1110766-97-6 | (S,E)-3-(2,6-Dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid

Packsize	Purity	Availability	Price	Discounted Price
1mg	97%	in stock	$29.00	$20.00
2mg	97%	in stock	$36.00	$25.00
5mg	97%	in stock	$60.00	$42.00
50mg	97%	in stock	$246.00	$172.00
100mg	97%	in stock	$398.00	$278.00
250mg	97%	in stock	$672.00	$470.00

Description

• Catalog Number: AE19521
• Chemical Name: (S,E)-3-(2,6-Dichloro-4-((4-(3-(1-(hexyloxy)ethyl)-2-methoxyphenyl)thiazol-2-yl)carbamoyl)phenyl)-2-methylacrylic acid
• CAS Number: 1110766-97-6
• Molecular Formula: C29H32Cl2N2O5S
• Molecular Weight: 591.5458
• MDL Number: MFCD28502075
• SMILES: CCCCCCO[C@H](c1cccc(c1OC)c1csc(n1)NC(=O)c1cc(Cl)c(c(c1)Cl)/C=C(/C(=O)O)\C)C

Computed Properties

• Complexity: 822
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 39
• Hydrogen Bond Acceptor Count: 7
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 13
• XLogP3: 7.7

Upstream Synthesis Route

2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)- is a versatile compound widely used in chemical synthesis due to its unique structure and reactivity. Its application in synthesis plays a crucial role in creating complex organic molecules with specific properties and functions.This compound serves as a key building block in the preparation of various pharmaceuticals, agrochemicals, and functional materials. Its presence in chemical reactions allows for the introduction of specific functionalities and structural motifs, leading to the formation of novel compounds with tailored properties.In chemical synthesis, 2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)- acts as a strategic intermediate that undergoes diverse transformations to yield desired products. Its reactivity with various reagents and catalytic systems enables the construction of intricate molecular frameworks and the synthesis of complex molecules with high efficiency.Overall, the use of 2-Propenoic acid, 3-[2,6-dichloro-4-[[[4-[3-[(1S)-1-(hexyloxy)ethyl]-2-methoxyphenyl]-2-thiazolyl]amino]carbonyl]phenyl]-2-methyl-, (2E)- in chemical synthesis is vital for the development of innovative materials, pharmaceuticals, and functional molecules that have a wide range of applications in different industries.

Literature

• Development of a new knock-in mouse model and evaluation of pharmacological activities of lusutrombopag, a novel, nonpeptidyl small-molecule agonist of the human thrombopoietin receptor c-Mpl.

  Experimental hematology 20180301

• Efficacy of Repeated Lusutrombopag Administration for Thrombocytopenia in a Patient Scheduled for Invasive Hepatocellular Carcinoma Treatment.

  Internal medicine (Tokyo, Japan) 20171101

• Lusutrombopag increases hematocytes in a compensated liver cirrhosis patient.

  Clinical journal of gastroenterology 20170101

• [Avoidance of platelet transfusion with readministration of lusutrombopag before radiofrequency ablation in hepatocellular carcinoma:a case report].

  Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology 20170101

• Lusutrombopag: First Global Approval.

  Drugs 20160101