110-16-7 | Maleic acid

Packsize	Purity	Availability	Price	Discounted Price
100g	99%	in stock	$9.00	$6.00
500g	99%	in stock	$32.00	$22.00

Description

• Catalog Number: AB51414
• Chemical Name: Maleic acid
• CAS Number: 110-16-7
• Molecular Formula: C4H4O4
• Molecular Weight: 116.0722
• MDL Number: MFCD00063177
• SMILES: OC(=O)C=CC(=O)O
• NSC Number: 25940

Computed Properties

• Complexity: 119
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 8
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 2
• XLogP3: -0.3

Upstream Synthesis Route

Maleic Acid, a versatile chemical compound widely utilized in chemical synthesis, serves a crucial role as a precursor in various reactions. Its carboxyl groups enable it to undergo diverse chemical transformations, making it a fundamental building block in organic chemistry.Maleic Acid finds extensive application in the synthesis of polyester resins, essential components in the production of fiberglass, coatings, and adhesives. Its reactive nature allows for the formation of ester linkages with alcohols, leading to the creation of polyester polymers with desirable properties such as strength, flexibility, and heat resistance.Furthermore, Maleic Acid is an important intermediate in the manufacture of agricultural chemicals such as insecticides and herbicides. By reacting Maleic Acid with other compounds, chemists can synthesize pesticide formulations that effectively target pests while minimizing environmental impact.In addition, Maleic Acid plays a key role in the pharmaceutical industry, where it is utilized in the synthesis of various drugs and pharmaceutical intermediates. Its ability to form stable and bioactive compounds makes it a valuable component in the production of medications that target specific health conditions.Overall, the versatile applications of Maleic Acid in chemical synthesis make it a vital ingredient in various industries, contributing to the development of innovative products and materials.

Literature

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  British journal of pharmacology 20170501

• Profiling transcriptomes of human SH-SY5Y neuroblastoma cells exposed to maleic acid.

  PeerJ 20170101

• Forskolin-free cAMP assay for Gi-coupled receptors.

  Biochemical pharmacology 20151201

• Curcumin prevents maleate-induced nephrotoxicity: relation to hemodynamic alterations, oxidative stress, mitochondrial oxygen consumption and activity of respiratory complex I.

  Free radical research 20141101

• Evaluation of aggregating brain cell cultures for the detection of acute organ-specific toxicity.

  Toxicology in vitro : an international journal published in association with BIBRA 20130601

• Improved methodology for the preparation of water-soluble maleimide-functionalized small gold nanoparticles.

  Langmuir : the ACS journal of surfaces and colloids 20120821

• An assessment of the ocular safety of excipient maleic acid following intravitreal injection in rabbits.

  Toxicologic pathology 20120701

• [A randomized, double-blind, double-dummy, controlled, multicenter study of entecavir maleate versus entecavir for treatment of HBeAg-negative chronic hepatitis B: results at week 48].

  Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20120701

• Residual activity of chelating agents and their combinations with cetrimide on root canals infected with Enterococcus faecalis.

  Journal of endodontics 20120601

• Effect of different final irrigation solutions on dentinal tubule penetration depth and percentage of root canal sealer.

  Journal of endodontics 20120601

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• The guanidine and maleic acid (1:1) complex. The additional theoretical and experimental studies.

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• Synthesis, structural, optical and thermal studies of an organic nonlinear optical 4-aminopyridinium maleate single crystal.

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• Rationally designed oxaliplatin-nanoparticle for enhanced antitumor efficacy.

  Nanotechnology 20120224

• The dynamic viscoelasticity and water absorption characteristics of soft acrylic resin materials containing adipates and a maleate plasticizer.

  Dental materials journal 20120203

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  Chemosphere 20120201

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• Kinetic, equilibrium and thermodynamic studies of cadmium (II) adsorption by modified agricultural wastes.

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• Solid/Liquid phase diagram of the ammonium sulfate/maleic acid/water system.

  The journal of physical chemistry. A 20111201

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• Evaluation of decalcifying effect of maleic acid and EDTA on root canal dentin using energy dispersive spectrometer.

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• (rac)-1,1'-binaphthyl-based simple receptors designed for fluorometric discrimination of maleic and fumaric acids.

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• Renal cortical albumin gene induction and urinary albumin excretion in response to acute kidney injury.

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• Antimicrobial activity of maleic acid and combinations of cetrimide with chelating agents against Enterococcus faecalis biofilm.

  Journal of endodontics 20101001

• Spectroscopic and physicochemical studies on organic crystal of brucine hydrogen maleate pentahydrate.

  Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20100915

• Ozonolysis of maleic acid aerosols: effect upon aerosol hygroscopicity, phase and mass.

  Environmental science & technology 20100901

• A covalent succinylcysteine-like intermediate in the enzyme-catalyzed transformation of maleate to fumarate by maleate isomerase.

  Journal of the American Chemical Society 20100825

• Evaluation of the effect of maleic acid and ethylenediaminetetraacetic acid on the microhardness and surface roughness of human root canal dentin.

  Journal of endodontics 20100801

• Z and E isomers of butenedioic acid with 2-amino-1,3-thiazole: 2-amino-1,3-thiazolium hydrogen maleate and 2-amino-1,3-thiazolium hydrogen fumarate.

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• Disruption of BCAA metabolism in mice impairs exercise metabolism and endurance.

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• Dicarboxylic acid transport through hematite-coated sand.

  Chemosphere 20100201

• Growth and characterization of NLO based L-arginine maleate dihydrate single crystal.

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• Comparison of the efficacy of maleic acid and ethylenediaminetetraacetic acid in smear layer removal from instrumented human root canal: a scanning electron microscopic study.

  Journal of endodontics 20091101

• A comparative in vitro evaluation of cytotoxic effects of EDTA and maleic acid: root canal irrigants.

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• Factors influencing catalytic wet peroxide oxidation of maleic acid in aqueous phase over copper/micelle templated silica-3-aminopropyltrimethoxysilane catalyst.

  Water science and technology : a journal of the International Association on Water Pollution Research 20090101

• Kinetic modeling analysis of maleic acid-catalyzed hemicellulose hydrolysis in corn stover.

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• Endotoxin mediates recruitment of RNA polymerase II to target genes in acute renal failure.

  Journal of the American Society of Nephrology : JASN 20080701

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  International journal of pharmaceutics 20060831

• Protein adsorption from flowing solutions on pure and maleic acid copolymer modified glass particles.

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• Hydrophobic and electrostatic interactions in the adsorption of fibronectin at maleic acid copolymer films.

  The journal of physical chemistry. B 20060622

• Reversibility of structural transition of cytochrome c on interacting with and releasing from alternating copolymers of maleic Acid and alkene.

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• Probing the low-barrier hydrogen bond in hydrogen maleate in the gas phase: a photoelectron spectroscopy and ab initio study.

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• Effect of surfactants on the dissociation constants of ascorbic and maleic acids.

  Colloids and surfaces. B, Biointerfaces 20051125

• The chemometric resolution and quantification of overlapped peaks form comprehensive two-dimensional liquid chromatography.

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• Interactions of apo cytochrome C with alternating copolymers of maleic acid and alkene.

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• pH/temperature - sensitive imprinted ionic poly(N-tert-butylacrylamide-co-acrylamide/maleic acid) hydrogels for bovine serum albumin.

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• Double-quantum filtered 1H MAS NMR spectra.

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