1129-26-6 | 4-Methoxybenzenesulfonamide

Packsize	Purity	Availability	Price	Discounted Price
1g	98%	in stock	$6.00	$5.00
5g	98%	in stock	$23.00	$17.00
25g	98%	in stock	$42.00	$30.00
100g	98%	in stock	$161.00	$113.00

Description

• Catalog Number: AB67818
• Chemical Name: 4-Methoxybenzenesulfonamide
• CAS Number: 1129-26-6
• Molecular Formula: C7H9NO3S
• Molecular Weight: 187.21625999999998
• MDL Number: MFCD00025392
• SMILES: COc1ccc(cc1)S(=O)(=O)N
• NSC Number: 73188

Computed Properties

• Complexity: 224
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 12
• Hydrogen Bond Acceptor Count: 4
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 2
• XLogP3: 0.5

Upstream Synthesis Route

4-Methoxybenzenesulfonamide, also known as p-anisylsulfonamide, is a valuable compound widely used in chemical synthesis. This versatile molecule serves as a key building block in organic chemistry, particularly in the realm of medicinal and pharmaceutical chemistry.One of the primary applications of 4-Methoxybenzenesulfonamide lies in its role as a protecting group for amines in organic synthesis. By utilizing this compound as a protecting group, chemists can selectively mask the amino group of a molecule during various chemical reactions. This allows for specific modifications to be made elsewhere in the molecule, while safeguarding the amine functionality from unwanted side reactions.Additionally, 4-Methoxybenzenesulfonamide is utilized in the synthesis of diverse pharmaceutical compounds and agrochemicals. Its ability to participate in versatile chemical reactions, such as nucleophilic substitution and transition metal-catalyzed processes, makes it an indispensable tool in the creation of complex organic molecules with desired biological activities.In conclusion, 4-Methoxybenzenesulfonamide plays a crucial role in chemical synthesis, offering chemists a reliable and effective means to manipulate molecular structures and facilitate the development of novel drugs, materials, and compounds.

Literature

• Correlation analyses on binding affinity of substituted benzenesulfonamides with carbonic anhydrase using ab initio MO calculations on their complex structures (II).

  Bioorganic & medicinal chemistry letters 20110101

• Entropic contribution to the linking coefficient in fragment based drug design: a case study.

  Journal of medicinal chemistry 20100527

• Novel use of chemical shift in NMR as molecular descriptor: a first report on modeling carbonic anhydrase inhibitory activity and related parameters.

  Bioorganic & medicinal chemistry letters 20050215

• Topological modeling of lipophilicity, diuretic activity, and carbonic inhibition activity of benzene sulfonamides: a molecular connectivity approach.

  Bioorganic & medicinal chemistry letters 20041115