113507-06-5 | Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-

Packsize	Purity	Availability	Price	Discounted Price
100mg	98%	in stock	$11.00	$8.00
250mg	98%	in stock	$16.00	$11.00
1g	98%	in stock	$38.00	$27.00
5g	98%	in stock	$128.00	$90.00

Description

• Catalog Number: AI09444
• Chemical Name: Milbemycin B,5-O-demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-butenyl]-6,28-epoxy-23-(methoxyimino)-, (6R,23E,25S)-
• CAS Number: 113507-06-5
• Molecular Formula: C37H53NO8
• Molecular Weight: 639.8186
• MDL Number: MFCD00866560
• SMILES: CO/N=C/1\C[C@]2(C[C@@H]3C[C@H](O2)C/C=C(\C)/C[C@@H](C)/C=C/C=C\2/[C@]4([C@H](C(=O)O3)C=C(C)[C@H]([C@H]4OC2)O)O)O[C@@H]([C@H]1C)/C(=C/C(C)C)/C

Computed Properties

• Complexity: 1340
• Covalently-Bonded Unit Count: 1
• Defined Atom Stereocenter Count: 10
• Defined Bond Stereocenter Count: 5
• Heavy Atom Count: 46
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 2
• Rotatable Bond Count: 3
• XLogP3: 4.3

Literature

• Identification of a nonsense mutation in feline ABCB1.

  Journal of veterinary pharmacology and therapeutics 20151001

• Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance.

  Veterinary parasitology 20150615

• Canine ocular thelaziosis caused by Thelazia callipaeda in Portugal.

  Veterinary ophthalmology 20130701

• Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin.

  Journal of veterinary pharmacology and therapeutics 20130601

• P-gp substrate-induced neurotoxicity in an Abcb1a knock-in/Abcb1b knock-out mouse model with a mutated canine ABCB1 targeted insertion.

  Research in veterinary science 20130601

• Milbemycins: more than efflux inhibitors for fungal pathogens.

  Antimicrobial agents and chemotherapy 20130201

• Efficacy of a spot on combination containing imidacloprid 10% and moxidectin 1% (Advocate(®)/Advantage(®) Multi, Bayer Animal Health) against Ancylostoma ceylanicum in cats.

  Veterinary parasitology 20121123

• Isolation and characterization of degradation products of moxidectin using LC, LTQ FT-MS, H/D exchange and NMR.

  Analytical and bioanalytical chemistry 20121101

• Evaluation of the comparative efficacy of a moxidectin plus triclabendazole pour-on solution against adult and immature liver fluke, Fasciola hepatica, in cattle.

  Veterinary parasitology 20121026

• Efficacy of albendazole and moxidectin and resistance to ivermectin against Libyostrongylus douglassii and Libyostrongylus dentatus in ostriches.

  Veterinary parasitology 20121026

• Use of a long acting injectable formulation of moxidectin to control the periparturient rise in faecal Teladorsagia circumcincta egg output of ewes.

  Veterinary parasitology 20121026

• Assessing resistance against macrocyclic lactones in gastro-intestinal nematodes in cattle using the faecal egg count reduction test and the controlled efficacy test.

  Veterinary parasitology 20121026

• Efficacy and safety of imidacloprid 10%/moxidectin 1% spot-on formulation in the treatment of feline infection by Capillaria aerophila.

  Parasitology research 20121001

• Monthly application of 10 per cent moxidectin and 2.5 per cent imidacloprid spot-on to prevent relapses in generalised demodicosis: a pilot study.

  The Veterinary record 20120915

• Efficacy of major anthelmintics against horse cyathostomins in France.

  Veterinary parasitology 20120910

• Persistent efficacy of a long acting injectable formulation of moxidectin against natural infestations of the sheep nasal bot (Oestrus ovis) in Spain.

  Veterinary parasitology 20120910

• Allergic dermatitis by Dirofilaria repens in a dog: clinical picture and treatment.

  Parasitology research 20120701

• Pharmacological characterization of the Haemonchus contortus GABA-gated chloride channel, Hco-UNC-49: modulation by macrocyclic lactone anthelmintics and a receptor for piperazine.

  Veterinary parasitology 20120430

• Comparative in vitro characterization of moxidectin and doramectin percutaneous absorption through bovine skin.

  Journal of veterinary pharmacology and therapeutics 20120401

• An update on the therapy of canine demodicosis.

  Compendium (Yardley, PA) 20120401

• Amino acid residues of both the extracellular and transmembrane domains influence binding of the antiparasitic agent milbemycin to Haemonchus contortus AVR-14B glutamate-gated chloride channels.

  Biochemical and biophysical research communications 20120316

• Lethal and sublethal effects of avermectin/milbemycin parasiticides on the African malaria vector, Anopheles arabiensis.

  Journal of medical entomology 20120301

• The effect of a high-fat breakfast on the pharmacokinetics of moxidectin in healthy male subjects: a randomized phase I trial.

  The American journal of tropical medicine and hygiene 20120101

• Maize supplementation of Pelibuey sheep in a silvopastoral system: fodder selection, nutrient intake and resilience against gastrointestinal nematodes.

  Animal : an international journal of animal bioscience 20120101

• Efficacy of a combination of 10% imidacloprid and 1% moxidectin against Caparinia tripilis in African pygmy hedgehog (Atelerix albiventris).

  Parasites & vectors 20120101

• ABC transporters influence sensitivity of Brugia malayi to moxidectin and have potential roles in drug resistance.

  Experimental parasitology 20111001

• Effect of prolonged status epilepticus as a result of intoxication on epileptogenesis in a UK canine population.

  The Veterinary record 20111001

• Myiasis in a dog shelter in Greece: epidemiological and clinical features and therapeutic considerations.

  Veterinary parasitology 20110927

• Nematode and ciliate nasal infection in captive archey's frogs (Leiopelma archeyi).

  Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110901

• A comparison of the efficacy of subcutaneously administered ivermectin, doramectin, and moxidectin against naturally infected Toxocara vitulorum in calves.

  Tropical animal health and production 20110801

• Evaluation of the therapeutic and preventive efficacy of 2.5 % moxidectin / 10 % imidacloprid (Advocate(®), Bayer animal health) in dogs naturally infected or at risk of natural infection by Dirofilaria repens.

  Parasitology research 20110801

• Efficacy and safety of the combination imidacloprid 10 % / moxidectin 1.0 % spot-on (Advocate(®) spot-on for small cats and ferrets) in the treatment of ear mite infection (Otodectes cynotis) in ferrets.

  Parasitology research 20110801

• Progress and challenges in the discovery of macrofilaricidal drugs.

  Expert review of anti-infective therapy 20110801

• Pharmacokinetics of moxidectin in the southern hairy-nosed wombat (Lasiorhinus latifrons).

  Journal of wildlife diseases 20110701

• Efficacy of a single administration of a spot-on solution containing imidacloprid 10%/moxidectin 2.5% in eliminating Dirofilaria repens microfilariae in naturally infected dogs.

  Veterinary parasitology 20110630

• Reversal effects of two new milbemycin compounds on multidrug resistance in MCF-7/adr cells in vitro.

  European journal of pharmacology 20110601

• Design, synthesis, and biological activities of milbemycin analogues.

  Journal of agricultural and food chemistry 20110511

• Reduced activity of moxidectin and ivermectin on small strongyles in young horses on a farm (BC) in Central Kentucky in two field tests with notes on variable counts of eggs per gram of feces (EPGs).

  Parasitology research 20110501

• Administration of a long-acting antiparasitic to pre-pubertal ewe-lambs in Greece results in earlier reproductive activity and improved reproductive performance.

  Veterinary parasitology 20110419

• Efficacy and blood sera analysis of a long-acting formulation of moxidectin against Rhipicephalus (Boophilus) microplus (Acari: Ixodidae) on treated cattle.

  Journal of medical entomology 20110301

• Combined moxidectin and environmental therapy do not eliminate Chorioptes bovis infestation in heavily feathered horses.

  Veterinary dermatology 20110201

• Field tests demonstrating reduced activity of ivermectin and moxidectin against small strongyles in horses on 14 farms in Central Kentucky in 2007-2009.

  Parasitology research 20110201

• Pharmacokinetics of moxidectin following topical administration to New Zealand rabbits.

  Journal of veterinary pharmacology and therapeutics 20110201

• Efficacy of imidacloprid + moxidectin and selamectin topical solutions against the KS1 Ctenocephalides felis flea strain infesting cats.

  Parasites & vectors 20110101

• Clinical, laboratory and pathological findings in dogs experimentally infected with Angiostrongylus vasorum.

  Parasitology research 20101101

• Efficacy of a combination of imidacloprid 10%/moxidectin 2.5% spot-on (Advocate® for dogs) in the prevention of canine spirocercosis (Spirocerca lupi).

  Parasitology research 20101101

• Critical tests evaluating efficacy of moxidectin against small strongyles in horses from a herd for which reduced activity had been found in field tests in Central Kentucky.

  Parasitology research 20101101

• Shortened strongyle-type egg reappearance periods in naturally infected horses treated with moxidectin and failure of a larvicidal dose of fenbendazole to reduce fecal egg counts.

  Veterinary parasitology 20101029

• Lymphatic filariasis and onchocerciasis.

  Lancet (London, England) 20101002

• Teladorsagia circumcincta resistance to moxidectin and multiple anthelmintic groups in ewes following use of the persistent drug before lambing.

  The Veterinary record 20101002

• Efficacy of a spot-on formulation of pyriprole on dogs infested with Sarcoptes scabiei.

  The Veterinary record 20100918

• Reversal of P-glycoprotein-mediated multidrug resistance in vitro by milbemycin compounds in adriamycin-resistant human breast carcinoma (MCF-7/adr) cells.

  Toxicology in vitro : an international journal published in association with BIBRA 20100901

• Cattle nematodes resistant to macrocyclic lactones: comparative effects of P-glycoprotein modulation on the efficacy and disposition kinetics of ivermectin and moxidectin.

  Experimental parasitology 20100601

• Characterisation of milbemycin-, avermectin-, imidazothiazole- and benzimidazole-resistant Teladorsagia circumcincta from a sheep flock.

  The Veterinary record 20100529

• Efficacy of moxidectin microsphere sustained release formulation for the prevention of subcutaneous filarial (Dirofilaria repens) infection in dogs.

  Veterinary parasitology 20100528

• Experimental infection with Ancylostoma ceylanicum in dogs and efficacy of a spot on combination containing imidacloprid 10% and moxidectin 2.5% (Advocate/Advantage Multi, Bayer Animal Health).

  Parasitology research 20100501

• Evaluation of topical application of 10% imidacloprid-1% moxidectin to prevent Bartonella henselae transmission from cat fleas.

  Journal of the American Veterinary Medical Association 20100415

• Plasma dispositions of ivermectin, doramectin and moxidectin following subcutaneous administration in rabbits.

  Laboratory animals 20100401

• Brugia malayi: in vitro effects of ivermectin and moxidectin on adults and microfilariae.

  Experimental parasitology 20100401

• Onchodermatitis.

  Current opinion in infectious diseases 20100401

• Role of P-glycoprotein in the disposition of macrocyclic lactones: A comparison between ivermectin, eprinomectin, and moxidectin in mice.

  Drug metabolism and disposition: the biological fate of chemicals 20100401

• Elimination of Dirofilaria (syn. Nochtiella) repens microfilariae in dogs with monthly treatments of moxidectin 2.5%/imidacloprid 10% (Advocate, Bayer) spot-on.

  Parasitology research 20100401

• Milbemectin resistance in Tetranychus urticae (Acari: Tetranychidae): selection, stability and cross-resistance to abamectin.

  Experimental & applied acarology 20100301

• Evaluation of the persistent activity of moxidectin (10%) long-acting (LA) injectable formulation against Dictyocaulus viviparus, Haemonchus placei, Trichostrongylus axei and Oesophagostomum radiatum infections in cattle.

  Veterinary parasitology 20100120

• Larvicidal effect of imidacloprid/moxidectin spot-on solution in dogs experimentally inoculated with Angiostrongylus vasorum.

  Veterinary parasitology 20091223

• Licking induced changes to the pattern of moxidectin milk elimination after topical treatment in dairy cows.

  Journal of veterinary pharmacology and therapeutics 20091201

• Transplacental exchange of moxidectin after maternal or fetal intravenous administration in sheep.

  Journal of veterinary pharmacology and therapeutics 20091201

• A comparison of the effects of ivermectin and moxidectin on the nematode Caenorhabditis elegans.

  Veterinary parasitology 20091028

• Comparative therapeutic effect of moxidectin, doramectin and ivermectin on psoroptes mites infestation in buffalo (Bubalus bubalis).

  Tropical animal health and production 20091001

• Treatment of canine generalized demodicosis with a 'spot-on' formulation containing 10% moxidectin and 2.5% imidacloprid (Advocate, Bayer Healthcare).

  Veterinary dermatology 20091001

• Treatment of canine-generalized demodicosis: a blind, randomized clinical trial comparing the efficacy of Advocate(Bayer Animal Health) with ivermectin.

  Veterinary dermatology 20091001

• Efficacy of a single topical application of Advantage Multi (= Advocate) Topical Solution (10% imidocloprid + 2.5% moxidectin) in the treatment of dogs experimentally infected with Crenosoma vulpis.

  Parasitology research 20090801

• Efficacy and safety of imidacloprid 10%/moxidectin 1% spot-on formulation in the treatment of feline aelurostrongylosis.

  Parasitology research 20090801

• Comparative efficacy and safety of two treatment regimens with a topically applied combination of imidacloprid and moxidectin (Advocate) against generalised demodicosis in dogs.

  Parasitology research 20090801

• Toxicity in three dogs from accidental oral administration of a topical endectocide containing moxidectin and imidacloprid.

  Australian veterinary journal 20090801

• Efficacy of moxidectin against cyathostomins.

  The Veterinary record 20090718

• Effects of faecal residues of moxidectin and doramectin on the activity of arthropods in cattle dung.

  Ecotoxicology and environmental safety 20090701

• In vitro and in vivo interaction of moxidectin with BCRP/ABCG2.

  Chemico-biological interactions 20090615

• Moxidectin toxicity in senescence-accelerated prone and resistant mice.

  Comparative medicine 20090601

• Efficacy of moxidectin against cyathostomins after long-term use in a large herd of draught horses with a high stocking density.

  The Veterinary record 20090523

• Moxidectin-resistant nematodes in cattle in Brazil.

  Veterinary parasitology 20090512

• Comparative long-term efficacy of ivermectin and moxidectin over winter in Canadian horses treated at removal from pastures for winter housing.

  The Canadian veterinary journal = La revue veterinaire canadienne 20090501

• Import of Parafilaria bovicola in the Netherlands.

  Veterinary parasitology 20090406

• Long-acting moxidectin for the control of trichostrongylid infections of sheep in south-eastern Australia.

  Australian veterinary journal 20090401

• Moxidectin toxicosis in a puppy successfully treated with intravenous lipids.

  Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) 20090401

• Investigations into the prevention of neonatal Ancylostoma caninum infections in puppies by application of imidacloprid 10% plus moxidectin 2.5% topical solution to the pregnant dog.

  Zoonoses and public health 20090201

• Species-specific identification of equine cyathostomes resistant to fenbendazole and susceptible to oxibendazole and moxidectin by macroarray probing.

  Experimental parasitology 20090101

• Thermal stability of antiparasitic macrocyclic lactones milk residues during industrial processing.

  Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090101

• The effect of moxidectin 0,1% vs ivermectin 0,08% on milk production in sheep naturally infected by gastrointestinal nematodes.

  BMC veterinary research 20090101

• Comparing therapeutic efficacy between ivermectin, selamectin, and moxidectin in canaries during natural infection with Dermanyssus gallinae.

  Annals of the New York Academy of Sciences 20081201

• Plasma and milk kinetic of eprinomectin and moxidectin in lactating water buffaloes (Bubalus bubalis).

  Veterinary parasitology 20081107

• A comparative kinetic study of doramectin and moxidectin in zebu Gobra cattle (Bos indicus).

  Parasitology research 20081101

• Effects of strategic anthelmintic treatments on the milk production of dairy sheep naturally infected by gastrointestinal strongyles.

  Veterinary parasitology 20081001

• Field efficacy and safety of a combination of moxidectin and imidacloprid for the prevention of feline heartworm (Dirofilaria immitis) infection.

  Veterinary parasitology 20080614

• Efficacy of imidacloprid 10%/moxidectin 1% (Advocate/Advantage Multi) against fleas (Ctenocephalides felis felis) on ferrets (Mustela putorius furo).

  Parasitology research 20080601

• Use of a formulation containing imidacloprid and moxidectin in the treatment of lice infestation in guinea pigs.

  Veterinary dermatology 20080601

• Use of selamectin and moxidectin in the treatment of mouse fur mites.

  Journal of the American Association for Laboratory Animal Science : JAALAS 20080501

• Epidemiology of gastrointestinal nematode parasitism in a commercial sheep flock and its implications for control programmes.

  The Veterinary record 20080426

• Patent Toxocara canis infections in previously exposed and in helminth-free dogs after infection with low numbers of embryonated eggs.

  Veterinary parasitology 20080325

• Oral administration of moxidectin for treatment of murine acariosis due to Radfordia affinis.

  Veterinary parasitology 20080214

• Moxidectin interference on sexual behavior, penile erection and hypothalamic GABA levels of male rats.

  Research in veterinary science 20080201

• A nodular granulomatous posthitis caused by Halicephalobus sp. in a horse.

  Veterinary dermatology 20080201

• The persistence of benzimidazole-resistant cyathostomes on horse farms in Ontario over 10 years and the effectiveness of ivermectin and moxidectin against these resistant strains.

  The Canadian veterinary journal = La revue veterinaire canadienne 20080101

• Endectocide residues affect insect attraction to dung from treated cattle: implications for toxicity tests.

  Medical and veterinary entomology 20071201

• Economic efficacy of anthelmintic treatments in dairy sheep naturally infected by gastrointestinal strongyles.

  Parassitologia 20071201

• First report of multiple drug resistance in trichostrongyles affecting sheep under field conditions in Italy.

  Parasitology research 20071101

• Comparison of the pharmacokinetics of moxidectin and ivermectin after oral administration to beagle dogs.

  Biopharmaceutics & drug disposition 20071101

• What is your diagnosis? Mange due to Trixacarus caviae infestation.

  Lab animal 20071101

• Estimation of absolute oral bioavailability of moxidectin in dogs using a semi-simultaneous method: influence of lipid co-administration.

  Journal of veterinary pharmacology and therapeutics 20071001

• Pharmacokinetics assessment of moxidectin long-acting formulation in cattle.

  Veterinary parasitology 20070720

• Efficacy and safety of imidacloprid/moxidectin spot-on solution and fenbendazole in the treatment of dogs naturally infected with Angiostrongylus vasorum (Baillet, 1866).

  Veterinary parasitology 20070720

• Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae.

  Eukaryotic cell 20070701

• A novel approach for combining the use of in vitro and in vivo data to measure and detect emerging moxidectin resistance in gastrointestinal nematodes of goats.

  International journal for parasitology 20070601

• Macrocyclic lactone-resistant Parascaris equorum on stud farms in Canada and effectiveness of fenbendazole and pyrantel pamoate.

  Veterinary parasitology 20070430

• Efficacy of imidacloprid 10 per cent/moxidectin 2-5 per cent spot-on in the treatment of cheyletiellosis in dogs.

  The Veterinary record 20070414

• The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure.

  Analytica chimica acta 20070227

• Fecal egg count reductions and performance effect of Dectomax, Cydectin, and Cydectin plus Synanthic as used in feedlot steers.

  Veterinary therapeutics : research in applied veterinary medicine 20070101

• Review of methodology for the determination of macrocyclic lactone residues in biological matrices.

  Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061205

• Fumagillin, a new P-glycoprotein-interfering agent able to modulate moxidectin efflux in rat hepatocytes.

  Journal of veterinary pharmacology and therapeutics 20061201

• Evidence that moxidectin is a greater risk factor than ivermectin in the development of resistance to macrocyclic lactones by Ostertagia spp in sheep in south eastern Australia.

  New Zealand veterinary journal 20061201

• Influence of dyslipidemia on moxidectin distribution in plasma lipoproteins and on its pharmacokinetics.

  Pharmaceutical research 20061101

• Clinical and therapeutic studies on mange in horses.

  Veterinary parasitology 20061010

• Clinical presentation and management of moxidectin toxicity in two dogs.

  The Journal of small animal practice 20061001

• Cyathostomes in horses in Canada resistant to pyrantel salts and effectively removed by moxidectin.

  Veterinary parasitology 20060831

• Small strongyle infection: consequences of larvicidal treatment of horses with fenbendazole and moxidectin.

  Veterinary parasitology 20060630

• Efficacy of moxidectin 2 per cent oral gel against cyathostomins, particularly third-stage inhibited larvae, in horses.

  The Veterinary record 20060603

• Investigations into the prevention of prenatal and lactogenic Toxocara canis infections in puppies by application of moxidectin to the pregnant dog.

  Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20060601

• Comparison of efficacy of moxidectin and ivermectin in the treatment of Strongyloides fulleborni infection in rhesus macaques.

  Journal of medical primatology 20060601

• Dose determination of the persistent activity of moxidectin long-acting injectable formulations against various nematode species in cattle.

  Veterinary parasitology 20060430

• Comparative effects of milbemycin oxime-based and febantel-pyrantel embonate-based anthelmintic tablets on Toxocara canis egg shedding in naturally infected pups.

  Veterinary parasitology 20060430

• A multicenter evaluation of the effectiveness of Quest Gel (2% moxidectin) against parasites infecting equids.

  Veterinary parasitology 20060415

• The interaction between moxidectin and MDR transporters in primary cultures of rat hepatocytes.

  Journal of veterinary pharmacology and therapeutics 20060401

• Improving resilience against natural gastrointestinal nematode infections in browsing kids during the dry season in tropical Mexico.

  Veterinary parasitology 20060130

• Contribution of lymphatic transport to the systemic exposure of orally administered moxidectin in conscious lymph duct-cannulated dogs.

  European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060101

• The efficacy of an imidacloprid/moxidectin combination against naturally acquired Sarcoptes scabiei infestations on dogs.

  Australian veterinary journal 20060101

• A field trial evaluation of the effectiveness and benefit of cydectin long-acting injectable and ivomec injectable as used one time in grazing stocker cattle.

  Veterinary therapeutics : research in applied veterinary medicine 20060101

• Determination of abamectin, doramectin, emamectin, eprinomectin, ivermectin, and moxidectin in milk by liquid chromatography electrospray tandem mass specrometry.

  Journal of AOAC International 20060101

• Further characterisation of a triple resistant field isolate of Teladorsagia from a Scottish lowland sheep farm.

  Veterinary parasitology 20051210

• Efficacy of moxidectin 0.5% pour-on against naturally acquired nematode infections in cattle in the Mexican tropics.

  Veterinary parasitology 20051125

• Six-month prophylactic efficacy of moxidectin sustained release (SR) injectable for dogs against experimental heartworm infection in growing puppies.

  Veterinary parasitology 20051024

• Safety evaluation of moxidectin sustained-release injectable in 10-week-old puppies.

  Veterinary parasitology 20051024

• Imidacloprid/moxidectin topical solution for the prevention of heartworm disease and the treatment and control of flea and intestinal nematodes of cats.

  Veterinary parasitology 20051024

• Total synthesis of milbemycins: a synthesis of (6R)-6-hydroxy-3,4-dihydromilbemycin E.

  Organic & biomolecular chemistry 20051021

• A total synthesis of milbemycin G: approaches to the C1-C10-fragment and completion of the synthesis.

  Organic & biomolecular chemistry 20051021

• Moxidectin and ivermectin metabolic stability in sheep ruminal and abomasal contents.

  Journal of veterinary pharmacology and therapeutics 20051001

• Safety of imidacloprid plus moxidectin topical solution applied to cats heavily infected with adult heartworms (Dirofilaria immitis).

  Parasitology research 20051001

• Imidacloprid plus moxidectin topical solution for the prevention of heartworm disease (Dirofiloria immitis) in dogs.

  Parasitology research 20051001

• Efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of sarcoptic mange and otoacariosis in dogs: results af a European field study.

  Parasitology research 20051001

• Evaluation of the efficacy and safety of imidacloprid 10% plus moxidectin 2.5% spot-on in the treatment of generalized demodicosis in dogs: results of a European field study.

  Parasitology research 20051001

• Efficacy of a combination of imidacloprid and moxidectin against parasites of reptiles and rodents: case reports.

  Parasitology research 20051001

• Control of endoparasites in horses with a gel containing moxidectin and praziquantel.

  The Veterinary record 20050625

• Efficacy of moxidectin injectable and pour-on formulations in a pilot control program against bovine hypodermosis in Southern Italy.

  Preventive veterinary medicine 20050610

• Effect of moxidectin selection on the genetic variation within Cylicocyclus nassatus based on amplified fragment length polymorphism (AFLP).

  International journal for parasitology 20050601

• Selamectin is a potent substrate and inhibitor of human and canine P-glycoprotein.

  Journal of veterinary pharmacology and therapeutics 20050601

• Treatment of dog thelaziosis caused by Thelazia callipaeda (Spirurida, Thelaziidae) using a topical formulation of imidacloprid 10% and moxidectin 2.5%.

  Veterinary parasitology 20050420

• Characterization of moxidectin resistant Trichostrongylus colubriformis and Haemonchus contortus.

  Veterinary parasitology 20050310

• Efficacy of an injectable, sustained-release formulation of moxidectin in preventing experimental heartworm infection in mongrel dogs challenged 12 months after administration.

  Veterinary parasitology 20050310

• Effects of three anthelmintic regimes on milk yield of ewes and growth of lambs.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20050301

• Failure of moxidectin to control benzimidazole-, levamisole- and ivermectin-resistant Teladorsagia circumcinda in a sheep flock.

  The Veterinary record 20050122

• A single dose of topical moxidectin as an effective treatment for murine acariasis due to Myocoptes musculinus.

  Contemporary topics in laboratory animal science 20050101

• Therapeutic and persistent efficacy of a single injection treatment of ivermectin and moxidectin against Boophilus microplus (Acari: Ixodidae) on infested cattle.

  Experimental & applied acarology 20050101

• The use of sarmazenil in the treatment of a moxidectin intoxication in a foal.

  Journal of veterinary internal medicine 20050101

• Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.

  Parasitology 20050101

• Effects of subcutaneous injections of a long acting moxidectin formulation in grazing beef cattle on parasite fecal egg reduction and animal weight gain.

  Veterinary parasitology 20041215

• Evaluation of a single injection of a sustained-release formulation of moxidectin for prevention of experimental heartworm infection after 12 months in dogs.

  American journal of veterinary research 20041101

• Comparative depletion of ivermectin and moxidectin milk residues in dairy sheep after oral and subcutaneous administration.

  The Journal of dairy research 20041101

• Milk excretion of ivermectin and moxidectin in dairy sheep: assessment of drug residues during cheese elaboration and ripening period.

  Journal of agricultural and food chemistry 20041006

• Enhancement of oral moxidectin bioavailability in rabbits by lipid co-administration.

  Parasitology research 20041001

• Endectocide exchanges between grazing cattle after pour-on administration of doramectin, ivermectin and moxidectin.

  International journal for parasitology 20041001

• Characterisation of two triple resistant field isolates of Teladorsagia from Scottish lowland sheep farms.

  Veterinary parasitology 20040902

• Adverse drug event reports at the United States Food And Drug Administration Center for Veterinary Medicine.

  Journal of the American Veterinary Medical Association 20040815

• Benzimidazole resistance in cyathostomin populations on horse farms in western Anatolia, Turkey.

  Parasitology research 20040801

• The influence of parasitism on the pharmacokinetics of moxidectin in lambs.

  Parasitology research 20040601

• Mutations in the extracellular domains of glutamate-gated chloride channel alpha3 and beta subunits from ivermectin-resistant Cooperia oncophora affect agonist sensitivity.

  Journal of neurochemistry 20040601

• Amphids: the neuronal ultrastructure of macrocyclic-lactone-resistant Haemonchus contortus.

  Parassitologia 20040601

• Dermal safety study with imidacloprid/moxidectin topical solution in the ivermectin-sensitive collie.

  Veterinary parasitology 20040526

• Treatment of small lungworm infestation in sheep by using moxidectin.

  Veterinary parasitology 20040526

• Therapeutic and persistent efficacy of moxidectin 1% nonaqueous injectable formulation against natural and experimentally induced lung and gastrointestinal nematodes in cattle.

  Veterinary parasitology 20040415

• Evaluation of the chemoprophylactic efficacy of 10% long acting injectable moxidectin against gastrointestinal nematode infections in calves in Belgium.

  Veterinary parasitology 20040415

• Treatment protocols for demodicosis: an evidence-based review.

  Veterinary dermatology 20040401

• Current trends in the treatment of Sarcoptes, Cheyletiella and Otodectes mite infestations in dogs and cats.

  Veterinary dermatology 20040401

• Persistent activity of moxidectin long-acting injectable formulations against natural and experimentally enhanced populations of lice infesting cattle.

  Veterinary parasitology 20040325

• Agonist enhacement of macrocyclic lactone activity at a glutamate-gated chloride channel subunit from Haemonchus contortus.

  Biochemical pharmacology 20040315

• Development of a novel self-medicating applicator for control of internal and external parasites of wild and domestic animals.

  The Onderstepoort journal of veterinary research 20040301

• Field efficacy of moxidectin 1 per cent against Thelazia callipaeda in naturally infected dogs.

  The Veterinary record 20040131

• Use of an injectable, sustained-release formulation of moxidectin to prevent canine subcutaneous dirofilariosis.

  The Veterinary record 20040103

• Influence of verapamil on the pharmacokinetics of the antiparasitic drugs ivermectin and moxidectin in sheep.

  Parasitology research 20040101

• A detailed assessment of the pattern of moxidectin tissue distribution after pour-on treatment in calves.

  Journal of veterinary pharmacology and therapeutics 20031201

• Treatment and follow-up of clinical cyathostominosis in horses.

  Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20031201

• Multiresistant nematodes on a Devon farm.

  The Veterinary record 20031108

• Selection at a gamma-aminobutyric acid receptor gene in Haemonchus contortus resistant to avermectins/milbemycins.

  Molecular and biochemical parasitology 20031001

• The antiparasitic moxidectin: safety, tolerability, and pharmacokinetics in humans.

  Journal of clinical pharmacology 20031001

• The comparative serum disposition kinetics of subcutaneous administration of doramectin, ivermectin and moxidectin in the Australian Merino sheep.

  Journal of veterinary pharmacology and therapeutics 20031001

• Fly larvicidal activity in the faeces of cattle and pigs treated with endectocide products.

  Medical and veterinary entomology 20030901

• Resistance to prophylactic treatment with macrocyclic lactone anthelmintics in Teladorsagia circumcincta.

  Veterinary parasitology 20030814

• [Analysis of moxidectin by LC/MS and determination of residues in adipose and muscle tissues in commercial beef].

  Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20030801

• Evaluation of the efficacy of an imidacloprid 10%/moxidectin 1% spot-on against Otodectes cynotisin cats.

  Parasitology research 20030701

• Larvicidal and persistent efficacy of an imidacloprid and moxidectin topical formulation against endoparasites in cats and dogs.

  Parasitology research 20030701

• Evaluation of the efficacy of an imidacloprid 10%/moxidectin 2.5% spot-on against Sarcoptes scabieivar canison dogs.

  Parasitology research 20030701

• Feline Advantage Heart (imidacloprid and moxidectin) topical solution as monthly treatment for prevention of heartworm infection (Dirofilaria immitis) and control of fleas (Ctenocephalides felis) on cats.

  Parasitology research 20030701

• Evaluation of the efficacy of a combination of imidacloprid and moxidectin against immature Toxocara catiin cats.

  Parasitology research 20030701

• The anthelmintic efficacy and the safety of a combination of imidacloprid and moxidectin spot-on in cats and dogs under field conditions in Europe.

  Parasitology research 20030701

• The efficacy of two anthelmintics against ascarids and hookworms in naturally infected cats.

  Parasitology research 20030701

• Dose confirmation of moxidectin 0.5% pour-on against adults and fourth-stage larvae of various Cooperia spp. and Trichostrongylus colubriformis in Louisiana.

  Veterinary parasitology 20030625

• Anthelmintic treatment in horses: the extra-label use of products and the danger of under-dosing.

  Journal of the South African Veterinary Association 20030601

• Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin.

  Veterinary parasitology 20030325

• Effect of moxidectin against natural infestation of the cattle tick Boophilus microplus (Acarina: Ixodidae) in the Mexican tropics.

  Veterinary parasitology 20030213

• Efficacy of ivermectin and moxidectin against Otostrongylus circumlitus and Parafilaroides gymnurus in harbour seals (Phoca vitulina).

  The Veterinary record 20030201

• The effect of treatment with a 1% injectable formulation of moxidectin during the rainy season and at the beginning of the dry season on gastrointestinal nematodes in cattle from communal areas in Zimbabwe.

  Tropical animal health and production 20030201

• The effect of anthelmintic capsules on the egg output and larval viability of drug-resistant parasites.

  Veterinary research communications 20030201

• Simultaneous determination of residual antiparasitic lactones in bovine muscle and liver by liquid chromatography with fluorescence detection.

  Journal of AOAC International 20030101

• Persistent efficacy of moxidectin canine sustained-release injectable against experimental infections of Ancylostoma caninum and Uncinaria stenocephala in dogs.

  Veterinary therapeutics : research in applied veterinary medicine 20030101

• Field evaluation of moxidectin/praziquantel oral gel in horses.

  Veterinary therapeutics : research in applied veterinary medicine 20030101

• Full season efficacy of moxidectin microsphere sustained release formulation for the prevention of heartworm (Dirofilaria immitis) infection in dogs.

  Veterinary parasitology 20021211

• Reductions of non-pest insects in dung of cattle treated with endectocides: a comparison of four products.

  Bulletin of entomological research 20021201

• Strategic use of moxidectin or closantel in combination with levamisole in the control of nematodes of sheep in the highlands of central Kenya.

  Acta tropica 20021101

• Resistance to therapeutic treatment with macrocyclic lactone anthelmintics in Ostertagia circumcincta.

  Veterinary parasitology 20021016

• Pharmacokinetics and dose proportionality of oral moxidectin in beagle dogs.

  Biopharmaceutics & drug disposition 20021001

• Does the rate of fat deposition influence the pharmacokinetic disposition of subcutaneously administered moxidectin and ivermectin in pigs?

  Journal of veterinary pharmacology and therapeutics 20021001

• Equine faecal egg counts and comparison of fenbendazole and moxidectin.

  The Veterinary record 20020928

• Efficacy of macrocyclic lactone endectocides against Boophilus microplus (Acari: Ixodidae) infested cattle using different pour-on application treatment regimes.

  Journal of medical entomology 20020901

• Determination of ivermectin and moxidecin residues in bovine milk and examination of the effects of these residues on acid fermentation of milk.

  Food additives and contaminants 20020901

• Patterns of equine faecal egg counts following spring dosing with either fenbendazole or moxidectin.

  The Veterinary record 20020831

• Dose confirmation studies of moxidectin 1% non-aqueous injectable and moxidectin 0.5% pour-on formulations against experimentally induced infections of larval and adult stage Oesophagostomum radiatum and Trichuris discolor in cattle.

  Veterinary parasitology 20020830

• A review of moxidectin overdose cases in equines from 1998 through 2000.

  Veterinary and human toxicology 20020801

• Liquid chromatographic assay of moxidectin in human plasma for application to pharmacokinetic studies.

  Journal of pharmaceutical and biomedical analysis 20020731

• The effects of ivermectin and moxidectin on egg viability and larval development of ivermectin-resistant Haemonchus contortus.

  Veterinary parasitology 20020729

• Efficacy of moxidectin 1% injectable and 0.2% oral drench against natural infection by Dictyocaulus filaria in sheep.

  Veterinary parasitology 20020729

• Breed differences on the plasma availability of moxidectin administered pour-on to calves.

  Veterinary journal (London, England : 1997) 20020701

• The effects of body composition on the pharmacokinetics of subcutaneously injected ivermectin and moxidectin in pigs.

  Journal of veterinary pharmacology and therapeutics 20020601

• Persistent activity of moxidectin pour-on and injectable against sucking and biting louse infestations of cattle.

  Veterinary parasitology 20020402

• Loperamide-induced enhancement of moxidectin availability in cattle.

  Journal of veterinary pharmacology and therapeutics 20020401

• Use of moxidectin tablets in the control of canine subcutaneous dirofilariosis.

  The Veterinary record 20020323

• A glutamate-gated chloride channel subunit from Haemonchus contortus: expression in a mammalian cell line, ligand binding, and modulation of anthelmintic binding by glutamate.

  Biochemical pharmacology 20020315

• Apparent resistance of Parascaris equorum to macrocylic lactones.

  The Veterinary record 20020302

• Selection for resistance to macrocyclic lactones by Haemonchus contortus in sheep.

  Veterinary parasitology 20020103

• Efficacy of moxidectin 6-month injectable and milbemycin oxime/lufenuron tablets against naturally acquired toxocara canis infections in dogs.

  Veterinary therapeutics : research in applied veterinary medicine 20020101

• Efficacy of moxidectin 6-month injectable and milbemycin oxime/lufenuron tablets against naturally acquired trichuris vulpis infections in dogs.

  Veterinary therapeutics : research in applied veterinary medicine 20020101

• Efficacy of moxidectin 1% injectable against natural infection of Sarcoptes scabiei in sheep.

  Veterinary parasitology 20011203

• Reduced efficacy of ivermectin, abamectin and moxidectin against field isolates of Haemonchus contortus.

  Australian veterinary journal 20011201

• Activity of an injectable, sustained-release formulation of moxidectin administered prophylactically to mixed-breed dogs to prevent infection with Dirofilaria immitis.

  American journal of veterinary research 20011101

• Cyathostome fecal egg count trends in horses treated with moxidectin, ivermectin or fenbendazole.

  Veterinary parasitology 20011031

• Evaluation of the persistent activity of injectable endectocides against Psoroptes ovis.

  The Veterinary record 20011027

• Comparison of subcutaneous ivermectin and oral moxidectin for the treatment of notoedric acariasis in hamsters.

  The Veterinary record 20010915

• Extraction and isolation of avermectins and milbemycins from liver samples using unmodified supercritical CO2 with in-line trapping on basic alumina.

  Journal of chromatography. B, Biomedical sciences and applications 20010915

• Plasma pharmacokinetics and faecal excretion of ivermectin, doramectin and moxidectin following oral administration in horses.

  Equine veterinary journal 20010901

• In vitro metabolism of moxidectin in Haemonchus contortus adult stages.

  Parasitology research 20010901

• Efficacy of moxidectin for the prevention of adult heartworm (Dirofilaria immitis) infection in dogs.

  Parassitologia 20010901

• A comparison of the development and survival of the dung beetle, Onthophagus taurus (Schreb.) when fed on the faeces of cattle treated with pour-on formulations of eprinomectin or moxidectin.

  Veterinary parasitology 20010801

• Comparative efficacy, persistent effect, and treatment intervals of anthelmintic pastes in naturally infected horses.

  Veterinary parasitology 20010731

• In vitro metabolism of 14C-moxidectin by hepatic microsomes from various species.

  Veterinary research communications 20010701

• Cutaneous xanthomas with concurrent demodicosis and dermatophytosis in a cat.

  Australian veterinary journal 20010701

• Resistance of Cooperia to ivermectin treatments in grazing cattle of the Humid Pampa, Argentina.

  Veterinary parasitology 20010612

• Influence of verapamil on the efflux and metabolism of 14C moxidectin in cultured rat hepatocytes.

  Journal of veterinary pharmacology and therapeutics 20010601

• Milk kinetics of moxidectin and doramectin in goats.

  Research in veterinary science 20010601

• Selection of different genotype larvae and adult worms for anthelmintic resistance by persistent and short-acting avermectin/milbemycins.

  International journal for parasitology 20010515

• Development and optimisation of an improved derivatisation procedure for the determination of avermectins and milbemycins in bovine liver.

  The Analyst 20010501

• Persistent efficacy of doramectin and moxidectin against Cooperia oncophora infections in cattle.

  Veterinary parasitology 20010419

• Pharmacokinetics of moxidectin and ivermectin following intravenous injection in pigs with different body compositions.

  Journal of veterinary pharmacology and therapeutics 20010401

• Larvicidal activity of endectocides against pest flies in the dung of treated cattle.

  Medical and veterinary entomology 20010301

• Efficacy of moxidectin 2 per cent gel against naturally acquired strongyle infections in horses, with particular reference to larval cyathostomes.

  The Veterinary record 20010203

• Multi-residue analysis of avermectins and moxidectin by ion-trap LC-MSn.

  The Analyst 20010201

• Efficacy of macrocyclic lactones for the control of larvae of the Old World screw-worm fly (Chrysomya bezziana).

  Australian veterinary journal 20010201

• Faecal excretion profile of moxidectin and ivermectin after oral administration in horses.

  Veterinary journal (London, England : 1997) 20010101

• Evaluation of a strategic deworming program in dairy heifers in Quebec based on the use of moxidectin, an endectocide with a long persistency.

  The Canadian veterinary journal = La revue veterinaire canadienne 20010101