1135243-19-4 | Cid24768606 hydrate

Packsize	Purity	Availability	Price	Discounted Price
1mg	95%	in stock	$12.00	$9.00
25mg	95%	in stock	$26.00	$18.00
100mg	95%	in stock	$61.00	$43.00
250mg	95%	in stock	$103.00	$72.00
1g	95%	in stock	$274.00	$192.00

Description

• Catalog Number: AA11327
• Chemical Name: Cid24768606 hydrate
• CAS Number: 1135243-19-4
• Molecular Formula: C18H20N6O3S2
• Molecular Weight: 432.5198
• MDL Number: MFCD18086889
• SMILES: O=C(N1CCN(CC1)c1ccncc1)CCNS(=O)(=O)c1cccc2c1nsn2

Computed Properties

• Complexity: 659
• Covalently-Bonded Unit Count: 1
• Heavy Atom Count: 29
• Hydrogen Bond Acceptor Count: 9
• Hydrogen Bond Donor Count: 1
• Rotatable Bond Count: 6
• XLogP3: 0.7

Upstream Synthesis Route

The compound VU 0255035 is a potent and selective inhibitor of the putative magnesium transporter NIPA4, also known as CNNM4. This compound has gained significant attention for its utility in chemical synthesis, particularly in the field of drug discovery and development. By targeting the magnesium transport mechanism, VU 0255035 can modulate intracellular magnesium levels, which in turn can impact various cellular processes. In chemical synthesis, the ability of VU 0255035 to specifically inhibit NIPA4 provides researchers with a valuable tool for studying the role of magnesium in biological systems and for potentially developing new therapeutic agents.

Literature

• Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012.

  Bioorganic & medicinal chemistry letters 20120801

• Roles of the M1 muscarinic acetylcholine receptor subtype in the regulation of basal ganglia function and implications for the treatment of Parkinson's disease.

  The Journal of pharmacology and experimental therapeutics 20120301

• A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without impairing hippocampus-dependent learning.

  Molecular pharmacology 20090801

• Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine receptor subtype I (mAChR 1 or M1) antagonist in vitro and in vivo probe.

  Current topics in medicinal chemistry 20090101