109-11-5 | Morpholin-3-one

Packsize	Purity	Availability	Price	Discounted Price
5g	97%	in stock	$8.00	$5.00
10g	98% GC	in stock	$11.00	$8.00
25g	98% GC	in stock	$26.00	$18.00
100g	95%	in stock	$89.00	$63.00
500g	98% GC	in stock	$218.00	$153.00

Description

• Catalog Number: AB65191
• Chemical Name: Morpholin-3-one
• CAS Number: 109-11-5
• Molecular Formula: C4H7NO2
• Molecular Weight: 101.1039
• MDL Number: MFCD00631009
• SMILES: O=C1COCCN1
• NSC Number: 11688

Computed Properties

• Complexity: 81.8
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 7
• Hydrogen Bond Acceptor Count: 2
• Hydrogen Bond Donor Count: 1
• XLogP3: -0.8

Literature

• Remodelling of the natural product fumagillol employing a reaction discovery approach.

  Nature chemistry 20111201

• 4-(3-Fluoro-4-nitro-phen-yl)morpholin-3-one.

  Acta crystallographica. Section E, Structure reports online 20110601

• Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent.

  Bioorganic & medicinal chemistry letters 20110315

• Metabolism and excretion of rivaroxaban, an oral, direct factor Xa inhibitor, in rats, dogs, and humans.

  Drug metabolism and disposition: the biological fate of chemicals 20090501

• In vitro metabolism of rivaroxaban, an oral, direct factor Xa inhibitor, in liver microsomes and hepatocytes of rats, dogs, and humans.

  Drug metabolism and disposition: the biological fate of chemicals 20090501

• Morpholinone mediated oxazolone-free C-terminus amide coupling permitting a convergent strategy for peptide synthesis.

  Journal of peptide science : an official publication of the European Peptide Society 20090101

• Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells.

  Bioorganic & medicinal chemistry 20070601

• Acid- and base-catalyzed hydrolysis of chloroacetamide herbicides.

  Journal of agricultural and food chemistry 20060628

• Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12.

  Journal of molecular biology 20040820

• Synthesis and application of methyleneoxy pseudodipeptide building blocks in biologically active peptides.

  Amino acids 20040801

• Novel 6-hydroxy-3-morpholinones as cornea permeable calpain inhibitors.

  Bioorganic & medicinal chemistry 20031201

• N-Arylated pyrrolidin-2-ones and morpholin-3-ones as potassium channel openers.

  Bioorganic & medicinal chemistry 20021001

• Conformations and receptor activity of desmopressin analogues, which contain gamma-turn mimetics or a psi[CH(2)O] isostere.

  Journal of medicinal chemistry 20020606

• Novel morpholinone-based D-Phe-Pro-Arg mimics as potential thrombin inhibitors: design, synthesis, and X-ray crystal structure of an enzyme inhibitor complex.

  Bioorganic & medicinal chemistry 20020601

• In vitro inhibition studies of phytoene desaturase by bleaching ketomorpholine derivatives.

  Journal of agricultural and food chemistry 20010101