112883-41-7 | Fmoc-D-Nle-OH

Packsize	Purity	Availability	Price	Discounted Price
250mg	97%	in stock	$6.00	$4.00
1g	97%	in stock	$7.00	$5.00
5g	97%	in stock	$9.00	$6.00
10g	97%	in stock	$11.00	$8.00
25g	97%	in stock	$26.00	$18.00
100g	97%	in stock	$100.00	$70.00

Description

• Catalog Number: AI09081
• Chemical Name: Fmoc-D-Nle-OH
• CAS Number: 112883-41-7
• Molecular Formula: C21H23NO4
• Molecular Weight: 353.4116
• MDL Number: MFCD00155639
• SMILES: CCCC[C@H](C(=O)O)NC(=O)OCC1c2ccccc2c2c1cccc2

Computed Properties

• Complexity: 472
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 1
• Heavy Atom Count: 26
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 8
• XLogP3: 4.5

Upstream Synthesis Route

Fmoc-D-Nle-OH, or N-(9-fluorenylmethyloxycarbonyl)-D-norleucine, is a key reagent widely utilized in chemical synthesis for peptide and protein studies. This amino acid derivative serves as a versatile building block in solid-phase peptide synthesis (SPPS) due to its ability to protect the N-terminus of amino acids.In peptide synthesis, Fmoc-D-Nle-OH is commonly used as a protected fragment to add specific amino acids in a defined sequence. By coupling Fmoc-D-Nle-OH with other amino acids and selectively removing the Fmoc protection group under mild acidic conditions, researchers can achieve precise control over the stepwise assembly of peptides. This strategy enables the synthesis of complex peptides and proteins with high purity and yield.Furthermore, Fmoc-D-Nle-OH offers improved stability and compatibility with various coupling reagents commonly used in SPPS. Its Fmoc protecting group can be efficiently removed without affecting the integrity of the peptide chain, making it a valuable tool in the synthesis of bioactive peptides, drug molecules, and peptide mimetics for pharmaceutical and biological research applications.