1094873-14-9 | Jnj-31020028

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$12.00	$9.00
5mg	98%	in stock	$28.00	$19.00
10mg	98%	in stock	$42.00	$30.00
25mg	98%	in stock	$69.00	$49.00
50mg	98%	in stock	$116.00	$82.00

Description

• Catalog Number: AE10391
• Chemical Name: Jnj-31020028
• CAS Number: 1094873-14-9
• Molecular Formula: C34H36FN5O2
• Molecular Weight: 565.6803431999998
• MDL Number: MFCD18782744
• SMILES: CCN(C(=O)C(c1ccccc1)N1CCN(CC1)c1ccc(cc1F)NC(=O)c1ccccc1c1cccnc1)CC

Computed Properties

• Complexity: 857
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 42
• Hydrogen Bond Acceptor Count: 6
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 9
• Undefined Atom Stereocenter Count: 1
• XLogP3: 5.3

Literature

• Anorectic response to the trichothecene T-2 toxin correspond to plasma elevations of the satiety hormone glucose-dependent insulinotropic polypeptide and peptide YY(3-36).

  Toxicology 20180601

• Role of Y(2) receptors in the regulation of gastric tone in rats.

  American journal of physiology. Gastrointestinal and liver physiology 20120401

• Effects of a selective Y2R antagonist, JNJ-31020028, on nicotine abstinence-related social anxiety-like behavior, neuropeptide Y and corticotropin releasing factor mRNA levels in the novelty-seeking phenotype.

  Behavioural brain research 20110923

• The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide Y Y₂ receptor.

  Bioorganic & medicinal chemistry letters 20110915

• The novel, selective, brain-penetrant neuropeptide Y Y2 receptor antagonist, JNJ-31020028, tested in animal models of alcohol consumption, relapse, and anxiety.

  Alcohol (Fayetteville, N.Y.) 20110901

• In vitro and in vivo characterization of JNJ-31020028 (N-(4-{4-[2-(diethylamino)-2-oxo-1-phenylethyl]piperazin-1-yl}-3-fluorophenyl)-2-pyridin-3-ylbenzamide), a selective brain penetrant small molecule antagonist of the neuropeptide Y Y(2) receptor.

  Psychopharmacology 20100201

• Correlation of 14C-griseofulvin metabolism in rat liver microsomes, isolated perfused rat livers, and in rats with bile duct cannulas.

  Drug metabolism and disposition: the biological fate of chemicals 19750101