111812-58-9 | Fenpyroximate

Packsize	Purity	Availability	Price	Discounted Price
1mg	99%	1 week	$122.00	$85.00
5mg	99%	1 week	$193.00	$135.00
10mg	99%	1 week	$265.00	$185.00

Description

• Catalog Number: AD75300
• Chemical Name: Fenpyroximate
• CAS Number: 111812-58-9
• Molecular Formula: C24H27N3O4
• Molecular Weight: 421.4889
• MDL Number: MFCD00274596
• SMILES: Cc1nn(c(c1C=NOCc1ccc(cc1)C(=O)OC(C)(C)C)Oc1ccccc1)C

Computed Properties

• Complexity: 592
• Covalently-Bonded Unit Count: 1
• Defined Bond Stereocenter Count: 1
• Heavy Atom Count: 31
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 9
• XLogP3: 4.9

Upstream Synthesis Route

The product, 4-[[[[(1,3-Dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylene]amino]oxy]methyl]benzoic Acid tert-Butyl Ester, finds significant utility in chemical synthesis as a versatile reagent for the modification and functionalization of organic compounds. This compound serves as a key building block in the development of novel pharmaceuticals, agrochemicals, and materials. Its unique structure allows for precise control over molecular interactions and enables the synthesis of diverse molecular architectures with tailored properties. In organic synthesis, this compound acts as a valuable intermediate for the construction of complex molecules through its ability to undergo various chemical transformations, including nucleophilic additions, palladium-catalyzed couplings, and metal-catalyzed cross-coupling reactions. Its application extends to the creation of biologically active compounds, advanced materials, and molecular probes for biological studies.

Literature

• A case of near-fatal fenpyroximate intoxication: the role of percutaneous cardiopulmonary support and therapeutic hypothermia.

  Clinical toxicology (Philadelphia, Pa.) 20121101

• Fenpyroximate binds to the interface between PSST and 49 kDa subunits in mitochondrial NADH-ubiquinone oxidoreductase.

  Biochemistry 20120306

• Environmental impact on vascular development predicted by high-throughput screening.

  Environmental health perspectives 20111101

• Pyrethroid resistance in the tomato red spider mite, Tetranychus evansi, is associated with mutation of the para-type sodium channel.

  Pest management science 20110801

• Acute and population level toxicity of imidacloprid and fenpyroximate on an important egg parasitoid, Trichogramma cacoeciae (Hymenoptera: Trichogrammatidae).

  Ecotoxicology (London, England) 20110801

• Sublethal effects of fenpyroximate and pyridaben on two predatory mite species, Neoseiulus womersleyi and Phytoseiulus persimilis (Acari, Phytoseiidae).

  Experimental & applied acarology 20110701

• DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity.

  Journal of neurochemistry 20110501

• Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.

  Toxicology 20110328

• Compatibility of traditional and novel acaricides with bumblebees (Bombus terrestris): a first laboratory assessment of toxicity and sublethal effects.

  Pest management science 20100701

• Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program.

  Chemical research in toxicology 20100315

• In vitro and in vivo acute toxicity of fenpyroximate to flounder Paralichthys olivaceus and its gill cell line FG.

  Aquatic toxicology (Amsterdam, Netherlands) 20090409

• Synthesis and biological activities of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety.

  Journal of agricultural and food chemistry 20081126

• Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress.

  The Journal of neuroscience : the official journal of the Society for Neuroscience 20080507

• Evaluation of resistance pattern to fenpyroximate and pyridaben in Tetranychus urticae collected from greenhouses and apple orchards using lethal concentration-slope relationship.

  Experimental & applied acarology 20060101

• Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.

  The Journal of biological chemistry 20051230

• Identification of antitumor activity of pyrazole oxime ethers.

  Bioorganic & medicinal chemistry letters 20050701

• Fenpyroximate resistance in Tetranychus urticae (Acari: Tetranychidae): cross-resistance and biochemical resistance mechanisms.

  Pest management science 20041001

• The ND5 subunit was labeled by a photoaffinity analogue of fenpyroximate in bovine mitochondrial complex I.

  Biochemistry 20030128

• Potentiation of a propargite and fenpyroximate mixture against two-spotted spider mite, Tetranychus urticae (Acari: Tetranychidae).

  Experimental & applied acarology 20030101

• Cross-resistance, inheritance, and biochemistry of mitochondrial electron transport inhibitor-acaricide resistance in Tetranychus urticae (Acari: Tetranychidae).

  Journal of economic entomology 20011201

• Incidence and inheritance of resistance to METI-acaricides in European strains of the two-spotted spider mite (Tetranychus urticae) (Acari: Tetranychidae).

  Pest management science 20010501