318
• Covalently-Bonded Unit Count: 2
• Heavy Atom Count: 21
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 1
• Undefined Atom Stereocenter Count: 1

Upstream Synthesis Route

8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrobromide plays a crucial role in chemical synthesis as a versatile building block. Its unique chemical structure makes it a valuable intermediate in the creation of various organic compounds. This compound can be used to introduce the 8-bromo, 3-methyl, 5-phenyl, and hydroxyl functional groups into target molecules, allowing for the synthesis of complex and diverse chemical structures. With its ability to participate in a range of reactions, 8-Bromo-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrobromide is a valuable tool for chemists seeking to design and construct novel organic molecules for pharmaceuticals, materials science, and other applications.

Literature

• SKF 83566 attenuates the effects of ghrelin on performance in the object location memory task.

  Neuroscience letters 20111031

• SKF-83566, a D1-dopamine receptor antagonist, inhibits the dopamine transporter.

  Journal of neurochemistry 20110901

• Identification and evolutionary implications of neurotransmitter-ciliary interactions underlying the behavioral response to hypoxia in Lymnaea stagnalis embryos.

  The Journal of experimental biology 20110815

• D1 receptor antagonist-induced long-term depression in the medial prefrontal cortex of rat, in vivo: an animal model of psychiatric hypofrontality.

  Journal of psychopharmacology (Oxford, England) 20090801

• Ethanol facilitates glutamatergic transmission to dopamine neurons in the ventral tegmental area.

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090101

• Methamphetamine enhances HIV infection of macrophages.

  The American journal of pathology 20080601

• Evidence for the sensitivity of operant timing behaviour to stimulation of D1 dopamine receptors.

  Psychopharmacology 20071201

• Dopamine reduction of GABA currents in striatal medium-sized spiny neurons is mediated principally by the D(1) receptor subtype.

  Neurochemical research 20070201

• The serial reaction time task in the rat: effects of D1 and D2 dopamine-receptor antagonists.

  Behavioural brain research 20061215

• Effects of d-amphetamine and DOI (2,5-dimethoxy-4-iodoamphetamine) on timing behavior: interaction between D1 and 5-HT2A receptors.

  Psychopharmacology 20061201

• Evidence for a role of D1 dopamine receptors in d-amphetamine's effect on timing behaviour in the free-operant psychophysical procedure.

  Psychopharmacology 20060401

• The signal transduction pathway for the dopamine D1 receptor in the guinea-pig cochlea.

  Neuroscience 20060201

• Dopamine D1-like receptor-mediated inhibition of Cl/HCO3- exchanger activity in rat intestinal epithelial IEC-6 cells is regulated by G protein-coupled receptor kinase 6 (GRK 6).

  Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20060101

• Stepholidine protects against H2O2 neurotoxicity in rat cortical neurons by activation of Akt.

  Neuroscience letters 20050805

• Involvement of G protein-coupled receptor kinase 4 and 6 in rapid desensitization of dopamine D1 receptor in rat IEC-6 intestinal epithelial cells.

  American journal of physiology. Regulatory, integrative and comparative physiology 20041001

• Dopamine D3 receptor-mediated inhibition of Na+/H+ exchanger activity in normotensive and spontaneously hypertensive rat proximal tubular epithelial cells.

  British journal of pharmacology 20040801

• Dopamine stimulates snail albumen gland glycoprotein secretion through the activation of a D1-like receptor.

  The Journal of experimental biology 20040601

• Age-related modifications of the morphological organization of pituicytes are associated with alteration of the GABAergic and dopaminergic innervation afferent to the neurohypophysial lobe.

  The European journal of neuroscience 20031001

• Dopamine effect on the stimulus pattern related changes in response characteristics of R/G horizontal cells in carp retina.

  Brain research 20030530

• Dopamine modulation of activity of cat sensorimotor cortex neurons during conditioned reflexes.

  Neuroscience letters 20020920

• D2-like receptor-mediated inhibition of Na+-K+-ATPase activity is dependent on the opening of K+ channels.

  American journal of physiology. Renal physiology 20020701

• Dopamine antagonists alter response allocation but do not suppress appetite for food in rats: contrast between the effects of SKF 83566, raclopride, and fenfluramine on a concurrent choice task.

  Psychopharmacology 20020401

• Deafferentation-induced abnormal neurofilament phosphorylation in red nucleus neurones.

  Neuropathology and applied neurobiology 20011201

• Ouabain-insensitive acidification by dopamine in renal OK cells: primary control of the Na(+)/H(+) exchanger.

  American journal of physiology. Regulatory, integrative and comparative physiology 20010701

• Stimulus properties of 7-OH-DPAT versus auto- and postsynaptic receptor-specific doses of quinpirole.

  Pharmacology, biochemistry, and behavior 20010301

• Role of dopamine D1 receptors in the lethal effects of cocaine and a quaternary methiodide analog.

  The Journal of pharmacology and experimental therapeutics 19931001