110221-44-8 | Temocapril HCl

Packsize	Purity	Availability	Price	Discounted Price
1mg	98%	in stock	$23.00	$16.00
5mg	98%	in stock	$42.00	$29.00
10mg	98%	in stock	$67.00	$47.00
25mg	98%	in stock	$126.00	$88.00
50mg	98%	in stock	$197.00	$138.00
100mg	98%	in stock	$304.00	$213.00
250mg	98%	in stock	$681.00	$477.00

Description

• Catalog Number: AW55596
• Chemical Name: Temocapril HCl
• CAS Number: 110221-44-8
• Molecular Formula: C23H29ClN2O5S2
• Molecular Weight: 513.0698
• MDL Number: MFCD00933433
• SMILES: CCOC(=O)C(NC1CSC(CN(C1=O)CC(=O)O)c1cccs1)CCc1ccccc1.Cl

Computed Properties

• Complexity: 644
• Covalently-Bonded Unit Count: 2
• Defined Atom Stereocenter Count: 3
• Heavy Atom Count: 33
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 3
• Rotatable Bond Count: 11

Literature

• Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: temocapril as a model case.

  Journal of pharmaceutical sciences 20110901

• Prediction of human intestinal absorption of the prodrug temocapril by in situ single-pass perfusion using rat intestine with modified hydrolase activity.

  Drug metabolism and disposition: the biological fate of chemicals 20110701

• [A ten-year follow-up of a 109-year-old woman with myocardial infarction].

  Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20110101

• [Role of angiontensin receptors in remodeling perivascular nerves].

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20101101

• The effect of angiotensin-converting enzyme inhibitors of left atrial pressure in dogs with mitral valve regurgitation.

  Journal of veterinary internal medicine 20100101

• Effect of angiotensin-converting enzyme inhibitor on serum asymmetric dimethylarginine and coronary circulation in patients with type 2 diabetes mellitus.

  International journal of cardiology 20090220

• Olmesartan and temocapril prevented the development of hyperglycemia and the deterioration of pancreatic islet morphology in Otsuka-Long-Evans-Tokushima Fatty rats.

  Acta medica Okayama 20090201

• In half of hypertensive diabetics, co-administration of a calcium channel blocker and an angiotensin-converting enzyme inhibitor achieved a target blood pressure of <130/80 mmHg: the azelnidipine and temocapril in hypertensive patients with type 2 diabetes (ATTEST) study.

  Hypertension research : official journal of the Japanese Society of Hypertension 20080801

• Beneficial effects of olmesartan and temocapril on urinary liver-type fatty acid-binding protein levels in normotensive patients with immunoglobin A nephropathy.

  American journal of hypertension 20071101

• Effects of monotherapy of temocapril or candesartan with dose increments or combination therapy with both drugs on the suppression of diabetic nephropathy.

  Hypertension research : official journal of the Japanese Society of Hypertension 20070401

• Aldosterone breakthrough during therapy with angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers in proteinuric patients with immunoglobulin A nephropathy.

  Nephrology (Carlton, Vic.) 20061001

• Angiotensin I-converting enzyme inhibitor improves reactive hyperemia in elderly hypertensives with arteriosclerosis obliterans.

  Hypertension research : official journal of the Japanese Society of Hypertension 20060901

• Nephrotic syndrome and IgA nephropathy in polycystic kidney disease.

  Clinical and experimental nephrology 20060601

• Effects of organic anion transporting polypeptide 1B1 haplotype on pharmacokinetics of pravastatin, valsartan, and temocapril.

  Clinical pharmacology and therapeutics 20060501

• Effect on coronary flow velocity reserve in patients with type 2 diabetes mellitus: comparison between angiotensin-converting enzyme inhibitor and angiotensin II type 1 receptor antagonist.

  American heart journal 20060401

• Angiotensin converting enzyme inhibitor attenuates oxidative stress-induced endothelial cell apoptosis via p38 MAP kinase inhibition.

  Clinica chimica acta; international journal of clinical chemistry 20060201

• Identification of esterases expressed in Caco-2 cells and effects of their hydrolyzing activity in predicting human intestinal absorption.

  Drug metabolism and disposition: the biological fate of chemicals 20050801

• Renin-angiotensin system modulates oxidative stress-induced endothelial cell apoptosis in rats.

  Hypertension (Dallas, Tex. : 1979) 20050601

• Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats.

  Hypertension (Dallas, Tex. : 1979) 20050601

• Angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers effectively and directly potentiate superoxide scavenging by polymorphonuclear leukocytes from patients with type 2 diabetes mellitus.

  The American journal of the medical sciences 20050501

• Long-term inhibition of angiotensin prevents reduction of periarterial innervation of calcitonin gene-related peptide (CGRP)-containing nerves in spontaneously hypertensive rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20050501

• Endothelium-derived hydrogen peroxide accounts for the enhancing effect of an angiotensin-converting enzyme inhibitor on endothelium-derived hyperpolarizing factor-mediated responses in mice.

  Arteriosclerosis, thrombosis, and vascular biology 20050401

• Different accumulation of temocapril and enalapril during repeated dosing in elderly patients.

  British journal of clinical pharmacology 20050401

• Temporary angiotensin II blockade at the prediabetic stage attenuates the development of renal injury in type 2 diabetic rats.

  Journal of the American Society of Nephrology : JASN 20050301

• Angiotensin-converting-enzyme inhibitors slow renal decline in IgA nephropathy, independent of tubulointerstitial fibrosis at presentation.

  QJM : monthly journal of the Association of Physicians 20050301

• ACE inhibitor and angiotensin II type 1 receptor blocker differently regulate ventricular fibrosis in hypertensive diastolic heart failure.

  Journal of hypertension 20050201

• Exercise-related syncope induced by vasodilator therapy in an elderly hypertensive patient.

  Journal of the American Geriatrics Society 20050201

• Insulin sensitivity and endothelial function in hypertension: a comparison of temocapril and candesartan.

  American journal of hypertension 20050201

• Renal artery stenosis emerged after angiotensin-converting enzyme inhibitor treatment for myocardial infarction: a case report.

  Angiology 20050101

• Low-dose combination therapy with temocapril and losartan reduces proteinuria in normotensive patients with immunoglobulin a nephropathy.

  Hypertension research : official journal of the Japanese Society of Hypertension 20041201

• Blockade of the renin-angiotensin system decreases adipocyte size with improvement in insulin sensitivity.

  Journal of hypertension 20041001

• Additive beneficial effects of the combination of a calcium channel blocker and an angiotensin blocker on a hypertensive rat-heart failure model.

  Hypertension research : official journal of the Japanese Society of Hypertension 20041001

• Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress.

  Arteriosclerosis, thrombosis, and vascular biology 20040901

• Salutary effects of attenuation of angiotensin II on coronary perivascular fibrosis associated with insulin resistance and obesity.

  Journal of molecular and cellular cardiology 20040801

• Renoprotective effect of angiotensin-converting enzyme inhibitor combined with alpha1-adrenergic antagonist in spontaneously hypertensive rats with renal ablation.

  Hypertension research : official journal of the Japanese Society of Hypertension 20040701

• AT1 receptor blocker added to ACE inhibitor provides benefits at advanced stage of hypertensive diastolic heart failure.

  Hypertension (Dallas, Tex. : 1979) 20040301

• Regulation of skeletal muscle peroxisome proliferator-activated receptor gamma expression by exercise and angiotensin-converting enzyme inhibition in fructose-fed hypertensive rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20040101

• Comparison of urinary excretion of pravastatin and temocapril in bile duct-ligated rats and Eisai hyperbilirubinemic rats (EHBR).

  Journal of hepato-biliary-pancreatic surgery 20040101

• Pharmacological and clinical studies with temocapril, an angiotensin converting enzyme inhibitor that is excreted in the bile.

  Cardiovascular drug reviews 20040101

• Effects of exercise training on glomerular structure in fructose-fed spontaneously hypertensive rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20031101

• Successful treatment of severe hypertension with the combination of angiotensin converting enzyme inhibitor and angiotensin II receptor blocker.

  Hypertension research : official journal of the Japanese Society of Hypertension 20031001

• A newly developed angiotensin II type 1 receptor antagonist, CS866, promotes regression of cardiac hypertrophy by reducing integrin beta1 expression.

  Hypertension research : official journal of the Japanese Society of Hypertension 20030901

• Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO.

  American journal of physiology. Heart and circulatory physiology 20030801

• Human-derived vascular smooth muscle cells produce angiotensin II by changing to the synthetic phenotype.

  Journal of cellular physiology 20030801

• Beneficial effects of angiotensin-converting enzyme inhibition on sarcoplasmic reticulum function in the failing heart of the Dahl rat.

  Circulation journal : official journal of the Japanese Circulation Society 20030801

• Efficacy of various antihypertensive agents as evaluated by indices of vascular stiffness in elderly hypertensive patients.

  Hypertension research : official journal of the Japanese Society of Hypertension 20030801

• Blockade of the renin-angiotensin system increases adiponectin concentrations in patients with essential hypertension.

  Hypertension (Dallas, Tex. : 1979) 20030701

• Should increasing the dose or adding an AT1 receptor blocker follow a relatively low dose of ACE inhibitor initiated in acute myocardial infarction?

  Cardiovascular research 20030601

• Temocapril treatment ameliorates autoimmune myocarditis associated with enhanced cardiomyocyte thioredoxin expression.

  Molecular and cellular biochemistry 20030601

• [Temocapril treatment upregulated cardiomyocyte thioredoxin expression and improved autoimmune myocarditis].

  Zhonghua nei ke za zhi 20030501

• Temocapril prevents motor neuron damage and upregulation of cyclooxygenase-II in glutamate-induced neurotoxicity.

  Neurological research 20030401

• Chronic angiotensin II inhibition increases levels of calcitonin gene-related peptide mRNA of the dorsal root ganglia in spontaneously hypertensive rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20030301

• Effects of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on beta-adrenoceptor signaling in heart failure produced by myocardial Infarction in rabbits: reversal of altered expression of beta-adrenoceptor kinase and G i alpha.

  The Journal of pharmacology and experimental therapeutics 20030101

• Beneficial effects of combination of ACE inhibitor and angiotensin II type 1 receptor blocker on cardiac remodeling in rat myocardial infarction.

  Cardiovascular research 20030101

• Effects of temocapril and olmesartan on myocardial sympathetic nervous activity and fatty acid metabolism in rats with chronic beta-adrenergic stimulation.

  Journal of cardiovascular pharmacology 20030101

• [Successful treatment of combination therapy using an angiotensin-converting enzyme inhibitor and an angiotensin II receptor blocker in a patient with IgA nephropathy].

  Nihon Jinzo Gakkai shi 20030101

• Antiproteinuric effects of combined antihypertensive therapies in patients with overt type 2 diabetic nephropathy.

  Hypertension research : official journal of the Japanese Society of Hypertension 20021101

• Impact of exercise and angiotensin converting enzyme inhibition on tumor necrosis factor-alpha and leptin in fructose-fed hypertensive rats.

  Hypertension research : official journal of the Japanese Society of Hypertension 20021101

• Chronic angiotensin-converting enzyme inhibition and angiotensin II antagonism in rats with chronic renal failure.

  Journal of cardiovascular pharmacology 20021001

• An angiotensin-converting enzyme inhibitor, not an angiotensin II type-1 receptor blocker, prevents beta-aminopropionitrile monofumarate-induced aortic dissection in rats.

  Journal of vascular surgery 20021001

• CS-886, a new angiotensin II type 1 receptor antagonist, ameliorates glomerular anionic site loss and prevents progression of diabetic nephropathy in Otsuka Long-Evans Tokushima fatty rats.

  Molecular medicine (Cambridge, Mass.) 20021001

• ACE inhibitor improves insulin resistance in diabetic mouse via bradykinin and NO.

  Hypertension (Dallas, Tex. : 1979) 20020901

• Inhibition of renin-angiotensin system ameliorates endothelial dysfunction associated with aging in rats.

  Arteriosclerosis, thrombosis, and vascular biology 20020901

• [Effects of temocapril on the prevention of early diabetic nephropathy in OLETF rat, an animal model for type 2 diabetes].

  [Hokkaido igaku zasshi] The Hokkaido journal of medical science 20020901

• Beneficial effects of combined blockade of ACE and AT1 receptor on intimal hyperplasia in balloon-injured rat artery.

  Arteriosclerosis, thrombosis, and vascular biology 20020801

• Combination therapy of exercise and angiotensin-converting enzyme inhibitor markedly improves insulin sensitivities in hypertensive patients with insulin resistance.

  Circulation journal : official journal of the Japanese Circulation Society 20020701

• Differential effects of a long-acting angiotensin converting enzyme inhibitor (temocapril) and a long-acting calcium antagonist (amlodipine) on ventricular ectopic beats in older hypertensive patients.

  Hypertension research : official journal of the Japanese Society of Hypertension 20020501

• Combination therapy with an angiotensin-converting enzyme (ACE) inhibitor and a calcium antagonist: beyond the renoprotective effects of ACE inhibitor monotherapy in a spontaneous hypertensive rat with renal ablation.

  Hypertension research : official journal of the Japanese Society of Hypertension 20020501

• Combined effect of ACE inhibitor and exercise training on insulin resistance in type 2 diabetic rats.

  Life sciences 20020301

• Inhibitory effect of a novel angiotensin II type 1 receptor antagonist RNH-6270 on growth of vascular smooth muscle cells from spontaneously hypertensive rats: different anti-proliferative effect to angiotensin-converting enzyme inhibitor.

  Journal of cardiovascular pharmacology 20020201

• Temocapril, a long-acting non-SH group angiotensin converting enzyme inhibitor, modulates glomerular injury in chronic puromycin aminonucleoside nephrosis.

  Journal of nephrology 20020101

• [Effects of CS-866, an angiotensin II receptor antagonist, in 5/6 nephrectomized spontaneously hypertensive rats].

  Nihon Jinzo Gakkai shi 20011001

• Effects of long-acting ACE inhibitor (temocapril) and long-acting Ca channel blocker (amlodipine) on 24-h ambulatory BP in elderly hypertensive patients.

  Journal of human hypertension 20010901

• Differential subcellular actions of ACE inhibitors and AT(1) receptor antagonists on cardiac remodeling induced by chronic inhibition of NO synthesis in rats.

  Hypertension (Dallas, Tex. : 1979) 20010901

• Differential effects of angiotensin II versus endothelin-1 inhibitions in hypertrophic left ventricular myocardium during transition to heart failure.

  Circulation 20010731

• Angiotensin-converting enzyme inhibition attenuates hypofibrinolysis and reduces cardiac perivascular fibrosis in genetically obese diabetic mice.

  Circulation 20010626

• Angiotensin blockade inhibits increased JNKs, AP-1 and NF- kappa B DNA-binding activities in myocardial infarcted rats.

  Journal of molecular and cellular cardiology 20010401

• Effects of troglitazone and temocapril in spontaneously hypertensive rats with chronic renal failure.

  Journal of hypertension 20010301

• Effect of temocapril hydrochloride on serum lipid levels in patients with hypertensive type 2 diabetes mellitus.

  Journal of atherosclerosis and thrombosis 20010101

• Prevention of doxorubicin (adriamycin)-induced cardiomyopathy by simultaneous administration of angiotensin-converting enzyme inhibitor assessed by acoustic densitometry.

  Journal of cardiovascular pharmacology 20000901

• Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver.

  Biological & pharmaceutical bulletin 19970801

• Pharmacokinetics of temocapril, an ACE inhibitor with preferential biliary excretion, in patients with impaired liver function.

  European journal of clinical pharmacology 19930101

• Pharmacokinetics of temocapril hydrochloride, a novel angiotensin converting enzyme inhibitor, in renal insufficiency.

  European journal of clinical pharmacology 19920101