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From the Cover: Sperm Molecular Biomarkers Are Sensitive Indicators of Testicular Injury following Subchronic Model Toxicant Exposure.
Toxicological sciences : an official journal of the Society of Toxicology 20161001
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Apoptosis of rat ovarian granulosa cells by 2,5-hexanedione in vitro and its relevant gene expression.
Journal of applied toxicology : JAT 20130701
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2,5-hexanedione altered the degradation of low-molecular-weight neurofilament in rat nerve tissues.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20121201
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Exposure to 2,5-hexanedione can induce neural malformations in chick embryos.
Neurotoxicology 20121001
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Molecular alterations underlying the enhanced disruption of spermatogenesis by 2,5-hexanedione and carbendazim co-exposure.
Reproductive toxicology (Elmsford, N.Y.) 20120601
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[Effect of 2,5-hexanedione on light-molecular-weight neurofilaments (NF-L) degradation of rat nerve tissues].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20120601
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[Studying the damages of mouse retina induced by 2,5-hexanedione].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20120501
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2,5-Hexanedione induces human ovarian granulosa cell apoptosis through BCL-2, BAX, and CASPASE-3 signaling pathways.
Archives of toxicology 20120201
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The effects of idebenone on mitochondrial bioenergetics.
Biochimica et biophysica acta 20120201
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Optimization of a filter-lysis protocol to purify rat testicular homogenates for automated spermatid counting.
Journal of andrology 20120101
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Analysis of volatile organic compounds released from human lung cancer cells and from the urine of tumor-bearing mice.
Cancer cell international 20120101
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Sperm mRNA transcripts are indicators of sub-chronic low dose testicular injury in the Fischer 344 rat.
PloS one 20120101
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Communication: stabilization of radical anions with weakly bound electron in condensed media: a case study of diacetonyl radical anion.
The Journal of chemical physics 20110914
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The high dosage of earthworm (Eisenia andrei) extract decreases cell proliferation and neuroblast differentiation in the mouse hippocampal dentate gyrus.
Anatomy & cell biology 20110901
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External quality assessment scheme for biological monitoring of occupational exposure to toxic chemicals.
Safety and health at work 20110901
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The effect of 2,5-hexanedione on myelin protein zero expression, and its mitigation using Ginkgo biloba extract.
Biomedical and environmental sciences : BES 20110801
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E6 and E7 from beta HPV38 cooperate with ultraviolet light in the development of actinic keratosis-like lesions and squamous cell carcinoma in mice.
PLoS pathogens 20110701
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[Effects of n-hexane exposure on human serum myelin basic proteins].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20110601
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Carboxyl-terminus of Hsc70 interacting protein mediates 2,5-hexanedione-induced neurofilament medium chain degradation.
Biochemical pharmacology 20110315
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Mitochondrial optic neuropathies - disease mechanisms and therapeutic strategies.
Progress in retinal and eye research 20110301
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The chemistry of acetone at extreme conditions by density functional molecular dynamics simulations.
The Journal of chemical physics 20110214
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[Effects on serum myelin proteins of n-hexane exposure].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20110201
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Leber's Hereditary Optic Neuropathy-Gene Therapy: From Benchtop to Bedside.
Journal of ophthalmology 20110101
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Spinal cord injury causes sustained disruption of the blood-testis barrier in the rat.
PloS one 20110101
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Microwave assisted solvent free synthesis of 1,3-diphenylpropenones.
Chemistry Central journal 20110101
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[Effects of garlic oil, age and sex on n-hexane metabolism in rats].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20110101
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Physiologically based pharmacokinetic modeling: methodology, applications, and limitations with a focus on its role in pediatric drug development.
Journal of biomedicine & biotechnology 20110101
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A case study on co-exposure to a mixture of organic solvents in a Tunisian adhesive-producing company.
Journal of occupational medicine and toxicology (London, England) 20110101
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Occupational neurological disorders in Korea.
Journal of Korean medical science 20101201
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Occupational diseases in Korea.
Journal of Korean medical science 20101201
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Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. III. Candidate gene analysis identifies a role for fas in the attenuation of X-ray-induced apoptosis.
Toxicological sciences : an official journal of the Society of Toxicology 20101001
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Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. I. Histopathological analysis reveals stage dependence of attenuated apoptosis.
Toxicological sciences : an official journal of the Society of Toxicology 20101001
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Suppression of radiation-induced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. II. Gene array analysis reveals adaptive changes in cell cycle and cell death pathways.
Toxicological sciences : an official journal of the Society of Toxicology 20101001
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Gamma-diketone axonopathy: analyses of cytoskeletal motors and highways in CNS myelinated axons.
Toxicological sciences : an official journal of the Society of Toxicology 20100901
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The effect of 2,5-hexanedione on permeability of blood-nerve barrier in rats.
Human & experimental toxicology 20100601
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Occupational neurologic disorders in Korea.
Journal of clinical neurology (Seoul, Korea) 20100601
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[Effect of 2,5-hexanedione on myelin protein zero in sciatic nerve and its antibody in serum of rats at different time points].
Wei sheng yan jiu = Journal of hygiene research 20100501
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Highly efficient and stereoselective biosynthesis of (2S,5S)-hexanediol with a dehydrogenase from Saccharomyces cerevisiae.
Organic & biomolecular chemistry 20100407
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Remarkable iodine-catalyzed synthesis of novel pyrrole-bearing N-polyaromatic beta-lactams.
Molecules (Basel, Switzerland) 20100223
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Degradation of hexane and other recalcitrant hydrocarbons by a novel isolate, Rhodococcus sp. EH831.
Environmental science and pollution research international 20100101
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[The effect of 2,5-hexanedione on nerve growth factor in sciatic nerve of rats and VSC4.1 cell].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20100101
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Engineering cofactor preference of ketone reducing biocatalysts: A mutagenesis study on a γ-diketone reductase from the yeast Saccharomyces cerevisiae serving as an example.
International journal of molecular sciences 20100101
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New automated and high-throughput quantitative analysis of urinary ketones by multifiber exchange-solid phase microextraction coupled to fast gas chromatography/negative chemical-electron ionization/mass spectrometry.
Journal of automated methods & management in chemistry 20100101
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Evidence for sub-haplogroup h5 of mitochondrial DNA as a risk factor for late onset Alzheimer's disease.
PloS one 20100101
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Mitochondrial DNA sequence variation and haplogroup distribution in Chinese patients with LHON and m.14484T>C.
PloS one 20100101
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Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging: a GEHA study.
PloS one 20100101
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New insights into mechanisms of gamma-diketone-induced axonopathy.
Neurochemical research 20091101
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1,5-Bis(2,5-dimethyl-1H-pyrrol-1-yl)naphthalene.
Acta crystallographica. Section E, Structure reports online 20091101
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Workplace exposures and the risk of amyotrophic lateral sclerosis.
Environmental health perspectives 20090901
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The effect of workload on biological monitoring of occupational exposure to toluene and n-Hexane: contribution of physiologically based toxicokinetic modeling.
Journal of occupational and environmental hygiene 20090701
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2,2',5,5'-Tetra-methyl-1,1'-(hexane-1,6-di-yl)di-1H-pyrrole.
Acta crystallographica. Section E, Structure reports online 20090701
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Neurotoxic effect of 2,5-hexanedione on neural progenitor cells and hippocampal neurogenesis.
Toxicology 20090616
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Determination of 2,5-hexanedione in urine by headspace solid-phase microextraction and gas chromatography.
Journal of analytical toxicology 20090501
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[Effects of garlic oil on n-hexane metabolized to 2, 5-hexanedione in mice serum].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20090501
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Probing mechanisms of axonopathy. Part II: Protein targets of 2,5-hexanedione, the neurotoxic metabolite of the aliphatic solvent n-hexane.
Toxicological sciences : an official journal of the Society of Toxicology 20090201
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Comparative covalent protein binding of 2,5-hexanedione and 3-acetyl-2,5-hexanedione in the rat.
Journal of toxicology and environmental health. Part A 20090101
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The background of mitochondrial DNA haplogroup J increases the sensitivity of Leber's hereditary optic neuropathy cells to 2,5-hexanedione toxicity.
PloS one 20090101
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[Effects of garlic oil on 2, 5-HD induced lipid peroxidation damage in rat nerve tissues].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20081101
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2,5-hexanedione (HD) treatment alters calmodulin, Ca2+/calmodulin-dependent protein kinase II, and protein kinase C in rats' nerve tissues.
Toxicology and applied pharmacology 20081001
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[Dynamic study of neurofilament contents in rat's spinal cord induced by 2, 5-hexanedione].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20081001
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Resveratrol reestablishes spermatogenesis after testicular injury in rats caused by 2, 5-hexanedione.
Chinese medical journal 20080705
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Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures.
Extremophiles : life under extreme conditions 20080701
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Involvement of cyclin-dependent kinase 5 in 2,5-hexanedione-induced neuropathy.
Toxicology 20080603
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Re-establishment of spermatogenesis by diethylstilbestrol after 2,5-hexanedione-induced irreversible testicular atrophy in rats.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080401
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Polyneuropathy induced by n-hexane intoxication in Taiwan.
Acta neurologica Taiwanica 20080301
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Changes of cytoskeletal proteins in nerve tissues and serum of rats treated with 2,5-hexanedione.
Toxicology 20080227
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The reversibility of neurofilaments decline induced by 2,5-hexanedione in rat nerve tissues.
Biochemical pharmacology 20080201
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A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y.
Basic & clinical pharmacology & toxicology 20080101
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Inhalant abuse detection and evaluation in young Tunisians.
Journal of forensic sciences 20080101
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Spermatid head retention as a marker of 2,5-hexanedione-induced testicular toxicity in the rat.
Toxicologic pathology 20080101
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Expression of Bcl-2, Bax and Caspase-3 in nerve tissues of rats chronically exposed to 2,5-hexanedione.
Neurochemical research 20070901
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Enzymatic characteristics of an aldo-keto reductase family protein (AKR1C15) and its localization in rat tissues.
Archives of biochemistry and biophysics 20070901
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Time-dependent alteration of cytoskeletal proteins in cerebral cortex of rat during 2,5-hexanedione-induced neuropathy.
Neurochemical research 20070801
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Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2-ethylhexyl) phthalate in adult rat testis.
Toxicologic pathology 20070801
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Effect of physical exertion on the biological monitoring of exposure to various solvents following exposure by inhalation in human volunteers: II. n-Hexane.
Journal of occupational and environmental hygiene 20070701
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[Resveratrol helps restore spermatogenesis after testis injury induced by 2,5-hexanedione].
Zhonghua nan ke xue = National journal of andrology 20070701
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Diketone radical cations: ketonic and enolic forms as revealed by matrix EPR studies and DFT calculations.
The journal of physical chemistry. A 20070503
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[Effect of nerve growth factor on mitochondrion dysfunction of motor neuron induced by 2,5-hexanedione].
Wei sheng yan jiu = Journal of hygiene research 20070501
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Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH.
Toxicology 20070307
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Two new reactive targets of 2,5-hexanedione in vitro - beta-alanine and glycine.
Amino acids 20070201
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Activation of soluble guanylate cyclase by nitric oxide is increased in lymphocytes from both rats chronically exposed to 2,5-hexanedione and workers chronically exposed to n-hexane.
Toxicology 20070105
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Grand rounds: could occupational exposure to n-hexane and other solvents precipitate visual failure in leber hereditary optic neuropathy?
Environmental health perspectives 20070101
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Working conditions and related neuropsychiatric problems among shoemakers in Turkey: Do child workers differ from others?
Indian journal of occupational and environmental medicine 20070101
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The toxicity of hexanedione isomers in neural and astrocytic cell lines.
Environmental toxicology and pharmacology 20061101
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Synthesis of enantiopure (5R)-hydroxyhexane-2-one with immobilised whole cells of Lactobacillus kefiri.
Applied microbiology and biotechnology 20060701
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Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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[Effect of 2, 5-hexanedione on calcium homeostasis of motor neuron].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060501
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Changes in cytosolic Ca2+ levels regulate Bcl-xS and Bcl-xL expression in spermatogenic cells during apoptotic death.
The Journal of biological chemistry 20060127
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Association between metabolic gene polymorphisms and susceptibility to peripheral nerve damage in workers exposed to n-hexane: a preliminary study.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20060101
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Gamma-Diketone central neuropathy: quantitative analyses of cytoskeletal components in myelinated axons of the rat rubrospinal tract.
Neurotoxicology 20051201
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Protein adduct formation as a molecular mechanism in neurotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology 20050801
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Effects of male reproductive toxicants on gene expression in rat testes.
The Journal of toxicological sciences 20050801
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2,5-Hexanedione induced reduction in protein content and mRNA expression of neurofilament in rat cerebral cortex.
Environmental toxicology and pharmacology 20050701
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Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants.
The Journal of toxicological sciences 20050501
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[Effects of 2,5-hexanedione on NGF expression in motor and sensory neuronal cells of rats].
Wei sheng yan jiu = Journal of hygiene research 20050501
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2,5-Hexanedione-induced changes in the neurofilament subunit pools of rat peripheral nerve.
Neurotoxicology 20050301
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Physiologically based modeling of n-hexane kinetics in humans following inhalation exposure at rest and under physical exertion: impact on free 2,5-hexanedione in urine and on n-hexane in alveolar air.
Journal of occupational and environmental hygiene 20050201
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2,5-Hexanedione induced decrease in cytoskeletal proteins of rat sciatic-tibial nerve.
Neurochemical research 20050201
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Are sperm parameters the best indicator of 2,5-hexanedione reproductive toxicity in male rats?
Reproductive toxicology (Elmsford, N.Y.) 20050101
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Microwave-assisted derivatization of 2,5-hexanedione in urine: evaluation using GC-MS and GC-ECD.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041225
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Some pyrrole substituted aryl pyridazinone and phthalazinone derivatives and their antihypertensive activities.
European journal of medicinal chemistry 20041201
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gamma-Diketone neuropathy: axon atrophy and the role of cytoskeletal protein adduction.
Toxicology and applied pharmacology 20040815
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2,5-hexanedione and carbendazim coexposure synergistically disrupts rat spermatogenesis despite opposing molecular effects on microtubules.
Toxicological sciences : an official journal of the Society of Toxicology 20040701
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2,5-Hexanedione-induced changes in the monomeric neurofilament protein content of rat spinal cord fractions.
Toxicology and applied pharmacology 20040701
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Nature is complex: our orchestra seats at the most wonderful show on earth.
Toxicological sciences : an official journal of the Society of Toxicology 20040701
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Comparison of unchanged n-hexane in alveolar air and 2,5-hexanedione in urine for the biological monitoring of n-hexane exposure in human volunteers.
International archives of occupational and environmental health 20040501
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Pyridoxamine: an extremely potent scavenger of 1,4-dicarbonyls.
Chemical research in toxicology 20040301
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2,5-Hexanedione inhibits rat brain acetylcholinesterase activity in vitro.
Toxicology letters 20040202
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Free and total 2,5-hexanedione in biological monitoring of workers exposed to n-hexane in the shoe industry.
Toxicology letters 20031210
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gamma-diketone central neuropathy: quantitative morphometric analysis of axons in rat spinal cord white matter regions and nerve roots.
Toxicology and applied pharmacology 20031115
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Protection of the amino group of adenosine and guanosine derivatives by elaboration into a 2,5-dimethylpyrrole moiety.
Organic letters 20030904
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Chronic exposure to 2,5-hexanedione impairs the glutamate-nitric oxide-cyclic GMP pathway in cerebellar neurons in culture and in rat brain in vivo.
Neurochemistry international 20030601
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Poor metabolization of n-hexane in Parkinson's disease.
Journal of neurology 20030501
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Occupational exposure to n-hexane in Italy--analysis of a registry of biological monitoring.
International archives of occupational and environmental health 20030501
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2,5-hexanedione-induced testicular injury.
Annual review of pharmacology and toxicology 20030101
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Evidence of zinc protection against 2,5-hexanedione neurotoxicity: correlation of neurobehavioral testing with biomarkers of excretion.
Neurotoxicology 20021201
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Behavioral and electrophysiological responses of natural enemies to synomones from tea shoots and kairomones from tea aphids, Toxoptera aurantii.
Journal of chemical ecology 20021101
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Evaluation of 2,5-hexanedione in urine of workers exposed to n-hexane in Brazilian shoe factories.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021005
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Finnish quality assurance programme for biological monitoring of organic solvents.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021005
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Amino acid and protein targets of 1,2-diacetylbenzene, a potent aromatic gamma-diketone that induces proximal neurofilamentous axonopathy.
Toxicology and applied pharmacology 20020815
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Changes in n-hexane toxicokinetics in short-term single exposure due to co-exposure to methyl ethyl ketone in volunteers.
International archives of occupational and environmental health 20020801
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Selective regional alterations in the content or distribution of neuronal and glial cytoskeletal proteins in brain of rats chronically exposed to 2,5-hexanedione.
Toxicology and industrial health 20020801
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Partial conduction blocks in N-hexane neuropathy.
Muscle & nerve 20020701
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Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione.
Neurotoxicology 20020501
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Diastereoselective synthesis of optically active (2 R,5 R)-hexanediol.
Applied microbiology and biotechnology 20020401
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Early spatial memory deficit induced by 2,5-hexanedione in the rat.
Toxicology letters 20020310
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Aromatic as well as aliphatic hydrocarbon solvent axonopathy.
International journal of hygiene and environmental health 20020301
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Toxicokinetic interaction of 2,5-hexanedione and methyl ethyl ketone.
Archives of toxicology 20020101
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Computerized posturography with sway frequency analysis: application in occupational and environmental health.
Industrial health 20020101
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Cytogenetic analysis of buccal cells from shoe-workers and pathology and anatomy laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20020101
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Urinary 2,5 hexanedione as a biomarker of n-hexane exposure.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 20020101
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Spectrophotometric analysis of solubilized rat hair proteins following intraperitoneal injection of 2,5-hexanedione.
Toxicology mechanisms and methods 20020101
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Overview of studies on rat sperm motion analysis using a Hamilton-Thorne Sperm Analyzer--collaborative working study.
The Journal of toxicological sciences 20011201
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Biological monitoring of n-hexane exposure in Portuguese shoe manufacturing workers.
Applied occupational and environmental hygiene 20010701
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Neurofilaments are nonessential to the pathogenesis of toxicant-induced axonal degeneration.
The Journal of neuroscience : the official journal of the Society for Neuroscience 20010401
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Gamma-diketone peripheral neuropathy III. Neurofilament gene expression.
Neurotoxicology 20010401
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Novel 2,5-hexanedione analogues. Substituent-induced control of the protein cross-linking potential and oxidation susceptibility of the resulting primary amine-derived pyrroles.
Chemical research in toxicology 20010301
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Interaction of zinc on biomarker responses in rats exposed to 2,5-hexanedione by two routes of exposure.
Toxicology letters 20010203
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Spermatogenesis by Sisyphus: proliferating stem germ cells fail to repopulate the testis after 'irreversible' injury.
Advances in experimental medicine and biology 20010101
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Functional Cyp2e1 is required for substantial in vivo formation of 2,5-hexanedione from n-hexane in the mouse.
Archives of toxicology 20001201
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Rat epididymal sperm motion changes induced by ethylene glycol monoethyl ether, sulfasalazine, and 2,5-hexandione.
Reproductive toxicology (Elmsford, N.Y.) 20000101
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Effects of n-hexane and its metabolites on cloned voltage-operated neuronal potassium channels.
Archives of toxicology 19970101
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Endpoints of spermatotoxicity in the rat after short duration exposures to fourteen reproductive toxicants.
Reproductive toxicology (Elmsford, N.Y.) 19920101
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Phenylmethanesulfonyl fluoride elicits and intensifies the clinical expression of neuropathic insults.
Archives of toxicology 19920101
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The same chemicals induce different neurotoxicity when administered in high doses for short term or low doses for long term to rats and dogs.
Molecular and chemical neuropathology 19920101
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Dose-dependent cytotoxicity of chlorinated hydrocarbons in isolated rat hepatocytes.
Fundamental and applied toxicology : official journal of the Society of Toxicology 19900501
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Ultrastructural studies of the dying-back process. VI. Examination of nerve fibers undergoing giant axonal degeneration in organotypic culture.
Journal of neuropathology and experimental neurology 19830301
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The neurotoxins 2,5-hexanedione and acrylamide promote aggregation of intermediate filaments in cultured fibroblasts.
Muscle & nerve 19830101
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Potentiation of chlorinated hydrocarbon toxicity by 2,5-hexanedione in primary cultures of adult rat hepatocytes.
Fundamental and applied toxicology : official journal of the Society of Toxicology 19830101
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Role of biotransformation in the potentiation of halocarbon hepatotoxicity by 2,5-hexanedione.
Journal of toxicology and environmental health 19820101
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Clioquinol and 2,5-hexanedione induce different types of distal axonopathy in the dog.
Acta neuropathologica 19790801
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Experimental neuropathy produced by 2,5-hexanedione--a major metabolite of the neurotoxic industrial solvent methyl n-butyl ketone.
Journal of neurology, neurosurgery, and psychiatry 19750801