1112980-86-5 | N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide

Packsize	Purity	Availability	Price	Discounted Price
25mg	95%	2 weeks	$347.00	$243.00
100mg	95%	2 weeks	$1,007.00	$705.00
250mg	95%	2 weeks	$1,831.00	$1,282.00
1g	95%	2 weeks	$3,470.00	$2,429.00

Description

• Catalog Number: AB76891
• Chemical Name: N-(6-(6-Chloro-5-(4-fluorophenylsulfonamido)pyridin-3-yl)benzo[d]thiazol-2-yl)acetamide
• CAS Number: 1112980-86-5
• Molecular Formula: C20H14ClFN4O3S2
• Molecular Weight: 476.9316
• MDL Number: MFCD19443166
• SMILES: CC(=O)Nc1nc2c(s1)cc(cc2)c1cnc(c(c1)NS(=O)(=O)c1ccc(cc1)F)Cl

Computed Properties

• Complexity: 747
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 8
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 5
• XLogP3: 4

Literature

• Synthesis and structure-activity relationships of dual PI3K/mTOR inhibitors based on a 4-amino-6-methyl-1,3,5-triazine sulfonamide scaffold.

  Bioorganic & medicinal chemistry letters 20120901

• Structure-activity relationships of phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: investigations of various 6,5-heterocycles to improve metabolic stability.

  Journal of medicinal chemistry 20110728

• Phospshoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors: discovery and structure-activity relationships of a series of quinoline and quinoxaline derivatives.

  Journal of medicinal chemistry 20110714

• Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitors.

  Journal of medicinal chemistry 20110324